UNC9994
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货号：A1549582
UNC9994 化学结构
CAS号：1354030-51-5
UNC9994 3D分子结构
CAS号：1354030-51-5
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UNC9994 纯度/质量文件 产品仅供科研
货号：A1549582
标准纯度：
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UNC9994 质控信息
- 多巴胺受体 亚型比较
- 5-羟色胺受体 亚型比较
- 组胺受体 亚型比较
| Penfluridol |
+
Dopamine receptor, Ki: 1.6 μM
|
|
|
|
|
|
|
|
98% |
| Ansofaxine HCl |
++
Dopamine receptor, IC50: 491 nM
|
|
|
|
|
|
|
|
98% |
| Tetrahydroberberine,THB |
|
+
|
|
|
|
|
|
|
98+% |
| Prochlorperazine Maleate |
|
✔
|
|
|
|
|
|
|
95% |
| Olanzapine |
|
✔
|
|
|
|
|
|
|
99+% |
| Trifluoperazine |
|
++++
Dopamine D2 receptor, IC50: 1.1 nM
|
|
|
|
|
|
|
98% |
| Ropinirole hydrochloride |
|
++
|
|
|
|
|
|
|
99% |
| Lurasidone |
|
++++
|
|
|
|
|
|
|
98% |
| Levosulpiride |
|
✔
|
|
|
|
|
|
|
99+% |
| Pridopidine |
|
✔
|
|
|
|
|
|
|
95% |
| Metoclopramide |
|
✔
|
|
|
|
|
✔
|
|
99+% |
| Molindone HCl |
|
✔
|
|
|
|
|
|
|
98% |
| Sulpiride |
|
✔
|
|
|
|
|
|
|
99+% |
| Perospirone |
|
++++
|
|
|
|
|
|
|
99% |
| Perospirone HCl |
|
++++
|
|
|
|
|
|
|
98+% |
| Phenothiazine |
|
✔
|
|
|
|
|
|
|
98% |
| Pimozide |
+
Dopamine D1 receptor, Ki: 6600 nM
|
+++
Dopamine D2 receptor, Ki: 3.0 nM
|
++++
Dopamine D3 receptor, Ki: 0.83 nM
|
|
|
|
|
|
98% |
| Rotundine |
++
D1 receptor, IC50: 166 nM
|
+
D2 receptor, IC50: 1.47 μM
|
+
D3 receptor, IC50: 3.25 μM
|
|
|
|
|
|
98% |
| Domperidone |
|
✔
|
|
|
|
|
|
|
99+% |
| ONC206 |
|
✔
|
|
|
|
|
|
|
97% |
| Pimethixene maleate |
++
Dopamine D1 Receptor, pKi: 6.37
|
+++
Dopamine D2 Receptor, pKi: 8.19
|
|
++
Dopamine D4.4 Receptor, pKi: 7.54
|
|
|
|
|
97% |
| Loxapine succinate |
++
D2 receptor (Human), Ki: 62 nM
D1 receptor (human), Ki: 26 nM
|
++
D2 receptor (bovine), Ki: 26 nM
D2 receptor (human), Ki: 24 nM
|
|
+++
D4 receptor (human), Ki: 7.5 nM
|
|
|
|
|
99% |
| Chlorprothixene |
+++
|
+++
|
+++
|
|
+++
|
|
|
|
98% |
| SCH-23390 HCl |
++++
D1 dopamine receptor, Ki: 0.2 nM
|
|
|
|
++++
D5 dopamine receptor, Ki: 0.3 nM
|
|
|
|
98% |
| MPP+ iodide |
|
|
|
|
|
✔
|
|
|
97% |
| σ1 Receptor antagonist-1 |
|
|
|
|
|
+
|
|
|
97% |
| Benztropine mesylate |
|
|
|
|
|
++
|
|
|
98% |
| Azaperone |
|
|
|
|
|
|
✔
|
|
98% |
| Ziprasidone HCl |
|
|
|
|
|
|
✔
|
|
98+% |
| Paliperidone |
|
|
|
|
|
|
✔
|
|
98% |
| Alizapride HCl |
|
|
|
|
|
|
✔
|
|
99+% |
| Amisulpride |
|
|
|
|
|
|
✔
|
|
98% |
| Quetiapine hemifumarate |
|
|
|
|
|
|
✔
|
Adrenergic Receptor
|
98% |
| Clozapine N-oxide |
|
|
|
|
|
|
✔
|
|
99% |
|
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
|
| Desvenlafaxine |
++
|
|
|
|
|
|
|
|
98% |
| Lamotrigine |
+
5-HT (rat brain synaptosomes), IC50: 474 μM
