Paliperidone is a potent serotonin-2A and dopamine-2 receptor antagonist, it is the main active metabolite of risperidone and used in the treatment of schizophrenia.
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Paliperidone is a second-generation antipsychotic drug belonging to the class of benzisoxasole derivatives. Paliperidone is the major active metabolite of risperidone (9-OH-risperidone) and, as such, is comparable to the latter in terms of pharmacodynamic properties[3]. Paliperidone has demonstrated efficacy in the reduction of acute schizophrenia symptoms and clinical benefits were maintained also in the long-term treatments. Paliperidone ER (extended-release) and PP (paliperidone palmitate) are generally well tolerated with a predictable adverse event profile[4]. Paliperidone inhibited MK-801 induced neurotoxicity both in MTT metabolism assay and in lactate dehydrogenase (LDH) activity assay. Time course studies revealed that paliperidone effectively attenuated the elevation of intracellular free calcium concentration ([Ca(2+)]i) induced by exposure to MK-801. Moreover, paliperidone could significantly retard MK-801-mediated inhibition of neurite outgrowth and reverse MK-801-induced decreases of gene expression and phosphorylation of Akt1 and GSK3β[5]. Moreover, paliperidone works finely at low concentrations (10 and 50 μM) against Aβ(25-35) and MPP(+) and solely protected SH-SY5Y from hydrogen peroxide. At 100 μM, paliperidone completely diminished cell reduction induced by different stressors, regardless of their dosages. Paliperidone was demonstrated with a higher oxidative stress-scavenging properties than other APDs (Antipsychotic drugs) in several aspects, such as generated bulk glutathione, low HNE, and protein carbonyl productions[6].
Sexual Dysfunction
... 展开 >> Hyperprolactinemia 收起 <<
Phase 4
Unknown
June 2014
China, Beijing
... 展开 >> Institute of mental health, Peking University
Not yet recruiting
Beijing, Beijing, China, 100191
Contact: Tianmei Si, MD. 8610-82801948 si.tian-mei@163.cm
Principal Investigator: Tianmei Si, MD.
China, Hebei
The first hospital of Hebei Province University
Recruiting
Shijiazhuang, Hebei, China, 050000
Contact: Xueyi Wang, Professor 0311-85917290
Sub-Investigator: Xueyi Wang 收起 <<
Sexual Dysfunction
... 展开 >> Hyperprolactinemia 收起 <<
Phase 4
Unknown
June 2014
China, Beijing
... 展开 >> Institute of mental health, Peking University
Not yet recruiting
Beijing, Beijing, China, 100191
Contact: Tianmei Si, MD. 8610-82801948 si.tian-mei@163.cm
Principal Investigator: Tianmei Si, MD.
China, Hebei
The first hospital of Hebei Province University
Recruiting
Shijiazhuang, Hebei, China, 050000
Contact: Xueyi Wang, Professor 0311-85917290
Sub-Investigator: Xueyi Wang 收起 <<
United States, California
... 展开 >>
UC Irvine
Recruiting
Irvine, California, United States, 92697
Contact: Steven G Potkin, M.D. 949-824-8040 sgpotkin@uci.edu
Contact: Liv McMillan, B.S. 949-824-3770 liv@uci.edu
Principal Investigator: Steven G Potkin, M.D. 收起 <<
United States, California
... 展开 >>
Cerritos, California, United States
Chino, California, United States
Garden Grove, California, United States
Huntington Beach, California, United States
Santa Ana, California, United States
Torrance, California, United States
United States, Florida
Fort Lauderdale, Florida, United States
Hollywood, Florida, United States
Kissimmee, Florida, United States
United States, Louisiana
Lake Charles, Louisiana, United States
United States, Mississippi
Flowood, Mississippi, United States
United States, Missouri
Kansas City, Missouri, United States
United States, New Jersey
Clementon, New Jersey, United States
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Albuquerque, New Mexico, United States
United States, New York
Staten Island, New York, United States
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Cincinnati, Ohio, United States
United States, Pennsylvania
Norristown, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
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Sioux Falls, South Dakota, United States
United States, Texas
Irving, Texas, United States
United States, Vermont
White River Junction, Vermont, United States 收起 <<
Brazil
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Porto Alegre, Brazil
Riberao Preto, Brazil
Sao Jose, Brazil
Sao Paulo, Brazil
Colombia
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Bogota, Colombia
Bucarmanga, Colombia
Medellin, Colombia
Mexico
Acapulco, Mexico
Guadalajara, Mexico
Mexico, Mexico
Monterrey, Mexico 收起 <<
United States, California
... 展开 >>
UCLA Semel Institute for Neuroscience and Human Behavior
Recruiting
Los Angeles, California, United States, 90095
Contact: Keith H Nuechterlein, Ph.D. 310-825-0036 keithn@ucla.edu
Contact: Kenneth L Subotnik, Ph.D. (310) 825-0334 ksubotnik@mednet.ucla.edu
Principal Investigator: Keith H Nuechterlein, Ph.D.
Sub-Investigator: Kenneth L Subotnik, Ph.D. 收起 <<
Australia
... 展开 >>
Bendigo, Australia
Box Hill, Australia
Elizabeth Vale, Australia
Epping, Australia
Fitzroy, Australia
Fremantle, Australia
Glenside, Australia
Meadowbrook, Australia
Waratah, Australia
Wollongong, Australia 收起 <<
China
... 展开 >>
Huzhou, China
Shanghai, China
Shantou, China
Suzhou, China
Wenzhou, China
Wuxi, China
Korea, Republic of
Busan, Korea, Republic of
Goyang, Korea, Republic of
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Jeonju-Si, Korea, Republic of
Kyounggi, Korea, Republic of
Seoul, Korea, Republic of
Suwon, Korea, Republic of
Malaysia
Johor Bahru, Malaysia
Kuala Lumpur, Malaysia
Tanjong Rambutan, Malaysia
Taiwan
Douliou City, Yunlin County, Taiwan
Kaohsiung City, Taiwan
Kaohsiung, Taiwan
New Taipei City, Taiwan
Taichung, Taiwan
Taipei, Taiwan 收起 <<
United States, Florida
... 展开 >>
University of South Florida
St. Petersburg, Florida, United States, 33701
United States, Indiana
University Hospital Outpatient Center, Psychiatry
Indianapolis, Indiana, United States, 46202 收起 <<
China
... 展开 >>
Baoding, China
Beijing, China
Chengdu, China
Chongqing, China
Fuzhou, China
Guangzhou, China
Hangzhou, China
Jinan, China
Nanjing, China
Qingdao, China
Shantou, China
Shenzhen, China
Shijiazhuang, China
Suzhou, China
Taiyuan, China
Tianjin, China
Wuhan, China 收起 <<
Jordan
... 展开 >> Al-Esraa Hospital
Amman, Jordan
King Abdullah University Hospital
Ar Ramtha, Jordan
Princes Basma Teaching Hospital
Irbid, Jordan 收起 <<
China
... 展开 >>
Baoding, China
Beijing, China
Changsha, China
Chengdu, China
Guangzhou, China
Hangzhou, China
Kunming, China
Nanjing, China
Shijiazhuang, China
Taiyuan, China
Wuhan, China
Xian, China 收起 <<
Brazil
... 展开 >>
Belo Horizonte, Brazil
Criciúma, Brazil
Curitiba, Brazil
Goiânia, Brazil
Itapira, Brazil
Marília, Brazil
Rio De Janeiro, Brazil
Salvador, Brazil
Sao Paulo, Brazil
Sorocaba, Brazil
São Paulo, Brazil 收起 <<
United States, Florida
... 展开 >>
Kissimmee, Florida, United States
United States, Texas
Austin, Texas, United States
United States, Virginia
Portsmount, Virginia, United States 收起 <<
Argentina
... 展开 >>
Buenos Aires N/A, Argentina
Buenos Aires, Argentina
Rosario, Argentina
Colombia
Bogota, Colombia
Cali, Colombia
Medellin, Colombia 收起 <<
Croatia
... 展开 >>
Zagreb, Croatia
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Dieppe N/A, France
La Charite Sur Loire, France
Metz Cedex 01, France
Germany
Augsburg, Germany
Bonn, Germany
Mainz, Germany
Mannheim, Germany
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Wasserburg, Germany
Israel
Be-Er Ya-Acov, Israel
Beer Sheva, Israel
Hod-Hasharon, Israel
Pardesia, Israel
Ramat Gan, Israel
Lithuania
Klaipeda, Lithuania
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Vilnius, Lithuania
Poland
Gda Sk Poland, Poland
Lubliniec, Poland
Lublin, Poland
Skape, Poland
Swiecie, Poland
Torun N/A, Poland
Zabki, Poland
Łódź, Poland
Romania
Bucharest, Romania
Cluj-Napoca, Romania
Craiova, Romania 收起 <<
China
... 展开 >>
Baoding, China
