Nicardipine | YC-93 free base | Calcium Channel Blocker | AmBeed-信号通路专用抑制剂

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尼卡地平 /Nicardipine 98%

货号：A407345 同义名： YC-93 free base

Nicardipine is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage.

Nicardipine 化学结构
CAS号：55985-32-5

Nicardipine 3D分子结构
CAS号：55985-32-5

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Nicardipine 纯度/质量文件产品仅供科研

货号：A407345 标准纯度： 98% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024, 67(17): 14974-14985. Ambeed. [ A288696 ]; • JMC, 2024, 67(17): 15061-15079. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

Calcium Channel 亚型比较

产品名称	Ca2+ channel-like protein ↓ ↑	Calcium Channel ↓ ↑	Cav 2.2 ↓ ↑	其他靶点	纯度
CDC25B-IN-2	✔			Akt	99%+
Clevidipine		✔			97%
Verapamil HCl		✔			99%
Amlodipine		✔			99%
Amlodipine maleate		✔			98%
(+)-cis-Diltiazem HCl		✔			95%
Zegocractin		++ Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM			99%+
Tanshinone IIA sulfonate sodium		✔			98%
Ulixacaltamide		++ hCaV3.1, IC50: 50 nM hCaV3.2, IC50: 110 nM			99%+
Dronedarone Hydrochloride		✔			95%
Nitrendipine		+ Calcium channel, IC50: 95 nM			98%
Efonidipine HCl monoethanolate		✔			98%
Cinnarizine		✔			98%
SEA0400		++ NCX, IC50: 33 nM		ROS,ERK,p38 MAPK	99%+
Fasudil HCl		✔		Rho,PKA	98%
ML-9		✔		MLCK,Akt	99%+
Flunarizine 2HCl		+ Calcium channel, Ki: 68 nM			95%
Lomerizine 2HCl		✔			98%
Efonidipine		✔			98%
Levamlodipine		✔			97%
Nisoldipine		++ L-type Cav1.2, IC50: 10 nM			97%
Isradipine		✔			98%
Lacidipine		✔			98%
Lercanidipine		✔			98%
Loureirin B		✔		Potassium Channel	99%+
Tetracaine HCl		✔			98%
Manidipine		+++ Calcium channel, IC50: 2.6 nM			98%
Manidipine Dihydrochlorid		+++ Calcium channel, IC50: 2.6 nM			98%
Nicardipine		✔			98%
Wilforgine		✔			98+%
Econazole		✔			99%+
Ginsenoside Rd		✔		NF-κB	98%
Fendiline HCl		✔			98+%
Mesaconitine		✔			98%
Tetrandrine		✔			95%
Nifedipine		✔			95%
Nilvadipine		++++ Calcium channel, IC50: 0.03 nM			98%
Barnidipine		++++ [³H]nitrendipine, Ki: 0.21 nM			95+%
Azelnidipine		✔			97%
Levetiracetam		✔			98%
Nimodipine		✔			95%
Benidipine HCl		✔			98%
Pinaverium bromide		✔			98%
Pranidipine		✔			98%
NP118809		+ L-type calcium channel, IC50: 12.2 μM N-type Ca2+ channel, IC50: 0.11 μM			98%
Amlodipine Besylate		+++ Calcium channel, IC50: 1.9 nM			97%
Cilnidipine		✔			98%
Cinepazide Maleate		✔			98%
Terfenadine		✔			98%
YM-58483		✔			99%+
Ranolazine		✔			98%
Praeruptorin A		✔		p38 MAPK,Akt	98%
Ranolazine 2HCl		✔			98%
Felodipine		++++ L-type calcium channel, IC50: 0.15 nM			98%
PD173212		+++ N-type Ca2+ channel, IC50: 36 nM			98%
Levamlodipine besylate		✔			97%
Carboxyamidotriazole Orotate		✔			98%
IGS-1.76		✔			98+%
WH-4-023		++++ Cav 2.2, IC50: 0.001 μM	++++ Cav 2.2, IC50: 0.001 μM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Nicardipine 生物活性

靶点

Calcium Channel

描述

Nicardipine is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure. Nicardipine is a less potent Ca++ antagonist than nifedipine in atrial fibers and that the reduction of delayed potassium current, which occurs in a similar range of concentrations to the blockade of Isi, could also be involved in its therapeutic effects^[3]. Nicardipine is more specific for vascular smooth muscle than for cardiac smooth muscle and for coronary than peripheral vasculature^[4]. Nicardipine (10-12 to 10-8 M) decreased active tension and frequency of contraction in a concentration-dependent manner. The EC50 and EC95 of nicardipine in the inhibition of active tension of the uterine smooth muscle were 2.41 × 10-10 M and 3.06 × 10-7 M, respectively. The EC50 and EC95 of nicardipine in the inhibition of frequency of contraction of the uterine smooth muscle were 9.04 × 10-11 and 4.18 × 10-7 M, respectively^[5]. CaMKII down-regulation/proteasome inhibition/cytosolic calcium up-regulation/cathepsin B activation/trypsinogen activation axis was present in pancreatic acinar cells injury under nicardipine treatment^[6].

