Manidipine | 美尼地平 | CV-4093 | Calcium Channel Inhibitor

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马尼地平 /Manidipine 98%

货号：A268936 同义名： 美尼地平 / CV-4093;Franidipine

Manidipine is a calcium channel blocker that is used clinically as an antihypertensive.

Manidipine 化学结构
CAS号：89226-50-6

Manidipine 3D分子结构
CAS号：89226-50-6

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Manidipine 纯度/质量文件产品仅供科研

货号：A268936 标准纯度： 98% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024, 67(17): 14974-14985. Ambeed. [ A288696 ]; • JMC, 2024, 67(17): 15061-15079. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

Calcium Channel 亚型比较

产品名称	Ca2+ channel-like protein ↓ ↑	Calcium Channel ↓ ↑	Cav 2.2 ↓ ↑	其他靶点	纯度
CDC25B-IN-2	✔			Akt	99%+
Clevidipine		✔			97%
Verapamil HCl		✔			99%
Amlodipine		✔			99%
Amlodipine maleate		✔			98%
(+)-cis-Diltiazem HCl		✔			95%
Zegocractin		++ Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM			99%+
Tanshinone IIA sulfonate sodium		✔			98%
Ulixacaltamide		++ hCaV3.1, IC50: 50 nM hCaV3.2, IC50: 110 nM			99%+
Dronedarone Hydrochloride		✔			95%
Nitrendipine		+ Calcium channel, IC50: 95 nM			98%
Efonidipine HCl monoethanolate		✔			98%
Cinnarizine		✔			98%
SEA0400		++ NCX, IC50: 33 nM		ROS,ERK,p38 MAPK	99%+
Fasudil HCl		✔		Rho,PKA	98%
ML-9		✔		MLCK,Akt	99%+
Flunarizine 2HCl		+ Calcium channel, Ki: 68 nM			95%
Lomerizine 2HCl		✔			98%
Efonidipine		✔			98%
Levamlodipine		✔			97%
Nisoldipine		++ L-type Cav1.2, IC50: 10 nM			97%
Isradipine		✔			98%
Lacidipine		✔			98%
Lercanidipine		✔			98%
Loureirin B		✔		Potassium Channel	99%+
Tetracaine HCl		✔			98%
Manidipine		+++ Calcium channel, IC50: 2.6 nM			98%
Manidipine Dihydrochlorid		+++ Calcium channel, IC50: 2.6 nM			98%
Nicardipine		✔			98%
Wilforgine		✔			98+%
Econazole		✔			99%+
Ginsenoside Rd		✔		NF-κB	98%
Fendiline HCl		✔			98+%
Mesaconitine		✔			98%
Tetrandrine		✔			95%
Nifedipine		✔			95%
Nilvadipine		++++ Calcium channel, IC50: 0.03 nM			98%
Barnidipine		++++ [³H]nitrendipine, Ki: 0.21 nM			95+%
Azelnidipine		✔			97%
Levetiracetam		✔			98%
Nimodipine		✔			95%
Benidipine HCl		✔			98%
Pinaverium bromide		✔			98%
Pranidipine		✔			98%
NP118809		+ L-type calcium channel, IC50: 12.2 μM N-type Ca2+ channel, IC50: 0.11 μM			98%
Amlodipine Besylate		+++ Calcium channel, IC50: 1.9 nM			97%
Cilnidipine		✔			98%
Cinepazide Maleate		✔			98%
Terfenadine		✔			98%
YM-58483		✔			99%+
Ranolazine		✔			98%
Praeruptorin A		✔		p38 MAPK,Akt	98%
Ranolazine 2HCl		✔			98%
Felodipine		++++ L-type calcium channel, IC50: 0.15 nM			98%
PD173212		+++ N-type Ca2+ channel, IC50: 36 nM			98%
Levamlodipine besylate		✔			97%
Carboxyamidotriazole Orotate		✔			98%
IGS-1.76		✔			98+%
WH-4-023		++++ Cav 2.2, IC50: 0.001 μM	++++ Cav 2.2, IC50: 0.001 μM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Manidipine 生物活性

靶点	Calcium Channel Calcium channel, IC50:2.6 nM
描述	Manidipine is a calcium channel blocker that is used clinically as an antihypertensive.

