货号:A901971 同义名: D,L-文拉法辛 / Wy 45030
Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
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描述 | Venlafaxine is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant. Venlafaxine inhibited binding to the human NE and 5-HT transporters with K(i) values of 2480 and 82 nM, respectively, and with a K(i) ratio of 30. Venlafaxine inhibited ex vivo binding to rat 5-HT transporters and NE transporters with ED(50) values of 2 and 54 mg/kg, respectively. Venlafaxine had ED(50) values of 5.9 and 94 mg/kg for blocking p-chloramphetamine- and 6-hydroxydopamine-induced monoamine depletion, respectively[3]. Compared to acetic acid control, venlafaxine at dose of 40 mg/kg as well as dexamethasone significantly improved colitis parameters in both reserpinised and non-reserpinised animals. Venlafaxine reduced inflammatory injury in this animal model of induced ulcerative colitis[4]. Venlafaxine (16 mg/kg) reversed STZ-induced elevated thiobarbituric acid reactive substance (TBARS) levels and also restored the glutathione (GSH) levels in diabetic mice. Venlafaxine (8 and 16 mg/kg) per se does not produce any significant effect in normal animals. A dose-dependent antidepressant action of venlafaxine in diabetes-induced depressive mice[5]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00788944 | Depression | Phase 4 | Completed | - | - |
NCT00205491 | TBI (Traumatic Brain Injury) | Phase 4 | Completed | - | United States, Virginia ... 展开 >> Virginia Commonwealth University Richmond, Virginia, United States, 23298 收起 << |
NCT00316160 | Depressive Disorder, Major ... 展开 >> Major Depressive Disorder (MDD) 收起 << | Phase 4 | Completed | - | - |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.60mL 0.72mL 0.36mL |
18.02mL 3.60mL 1.80mL |
36.05mL 7.21mL 3.60mL |
CAS号 | 93413-69-5 |
分子式 | C17H27NO2 |
分子量 | 277.402 |
别名 | D,L-文拉法辛 ;Wy 45030 |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Keep in dark place,Inert atmosphere,2-8°C |
溶解度 |
DMSO: 250 mg/mL(901.22 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |