Penfluridol, a T-typecalcium channel blocker, is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
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Penfluridol has robust antipsychotic efficacy and is a first-generation diphenylbutylpiperidine. Its effects last for several days after a single oral dose and it can be administered once a week to provide better compliance and symptom control. In addition; the anti-cancer effects of penfluridol have been demonstrated in vivo: results showed slight changes in the volume and weight of organs at doses tested in animals[3]. Penfluridol concentration-dependently suppressed the cell viability of AML cells with FLT3-WT (Fms-like tyrosine kinase 3) (HL-60 and U937) and FLT3-ITD (MV4-11); penfluridol's augmentation of intracellular ROS levels was critical for the penfluridol-induced autophagic response. The combination of penfluridol with an autophagy inhibitor may be a novel strategy for AML (acute myeloid leukemia) harboring FLT3-WT and FLT3-ITD[4]. Penfluridol treatment suppressed the growth of BxPC-3 tumor xenografts by 48% as compared to 17% when treated in combination with chloroquine. Similarly, penfluridol suppressed the growth of AsPC-1 tumors by 40% versus 16% when given in combination with chloroquine[5].
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