Manidipine 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00627952	Hypertension	Phase 3	Completed	-	Germany ... 展开 >> Clinical Research Center, Department of Nephrology and Hypertension, University of Erlangen-Nurnberg Erlangen, Bavaria, Germany, 91054 收起 <<
NCT00157586	Type 2 Diabetes	Phase 3	Completed	-	Italy ... 展开 >> ASL of Ponte San Pietro - Diabetologic Unit Ponte San Pietro, Bergamo, Italy, 24036 Clinical Research Center for Rare Diseases Ranica, Bergamo, Italy, 24020 Hospital of Romano di Lombardia - Diabetologic Unit Romano di Lombardia, Bergamo, Italy, 24058 Hospital " Bolognini " - Medicine Unit Seriate, Bergamo, Italy, 24068 Hospital " Treviglio Caravaggio" - Diabetologic Unit Treviglio, Bergamo, Italy, 24128 Humanitas Institute - Endocrinology and Diabetologic Unit Rozzano, Milano, Italy, 20089 Hospital "Ospedali Riuniti di Bergamo" - Diabetologic Unit Bergamo, Italy, 24128 Slovenia Department of Endocrinolgy, Diabetes and Metabolic Disease - University Medical Center Lubiana, Slovenia 收起 <<
NCT00741585	Essential Hypertension ... 展开 >> Cardiovascular Disease Stroke Chronic Kidney Disease 收起 <<	Phase 4	Completed	-	Spain ... 展开 >> CS Friol Friol, Lugo, Spain, 27220 CS Baiona Baiona, Pontevedra, Spain, 36300 CS Bueu Bueu, Pontevedra, Spain, 36930 CS A Estrada La Estrada, Pontevedra, Spain, 26680 CS A Guarda La Guardia, Pontevedra, Spain, 36780 CS Valmiñor Nigran, Pontevedra, Spain, 36250 CS Panxón Nigrán, Pontevedra, Spain, 36340 CS Tomiño Tomiño, Pontevedra, Spain, 36200 Bioengineering & Chronobilogy Labs., University of Vigo Vigo, Pontevedra, Spain, 36200 Hospital do Meixoeiro Vigo, Pontevedra, Spain, 36200 CS Calle Cuba Vigo, Pontevedra, Spain, 36202 CS A Doblada Vigo, Pontevedra, Spain, 36205 CS Coia Vigo, Pontevedra, Spain, 36209 CS Sardoma Vigo, Pontevedra, Spain, 36214 CS Teis Vigo, Pontevedra, Spain, 36216 CS Vilaboa Vilaboa, Pontevedra, Spain, 36141 CS San Roque Vilagarcía De Arousa, Pontevedra, Spain, 36600 CS Fingoi Lugo, Spain, 27002 Complexo Hospitalario Universitario de Ourense Orense, Spain, 32005 CS Lerez Pontevedra, Spain, 36156 收起 <<

Manidipine 参考文献

[1]Rossoni G, Manfredi B, et al. Combined simvastatin-manidipine protect against ischemia-reperfusion injury in isolated hearts from normocholesterolemic rats. Eur J Pharmacol. 2008 Jun 10;587(1-3):224-30.

[2]Roth M, Keul R, et al. Manidipine regulates the transcription of cytokine genes. Proc Natl Acad Sci U S A. 1992 May 1;89(9):4071-5.

