Metoclopramide | 甲氧氯普胺 | Dopamine Receptor | AmBeed-信号通路专用抑制剂

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胃复安 /Metoclopramide {[allProObj[0].p_purity_real_show]}

货号：A127869 同义名： 甲氧氯普胺

Metoclopramide is an antagonist of dopamine D2 and is commonly used as an antiemetic.

Metoclopramide 化学结构
CAS号：364-62-5

Metoclopramide 3D分子结构
CAS号：364-62-5

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Metoclopramide 纯度/质量文件产品仅供科研

货号：A127869 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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多巴胺受体亚型比较

产品名称	D1 receptor ↓ ↑	D2 receptor ↓ ↑	D3 receptor ↓ ↑	D4 receptor ↓ ↑	D5 receptor ↓ ↑	DAT ↓ ↑	Dopamine receptor ↓ ↑	其他靶点	纯度
Penfluridol	+ Dopamine receptor, Ki: 1.6 μM								98%
Ansofaxine HCl	++ Dopamine receptor, IC50: 491 nM								98%
Tetrahydroberberine,THB		+ D2 receptor, pKi: 6.08							98+%
Prochlorperazine Maleate		✔							95%
Olanzapine		✔							99+%
Trifluoperazine		++++ Dopamine D2 receptor, IC50: 1.1 nM							98%
Ropinirole hydrochloride		++ D2 receptor, Ki: 29 nM							99%
Lurasidone		++++ D2 receptor, Ki: 1 nM							98%
Levosulpiride		✔							99+%
Pridopidine		✔							95%
Metoclopramide		✔					✔		99+%
Molindone HCl		✔							98%
Sulpiride		✔							99+%
Perospirone		++++ D2 receptor, Ki: 1.4 nM							99%
Perospirone HCl		++++ D2 receptor, Ki: 1.4 nM							98+%
Phenothiazine		✔							98%
Pimozide	+ Dopamine D1 receptor, Ki: 6600 nM	+++ Dopamine D2 receptor, Ki: 3.0 nM	++++ Dopamine D3 receptor, Ki: 0.83 nM						98%
Rotundine	++ D1 receptor, IC50: 166 nM	+ D2 receptor, IC50: 1.47 μM	+ D3 receptor, IC50: 3.25 μM						98%
Domperidone		✔							99+%
ONC206		✔							97%
Pimethixene maleate	++ Dopamine D1 Receptor, pKi: 6.37	+++ Dopamine D2 Receptor, pKi: 8.19		++ Dopamine D4.4 Receptor, pKi: 7.54					97%
Loxapine succinate	++ D2 receptor (Human), Ki: 62 nM D1 receptor (human), Ki: 26 nM	++ D2 receptor (bovine), Ki: 26 nM D2 receptor (human), Ki: 24 nM		+++ D4 receptor (human), Ki: 7.5 nM					99%
Chlorprothixene	+++ D1 receptor, Ki: 18 nM	+++ D2 receptor, Ki: 2.96 nM	+++ D3 receptor, Ki: 4.56 nM		+++ D5 receptor, Ki: 9 nM				98%
SCH-23390 HCl	++++ D1 dopamine receptor, Ki: 0.2 nM				++++ D5 dopamine receptor, Ki: 0.3 nM				98%
MPP+ iodide						✔			97%
σ1 Receptor antagonist-1						+ DAT, pKi: 5.8			97%
Benztropine mesylate						++ DAT, IC50: 118 nM			98%
Azaperone							✔		98%
Ziprasidone HCl							✔		98+%
Paliperidone							✔		98%
Alizapride HCl							✔		99+%
Amisulpride							✔		98%
Quetiapine hemifumarate							✔	Adrenergic Receptor	98%
Clozapine N-oxide							✔		99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Metoclopramide 生物活性

靶点

Dopamine receptor
D2 receptor

描述

Metoclopramide acts on several different receptors; primarily as a dopamine receptor antagonist, both peripherally improving gastric emptying, and centrally resulting in an anti-emetic effect. Metoclopramide side effects, mostly related to its ability to cross the blood-brain barrier, include drowsiness, restlessness, hyperprolactinemia, and tardive dyskinesia (TD), a movement disorder that may be irreversible^[3]. Intranasal metoclopramide 80 mg significantly reduced the frequency of acute vomiting in 43 patients receiving highly emetogenic chemotherapy. Intranasal metoclopramide caused minor irritation of the nasal membrane and unpleasant taste in some patients, but was otherwise well tolerated^[4]. Metoclopramide's effect on the medullary chemoreceptor trigger zone makes it useful as a routine anti-emetic and in preventing vomiting induced by antineoplastic drugs, particularly cisplatin. Metoclopramide's gastrointestinal smooth muscle stimulatory effects are related to its ability to antagonize the inhibitory neurotransmitter, dopamine; to augment acetylcholine release and sensitize the muscarinic receptors of the gastrointestinal smooth muscle; and to coordinate gastric-pyloric-small intestinal motor function^[5]. Patients with severe migraine attacks treated with metoclopramide as monotherapy showed a significant improvement in terms of pain relief and a faster improvement in pain intensity compared to those treated with paracetamol^[6].

