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Venlafaxine/文拉法辛 {[allProObj[0].p_purity_real_show]}

货号:A901971 同义名: D,L-文拉法辛 / Wy 45030

Venlafaxine是一种抗抑郁药,属于 5-HT 和去甲肾上腺素再摄取抑制剂 (SNRI),用于治疗重度抑郁症 (MDD)、广泛性焦虑症 (GAD)、恐慌症和社交恐惧症。

Venlafaxine/文拉法辛 化学结构 CAS号:93413-69-5
Venlafaxine/文拉法辛 化学结构
CAS号:93413-69-5
Venlafaxine/文拉法辛 3D分子结构
CAS号:93413-69-5
Venlafaxine/文拉法辛 化学结构 CAS号:93413-69-5
Venlafaxine/文拉法辛 3D分子结构 CAS号:93413-69-5
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Venlafaxine/文拉法辛 纯度/质量文件 产品仅供科研

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Venlafaxine/文拉法辛 生物活性

靶点
  • 5-HT

描述 Venlafaxine is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant. Venlafaxine inhibited binding to the human NE and 5-HT transporters with K(i) values of 2480 and 82 nM, respectively, and with a K(i) ratio of 30. Venlafaxine inhibited ex vivo binding to rat 5-HT transporters and NE transporters with ED(50) values of 2 and 54 mg/kg, respectively. Venlafaxine had ED(50) values of 5.9 and 94 mg/kg for blocking p-chloramphetamine- and 6-hydroxydopamine-induced monoamine depletion, respectively[3]. Compared to acetic acid control, venlafaxine at dose of 40 mg/kg as well as dexamethasone significantly improved colitis parameters in both reserpinised and non-reserpinised animals. Venlafaxine reduced inflammatory injury in this animal model of induced ulcerative colitis[4]. Venlafaxine (16 mg/kg) reversed STZ-induced elevated thiobarbituric acid reactive substance (TBARS) levels and also restored the glutathione (GSH) levels in diabetic mice. Venlafaxine (8 and 16 mg/kg) per se does not produce any significant effect in normal animals. A dose-dependent antidepressant action of venlafaxine in diabetes-induced depressive mice[5].

Venlafaxine/文拉法辛 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00788944 Depression Phase 4 Completed - -
NCT00205491 TBI (Traumatic Brain Injury) Phase 4 Completed - United States, Virginia ... 展开 >> Virginia Commonwealth University Richmond, Virginia, United States, 23298 收起 <<
NCT00316160 Depressive Disorder, Major ... 展开 >> Major Depressive Disorder (MDD) 收起 << Phase 4 Completed - -

Venlafaxine/文拉法辛 参考文献

[1]Bymaster FP, Dreshfield-Ahmad LJ, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.

[2]Goeringer KE, McIntyre IM, et al. Postmortem tissue concentrations of venlafaxine. Forensic Sci Int. 2001 Sep 15;121(1-2):70-5.

[3]Bymaster FP, Dreshfield-Ahmad LJ, Threlkeld PG, Shaw JL, Thompson L, Nelson DL, Hemrick-Luecke SK, Wong DT. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80

[4]Minaiyan M, Hajhashemi V, Rabbani M, Fattahian E, Mahzouni P. Effect of venlafaxine on experimental colitis in normal and reserpinised depressed rats. Res Pharm Sci. 2015 Jul-Aug;10(4):295-306

[5]Khanam R, Najfi H, Akhtar M, Vohora D. Evaluation of venlafaxine on glucose homeostasis and oxidative stress in diabetic mice. Hum Exp Toxicol. 2012 Dec;31(12):1244-50

Venlafaxine/文拉法辛 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.60mL

0.72mL

0.36mL

18.02mL

3.60mL

1.80mL

36.05mL

7.21mL

3.60mL

Venlafaxine/文拉法辛 技术信息

CAS号93413-69-5
分子式C17H27NO2
分子量 277.4
SMILES Code OC1(C(C2=CC=C(OC)C=C2)CN(C)C)CCCCC1
MDL No. MFCD00864385
别名 D,L-文拉法辛 ;Wy 45030
运输蓝冰
InChI Key PNVNVHUZROJLTJ-UHFFFAOYSA-N
Pubchem ID 5656
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, 2-8°C

溶解方案

DMSO: 250 mg/mL(901.22 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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