Clozapine, an antipsychotic drug, is antagonist of dopamine and other receptors used to treat schizophrenia with a Ki value of 9.5 nM for M1 receptor.
HazMat Fee +
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Clozapine was a full agonist at the muscarinic M4 receptor (EC50 = 11 nM), producing inhibition of forskolin-stimulated cAMP accumulation. In contrast, clozapine potently antagonized agonist-induced responses at the other four muscarinic receptor subtypes[3]. The chemical structure of clozapine facilitates a relatively rapid dissociation from D2 receptors. Clozapine is very potent at D2 receptor with a Ki of 75 nM. Clozapine is also potent at the α2-adrenoceptor with a Ki value of 51 nM[4]. Mice were treated chronically (21 days) with 25 mg/kg/day clozapine. Head-twitch response was decreased and [(3)H]ketanserin binding was downregulated in 1, 7, and 14 days after chronic clozapine. 5-HT ( 2A ) mRNA was reduced 1 day after chronic clozapine[5]. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine can lower the seizure threshold in a dose- and time-dependent manner. Careful patient selection and monitoring are required when clozapine therapy is used in patients with schizophrenia[6].
United States, Arkansas
... 展开 >>
Veterans Health Care System of the Ozarks, Fayetteville, AR
Fayetteville, Arkansas, United States, 72703
Central Arkansas Veterans Healthcare System Eugene J. Towbin Healthcare Center, Little Rock, AR
No. Little Rock, Arkansas, United States, 72114-1706
United States, Ohio
Dayton VA Medical Center, Dayton, OH
Dayton, Ohio, United States, 45428
United States, Texas
Michael E. DeBakey VA Medical Center, Houston, TX
Houston, Texas, United States, 77030 收起 <<
Australia, Victoria
... 展开 >>
Ballarat Health Service Psychiatric Services
Recruiting
Ballarat, Victoria, Australia
Principal Investigator: Abdul Khalid
Sub-Investigator: Rajul Tandon
Sub-Investigator: Sonia Ghai
Sub-Investigator: Arup Dhar
Sub-Investigator: Sarah Tremethick
Sub-Investigator: Jennifer Grigo
Sub-Investigator: Pella Karalis
Monash Medical Centre - Monash Health
Recruiting
Clayton, Victoria, Australia
Principal Investigator: David Barton
Sub-Investigator: Arup Dhar
Sub-Investigator: Sarah Tremethick
Sub-Investigator: Jennifer Grigo
Sub-Investigator: Krishna Vaddadi
Alfred and Baker Medical Unit - Alfred Hospital
Recruiting
Melbourne, Victoria, Australia
Principal Investigator: Gavin Lambert
Sub-Investigator: Markus Schlaich
Sub-Investigator: Elisabeth Lambert
Sub-Investigator: Murray Esler
Sub-Investigator: Geoff Head
Sub-Investigator: Dagmara Hering
Sub-Investigator: Nina Eikelis
Sub-Investigator: Carolina Ika Sari
Sub-Investigator: Petra Marusic
Sub-Investigator: Toni Rice
Sub-Investigator: Mariee Grima
Sub-Investigator: David Barton
Sub-Investigator: Arup Dhar
Sub-Investigator: Sarah Tremethick
Sub-Investigator: Nora Straznicky
Sub-Investigator: John Dixon
Sub-Investigator: Jennifer Grigo
Sub-Investigator: Donna Vizi
Sub-Investigator: Louise Hammond
Baker IDI Heart & Diabetes Institute
Recruiting
Melbourne, Victoria, Australia
Principal Investigator: Gavin Lambert
Sub-Investigator: Markus Schlaich
Sub-Investigator: Elisabeth Lambert
Sub-Investigator: Murray Esler
Sub-Investigator: Geoff Head
Sub-Investigator: Dagmara Hering
Sub-Investigator: Nina Eikelis
Sub-Investigator: Carolina Ika Sari
Sub-Investigator: Petra Marusic
Sub-Investigator: Toni Rice
Sub-Investigator: Mariee Grima
Sub-Investigator: David Barton
Sub-Investigator: Arup Dhar
Sub-Investigator: Sarah Tremethick
Sub-Investigator: Nora Straznicky
Sub-Investigator: John Dixon
Sub-Investigator: Jennifer Grigo
Sub-Investigator: Donna Vizi
Sub-Investigator: Louise Hammond 收起 <<
United States, New York
... 展开 >>
Bronx Children's Psychiatric Center
Bronx, New York, United States, 10461
Sagamore Children's Psychiatric Center
Dix Hills, New York, United States, 11746
Long Island Jewish Medical Center
Glen Oaks, New York, United States, 11004 收起 <<
Withdrawn(Pairing D-Cycloserin... 展开 >>e with Clozapine was found to worsen negative side effects in patients with Schizophrenia, so the study was suspended.) 收起 <<
-
United States, Massachusetts
... 展开 >>
Freedom Trail Clinic
Boston, Massachusetts, United States, 02114 收起 <<
Refractory Schizophrenia
... 展开 >> Super Refractory Schizophrenia 收起 <<
Phase 4
Unknown
-
Brazil
... 展开 >> Institute of Psychiatry - Clinics Hospital - University of Sao Paulo
Recruiting
Sao Paulo, Brazil, 05403010
Contact: Helio Elkis, Md PhD +55-11-2661-7322
Contact: Debora Melzer, MD +551126616525 deboramelzer@yahoo.com.br
Principal Investigator: Helio Elkis, MD PhD 收起 <<
United States, California
... 展开 >>
For additional information regarding investigative sites for this trial, contact SyneuRx International Corp.
Recruiting
Pasadena, California, United States, 91101
Contact: Felicia Yao 027-742-2699 ext 136 felicia.yao@syneurx.com 收起 <<
United States, New York
... 展开 >>
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Manhattan Psychiatric Center
New York, New York, United States, 10035
Pilgrim Psychiatric Center
W. Brentwood, New York, United States, 11717 收起 <<
United States, Connecticut
... 展开 >>
Connecticut Mental Health Center
New Haven, Connecticut, United States, 06508
VA Connecticut Healthcare System
West Haven, Connecticut, United States, 06516 收起 <<
United Kingdom
... 展开 >> University College London
London, United Kingdom, NW3 2PF
Imperial College London
London, United Kingdom, W6 8LN
University of Manchester
Manchester, United Kingdom, M13 9WL 收起 <<
United States, California
... 展开 >>
Pacific Neuropsychiatric Specialists
Costa Mesa, California, United States, 92626
United States, North Carolina
Gihwala & Associates
Gastonia, North Carolina, United States, 28054 收起 <<
United States, Virginia
... 展开 >>
Virginia Commonwealth University
Recruiting
Richmond, Virginia, United States, 23298
Contact: Alanda P Jones, MA 804-629-9394 cctrctgov@vcu.edu 收起 <<
United Kingdom
... 展开 >> Lancashire Care NHS Foundation Trust
Preston, Lancashire, United Kingdom
Mersey Care NHS Trust
Liverpool, Merseyside, United Kingdom 收起 <<
Korea, Republic of
... 展开 >>
Konkuk University Hospital
Choongju, Korea, Republic of
Wonkwang University
Iksan, Korea, Republic of
Naju National Hospital
Naju, Korea, Republic of
The Catholic University of Korea, yeouido St.Mary's Hospital
Seoul, Korea, Republic of, 150-896
Seoul National Hospital
Seoul, Korea, Republic of 收起 <<
Brazil
... 展开 >> Hospital de Clínicas de Porto Alegre
Recruiting
Porto Alegre, Rio Grande Do Sul, Brazil, 90540001
Contact: PEDRO V MAGALHAES, M.D., Ph.D. 收起 <<
United States, New Hampshire
... 展开 >>
New Hampshire Hospital
Concord, New Hampshire, United States, 03301
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
West Central Behavioral Health
Lebanon, New Hampshire, United States, 03766
Mental Health Center of Greater Manchester
Manchester, New Hampshire, United States, 03101
Center for Psychiatric Advancement & Community Council of Nashua
Nashua, New Hampshire, United States, 03060 收起 <<
Japan
... 展开 >> Novartis Investigational Site
Chiba, Japan
Novartis Investigative Site
Fukuoka, Japan
Novartis Investigative Site
Ishikawa, Japan
Novartis Investigative Site
Osaka, Japan
Novartis Investigative Site
Saga, Japan
Novartis Investigative Site
Tokyo, Japan
Novartis Investigative Site
Toyama, Japan
Novartis Investigative Site
Yamanashi, Japan 收起 <<
United States, California
... 展开 >>
West LA VAHCS
Los Angeles, California, United States, 90073
United States, Missouri
University Missouri
Kansas City, Missouri, United States, 64108
United States, New Hampshire
Mental Health Center of Greater Manchester
Manchester, New Hampshire, United States, 03101
United States, South Carolina
University South Carolina
Columbia, South Carolina, United States, 29203 收起 <<
United States, California
... 展开 >>
CNS Network Inc
Garden Grove, California, United States, 92845
Pacific Research Partners
Oakland, California, United States, 94607
United States, Florida
University of Miami
Miami, Florida, United States, 33136
United States, Massachusetts
Unversity of Massachusetts Medical School
Worcester, Massachusetts, United States, 01605
United States, Michigan
Michigan State University / Cherry Street Health Services
Grand Rapids, Michigan, United States, 49503
United States, New Hampshire
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
United States, North Carolina
University of North Carolina/UNC Center for Excellence in Community Mental Health
Raleigh, North Carolina, United States, 27610
United States, South Carolina
University of South Carolina
Columbia, South Carolina, United States, 29203
United States, Vermont
Rutland Regional Medical Center
Rutland, Vermont, United States, 05701 收起 <<
Korea, Republic of
... 展开 >>
Seoul National University Bundang Hospital
Recruiting
Seongnam, Korea, Republic of, 13620
Contact: Seoyoung Kim, MD 031-787-8219 zentiana0@gmail.com 收起 <<
United States, New York
... 展开 >>
Manhattan Psychiatric Center, 125th Street, Out Patient Clinic
New York, New York, United States, 10027
Manhattan Psychiatric Center, Inpatient Unit
New York, New York, United States, 10035 收起 <<
Korea, Republic of
... 展开 >>
Seoul National University Bundang Hospital
Recruiting
Seongnam, Gyeonggi, Korea, Republic of, 463-707
Contact: Se Young Lee, MD 82 31 787 7439 zoayo2000@hanmail.net
Principal Investigator: Kyooseob Ha, MD, PhD 收起 <<
搜索
HazMat Fee +
