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度洛西汀 /Duloxetine {[allProObj[0].p_purity_real_show]}

货号:A683411 同义名: (S)-Duloxetine;LY248686

Duloxetine is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).

Duloxetine 化学结构 CAS号:116539-59-4
Duloxetine 化学结构
CAS号:116539-59-4
Duloxetine 3D分子结构
CAS号:116539-59-4
Duloxetine 化学结构 CAS号:116539-59-4
Duloxetine 3D分子结构 CAS号:116539-59-4
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Duloxetine 纯度/质量文件 产品仅供科研

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Duloxetine 生物活性

靶点
  • 5-HT

描述 Duloxetine is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).

Duloxetine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00190645 Stress Urinary Incontinence Phase 3 Completed - United States, Colorado ... 展开 >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST) or speak with your personal physician Denver, Colorado, United States, 80220 Canada, Ontario For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559,1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST) or speak with your personal physician Oakville, Ontario, Canada, L6H3P1 收起 <<
NCT00387413 Hyperalgesia Phase 1 Completed - United Kingdom ... 展开 >> GSK Investigational Site Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ 收起 <<
NCT00945945 Osteoarthritis Knee Pain Phase 3 Completed - -

Duloxetine 参考文献

[1]De Berardis D, Conti CM, et al. The effect of newer serotonin-noradrenalin antidepressants on cytokine production: a review of the current literature. Int J Immunopathol Pharmacol. 2010 Apr-Jun;23(2):417-22.

[2]Wang SY, Calderon J, et al. Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner. Anesthesiology. 2010 Sep;113(3):655-65.

Duloxetine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.36mL

0.67mL

0.34mL

16.81mL

3.36mL

1.68mL

33.62mL

6.72mL

3.36mL

Duloxetine 技术信息

CAS号116539-59-4
分子式C18H19NOS
分子量 297.415
别名 (S)-Duloxetine;LY248686
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

溶解度
动物实验配方
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