Nicardipine 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02286089	Age-related Macular Degenerati... 展开 >>on 收起 <<	Phase 1 Phase 2	Recruiting	December 2019	United States, California ... 展开 >> Retina Vitreous Associates Medical Group Recruiting Los Angeles, California, United States, 900211 Contact: Janet Kurokouchi, B.Sc. 310-289-2478 ext 1243 JKurokouchi@laretina.com Contact: Gerard Aquino, B.Sc. 310-289-2478 ext 1225 GAquino@laretina.com Principal Investigator: David Boyer, MD Byers Eye Institute, Stanford School of Medicine Recruiting Palo Alto, California, United States, 94303 Contact: Lisa Greer, MBA 650-725-9184 lgreer7@stanford.edu Principal Investigator: Diana Do, Prof. Retinal Consultants Medical Group Recruiting Sacramento, California, United States, 95819 Contact: Erin Nickerman 916-453-5429 nickermane@retinalMD.com Contact: Whitney Lewis 916-453-5429 lewisw@retinalmd.com Principal Investigator: David Telander, MD West Coast Retina Medical Group, Inc Recruiting San Francisco, California, United States, 94109 Contact: Kaitlin E. Miani, BA 415-972-4607 kmiani@westcoastretina.com Contact: C. Principal Investigator: Richard McDonald, MD Israel Hadassah Ein Kerem University Hospital Recruiting Jerusalem, Israel, 91120 Contact: Devora Marks Ohana 972-2-6776324 dryamdstudy@gmail.com Principal Investigator: Tareq Jaouni, MD Rabin Medical Center Recruiting Petah Tikva, Israel Contact: Vivi Dagan 972-3-9377199 eyeclinic@clalit.org.il Principal Investigator: Rita Ehrlich, MD Kaplan Medical Center Recruiting Rehovot, Israel Contact: Michal Scwartzberg 972-8-9441691 kaplaneye1@gmail.com Principal Investigator: Haia Morori-Katz, MD Tel Aviv Souraski Medical Center Recruiting Tel Aviv, Israel, 91121 Contact: Sagit Bechor 03-6974361 sagitba@tlvmc.gov.il Principal Investigator: Adiel Barak, MD, Prof. 收起 <<
NCT02341560	Non Arteritic Anterior Ischemi... 展开 >>c Optic Neuropathy 收起 <<	Phase 2 Phase 3	Recruiting	October 2020	-
NCT03077243	Carcinoma, Squamous Cell ... 展开 >> Head and Neck Neoplasms Oropharyngeal Neoplasms 收起 <<	Phase 2	Recruiting	February 2025	United States, Florida ... 展开 >> University of Florida Recruiting Gainesville, Florida, United States, 32610 Contact: Robert Amdur, MD 352-265-0287 amdurr@shands.ufl.edu University of Florida Proton Therapy Institute Recruiting Jacksonville, Florida, United States, 32206 Contact: Roi Dagan, MD 904-588-1445 rdagan@floridaproton.org United States, North Carolina University of North Carolina at Chapel Hill, Department of Radiation Oncology Recruiting Chapel Hill, North Carolina, United States, 27599 Contact: Bhishamjit Chera, MD 984-974-0400 bchera@med.unc.edu Contact: Rebecca Green, MSW (984) 974-8440 rlgreen@med.unc.edu Rex Healthcare Recruiting Raleigh, North Carolina, United States, 27607 Contact: Nathan Sheets, MD 919-784-1251 nathan.sheets@unchealth.unc.edu 收起 <<

Nicardipine 参考文献

[1]Huang BR, Chang PC, et al. Anti-neuroinflammatory effects of the calcium channel blocker nicardipine on microglial cells: implications for neuroprotection. PLoS One. 2014 Mar 12;9(3):e91167.

[2]Amenta F, Strocchi P, et al. Vascular and neuronal hypertensive brain damage: protective effect of treatment with nicardipine. J Hypertens Suppl. 1996 Oct;14(3):S29-35.

[3]LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Nicardipine. 2017 Jan 11

[4]Pepine C. Nicardipine, a new calcium channel blocker: role for vascular selectivity. Clin Cardiol. 1989 May;12(5):240-6

[5]Kim DJ, Hwang MH, An TH, Jung KT. The relaxant effect of nicardipine on the isolated uterine smooth muscle of the pregnant rat. Anesth Pain Med (Seoul). 2019 Oct 31;14(4):429-433

[6]Xiao J, Lin H, Liu B, Jin J. CaMKII/proteasome/cytosolic calcium/cathepsin B axis was present in tryspin activation induced by nicardipine. Biosci Rep. 2019 Jul 2;39(7):BSR20190516