5-HT (human platelets), IC50: 240 μM
|
|
|
|
|
|
|
|
98% |
| Venlafaxine |
✔
|
|
|
|
|
|
|
|
98% |
| Fluvoxamine maleate |
✔
|
|
|
|
|
|
|
|
99% |
| Iloperidone |
✔
|
|
|
|
|
|
|
|
98% |
| Ziprasidone HCl |
✔
|
|
|
|
|
|
|
|
98+% |
| Atomoxetine HCI |
+
|
|
|
|
|
|
|
|
98% |
| Dapoxetine HCl |
✔
|
|
|
|
|
|
|
|
97% |
| Trazodone |
✔
|
|
|
|
|
|
|
|
98+% |
| Clomipramine HCl |
✔
|
|
|
|
|
|
|
|
98% |
| Mirtazapine |
✔
|
|
|
|
|
|
|
|
99+% |
| Escitalopram oxalate |
+++
|
|
|
|
|
|
|
|
97% |
| Duloxetine |
✔
|
|
|
|
|
|
|
|
98+% |
| Sertraline HCl |
++
|
|
|
|
|
|
|
|
98% |
| Citalopram HBr |
+++
serotonin reuptake, IC50: 1.8 nM
|
|
|
|
|
|
|
|
98% |
| Latrepirdine 2HCl |
✔
|
|
|
|
|
|
|
GluR
|
98% |
| Fluoxetine HCl |
✔
|
|
|
|
|
|
|
|
99.5% |
| Paroxetine hydrochloride |
✔
|
|
|
|
|
|
|
AChR
|
97% |
| BMY 7378 |
|
++
5-HT1A, pIC50: 6.4
5-HT1D, pIC50: 5.9
|
+
|
|
|
|
|
|
97% |
| Flibanserin |
|
+++
|
+
|
|
|
|
|
|
98% |
| LY310762 |
|
+
|
|
|
|
|
|
|
99%+ |
| Cyclobenzaprine HCI |
|
|
✔
|
|
|
|
|
|
99% |
| Blonanserin |
|
|
+++
|
|
|
|
|
|
98% HPLC |
| Cyproheptadine HCl |
|
|
++++
|
|
|
|
|
|
99+% |
| Olanzapine |
|
|
✔
|
|
|
|
|
|
99+% |
| Pimavanserin hemitartrate |
|
|
+++
|
|
|
|
|
|
99% |
| Ketanserin |
|
|
+++
5-HT2C (Rat), Ki: 50 nM
5-HT2C (Human), Ki: 2.5 nM
|
|
|
|
|
|
99%+ |
| Loxapine succinate |
|
|
++
5-HT2 (human), Ki: 6.8 nM
5-HT2 (bovine), Ki: 6.6 nM
|
|
|
|
|
|
99% |
| Agomelatine |
|
|
✔
|
|
|
|
|
|
98% |
| Clozapine |
|
|
✔
|
|
|
|
|
|
98% |
| Amitriptyline |
|
|
+
|
|
|
|
|
SERT
|
98% |
| PRX-08066 maleate |
|
|
+++
|
|
|
|
|
|
98+% |
| RS-127445 |
|
|
++++
5-HT2B, pIC50: 10.4
5-HT2B, pKi: 9.5
|
|
|
|
|
|
99%+ |
| Sarpogrelate HCl |
|
|
++++
5-HT2C, Kd: 1.1 nM
5-HT2A, Kd: 2.1 nM
|
|
|
|
|
|
98% |
| Tropisetron |
|
|
|
✔
|
|
|
|
|
99% |
| Palonosetron |
|
|
|
✔
|
|
|
|
|
98+% |
| Ramosetron HCl |
|
|
|
++++
5-HT3 receptor, Ki: 0.091 nM
|
|
|
|
|
98% |
| Ondansetron |
|
|
|
✔
|
|
|
|
|
99% |
| Granisetron |
|
|
|
✔
|
|
|
|
|
98% |
| Alosetron HCl |
|
|
|
✔
|
|
|
|
|
98% |
| Ondansetron hydrochloride dihydrate |
|
|
|
✔
|
|
|
|
|
98% |
| VUF10166 |
|
|
|
++++
5-HT3A, Ki: 0.04 nM
5-HT3AB, Ki: 22 nM
|
|
|
|
|
99%+ |
| Azasetron hydrochloride |
|
|
|
++++
|
|
|
|
|
98% |
| Asenapine maleate |
|
+++
5-HT1A, pKi: 8.6
5-HT1B, pKi: 8.4
|
++++
5-HT2A, pKi: 9.75
5-HT2C, pKi: 10.46
|
|
+++
|
++++
|
++++
|
|
97% |
| Risperidone |
|
++
5-HT1B, Ki: 14.9 nM
5-HT1D, Ki: 84.6 nM
|
++++
5-HT2A, Ki: 61.9 nM
5-HT2C, Ki: 12 nM
|
|
+
|
|
++
|
|
98% |
| SB 271046 HCl |
|
|
|
|
|
+++
|
|
|
99%+ |
| Intepirdine |
|
|
|
|
|
++++
|
|
|
99%+ |
| SB-269970 HCl |
|
|
|
|
|
|
++
|
|
98+% |
| BRL 15572 |