Metoclopramide 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02627950	Acute Myocardial Infarction	Phase 4	Unknown	September 2017	Germany ... 展开 >> University of Luebeck Recruiting Luebeck, Germany, 23538 Contact: Holger Thiele holger.thiele@uksh.de Contact: Roza Meyer-Saraei roza.meyer-saraei@uksh.de Principal Investigator: Holger Thiele 收起 <<
NCT00817934	-		Unknown	January 2010	United States, Delaware ... 展开 >> Cedar Tree Surgical Center Millsboro, Delaware, United States, 19966 收起 <<
NCT00977223	Healthy Volunteers	Phase 4	Completed	-	France ... 展开 >> Rouen Clinical research Centre (CIC 0204) Rouen, Haute Normandie, France, 76031 收起 <<

Metoclopramide 参考文献

[1]Navari RM, Nagy CK, Gray SE. The use of olanzapine versus metoclopramide for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy. Support Care Cancer. 2013 Jan 12.

[2]Matok I, Gorodischer R, et al. The safety of metoclopramide use in the first trimester of pregnancy. N Engl J Med. 2009 Jun 11;360(24):2528-35.

[3]Shakhatreh M, Jehangir A, Malik Z, Parkman HP. Metoclopramide for the treatment of diabetic gastroparesis. Expert Rev Gastroenterol Hepatol. 2019;13(8):711‐721

[4]Ormrod D, Goa KL. Intranasal metoclopramide. Drugs. 1999;58(2):315‐324

[5]Albibi R, McCallum RW. Metoclopramide: pharmacology and clinical application. Ann Intern Med. 1983;98(1):86‐95

[6]Salazar G, Fragoso M, Vergez L, Sergio P, Cuello D. Metoclopramide as an analgesic in severe migraine attacks: an open, single-blind, parallel control study. Recent Pat CNS Drug Discov. 2011;6(2):141‐145