Nicardipine 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.09mL

0.42mL

0.21mL

10.43mL

2.09mL

1.04mL

20.85mL

4.17mL

2.09mL

Nicardipine 技术信息

CAS号	55985-32-5
分子式	C₂₆H₂₉N₃O₆
分子量	479.525

别名	YC-93 free base
运输	蓝冰

存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(218.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02286089	Age-related Macular Degenerati... 展开 >>on 收起 <<	Phase 1 Phase 2	Recruiting	December 2019	United States, California ... 展开 >> Retina Vitreous Associates Medical Group Recruiting Los Angeles, California, United States, 900211 Contact: Janet Kurokouchi, B.Sc. 310-289-2478 ext 1243 JKurokouchi@laretina.com Contact: Gerard Aquino, B.Sc. 310-289-2478 ext 1225 GAquino@laretina.com Principal Investigator: David Boyer, MD Byers Eye Institute, Stanford School of Medicine Recruiting Palo Alto, California, United States, 94303 Contact: Lisa Greer, MBA 650-725-9184 lgreer7@stanford.edu Principal Investigator: Diana Do, Prof. Retinal Consultants Medical Group Recruiting Sacramento, California, United States, 95819 Contact: Erin Nickerman 916-453-5429 nickermane@retinalMD.com Contact: Whitney Lewis 916-453-5429 lewisw@retinalmd.com Principal Investigator: David Telander, MD West Coast Retina Medical Group, Inc Recruiting San Francisco, California, United States, 94109 Contact: Kaitlin E. Miani, BA 415-972-4607 kmiani@westcoastretina.com Contact: C. Principal Investigator: Richard McDonald, MD Israel Hadassah Ein Kerem University Hospital Recruiting Jerusalem, Israel, 91120 Contact: Devora Marks Ohana 972-2-6776324 dryamdstudy@gmail.com Principal Investigator: Tareq Jaouni, MD Rabin Medical Center Recruiting Petah Tikva, Israel Contact: Vivi Dagan 972-3-9377199 eyeclinic@clalit.org.il Principal Investigator: Rita Ehrlich, MD Kaplan Medical Center Recruiting Rehovot, Israel Contact: Michal Scwartzberg 972-8-9441691 kaplaneye1@gmail.com Principal Investigator: Haia Morori-Katz, MD Tel Aviv Souraski Medical Center Recruiting Tel Aviv, Israel, 91121 Contact: Sagit Bechor 03-6974361 sagitba@tlvmc.gov.il Principal Investigator: Adiel Barak, MD, Prof. 收起 <<
NCT02341560	Non Arteritic Anterior Ischemi... 展开 >>c Optic Neuropathy 收起 <<	Phase 2 Phase 3	Recruiting	October 2020	-
NCT03077243	Carcinoma, Squamous Cell ... 展开 >> Head and Neck Neoplasms Oropharyngeal Neoplasms 收起 <<	Phase 2	Recruiting	February 2025	United States, Florida ... 展开 >> University of Florida Recruiting Gainesville, Florida, United States, 32610 Contact: Robert Amdur, MD 352-265-0287 amdurr@shands.ufl.edu University of Florida Proton Therapy Institute Recruiting Jacksonville, Florida, United States, 32206 Contact: Roi Dagan, MD 904-588-1445 rdagan@floridaproton.org United States, North Carolina University of North Carolina at Chapel Hill, Department of Radiation Oncology Recruiting Chapel Hill, North Carolina, United States, 27599 Contact: Bhishamjit Chera, MD 984-974-0400 bchera@med.unc.edu Contact: Rebecca Green, MSW (984) 974-8440 rlgreen@med.unc.edu Rex Healthcare Recruiting Raleigh, North Carolina, United States, 27607 Contact: Nathan Sheets, MD 919-784-1251 nathan.sheets@unchealth.unc.edu 收起 <<
NCT01893307	Head And Neck Cancer	Phase 2 Phase 3	Recruiting	August 2023	United States, Arizona ... 展开 >> Mayo Clinic - Arizona Recruiting Scottsdale, Arizona, United States, 85259 United States, California University of California at San Diego Recruiting La Jolla, California, United States, 92093 Contact: Loren Mell, MD United States, Florida Florida Health Protocol Institute Recruiting West Palm Beach, Florida, United States, 33407 Contact: Roi Dagan, MD United States, Illinois Northwestern Memorial Hospital Recruiting Chicago, Illinois, United States, 60611 Contact: John H. Han-Chang, MD United States, Maryland University of Maryland Recruiting College Park, Maryland, United States, 20742 Contact: William Regine, MD Contact: Charles Simone, MD United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Paul Busse, MD United States, Minnesota Mayo Clinic Recruiting Rochester, Minnesota, United States, 55905 Contact: Robert Foote, MD United States, New York Memorial-Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Nancy Y. Lee, MD United States, Pennsylvania University of Pennsylvania Health System Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Alexander Lin, MD United States, Texas University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 United States, Washington University of Washington Recruiting Seattle, Washington, United States, 98105 Contact: Upendra Parvathaneni, MD 收起 <<
