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货号 产品名 纯度
A156825 现货 (+)-PD 128907 hydrochloride

(+)-PD 128,907 HCl is an agonist of D3 dopamine receptor with Ki of 2.3 nM.

98%
A1173546 现货 Haloperidol (D4')/氟哌啶醇 (D4')

Haloperidol (D4')是一种 dopamine D2 受体拮抗剂,常用于精神分裂症等精神障碍的治疗。该化合物通过抑制多巴胺受体的作用机制,使其在抗精神病药物研究中具有重要应用价值。

98% 98%atom%D
A1249420 现货 FAUC 213

FAUC 213是一种口服活性高的多巴胺 D4 受体拮抗剂,Ki 值为 2.2 nM,对 D2 和 D3 受体的活性较低。FAUC 213 能够透过血脑屏障,具有非典型抗精神病活性,适用于神经精神疾病的研究。

99%+
A148233 现货 L-745870 HCl

L-745870 HCl是一种有效的、选择性的能够透过血脑屏障且具有口服活性的多巴胺 D4 受体拮抗剂,Ki 值为 0.43 nM。它对 D2 (Ki 为 960 nM) 和 D3 (Ki 为 2300 nM) 受体的亲和力较弱,对 5-HT2 受体、sigma 位点和 α-肾上腺素受体具有中等亲和力。

99%+
A967105 现货 Paliperidone Palmitate

Paliperidone palmitate (9-Hydroxyrisperidone palmitate), an atypical long-acting antipsychotic agent, is an ester prodrug of Paliperidone. Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against schizophrenia.

98%
A744486 现货 Lumateperone

Lumateperone, namely ITI-007, is an antagonist of 5-HT2A with Ki of 0.54 nM and exhibits therapeutic efficacy for sleep maintenance insomnia.

98%
A1213192 现货 Clozapine-d8

Clozapine-d8是Clozapine的氘代同位素化合物。Clozapine 是一种抗精神病药物,具有高效结合多种神经受体的能力,广泛用于精神分裂症的研究。

cp98%, 98%D
A363715 现货 Rimcazole 2HCl

Rimcazole 2HCl 是一种咔唑衍生物,部分用作 σ 受体拮抗剂。它以中等亲和力结合多巴胺转运蛋白并抑制多巴胺摄取,从而减弱运动活动和致敏作用,也可用于癌症研究。

95%
A452552 现货 2'-O-Methylisoliquiritigenin

2'-O-Methylisoliquiritigenin is a natural product isolated and purified from the roots of Glycyrrhiza glabra L..

98%+
A1155605 现货 ONC206

ONC206 是 ONC201 的类似物。ONC206 是一种选择性拮抗剂,对多巴胺 D2 类受体 (DRD2/3/4) 具有纳摩尔效力。ONC206 表现出广谱抗肿瘤活性。

97%
A1251037 现货 GBR 12783 2HCl

GBR 12783 2HCl是一种选择性多巴胺摄取抑制剂,能够有效抑制大鼠和小鼠纹状体突触体对 [3H] 多巴胺的摄取 (IC50 分别为 1.8 nM 和 1.2 nM)。此外,它还能够改善大鼠的记忆力并增加海马通路中乙酰胆碱的释放,适用于神经退行性疾病和记忆障碍的研究。

99%+
A1209538 现货 L-745870 trihydrochloride

L-745870 trihydrochloride是一种选择性的、多巴胺 D4 受体拮抗剂,具有口服活性和透过血脑屏障的能力,Ki 为 0.43 nM,对 D2 和 D3 受体的亲和力较弱,并对 5-HT2 受体、σ 位点和 α-肾上腺素受体显示中等亲和力。

99%+
A1154387 现货 (Rac)-Rotigotine

(Rac)-Rotigotine (N-0437) 是 Rotigotine 的外消旋体,是多巴胺受体激动剂,部分激动 5-HT1A 受体,并拮抗 α2B-肾上腺素受体

97%
A1250019 现货 LY3154207

Y3154207 is a novel, potent, and subtype selective human D1 positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50 = 3 nM). In contrast to orthosteric agonists, LY3154207 showed a distinct pharmacological profile without a bell-shaped dose-response relationship or tachyphylaxis in preclinical models. Identification of a crystalline form of free LY3154207 from the discovery lots was not successful. Instead, a novel cocrystal form with superior solubility was discovered and determined to be suitable for development. LY3154207 is now in clinical development as a potential first-in-class D1 PAM for Lewy body dementia.