Beijing, China
Changsha, China
Chengdu, China
Guangzhou, China
Harbin, China
Kunming, China
Nanjing, China
Shanghai, China
Taiyuan, China
Tianjin, China
Wuhan, China
Xi'An, China
Xian, China
Xinxiang, China 收起 <<
Korea, Republic of
... 展开 >>
Buchun, Korea, Republic of
Cheonan City, Korea, Republic of
Chungcheongbuk-Do, Korea, Republic of
Daegu, Korea, Republic of
Goyang, Korea, Republic of
Gyeonggi-Do, Korea, Republic of
Incheon, Korea, Republic of
Seognam-Si, Kyungki-Do, Korea, Republic of
Seoul, Korea, Republic of 收起 <<
Japan
... 展开 >>
Asahi, Japan
Fujioka, Japan
Fujisawa, Japan
Hachioji, Japan
Higashimurayama, Japan
Hiroshima, Japan
Iizuka, Japan
Kanuma, Japan
Kashihara, Japan
Kashiwara, Japan
Kochi, Japan
Kure, Japan
Maebashi, Japan
Moriguchi, Japan
Nagasaki, Japan
Nirasaki, Japan
Ohta, Japan
Sapporo, Japan
Shimonoseki, Japan
Shinjyuku, Japan
Takatsuki, Japan
Tama, Japan
Tokushima, Japan
Tokyo, Japan
Ube, Japan
Ueda, Japan
Uji, Japan
Yokohama, Japan
Yokosuka, Japan 收起 <<
Korea, Republic of
... 展开 >>
Busan, Korea, Republic of
Changnyeong-Gun, Korea, Republic of
Chonju, Korea, Republic of
Chun-An, Korea, Republic of
Chungcheongbuk-Do, Korea, Republic of
Dae-Jeon, Korea, Republic of
Daegu, Korea, Republic of
Daejeon, Korea, Republic of
Hwasun Gun, Korea, Republic of
Iksan, Korea, Republic of
Kwangjoo, Korea, Republic of
Naju, Korea, Republic of 收起 <<
Korea, Republic of
... 展开 >>
Bucheon-Si Gyeonggi-Do, Korea, Republic of
Changnyung, Korea, Republic of
Chungnam, Korea, Republic of
Chunjoo, Korea, Republic of
Daejeon, Korea, Republic of
Daejun, Korea, Republic of
Geonggi-Do, Korea, Republic of
Gyeonggi-Do, Korea, Republic of
Incheon, Korea, Republic of
Inchun, Korea, Republic of
Jinju, Korea, Republic of
Kwangjoo, Korea, Republic of
Kyounggi, Korea, Republic of
Kyunggi-Do, Korea, Republic of
Kyungju, Korea, Republic of
Kyungki, Korea, Republic of
Kyunki, Korea, Republic of
Pusan, Korea, Republic of
Seoul, Korea, Republic of
Ulsan, Korea, Republic of 收起 <<
Korea, Republic of
... 展开 >>
Busan, Korea, Republic of
Chunjoo, Korea, Republic of
Dae-Gu, Korea, Republic of
Goyang-Si, Korea, Republic of
Ilsan, Korea, Republic of
Kyounggi, Korea, Republic of
Kyunggi-Do, Korea, Republic of
Seoul, Korea, Republic of 收起 <<
Korea, Republic of
... 展开 >>
Chunchun, Korea, Republic of
Incheon, Korea, Republic of
Inchun, Korea, Republic of
Kangwondo, Korea, Republic of
Kyunggido, Korea, Republic of
Kyungki, Korea, Republic of
Kyunki, Korea, Republic of
Seoul, Korea, Republic of 收起 <<
Korea, Republic of
... 展开 >>
Dongguk University International Hospital
Recruiting
Goyang-si, Korea, Republic of, 410-773
Contact: Nam Young Lee, MD fallandwinterny@gmail.com
Sub-Investigator: Yong Sik Kim, MD, PhD
Sub-Investigator: In-Won Chung, MD
Sub-Investigator: Tak Youn, MD
Sub-Investigator: Nam Young Lee, MD
Seoul National University Hospital
Recruiting
Seoul, Korea, Republic of
Contact: Eunyoung Kim, MD npeunyoung@gmail.com
Principal Investigator: Yong Min Ahn, MD 收起 <<
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