NCT01746966	-		Unknown	September 2015	Israel ... 展开 >> Rheumatology unit Recruiting Haifa, Israel, 31096 Contact: Alexander Rozin, MD 972-48542268 a_rozin@rambam.health.gov.il Sub-Investigator: Amir Dagan, MD Sub-Investigator: Kohava Toledano, MD 收起 <<
NCT02725840	-		Recruiting	April 2021	United States, Florida ... 展开 >> Department of Radiation Oncology Davis Cancer Pavilion Recruiting Gainesville, Florida, United States, 32611 Contact: John M Lybarger, MPH 352-265-0680 ext 87829 lybarj@shands.ufl.edu Principal Investigator: Walter O'Dell, PhD Sub-Investigator: Karen Daily, DO Sub-Investigator: Coy Heldermon, MD, PhD Sub-Investigator: David Wymer, MD Sub-Investigator: Fei Zou, PhD Sub-Investigator: Paul Okunieff, MD Sub-Investigator: Jorge Lascano, MD University of Florida Health Proton Therapy Institute Recruiting Jacksonville, Florida, United States, 32206 Contact: Julie Bradley, MD 904-588-1800 jbradley@floridaproton.org Sub-Investigator: Nancy Mendenhall, MD Sub-Investigator: Christopher Klassen, MD, PhD Sub-Investigator: Michael Rutenberg, MD Sub-Investigator: Roi Dagan, MD, MS Principal Investigator: Julie Bradley 收起 <<
NCT01363726	-		Unknown	-	Israel ... 展开 >> Pediatric infectious disease unit Soroka U medical center Recruiting Beer Sheva, Israel, 84101 Contact: David Greenberg, MD 97286400547 dudi@bgu.ac.il Contact: Oshrit Sabach 97286400547 sabacho@bgu.ac.il Principal Investigator: Ron Dagan, MD 收起 <<
NCT03586791	Cholecystectomy, Laparoscopic ... 展开 >> Anesthesia, General Reflex, Pupillary 收起 <<	Not Applicable	Recruiting	December 2019	Korea, Republic of ... 展开 >> Eugene Kim Recruiting Daegu, Nam-gu, Korea, Republic of, 42472 Contact: Eugene Kim, MD, PhD 82-53-650-3265 tomomie@hanmail.net Contact: JongHae Kim, MD 82-53-650-4979 usmed@cu.ac.kr Principal Investigator: Eugene Kim, MD,PhD Sub-Investigator: JongHae Kim, MD 收起 <<
NCT01688648	Unstable Angina ... 展开 >> Coronary Artery Bypass Graft Dexmedetomidine Lidocaine Myocardial Injury Arrhythmia Blood Electrolyte Balance 收起 <<	Not Applicable	Completed	-	Korea, Republic of ... 展开 >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 收起 <<
NCT02007798	Brain Neoplasms ... 展开 >> Surgery 收起 <<	Not Applicable	Unknown	December 2014	China, Liaoning ... 展开 >> Yue Yun Recruiting Shenyang, Liaoning, China, 110001 Contact: Yue Yun, Master 008613889168717 crazy_mouse0707@hotmail.com Principal Investigator: Ling Pei, Ph.D. 收起 <<
NCT01890252	Corneal Edema	Not Applicable	Unknown	April 2014	Israel ... 展开 >> Rabin Medical Center Not yet recruiting Petach Tikva, Israel, 49774 Contact: Vivi Dagan +972-3-9377199 eyeclinic@clalit.org.il 收起 <<
NCT01170962	Hepatitis C Virus	Phase 2	Completed	-	-
NCT00803634	Hypertension ... 展开 >>Heart Failure 收起 <<	Phase 3	Completed	-	United States, Alabama ... 展开 >> Jackson Hospital Montgomery, Alabama, United States, 36106 United States, California Centinela Hospital Inglewood, California, United States, 90301 United States, Louisiana Louisiana State University Health Sciences Center Baton Rouge, Louisiana, United States, 70805 Louisiana State University Health Sciences Center - Emergency Medicine New Orleans, Louisiana, United States, 70112 United States, Missouri Washington University School of Medicine St. Louis, Missouri, United States, 63110 United States, New York Stony Brook University and Medical Center Stony Brook, New York, United States, 11794 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Ohio University of Cincinnati Cincinnati, Ohio, United States, 45267 The Cleveland Clinic Cleveland, Ohio, United States, 44195 France Hopial AP-HP Hotel-Dieu Paris, France, 75004 Hopital AP-HP La Pitie Sapetriere Paris, France, 75013 Hopital AP-HP Lariboisiere Urgencies-SMUR Paris, France, 75475 Germany Charité - Universitätsmedizin Berlin Berlin, Germany, 13353 收起 <<
NCT00803634	-		Completed	-	-
NCT00255359	Chronic Hepatitis C Virus Infe... 展开 >>ction 收起 <<	Phase 1	Withdrawn	-	Israel ... 展开 >> Hadassah Medical Organization Jerusalem, Israel, 91120 收起 <<
NCT00708136	Stability Bal... 展开 >>ance 收起 <<	Not Applicable	Completed	-	Israel ... 展开 >> SorokaUMC Beer-Sheva, Israel, 84105 收起 <<
NCT01307436	Hepatitis A	Phase 3	Completed	-	Israel ... 展开 >> Pediatric Infectious Diseases Unit, Soraka Medical Center Beer Sheva, Israel, 84101 Schneider Children's Medical Center of Israel Petah Tiqva, Israel, 49202 收起 <<