|
++
5-HT1D, pKi: 6
5-HT1B, pKi: 6.1
|
++
5-HT2B, pKi: 6.2
5-HT2A, pKi: 6.6
|
|
|
+
|
+
|
|
98% |
|
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
|
| Hydroxyzine 2HCl |
|
|
|
|
|
|
99+% |
| Cyclizine |
✔
|
|
|
|
|
|
97% |
| Loratadine |
+
|
|
|
|
|
|
98% |
| Desloratadine |
++
Histamine H1 receptor, IC50: 51 nM
|
|
|
|
|
|
98% |
| Doxylamine succinate |
✔
|
|
|
|
|
|
99% |
| Ebastine |
✔
|
|
|
|
|
|
98% |
| Tripelennamine HCl |
+
|
|
|
|
|
|
98% |
| Meclizine dihydrochloride |
✔
|
|
|
|
|
|
98% |
| Chlorpheniramine maleate |
+++
Histamine H1 receptor, IC50: 12 nM
|
|
|
|
|
|
99% |
| Diphenhydramine HCl |
✔
|
|
|
|
|
|
99% |
| Alcaftadine |
++++
|
++
|
|
|
|
|
99%+ |
| Fexofenadine HCl |
++
Histamine H1 receptor, IC50: 246 nM
|
|
|
|
|
|
99%+ |
| Bilastine |
+++
H1 receptor, Ki: 44.15 nM
|
|
|
|
|
|
98% |
| Pemirolast potassium |
✔
|
|
|
|
|
|
98% |
| Bepotastine besilate |
+
Histamine H1 receptor, pIC50: 5.7
|
|
|
|
|
|
98% |
| Mizolastine |
+++
Histamine H1 receptor, IC50: 47 nM
|
|
|
|
|
|
98% |
| Brompheniramine maleate |
✔
|
|
|
|
|
|
98% |
| Carbinoxamine maleate salt |
✔
|
|
|
|
|
|
99+% |
| Clemastine fumarate |
++++
Histamine H1 receptor, IC50: 3 nM
|
|
|
|
|
|
98% |
| Ketotifen fumarate salt |
✔
|
|
|
|
|
|
95% |
| Rupatadine Fumarate |
++
Histamine H1 receptor, Ki: 102 nM
|
|
|
|
|
PAFR
|
98% |
| Famotidine |
|
✔
|
|
|
|
|
97% |
| Roxatidine Acetate HCl |
|
+
Histamine H2 receptor, IC50: 3.2 μM
|
|
|
|
|
98% |
| Lafutidine |
|
✔
|
|
|
|
|
99% |
| Cimetidine |
|
✔
|
|
|
|
|
98% |
| Nizatidine |
|
++++
Histamine H2 receptor, IC50: 0.9 nM
|
|
|
|
AChE
|
98% |
| Ranitidine |
|
✔
|
|
|
|
|
99% |
| Betahistine |
|
|
+
Histamine H3 receptor, IC50: 1.9 μM
|
|
|
|
98% |
| Ciproxifan maleate |
|
|
+++
Histamine H3 receptor, IC50: 9.2 nM
|
|
|
|
99%+ |
| S 38093 |
|
|
++
rat H3 receptor, Ki: 1.44 μM
human H3 receptor, Ki: 1.2 μM
|
|
|
|
98% |
| JNJ-7777120 |
|
|
|
++++
Histamine H4 receptor, Ki: 4.5 nM
|
|
|
98% |
| Azelastine HCl |
|
|
|
|
✔
|
|
98% |
| Epinastine HCl |
|
|
|
|
✔
|
|
98% |
| Levodropropizine |
|
|
|
|
✔
|
|
97% |
| Cyproheptadine hydrochloride |
|
|
|
|
✔
|
|
98% |
| Hesperetin |
|
|
|
|
✔
|
|
97% |
| Olopatadine HCl |
|
|
|
|
✔
|
|
98% |
| Mianserin hydrochloride |
|
|
|
|
✔
|
|
99+% |
| Buclizine 2HCl |
|
|
|
|
✔
|
|
97% |
| Latrepirdine 2HCl |
|
|
|
|
✔
|
GluR
|
98% |
| Cetirizine 2HCl |
|
|
|
|
✔
|
|
98% |
|
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
|
UNC9994 实验方案
| 计算器 |
|
| 存储液制备 |
 |
1mg |
5mg |
10mg |
|
1 mM
5 mM
10 mM
|
2.37mL
0.47mL
0.24mL
|
11.87mL
2.37mL
1.19mL
|
23.73mL
4.75mL
2.37mL
|
UNC9994 技术信息
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