Piperlongumine/荜茇酰胺
Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and an inhibitor of CRM1 and is also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.