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/ Clomipramine HCl

盐酸氯米帕明 /Clomipramine HCl {[allProObj[0].p_purity_real_show]}

货号：A129557 同义名： 氯丙咪嗪盐酸盐 / Chlorimipramine hydrochloride;NSC-169865 hydrochloride Ambeed 开学季，买赠积分，赢豪礼

Clomipramine HCl is a dibenzazepine-derived 5-HT reuptake inhibitor and a tricyclic antidepressant.

Clomipramine HCl 化学结构 CAS号：17321-77-6
Clomipramine HCl 化学结构
CAS号：17321-77-6
Clomipramine HCl 3D分子结构
CAS号：17321-77-6
Clomipramine HCl 化学结构 CAS号：17321-77-6
Clomipramine HCl 3D分子结构 CAS号：17321-77-6
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Clomipramine HCl 纯度/质量文件 产品仅供科研

货号：A129557 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 5-HT ↓ 5-HT1 ↓ 5-HT2 ↓ 5-HT3 ↓ 5-HT5 ↓ 5-HT6 ↓ 5-HT7 ↓ 其他靶点 纯度
Desvenlafaxine ++

5-HT, Ki: 40.2 nM

 		{[allProObj[0].p_purity_real_show]}
Lamotrigine +

5-HT (rat brain synaptosomes), IC50: 474 μM

5-HT (human platelets), IC50: 240 μM

 		{[allProObj[0].p_purity_real_show]}
Venlafaxine ✔ {[allProObj[0].p_purity_real_show]}
Fluvoxamine maleate ✔ {[allProObj[0].p_purity_real_show]}
Iloperidone ✔ {[allProObj[0].p_purity_real_show]}
Ziprasidone HCl ✔ {[allProObj[0].p_purity_real_show]}
Atomoxetine HCI +

5-HT, Ki: 77 nM

 		{[allProObj[0].p_purity_real_show]}
Dapoxetine HCl ✔ {[allProObj[0].p_purity_real_show]}
Trazodone ✔ {[allProObj[0].p_purity_real_show]}
Clomipramine HCl ✔ {[allProObj[0].p_purity_real_show]}
Mirtazapine ✔ {[allProObj[0].p_purity_real_show]}
Escitalopram oxalate +++

5-HT, Ki: 0.89 nM

 		{[allProObj[0].p_purity_real_show]}
Duloxetine ✔ {[allProObj[0].p_purity_real_show]}
Sertraline HCl ++

5-HT, Ki: 13 nM

 		{[allProObj[0].p_purity_real_show]}
Citalopram HBr +++

serotonin reuptake, IC50: 1.8 nM

 		{[allProObj[0].p_purity_real_show]}
Latrepirdine 2HCl ✔ GluR {[allProObj[0].p_purity_real_show]}
Fluoxetine HCl ✔ {[allProObj[0].p_purity_real_show]}
Paroxetine hydrochloride ✔ AChR {[allProObj[0].p_purity_real_show]}
BMY 7378 ++

5-HT1D, pIC50: 5.9

5-HT1A, pIC50: 6.4

 		+

5-HT2, pIC50: 5.5

 		{[allProObj[0].p_purity_real_show]}
Flibanserin +++

5-HT1A, Ki: 1 nM

 		+

5-HT2A, Ki: 49 nM

 		{[allProObj[0].p_purity_real_show]}
LY310762 +

5-HT1D, Ki: 249 nM

 		{[allProObj[0].p_purity_real_show]}
Cyclobenzaprine HCI ✔ {[allProObj[0].p_purity_real_show]}
Blonanserin +++

5-HT2, Ki: 3.98 nM

 		{[allProObj[0].p_purity_real_show]}
Cyproheptadine HCl ++++

5-HT2, IC50: 0.6 nM

 		{[allProObj[0].p_purity_real_show]}
Olanzapine ✔ {[allProObj[0].p_purity_real_show]}
Pimavanserin hemitartrate +++

5-HT2A, pIC50: 8.7

 		{[allProObj[0].p_purity_real_show]}
Ketanserin +++

5-HT2C (Rat), Ki: 50 nM

5-HT2C (Human), Ki: 2.5 nM

 		{[allProObj[0].p_purity_real_show]}
Loxapine succinate ++

5-HT2 (human), Ki: 6.8 nM

5-HT2 (bovine), Ki: 6.6 nM

 		{[allProObj[0].p_purity_real_show]}
Agomelatine ✔ {[allProObj[0].p_purity_real_show]}
Clozapine ✔ {[allProObj[0].p_purity_real_show]}
Amitriptyline +

5-HT2, Ki: 235 nM

 		SERT {[allProObj[0].p_purity_real_show]}
PRX-08066 maleate +++

5-HT2B, IC50: 3.4 nM

 		{[allProObj[0].p_purity_real_show]}
RS-127445 ++++

5-HT2B, pIC50: 10.4

5-HT2B, pKi: 9.5

 		{[allProObj[0].p_purity_real_show]}
Sarpogrelate HCl ++++

5-HT2C, Kd: 1.1 nM

5-HT2A, Kd: 2.1 nM

 		{[allProObj[0].p_purity_real_show]}
Tropisetron ✔ {[allProObj[0].p_purity_real_show]}
Palonosetron ✔ {[allProObj[0].p_purity_real_show]}
Ramosetron HCl ++++

