Mianserin Hydrochloride is an potent antagonist of H1 histamine receptor and 5-HT serotonin receptors, used for the treatment of depression. Mianserin (2 mg/kg s.c.) causes a modest increase of DOPAC (Dihydroxyphenylacetic acid) levels up to about 30% above base-line, which is statistically significant when compared to saline. Mianserin increases extracellular norepinephnne, but a comparison with desipramine and idazoxan showed that both NE reuptake inhibition and alpha-2 autoreceptor blockade contributed to the mianserin-induced increase in extracellular norepinephnne[3]. Mianserin (1, 5 and 10 mg/kg, SC) dose-dependently increases up to about 6 times extracellular dopamine in the medial prefrontal cortex of the rat. Mianserin also dose-dependently increases extracellular noradrenaline in the prefrontal cortex. Mianserin also dose-dependently increased extracellular noradrenaline in the prefrontal cortex[4]. Rats were chronically treated with mianserin (10 mg/kg i.p.) or eltoprazine (1 mg/kg i.p.) and were tested in the elevated plus-maze test for anxiety. Mianserin and eltoprazine displayed opposite effects in the elevated plus-maze: mianserin induced anxiolytic-like effects, while eltoprazine showed anxiogenic-like ones[5].
United States, Alabama
... 展开 >>
Tuscalossa VA Mental Health Clinic
Tuscaloosa, Alabama, United States, 35404
United States, California
Harbor UCLA Family Health Care Center
Harbor City, California, United States, 90710
UCLA Internal Medicine Clinic
Los Angeles, California, United States, 90024
Veterans Affairs Medical Center/FIRM Primary Care Clinic
San Diego, California, United States, 92161
United States, Illinois
Northwestern Psychiatric Outpatient Treatment Care Center
Chicago, Illinois, United States, 60611
United States, Kansas
Clinical Research Institute
Wichita, Kansas, United States, 67214
United States, Massachusetts
MGH/Northshore Medical Center (Salem Psychiatric Facility)
Salem, Massachusetts, United States, 01970
United States, Michigan
General Psychiatric Ambulatory Clinic
Ann Arbor, Michigan, United States, 48105
United States, New York
Irving Goldman Primary Care at North Shore Hospital
New York, New York, United States, 11040
United States, North Carolina
UNC Chapel Hill Adult Diagnostic & Treatment Clinic
Chapel Hill, North Carolina, United States, 27599-7160
United States, Oklahoma
Laureate Psychiatric Clinic and Hospital
Tulsa, Oklahoma, United States, 74135
United States, Pennsylvania
Bellefield Clinic of WPIC
Pittsburgh, Pennsylvania, United States, 15213
United States, Tennessee
Vine Hill Community Clinic
Nashville, Tennessee, United States, 37212
United States, Texas
UT Southwestern Family Medicine Clinic
Dallas, Texas, United States, 75390
United States, Virginia
VCU Outpatient Psychiatry Clinic
Richmond, Virginia, United States, 23298 收起 <<
Germany
... 展开 >> Department of Psychiatry and Psychotherapy, University Erlangen-Nuremberg
Recruiting
Erlangen, Bavaria, Germany, 91054
Contact: Stefan Bleich, MD 004991318534262 stefan.bleich@uk-erlangen.de
Principal Investigator: Stefan Bleich, MD
Sub-Investigator: Julia Wilhelm, MD
Sub-Investigator: Helge Frieling, MD 收起 <<
Brazil
... 展开 >> Clinics Hospital, Ribeirão Preto Medical School, University of São Paulo
Not yet recruiting
Ribeirão Preto, São Paulo, Brazil, 14048900
Contact: Nereida KC Lima, MD, PhD +5516992770522 nereida@fmrp.usp.br 收起 <<
United States, California
... 展开 >>
San Francisco Department of Public Health, Substance Use Research Unit
San Francisco, California, United States, 94102 收起 <<
United States, New Hampshire
... 展开 >>
Dartmouth Medical School Department of Psychiatry's Addition Research Center
Bedford, New Hampshire, United States, 03110
Dartmouth Medical School Department of Psychiatry's Addiction Research Center
Hanover, New Hampshire, United States, 03755 收起 <<
Malaysia
... 展开 >> University Malaya Medical Centre
Recruiting
Kuala Lumpur, Malaysia, 50603
Contact: Chong Guan Ng, MBBS, MPM 0379492068 chong_guan1975@yahoo.co.uk
University Malaya Medical Centre
Not yet recruiting
Kuala Lumpur, Malaysia, 59100
Contact: Chong Guan Ng, MBBS, MPM 60379604367 chong_guan@hotmail.com
Principal Investigator: Chong Guan Ng, MBBS, MPM 收起 <<
Malaysia
... 展开 >> University Science Malaysia
Recruiting
Kota bharu, Kelantan, Malaysia, 16010
Contact: Vicknasingam B Kasinather, PhD 6046532140 vickna@usm.my
Contact: Imran Ahmad 6097676603 profimran@usm.my 收起 <<
Terminated(This trial was stop... 展开 >>ped prematurely due to the Sponsor's decision not to continue the development of esmertazapine for this indication.) 收起 <<
Terminated(This trial was stop... 展开 >>ped prematurely due to the Sponsor's decision not to continue the development of esmertazapine for this indication.) 收起 <<
United States, New Mexico
... 展开 >>
University of New Mexico Cancer Center @ Lovelace Medical Center
Albuquerque, New Mexico, United States, 87102
Universtiy of New Mexico - Cancer Center
Albuquerque, New Mexico, United States, 87106 收起 <<
Korea, Republic of
... 展开 >>
Samsung Medical Center
Recruiting
Kangnam, Seoul, Korea, Republic of, 135-710
Contact: Samsung Medical Center Kim, phD, MD 82-2-3410-3582 dohkwan.kim@samsung.com 收起 <<
Brazil
... 展开 >> Brasilia University
Recruiting
Brasilia, Distrito Federal, Brazil, 70840
Contact: Francisca M Scoralick franciscascoralick@gmail.com
Sub-Investigator: Francisca M Scoralick 收起 <<
United Kingdom
... 展开 >> Sube Banerjee
Recruiting
Brighton, Sussex, United Kingdom, BN1 9RY
Contact: Sube Banerjee, MD 01273877896 s.banerjee@bsms.ac.uk
Principal Investigator: Naji Tabet, MD
Principal Investigator: Chris Fox, MD
Principal Investigator: Alan Thomas, MD
Principal Investigator: Ross Dunne, MD
Principal Investigator: Gill Livingston, MD
Principal Investigator: Peter Bentham, MD
Principal Investigator: Annabel Price, MD
Principal Investigator: Ramin Nilforooshan, MD
Principal Investigator: Carol Bannister, MD
Principal Investigator: Sushanth Kamath, MD 收起 <<
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