99%+
A127869 现货 Metoclopramide/胃复安

Metoclopramide is an antagonist of dopamine D2 and is commonly used as an antiemetic.

99+%
A1000642 现货 ABT-724

ABT-724 is a potent and highly selective dopamine D4 receptor agonist with EC50s of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 receptor and ferret D4 receptor.

98%+
A819643 现货 GR 103691

GR 103691 is an effective and selective receptor antagonist of the dopamine D3 receptor (D3DR).

98+%
A747660 现货 Ro 10-5824 2HCl

Ro 10-5824 2HCl is an agonist of dopamine D4 receptor with Ki of 5.2 nM.

99%+
A111766 现货 Dexpramipexole 2HCl/右旋普拉克索二盐酸盐

Dexpramipexole 2HCl is the HCl form of Dexpramipexole which is a non-ergoline dopamine agonist for treatment of parkinson's disease and restless leg syndrome.Dexpramipexole is an (R)-(+) optical enantiomer of pramipexole.

99+%
A185949 现货 BP 897 HCl

BP 897 hydrochloride是一种有效的部分多巴胺D3受体激动剂和弱D2受体拮抗剂。BP 897盐酸盐对多巴胺D3受体具有高亲和力(Ki=0.92 nM),对D2受体的亲和力是其的70倍(Ki=61 nM)。

98%
产品名 D1 receptor D2 receptor D3 receptor D4 receptor D5 receptor DAT Dopamine receptor 其他靶点 纯度
Penfluridol +

Dopamine receptor, Ki: 1.6 μM

98%
Ansofaxine HCl ++

Dopamine receptor, IC50: 491 nM

98%
Tetrahydroberberine,THB +

D2 receptor, pKi: 6.08

98+%
Prochlorperazine Maleate 95%
Olanzapine 99+%
Trifluoperazine ++++

Dopamine D2 receptor, IC50: 1.1 nM

98%
Ropinirole hydrochloride ++

D2 receptor, Ki: 29 nM

99%
Lurasidone ++++

D2 receptor, Ki: 1 nM

98%
Levosulpiride 99+%
Pridopidine 95%
Metoclopramide 99+%
Molindone HCl 98%
Sulpiride 99+%
Perospirone ++++

D2 receptor, Ki: 1.4 nM

99%
Perospirone HCl ++++

D2 receptor, Ki: 1.4 nM

98+%
Phenothiazine 98%
Pimozide +

Dopamine D1 receptor, Ki: 6600 nM

+++

Dopamine D2 receptor, Ki: 3.0 nM

++++

Dopamine D3 receptor, Ki: 0.83 nM

98%
Rotundine ++

D1 receptor, IC50: 166 nM

+

D2 receptor, IC50: 1.47 μM

+

D3 receptor, IC50: 3.25 μM

98%
Domperidone 99+%
ONC206 97%
Pimethixene maleate ++

Dopamine D1 Receptor, pKi: 6.37

+++

Dopamine D2 Receptor, pKi: 8.19

++

Dopamine D4.4 Receptor, pKi: 7.54

97%
Loxapine succinate ++

D1 receptor (human), Ki: 26 nM

D2 receptor (Human), Ki: 62 nM

++

D2 receptor (human), Ki: 24 nM

D2 receptor (bovine), Ki: 26 nM

+++

D4 receptor (human), Ki: 7.5 nM

99%
Chlorprothixene +++

D1 receptor, Ki: 18 nM

+++

D2 receptor, Ki: 2.96 nM

+++

D3 receptor, Ki: 4.56 nM

+++

D5 receptor, Ki: 9 nM

98%
SCH-23390 HCl ++++

D1 dopamine receptor, Ki: 0.2 nM

++++

D5 dopamine receptor, Ki: 0.3 nM

98%
MPP+ iodide 97%
σ1 Receptor antagonist-1 +

DAT, pKi: 5.8

97%
Benztropine mesylate ++

DAT, IC50: 118 nM

98%
Azaperone 98%
Ziprasidone HCl 98+%
Paliperidone 98%
Alizapride HCl 99+%
Amisulpride 98%
Quetiapine hemifumarate Adrenergic Receptor 98%
Clozapine N-oxide 99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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