5-HT3 receptor, Ki: 0.091 nM

 		{[allProObj[0].p_purity_real_show]}
Ondansetron ✔ {[allProObj[0].p_purity_real_show]}
Granisetron ✔ {[allProObj[0].p_purity_real_show]}
Alosetron HCl ✔ {[allProObj[0].p_purity_real_show]}
Ondansetron hydrochloride dihydrate ✔ {[allProObj[0].p_purity_real_show]}
VUF10166 ++++

5-HT3AB, Ki: 22 nM

5-HT3A, Ki: 0.04 nM

 		{[allProObj[0].p_purity_real_show]}
Azasetron hydrochloride ++++

5-HT3, IC50: 0.33 nM

 		{[allProObj[0].p_purity_real_show]}
Asenapine maleate +++

5-HT1A, pKi: 8.6

5-HT1B, pKi: 8.4

 		++++

5-HT2C, pKi: 10.46

5-HT2A, pKi: 9.75

 		+++

5-HT5A, pKi: 8.84

 		++++

5-HT6, pKi: 9.6

 		++++

5-HT7, pKi: 9.94

 		{[allProObj[0].p_purity_real_show]}
Risperidone ++

5-HT1D, Ki: 84.6 nM

5-HT1B, Ki: 14.9 nM

 		++++

5-HT2C, Ki: 12 nM

5-HT2A, Ki: 61.9 nM

 		+

5-HT5A, Ki: 206 nM

 		++

5-HT7, Ki: 6.6 nM

 		{[allProObj[0].p_purity_real_show]}
SB 271046 HCl +++

5-HT6, pKi: 8.92

 		{[allProObj[0].p_purity_real_show]}
Intepirdine ++++

5-HT6, pKi: 9.63

 		{[allProObj[0].p_purity_real_show]}
SB-269970 HCl ++

5-HT7, pKi: 8.3

 		{[allProObj[0].p_purity_real_show]}
BRL 15572 ++

5-HT1D, pKi: 6

5-HT1B, pKi: 6.1

 		++

5-HT2A, pKi: 6.6

5-HT2B, pKi: 6.2

 		+

5-HT6, pKi: 5.9

 		+

5-HT7, pKi: 6.3

 		{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Clomipramine HCl 生物活性

靶点

  • 5-HT
描述 Clomipramine Hydrochloride is monoamine reuptake inhibitor and tricyclic antidepressant[3]. Preclinical studies in rodents indicated that clomipramine negatively affects hippocampus-dependent spatial learning and memory and clomipramine treatment reduced neuronal autophagic flux in primary dissociated neurons[4]. Clomipramine was inactive alone but produced a proportion-dependent enhancement of the antinociceptive effects of nalbuphine > morphine > methadone[5].

Clomipramine HCl 参考文献

[1]Ortiz J, Artigas F. Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluoxetine. Br J Pharmacol. 1992 Apr;105(4):941-6.

[2]McTavish D, Benfield P. Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs. 1990 Jan;39(1):136-53.

[3]Polonini HC, Silva SL, de Almeida TR, Brandão MAF, Ferreira AO. Compatibility of caffeine, carvedilol, clomipramine hydrochloride, folic acid, hydrochlorothiazide, loperamide hydrochloride, methotrexate, nadolol, naltrexone hydrochloride and pentoxifylline in SyrSpend SF PH4 oral suspensions. Eur J Hosp Pharm. 2016 Nov;23(6):352-358. doi: 10.1136/ejhpharm-2016-000903. Epub 2016 Mar 24. PMID: 31156882; PMCID: PMC6451465.

[4]Cavaliere F, Fornarelli A, Bertan F, Russo R, Marsal-Cots A, Morrone LA, Adornetto A, Corasaniti MT, Bano D, Bagetta G, Nicotera P. The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux. Sci Rep. 2019 Mar 19;9(1):4881. doi: 10.1038/s41598-019-40887-x. PMID: 30890728; PMCID: PMC6424961.

[5]Banks ML, Rice KC, Negus SS. Antinociceptive interactions between Mu-opioid receptor agonists and the serotonin uptake inhibitor clomipramine in rhesus monkeys: role of Mu agonist efficacy. J Pharmacol Exp Ther. 2010 Nov;335(2):497-505. doi: 10.1124/jpet.110.169276. Epub 2010 Jul 30. PMID: 20675432; PMCID: PMC2967402.

Clomipramine HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.85mL

0.57mL

0.28mL

14.23mL

2.85mL

1.42mL

28.46mL

5.69mL

2.85mL

Clomipramine HCl 技术信息

CAS号17321-77-6
分子式C19H24Cl2N2
分子量 351.313
别名 氯丙咪嗪盐酸盐 ;Chlorimipramine hydrochloride;NSC-169865 hydrochloride;Clomipramine (hydrochloride);Anafranil;G-34586 hydrochloride;Clomipramine hydrochloride
运输蓝冰
存储条件

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 50 mg/mL(142.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(142.32 mM)
动物实验配方

Tags: Clomipramine | 17321-77-6 | Chlorimipramine | G-34586 | NSC-169865 | G34586 | G 34586 | NSC169865 | NSC 169865 | 5-HT Reuptake Inhibitor | Neuronal Signaling | Serotonin Transporter | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Clomipramine HCl 纯度/质量文件 | Clomipramine HCl 亚型比较 | Clomipramine HCl 生物活性 | Clomipramine HCl 参考文献 | Clomipramine HCl 实验方案 | Clomipramine HCl 技术信息

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