NCT02839226	Wounds Other ... 展开 >>Ulcers Wounds and Skin Problems 收起 <<	Phase 2	Unknown	December 2017	Israel ... 展开 >> Sourasky Medical Center Recruiting Tel Aviv, Israel, 96105 Contact: Eyal Gur, MD Gur@tlvmc.gov.il Contact: Meirav Sela, MSc meiravs@tlvmc.gov.il Principal Investigator: Eyal Gur, MD Sub-Investigator: Eran Otremsky, MD 收起 <<
NCT01170962	-		Completed	-	-
NCT01460563	Cerebral Aneurysm	Not Applicable	Unknown	December 2011	Korea, Republic of ... 展开 >> Seoul National University Bundang hopital Recruiting Seongnam, Gyeonggi-Do, Korea, Republic of, 463-787 Contact: Mihyun Kim, Doctor 82-31-787-7499 snmd56@yahoo.com 收起 <<
NCT00781248	Intubation, Nasogastric	Phase 2	Completed	-	Israel ... 展开 >> "Bikur Cholim" Hospital Jerusalem, Israel 收起 <<
NCT00716079	Intracerebral Hemorrhage ... 展开 >> Stroke Hypertension 收起 <<	Not Applicable	Completed	-	-
NCT00282061	Delayed Sleep Phase Syndrome	Phase 1	Unknown	-	Israel ... 展开 >> The Institute for Sleep and Fatigue Medicine, Sheba Medical Center Recruiting Tel Hashomer, Israel Contact: Julia Tamir, MA 972-54-4811146 julia.tamir@sheba.health.gov.il 收起 <<
NCT00716079	-		Completed	-	-
NCT00797043	-		Terminated(Slow enrollment, fe... 展开 >>asibility issues) 收起 <<	-	United States, Florida ... 展开 >> University of Florida Proton Therapy Institute Jacksonville, Florida, United States, 32206 收起 <<
NCT00226096	CVA (Cerebrovascular Accident)... 展开 >> Cerebral Hemorrhage Intracranial Hemorrhages 收起 <<	Not Applicable	Completed	-	Australia, New South Wales ... 展开 >> Concord Hospital Concord, New South Wales, Australia, 2138 Gosford Hospital Gosford, New South Wales, Australia, 2250 St George Hospital Kogarah, New South Wales, Australia, 2217 John Hunter Hospital Newcastle, New South Wales, Australia, 2310 St Vincent's Hospital Sydney, New South Wales, Australia, 2010 Royal Prince Alfred Hospital Sydney, New South Wales, Australia, 2050 Westmead Hospital Westmead, New South Wales, Australia, 2145 Australia, South Australia Royal Adelaide Hospital Adelaide, South Australia, Australia, 5000 Australia, Victoria Royal Melbourne Hospital Melbourne, Victoria, Australia, 3050 St Vincent's Hospital Melbourne, Victoria, Australia, 3065 Box Hill Hospital Melbourne, Victoria, Australia, 3128 Alfred Hospital Melbourne, Victoria, Australia, 3181 Austin Health Melbourne, Victoria, Australia Monash Medical Centre Melbourne, Victoria, Australia Australia, Western Australia Sir Charles Gairdner Hospital Perth, Western Australia, Australia, 6009 China Regional Coordinating Centre: Peking University First Hospital Beijing, China, 100034 Hospitals in China, c/o The George Institute China Beijing, China Regional Coordinating Centre: Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Second Medical University Shanghai, China, 200025 New Zealand North Shore Hospital Auckland, New Zealand Christchurch Hospital Christchurch, New Zealand 收起 <<
NCT03492866	Hereditary Hypotrichosis Simpl... 展开 >>ex 收起 <<	Phase 2	Not yet recruiting	April 2019	-
NCT00564343	-		Completed	-	Israel ... 展开 >> SorokaUMC Beer-Sheva, Israel 收起 <<
NCT00797498	-		Completed	-	United States, Florida ... 展开 >> University of Florida Proton Therapy Institute Jacksonville, Florida, United States, 32206 收起 <<
NCT00797446	-		Terminated(Slow enrollment, fe... 展开 >>asibility issues) 收起 <<	-	United States, Florida ... 展开 >> University of Florida Proton Therapy Institute Jacksonville, Florida, United States, 32206 收起 <<
NCT01833325	Age-Related Macular Degenerati... 展开 >>on 收起 <<	Not Applicable	Completed	-	United States, Florida ... 展开 >> University of Florida Proton Therapy Institute Jacksonville, Florida, United States, 32206 收起 <<
NCT00797290	-		Terminated(Slow enrollment, Fe... 展开 >>asibility issues) 收起 <<	-	United States, Florida ... 展开 >> University of Florida Proton Therapy Institute Jacksonville, Florida, United States, 32206 收起 <<
NCT00848991	Cranitomy Surgery	Phase 3	Completed	-	United States, New Jersey ... 展开 >> Cooper University Hospital Camden, New Jersey, United States, 08103 收起 <<
NCT01214538	-		Unknown	July 2014	Israel ... 展开 >> Ben-Gurion University of the Negev Recruiting Beer Sheva, Israel, 84101 Contact: Ron Dagan, Prof MD +972 + 8-6400547 rdagan@bgu.ac.il 收起 <<
NCT01422616	Ischemic Stroke ... 展开 >> High Blood Pressure 收起 <<	Phase 3	Recruiting	February 2019	Australia, New South Wales ... 展开 >> Royal Prince Alfred Hospital Recruiting Sydney, New South Wales, Australia, 2050 Contact: Craig S Anderson, MD +61 2 933 4500 canderson@georgeinstitute.org.au 收起 <<
NCT01859221	Oligometastatic Prostate Cance... 展开 >>r 收起 <<	Not Applicable	Active, not recruiting	January 2020	United States, Florida ... 展开 >> University of Florida Proton Therapy Institute Jacksonville, Florida, United States, 32206 收起 <<
NCT01526876	Hypertension	Phase 4	Withdrawn(Terminated by Sponso... 展开 >>r) 收起 <<	-	-
NCT01232400	Subarachnoid Hemorrhage	Not Applicable	Withdrawn(Funding withdrawn. D... 展开 >>esign not feasible.) 收起 <<	August 2016	United States, Michigan ... 展开 >> University of Michigan Health System Ann Arbor, Michigan, United States, 48109 收起 <<
NCT02140892	Chronic Obstructive Pulmonary ... 展开 >>Disease Chronic Bronchitis 收起 <<	Not Applicable	Unknown	December 2015	-
NCT01893723	General Anesthesia	Not Applicable	Terminated(Changes of usual cl... 展开 >>inical practices) 收起 <<	-	Belgium ... 展开 >> University Hospital Erasme (ULB) Brussel, Belgium, 1070 France Clinique privée d'ANTONY Antony, France, 92160 University Hospital Claude Huriez Lille, France, 59000 University Hospital Roger Salengro Lille, France, 59000 University Hospital Saint Etienne, France, 42270 收起 <<
NCT02116868	Scheduled Laparoscopic Surgery	Not Applicable	Unknown	-	France ... 展开 >> Maternité Régionale Universitaire (MRU) Recruiting Nancy, Lorraine, France, 54000 Contact: Florence VIAL, MD. +33 3 83 34 44 67 f.vial@maternite.chu-nancy.fr Contact: Hervé BOUAZIZ, MD., PhD. +33 3 83 34 44 67 h.bouaziz@chu-nancy.fr Principal Investigator: Florence VIAL, MD. Sub-Investigator: Delphine HERBAIN, MD. Centre Hospitalier Universitaire, Brabois Recruiting Nancy, Lorraine, France, 54500 Contact: Philippe GUERCI, MD. +33 3 83 15 73 99 p.guerci@gmail.com Contact: Denis SCHMARTZ, MD. +33 3 83 15 74 82 d.schmartz@chu-nancy.fr Principal Investigator: Philippe GUERCI, MD. Sub-Investigator: Denis SCHMARTZ, MD. 收起 <<
NCT00684489	Hypertension	Not Applicable	Completed	-	-
NCT02216747	Glomerular Disease	Phase 4	Unknown	December 2015	Israel ... 展开 >> Shneider children Hospital Nephrology Institute Not yet recruiting Petach-Tikva, Israel Principal Investigator: Amit Dagan, Doctor 收起 <<
NCT02857647	Bariatric Surgery Candidates	Not Applicable	Unknown	December 2017	-
NCT02649413	Nephrotic Syndrome, Minimal Ch... 展开 >>ange 收起 <<	Phase 4	Not yet recruiting	June 2019	Israel ... 展开 >> Shneider children Hospital Nephrology Institute Petach-Tikva, Israel 收起 <<
NCT02135315	Acute Coronary Syndrome	Not Applicable	Recruiting	December 2017	Tunisia ... 展开 >> university of Monastir Recruiting Monastir, Tunisia, 5000 Contact: Nouirahead of departement 216073532014 semir.nouira@rns.tn Contact: Fattouma Bourguiba University Hospital +216 73 106 085 semir.nouira@rns.tn Principal Investigator: semir nouira, professor 收起 <<
NCT01634594	Mandibular Prognathism, ... 展开 >> Mandibular Retrognathism 收起 <<	Phase 4	Completed	-	Korea, Republic of ... 展开 >> Young Jun Oh Seoul, Korea, Republic of, 120-752 收起 <<
NCT03098680	Drug-Related Side Effects and ... 展开 >>Adverse Reactions Cardiovascular System Disease 收起 <<	Phase 1	Recruiting	February 29, 2020	United Kingdom ... 展开 >> Addenbrooke's Hospital Recruiting Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ Contact: Joseph Cheriyan, MBChB, MA, FRCP jc403@medschl.cam.ac.uk 收起 <<
NCT03497351	General Surgery	Not Applicable	Recruiting	December 31, 2018	China, Haidian ... 展开 >> Chinese PLA General Hospital Recruiting Beijing, Haidian, China, 100853 Contact: Zhe Xu, Master 收起 <<
NCT00490464	-		Completed	-	United States, Illinois ... 展开 >> University of Illinois at Chicago, UIC Chicago, Illinois, United States, 60612 收起 <<
NCT01171911	Acute Coronary Syndrome ... 展开 >> Coronary Artery Disease 收起 <<	Phase 4	Unknown	December 2010	China, Jiangsu ... 展开 >> Nanjing First Hospital,Nanjing Medical University Not yet recruiting Nanjing, Jiangsu, China, 210006 Contact: Shao-liang Chen, Director +86-25-52208048 chmengx@126.com 收起 <<
NCT01175746	Healthy Subjects	Not Applicable	Completed	-	-
NCT01996436	Cerebral Vasospasm	Phase 4	Recruiting	December 2020	United States, Connecticut ... 展开 >> Yale School of Medicine Recruiting New Haven, Connecticut, United States, 06520 Contact: Nils Petersen, MD nils.petersen@yale.edu Principal Investigator: Nils Petersen, MD United States, Illinois University of Illinois College of Medicine at Chicago Recruiting Chicago, Illinois, United States, 60612 Contact: Ali Alaraj, MD 312-996-4842 alaraj@uic.edu Principal Investigator: Ali Alaraj, MD United States, Michigan University of Michigan Not yet recruiting Ann Arbor, Michigan, United States, 48109 Contact: Aditya Pandey, MD 734-615-4486 adityap@med.umich.edu United States, New York Northwell Health Not yet recruiting Manhasset, New York, United States, 11030 Contact: David Ledoux, MD 516-562-3590 Lenox Hill Not yet recruiting New York, New York, United States, 10065 Contact: David Ledoux, MD United States, North Carolina Wake Forest University Health Sciences Recruiting Winston-Salem, North Carolina, United States, 27157 Contact: Stacey Wolfe, MD 336-716-3842 sqwolfe@wakehealth.edu Contact: Wendy Jenkins 336.716.3842 mailto:wejenkin@wakehealth.edu United States, Pennsylvania Geisinger Clinic Recruiting Danville, Pennsylvania, United States, 17822 Contact: Clemens Schirmer, MD Contact: Tejal Raichura 570.214.6084 taraichura@geisinger.edu Thomas Jefferson University Not yet recruiting Philadelphia, Pennsylvania, United States, 19107 Contact: Pascal M Jabbour, MD 215-955-7000 Pascal.Jabbour@jefferson.edu Principal Investigator: Pascal M Jabbour, MD Temple University Recruiting Philadelphia, Pennsylvania, United States, 19140 Contact: Kadir Erkmen, MD 617-697-4722 Kadir.Erkmen@tuhs.temple.edu Contact: Kathleen Hatala Kathleen.Hatala@tuhs.temple.edu United States, Texas University of Texas Medical School at Houston Recruiting Houston, Texas, United States, 77030 Contact: Sunil Sheth, MD Sunil.A.Sheth@uth.tmc.edu Contact: Aditya A Sanzgiri, MBBS MPH 713-704-7263 Aditya.A.Sanzgiri@uth.tmc.edu Principal Investigator: Sunil Sheth, MD 收起 <<
NCT01176565	Intracerebral Hemorrhage	Phase 3	Terminated(Planned interim ana... 展开 >>lysis no significant outcome differences between groups) 收起 <<	-	-
NCT01041066	Patients Who Are Intubated for... 展开 >> General Anesthesia Endotracheal Intubation 收起 <<	Not Applicable	Unknown	-	Korea, Republic of ... 展开 >> Seoul National University Bundang Hospital Recruiting Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707 Contact: Jung-Hee Ryu, Ph.D 82-31-787-7497 jinaryu@lycos.co.kr 收起 <<
NCT00093925	Hypertension	Phase 3	Completed	-	United States, Alabama ... 展开 >> Mobile Infirmary Medical Center Mobile, Alabama, United States, 36607 United States, Kansas Wesley Medical Center Wichita, Kansas, United States, 67214 United States, Louisiana Touro Infirmary New Orleans, Louisiana, United States, 70115 Ochsner Clinic Foundation New Orleans, Louisiana, United States, 70121 United States, New York Jack D. Weller Hospital Bronx, New York, United States, 10461 Montefiore Medical Center Bronx, New York, United States, 10467 Columbia University - College of Physicians and Surgeons New York, New York, United States, 10032 United States, Pennsylvania Hospital of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 United States, Virginia VA Medical Center McGuire Richmond, Virginia, United States, 23249 收起 <<
NCT00415610	Intracerebral Hemorrhage ... 展开 >> Hypertension Stroke 收起 <<	Phase 1	Completed	-	United States, California ... 展开 >> University of Southern California Los Angeles, California, United States, 90033 United States, Kansas Kansas University Medical Center Kansas City, Kansas, United States, 66160 The University of Kansas School of Medicine, Wichita Via Christi Regional Medical Center Kansas City, Kansas, United States, 66160 United States, Massachusetts Massachusetts General/Brigham Women's Hospital Boston, Massachusetts, United States, 02115 United States, Minnesota Clinical Coordinating Center: University of Minnesota, Fairview Hospital Minneapolis, Minnesota, United States, 55455 United States, Missouri Saint Louis University Saint Louis, Missouri, United States, 63108 United States, New Jersey JFK Medical Center Edison, New Jersey, United States, 08818 University of Medicine and Dentistry of New Jersey Newark, New Jersey, United States, 07107 United States, New York Columbia University Medical Center New York, New York, United States, 10032 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 Ohio State University Columbus, Ohio, United States, 43210 United States, South Carolina Statistical Coordinating Center: Medical University of South Carolina Charleston, South Carolina, United States, 29425 收起 <<
NCT00528827	Hypertension	Phase 2	Withdrawn(Due to the sale of C... 展开 >>ardene IV, the sponsor has stopped enrollment and withdrawn the study. No safety issues were identified.) 收起 <<	-	United States, California ... 展开 >> Beverly Hills, California, United States, 90211 United States, Florida Miami, Florida, United States, 33145 收起 <<
