Cilnidipine is a calcium channel blocker that blocks both L and N-type calcium channels and inhibits excessive release of norepinephrine from the sympathetic nerve ending. Cilnidipine which inhibits N-type calcium channels is more useful for patients with hypertension and diabetes mellitus from its effects on glucose and lipid metabolism and renal function[3]. Cilnidipine selectively reduced only L-type HVA I(Ca) at the low concentrations under 10(-7) and 10(-6) M. Cilnidipine blocked not only L- but also N-type HVA I(Ca). At the high concentration over 10(-6) M cilnidipine non-selectively blocked the T-type LVA and P/Q- and R-type HVA Ca2+ channels[4]. In the rat focal brain ischemia model, an anti-hypertensive and anti-sympathetic dose of cilnidipine could reduce the size of cerebral infarction, whereas an equipotent hypotensive dose of nilvadipine failed to affect it[5]. Cilnidipine is more effective than amlodipine at improving renal function and arterial stiffness in patients with essential hypertension[6]. Cilnidipine, a commercially available NTCC-blocking drug (N-type Ca2+-channels), prevents AF-induced autonomic, electrical and structural remodelling, along with associated AF (atrial fibrillation) promotion[7]. Cilnidipine has an advantage of causing less reflex tachycardia, less pedal edema and better control of proteinuria in comparison to L-type CCB (calcium channel blocker). By causing dilatation of efferent arteriole, it causes less damage to glomeruli and suppresses podocyte injury. Cilnidipine also increases insulin sensitivity. Cilnidipine as CCB can be a good choice in hypertensive patients with diabetes, chronic kidney disease and in patients developing pedal edema with other CCB[8].
Japan
... 展开 >> Kyorin University School of Medicine
Not yet recruiting
Mitaka, Tokyo, Japan, 181-8611
Contact: Eiji Higashihara, M.D. 81+422475511 ext 5813 ehigashi@kyorin-u.ac.jp
Contact: Kikuo Nutahara, M.D. 81-422475511 ext 5815 kinuta@kyorin-u.ac.jp
Department of Urology, National Hospital Organaization Chiba-East Hospital
Not yet recruiting
Chiba, Chiba, Japan, 260-8712
Contact: Koichi Kamura, MD 81+432615171 ext 7607 kamura@cehpnet.com
Toranomon Hospital Kajigaya, Kidney center
Not yet recruiting
Kanagawa, Japan, 213-8587
Contact: Yoshifumi Ubara, MD 81+448775111 ext 6064 ubara@toranomon.gr.jp
Toranomon Hospital, Kidney center
Not yet recruiting
Tokyo, Japan, 105-8470
Contact: Kenmei Tkaichi, MD 81+335881111 ext 7065 takaichi@toranomon.gr.jp
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
Not yet recruiting
Tokyo, Japan, 105-8471
Contact: Tatsuo Hosoya, MD 81+334331111 ext 3220 t-hosoya@jikei.ac.jp
Contact: Kazushige Hanaoka, MD 81+334331111 ext 3221 khanaoka@jikei.ac.jp
Department of Urology, Teikyo University, School of Medicine
Not yet recruiting
Tokyo, Japan, 173-8605
Contact: Shigeo Horie, MD 81+339641211 shorie@med.teikyo-u.ac.jp
Contact: Satoru Muto, MD 81+33964-1211 muto@med.teikyo-u.ac.jp 收起 <<
Japan
... 展开 >> Department of Medicine II, Hokkaido Univserity School of Medicine
Recruiting
Sapporo, Hokkaido, Japan, 0608638
Contact: Toshio Mochizuki, MD +81117065915 mtoshi@med.hokudai.ac.jp
Principal Investigator: Toshio Mochizuki, MD
Toranomon Hospital Kajigaya, Kidney center
Not yet recruiting
Kawasaki, Kanagawa, Japan, 2138587
Contact: Yoshihumi Ubara, MD +81448775111 ext 6064 ubara@toranomon.gr.jp
Principal Investigator: Yoshihumi Ubara, MD
Department of Medicine II, Nippon Medical School
Not yet recruiting
Bunkyo-ku, Tokyo, Japan, 1138602
Contact: Yasuhiko Iino, MD +81338222131 iinoyasuhiko@nms.ac.jp
Principal Investigator: Yasuhiko Iino, MD
Department of Urology, Teikyo University School of Medicine
Recruiting
Itabashi-ku, Tokyo, Japan, 1738605
Contact: Shigeo Horie, MD +81339642497 shorie@med.teikyo-u.ac.jp
Contact: Satoru Muto, MD +81339642497 muto@med.teikyo-u.ac.jp
Principal Investigator: Shigeo Horie, MD
Toranomon Hospital, Kidney center
Not yet recruiting
Minato-ku, Tokyo, Japan, 1058470
Contact: Kenmei Takaichi, MD +81335881111 ext 7065 takaichi@toranomon.gr.jp
Principal Investigator: Kenmei Takaichi, MD
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
Active, not recruiting
Minato-ku, Tokyo, Japan, 1058471