Manidipine 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.64mL

0.33mL

0.16mL

8.19mL

1.64mL

0.82mL

16.37mL

3.27mL

1.64mL

Manidipine 技术信息

CAS号	89226-50-6
分子式	C₃₅H₃₈N₄O₆
分子量	610.699

别名	美尼地平 ;CV-4093;Franidipine;Manidipine 6300;(±)-Manidipine
运输	蓝冰

存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00627952	Hypertension	Phase 3	Completed	-	Germany ... 展开 >> Clinical Research Center, Department of Nephrology and Hypertension, University of Erlangen-Nurnberg Erlangen, Bavaria, Germany, 91054 收起 <<
NCT00157586	Type 2 Diabetes	Phase 3	Completed	-	Italy ... 展开 >> ASL of Ponte San Pietro - Diabetologic Unit Ponte San Pietro, Bergamo, Italy, 24036 Clinical Research Center for Rare Diseases Ranica, Bergamo, Italy, 24020 Hospital of Romano di Lombardia - Diabetologic Unit Romano di Lombardia, Bergamo, Italy, 24058 Hospital " Bolognini " - Medicine Unit Seriate, Bergamo, Italy, 24068 Hospital " Treviglio Caravaggio" - Diabetologic Unit Treviglio, Bergamo, Italy, 24128 Humanitas Institute - Endocrinology and Diabetologic Unit Rozzano, Milano, Italy, 20089 Hospital "Ospedali Riuniti di Bergamo" - Diabetologic Unit Bergamo, Italy, 24128 Slovenia Department of Endocrinolgy, Diabetes and Metabolic Disease - University Medical Center Lubiana, Slovenia 收起 <<
NCT00741585	Essential Hypertension ... 展开 >> Cardiovascular Disease Stroke Chronic Kidney Disease 收起 <<	Phase 4	Completed	-	Spain ... 展开 >> CS Friol Friol, Lugo, Spain, 27220 CS Baiona Baiona, Pontevedra, Spain, 36300 CS Bueu Bueu, Pontevedra, Spain, 36930 CS A Estrada La Estrada, Pontevedra, Spain, 26680 CS A Guarda La Guardia, Pontevedra, Spain, 36780 CS Valmiñor Nigran, Pontevedra, Spain, 36250 CS Panxón Nigrán, Pontevedra, Spain, 36340 CS Tomiño Tomiño, Pontevedra, Spain, 36200 Bioengineering & Chronobilogy Labs., University of Vigo Vigo, Pontevedra, Spain, 36200 Hospital do Meixoeiro Vigo, Pontevedra, Spain, 36200 CS Calle Cuba Vigo, Pontevedra, Spain, 36202 CS A Doblada Vigo, Pontevedra, Spain, 36205 CS Coia Vigo, Pontevedra, Spain, 36209 CS Sardoma Vigo, Pontevedra, Spain, 36214 CS Teis Vigo, Pontevedra, Spain, 36216 CS Vilaboa Vilaboa, Pontevedra, Spain, 36141 CS San Roque Vilagarcía De Arousa, Pontevedra, Spain, 36600 CS Fingoi Lugo, Spain, 27002 Complexo Hospitalario Universitario de Ourense Orense, Spain, 32005 CS Lerez Pontevedra, Spain, 36156 收起 <<
NCT03106597	Hypertension	Phase 4	Recruiting	December 10, 2018	Korea, Republic of ... 展开 >> Yonsei University Severance Hospital Recruiting Seoul, Korea, Republic of, 03722 Contact: Sang Hak Lee, MD, PhD 82-10-5472-6911 shl1106@yuhs.ac Sub-Investigator: Sang Hak Lee, MD, PhD Korea University Guro Hospital Recruiting Seoul, Korea, Republic of, 08308 Contact: Seung-hoe Song, MBE 82-2-2626-1635 ssessong@korea.ac.kr Contact: Da-in Lee 82-2-2626-2279 0124dain@gmail.com Yonsei University Wonju Hospital Recruiting Wonju, Korea, Republic of, 26426 Contact: Jang Young Kim, PhD Contact 82-10-5360-0463 kimjy@yonsei.ac.kr Sub-Investigator: Jang Young Kim, PhD 收起 <<

马尼地平 /Manidipine 98%

Manidipine 纯度/质量文件产品仅供科研

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Manidipine 生物活性

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Manidipine 参考文献

Manidipine 实验方案

Manidipine 技术信息

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马尼地平 /Manidipine 98%

Manidipine 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Manidipine 质控信息

Manidipine 生物活性

Manidipine 临床研究

Manidipine 参考文献

Manidipine 实验方案

Manidipine 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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