NCT00409253	Hypertension During Pre-Eclamp... 展开 >>sia 收起 <<	Phase 3	Unknown	August 2010	France ... 展开 >> Hôpital Saint-Jacques, CHU de Besançon Recruiting BESANçON, France, 25000 Contact: Myriam KRAUSZ-GRIGNARD, MD 33381219014 mgrignardkrausz@chu-besancon.fr Principal Investigator: Myriam KRAUSZ-GRIGARD, MD Sub-Investigator: Ludovic VALENTIN, MD Sub-Investigator: Emmanuel SAMAIN, MD Maternité A. PINARD Recruiting Nancy, France, 54042 Contact: HERVE BOUAZIZ, MD 33383344490 h.bouaziz@chu-nancy.fr Principal Investigator: Hervé BOUAZIZ, MD Sub-Investigator: Eric SAVOYE, MD Sub-Investigator: Yves CHALOT, MD Sub-Investigator: Nour-Eddine BAKA, MD Sub-Investigator: Sylvie BOILEAU, MD Sub-Investigator: Florence VIAL, MD Sub-Investigator: Philippe JUDLIN, MD Sub-Investigator: Olivier THIEBAUGEORGES, MD Sub-Investigator: Amandine BARBIER-LEREBOURS, MD Sihcus-Cmco Recruiting Schiltigheim, France, 67303 Contact: Rita VIZITIU, MD 33388628404 rita.vizitiu@chru-strasbourg.fr Principal Investigator: Rita VIZITIU, MD Sub-Investigator: Germain-Alain AISSI, MD Sub-Investigator: Danielle LE MAHO, MD Service d'Anesthésie et de Réanimation Médicale, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg Recruiting Strasbourg, France, 67098 Contact: Pierre Auguste DIEMUNSCH, MD 33.3.88.12.70.78 Pierre.Diemunsch@chru-strasbourg.fr Principal Investigator: Pierre Auguste DIEMUNSCH, MD Sub-Investigator: Bruno LANGER, MD Sub-Investigator: Israël NISAND, MD Sub-Investigator: Yves NOUDEM KANA, MD 收起 <<
NCT00325793	Hypertension	Phase 4	Unknown	-	United States, Illinois ... 展开 >> OSF Stroke Center Recruiting Peoria, Illinois, United States, 61637 Principal Investigator: David Wang, DO 收起 <<
NCT00508118	-		Terminated(3/7 subjects experi... 展开 >>enced hypotension. Study was terminated.) 收起 <<	-	-
NCT00415610	-		Completed	-	-
NCT00765648	Hypertensive Urgency	Phase 4	Completed	-	United States, Ohio ... 展开 >> Cleveland Clinic Cleveland, Ohio, United States, 44122 United States, Texas University of Texas Health Science Center Houston, Texas, United States 收起 <<
NCT01176565	-		Terminated(Planned interim ana... 展开 >>lysis no significant outcome differences between groups) 收起 <<	-	-
NCT00508118	Aortic Aneurysm, Thoracic	Phase 2	Terminated(3/7 subjects experi... 展开 >>enced hypotension. Study was terminated.) 收起 <<	-	United States, North Carolina ... 展开 >> Duke University Medical Center Durham, North Carolina, United States, 27710 收起 <<
NCT00765648	-		Completed	-	-
NCT01951950	Brain Tumors	Phase 1	Completed	-	United States, Illinois ... 展开 >> Northwestern Memorial Hospital Chicago, Illinois, United States, 60611 收起 <<
NCT01872039	Hypertension Emergency ... 展开 >> End-organ Damage 收起 <<	Phase 4	Completed	-	China, Beijing ... 展开 >> Beijing, Beijing, China, 100005 China, Hebei Shijiazhuang, Hebei, China, 050000 China, Heilongjiang Harbin, Heilongjiang, China, 150086 China, Xinjiang Urumqi, Xinjiang, China, 830001 China Wuhan, China, 430050 收起 <<
NCT01951950	-		Completed	-	-
NCT01810302	Cerebral Vasospasm	Phase 2	Terminated(Unable to secure dr... 展开 >>ug.) 收起 <<	-	United States, Florida ... 展开 >> University of Florida Gainesville, Florida, United States, 32610 收起 <<
NCT03622060	Radial Artery Injury at Wrist ... 展开 >>and Hand Level Occlusion of Artery Vasodilation 收起 <<	Phase 3	Recruiting	December 30, 2018	Indonesia ... 展开 >> Hermina Heart Center Recruiting Jakarta Pusat, DKI Jakarta, Indonesia, 10630 Contact: Surya Dharma, MD, PhD +622122608771 ext 9 drsuryadharma@yahoo.com 收起 <<
NCT01810302	-		Terminated(Unable to secure dr... 展开 >>ug.) 收起 <<	-	-
NCT02558023	Hypertension ... 展开 >>Preeclampsia 收起 <<	Phase 3	Recruiting	September 2019	France ... 展开 >> Service d'Anesthésie - CMCO Not yet recruiting Schiltigheim, France, 67303 Contact: Pierre DIEMUNSCH, MD.PH Sub-Investigator: Rita VIZITIU, MD Sub-Investigator: Valentina FAITOT, MD Service d'Anesthésie et de Réanimation Médicale, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg Recruiting Strasbourg, France, 67098 Contact: Pierre DIMUNSCH, PUPH 33.3.88.12.70.78 pierre.diemunsch@chru-strasbourg.fr Principal Investigator: Pierre DIEMUNSCH, PUPH Sub-Investigator: Vincent GARCIA, CCU 收起 <<
NCT03761888	-		Recruiting	May 2019	France ... 展开 >> Hôpital Béclère Recruiting Clamart, France, 92140 Contact: Mickaël SOUED +33145374273 mickael.soued@aphp.fr 收起 <<
NCT03184155	Coronary Artery Disease	Early Phase 1	Not yet recruiting	July 2020	United States, Pennsylvania ... 展开 >> Thomas Jefferson University Not yet recruiting Philadelphia, Pennsylvania, United States, 19107 Contact: Melissa McCarey, MPH 215-503-7417 melissa.mccarey@jefferson.edu Contact: Thomas Salerno, RN 215-503-8954 thomas.salerno@jefferson.edu 收起 <<
NCT02271191	Spinal Stenosis	Phase 4	Completed	-	-

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