Department of Urology, Kyorin University School of Medicine
Not yet recruiting
Mitaka, Tokyo, Japan, 1818611
Contact: Eiji HIgashihara, MD 81422475511 ehigashi@kyorin-u.ac.jp
Contact: Kikuo Nutahara, MD 81422475511 kinuta@kyorin-u.ac.jp
Principal Investigator: Eiji Higashihara, MD
Sub-Investigator: Kikuo Nutahara, MD
Department of Urology, National Hospital Organaization Chiba-East Hospital
Not yet recruiting
Chiba, Japan, 2608712
Contact: Koichi Kamura, MD +81432615171 ext 7607 kamura@cehpnet.com
Principal Investigator: Koichi Kamura, MD
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences
Not yet recruiting
Niigata, Japan, 9518510
Contact: Ichiei Narita, MD +813252272193 naritai@med.niigata-u.ac.jp
Principal Investigator: Ichiei Narita, MD 收起 <<
Japan
... 展开 >> Kyorin University School of Medicine
Not yet recruiting
Mitaka, Tokyo, Japan, 181-8611
Contact: Eiji Higashihara, M.D. 81+422475511 ext 5813 ehigashi@kyorin-u.ac.jp
Contact: Kikuo Nutahara, M.D. 81-422475511 ext 5815 kinuta@kyorin-u.ac.jp
Department of Urology, National Hospital Organaization Chiba-East Hospital
Not yet recruiting
Chiba, Chiba, Japan, 260-8712
Contact: Koichi Kamura, MD 81+432615171 ext 7607 kamura@cehpnet.com
Toranomon Hospital Kajigaya, Kidney center
Not yet recruiting
Kanagawa, Japan, 213-8587
Contact: Yoshifumi Ubara, MD 81+448775111 ext 6064 ubara@toranomon.gr.jp
Toranomon Hospital, Kidney center
Not yet recruiting
Tokyo, Japan, 105-8470
Contact: Kenmei Tkaichi, MD 81+335881111 ext 7065 takaichi@toranomon.gr.jp
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
Not yet recruiting
Tokyo, Japan, 105-8471
Contact: Tatsuo Hosoya, MD 81+334331111 ext 3220 t-hosoya@jikei.ac.jp
Contact: Kazushige Hanaoka, MD 81+334331111 ext 3221 khanaoka@jikei.ac.jp
Department of Urology, Teikyo University, School of Medicine
Not yet recruiting
Tokyo, Japan, 173-8605
Contact: Shigeo Horie, MD 81+339641211 shorie@med.teikyo-u.ac.jp
Contact: Satoru Muto, MD 81+33964-1211 muto@med.teikyo-u.ac.jp 收起 <<
Japan
... 展开 >> Department of Medicine II, Hokkaido Univserity School of Medicine
Recruiting
Sapporo, Hokkaido, Japan, 0608638
Contact: Toshio Mochizuki, MD +81117065915 mtoshi@med.hokudai.ac.jp
Principal Investigator: Toshio Mochizuki, MD
Toranomon Hospital Kajigaya, Kidney center
Not yet recruiting
Kawasaki, Kanagawa, Japan, 2138587
Contact: Yoshihumi Ubara, MD +81448775111 ext 6064 ubara@toranomon.gr.jp
Principal Investigator: Yoshihumi Ubara, MD
Department of Medicine II, Nippon Medical School
Not yet recruiting
Bunkyo-ku, Tokyo, Japan, 1138602
Contact: Yasuhiko Iino, MD +81338222131 iinoyasuhiko@nms.ac.jp
Principal Investigator: Yasuhiko Iino, MD
Department of Urology, Teikyo University School of Medicine
Recruiting
Itabashi-ku, Tokyo, Japan, 1738605
Contact: Shigeo Horie, MD +81339642497 shorie@med.teikyo-u.ac.jp
Contact: Satoru Muto, MD +81339642497 muto@med.teikyo-u.ac.jp
Principal Investigator: Shigeo Horie, MD
Toranomon Hospital, Kidney center
Not yet recruiting
Minato-ku, Tokyo, Japan, 1058470
Contact: Kenmei Takaichi, MD +81335881111 ext 7065 takaichi@toranomon.gr.jp
Principal Investigator: Kenmei Takaichi, MD
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine
Active, not recruiting
Minato-ku, Tokyo, Japan, 1058471
Department of Urology, Kyorin University School of Medicine
Not yet recruiting
Mitaka, Tokyo, Japan, 1818611
Contact: Eiji HIgashihara, MD 81422475511 ehigashi@kyorin-u.ac.jp
Contact: Kikuo Nutahara, MD 81422475511 kinuta@kyorin-u.ac.jp
Principal Investigator: Eiji Higashihara, MD
Sub-Investigator: Kikuo Nutahara, MD
Department of Urology, National Hospital Organaization Chiba-East Hospital
Not yet recruiting
Chiba, Japan, 2608712
Contact: Koichi Kamura, MD +81432615171 ext 7607 kamura@cehpnet.com
Principal Investigator: Koichi Kamura, MD
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences
Not yet recruiting
Niigata, Japan, 9518510
Contact: Ichiei Narita, MD +813252272193 naritai@med.niigata-u.ac.jp
Principal Investigator: Ichiei Narita, MD 收起 <<
Korea, Republic of
... 展开 >>
Seoul National University Hospital
Not yet recruiting
Seoul, Korea, Republic of
Contact: Kyungsang Yu
Principal Investigator: Kyungsang Yu 收起 <<
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