Metoclopramide 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.34mL

0.67mL

0.33mL

16.68mL

3.34mL

1.67mL

33.36mL

6.67mL

3.34mL

Metoclopramide 技术信息

CAS号	364-62-5
分子式	C₁₄H₂₂ClN₃O₂
分子量	299.796

别名	甲氧氯普胺
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

DMSO: 105 mg/mL(350.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02627950	Acute Myocardial Infarction	Phase 4	Unknown	September 2017	Germany ... 展开 >> University of Luebeck Recruiting Luebeck, Germany, 23538 Contact: Holger Thiele holger.thiele@uksh.de Contact: Roza Meyer-Saraei roza.meyer-saraei@uksh.de Principal Investigator: Holger Thiele 收起 <<
NCT00817934	-		Unknown	January 2010	United States, Delaware ... 展开 >> Cedar Tree Surgical Center Millsboro, Delaware, United States, 19966 收起 <<
NCT00977223	Healthy Volunteers	Phase 4	Completed	-	France ... 展开 >> Rouen Clinical research Centre (CIC 0204) Rouen, Haute Normandie, France, 76031 收起 <<
NCT01220388	Male Healthy ... 展开 >>Volunteers 收起 <<	Not Applicable	Completed	-	France ... 展开 >> Rouen Clinical research Centre (CIC 0204) Rouen, France, 76031 收起 <<
NCT02965963	Health	Not Applicable	Recruiting	March 2019	Canada, Alberta ... 展开 >> Clinical Physiology Research Laboratory Recruiting Edmonton, Alberta, Canada, T6G 2J1 Contact: Wade W Michaelchuk 780-632-9310 wwmichae@ualberta.ca Contact: Michael K Stickland 780-492-3995 michael.stickland@ualberta.ca 收起 <<
NCT03606369	Breast Neoplasm ... 展开 >> Antineoplastic Agents Antiemetics Quality of Life 收起 <<	Phase 2 Phase 3	Recruiting	December 31, 2020	Mexico ... 展开 >> Instituto Nacional de Cancerología Recruiting Mexico City, Mexico, 14080 Contact: Julieta Santamaría Galicia, BD 56280400 ext 12065 ztinala@yahoo.es 收起 <<
NCT00650520	Healthy	Phase 1	Completed	-	Canada, Quebec ... 展开 >> MDS Pharma Services Montreal, Quebec, Canada, H4R 2N6 收起 <<
NCT00649168	Healthy	Phase 1	Completed	-	Canada, Quebec ... 展开 >> MDS Pharma Services Montreal, Quebec, Canada, H4R 2N6 收起 <<
NCT00131248	Gastroesophageal Reflux	Phase 3	Completed	-	United States, Texas ... 展开 >> Memorial Hermann Children's Hospital Houston, Texas, United States, 77030 收起 <<
NCT02681211	Migraine Headache	Not Applicable	Recruiting	June 2019	United States, Kentucky ... 展开 >> Norton Children's Hospital Recruiting Louisville, Kentucky, United States, 40202 Contact: Danielle M Graff, MD, MSc Principal Investigator: Danielle M Graff, MD, MSc Sub-Investigator: Mark McDonald, MD Sub-Investigator: Ron Paul, MD Sub-Investigator: Amy Hanson, MD Sub-Investigator: Keith Cross, MD Sub-Investigator: Brit Anderson, MD Norton Children's Medical Center Recruiting Louisville, Kentucky, United States, 40241 Contact: Danielle Graff, MD, MSc Principal Investigator: Danielle Graff, MD, MSc Sub-Investigator: Mark McDonald, MD Sub-Investigator: Keith Cross, MD Sub-Investigator: Amy Hanson, MD Sub-Investigator: Ron Paul, MD Sub-Investigator: Brit Anderson, MD 收起 <<
NCT01604785	Migraine Headache	Phase 2 Phase 3	Completed	-	United States, Oregon ... 展开 >> Oregon Health & Science University Portland, Oregon, United States, 97239 收起 <<
NCT00131248	-		Completed	-	-
NCT02703896	Pulmonary Aspiration of Gastri... 展开 >>c Contents 收起 <<	Phase 4	Completed	-	-
NCT02582996	Migraine	Phase 3	Not yet recruiting	June 2020	Brazil ... 展开 >> Centro de Pesquisa Clínica - CPEC / Associação Obras Sociais Irmã Dulce Not yet recruiting Salvador, Bahia, Brazil Centro de Pesquisa Clínica Hospital São Lucas da PUCRS Not yet recruiting Porto Alegre, Rio Grande Do Sul, Brazil Centro de Desenvolvimento em Estudos Clínicos Brasil - CDEC Brasil Not yet recruiting São Paulo, Brazil Cepic - Centro Paulista de Investigação Clínica Not yet recruiting São Paulo, Brazil CPCLIN - Centro de Pesquisas Clinicas Ltda Not yet recruiting São Paulo, Brazil Universidade Federal de São Paulo - Núcleo de Gestão de Pesquisa/HU/FAP Not yet recruiting São Paulo, Brazil 收起 <<
NCT03017430	Opioid Withdrawal	Phase 4	Recruiting	December 2019	Russian Federation ... 展开 >> St.-Petersburg Bekhterev Reserach Psychoneurological Institute Recruiting St.-Petersburg, Russian Federation, 192019 Contact: Evgeny M Krupitsky, MD, PhD +7-911-748-9989 kruenator@gmail.com Sub-Investigator: Ruslan D Ilyuk, MD 收起 <<
NCT03649009	Hyperlactatemia	Not Applicable	Recruiting	March 31, 2019	Malaysia ... 展开 >> Universiti Kebangsaan Malaysia Medical Centre Recruiting Cheras, Kuala Lumpur, Malaysia, 56000 Contact: Cheah SK Dr, M.D. 收起 <<
NCT03268941	Diabetes Mellitus and Gastropa... 展开 >>resis, Idiopathic Gastroparesis 收起 <<	Phase 1	Completed	-	United States, Arizona ... 展开 >> 9171 West Thunderbird Road Peoria, Arizona, United States, 85381 850 North Kolb Road Tucson, Arizona, United States, 85710 United States, Arkansas 11219 Financial Centre Parkway Little Rock, Arkansas, United States, 72211 United States, Florida 13055 Southwest 42nd Street Miami, Florida, United States, 33175 8200 Southwest 117th Avenue Miami, Florida, United States, 33183 United States, Georgia 125 Clairemont Avenue Decatur, Georgia, United States, 30030 United States, Louisiana 616 South Washington Street Bastrop, Louisiana, United States, 71220 United States, Tennessee 6035 Shallowford Road Chattanooga, Tennessee, United States, 37421 26 Stonecreek Circle Jackson, Tennessee, United States, 38305 收起 <<
NCT02528760	Cirrhosis	Not Applicable	Completed	-	India ... 展开 >> Institute of liver and Biliary Sciences New Delhi, Delhi, India, 110070 收起 <<
NCT01067677	Post Operative Nausea and Vomi... 展开 >>ting Rescue Emetic Therapy 收起 <<	Not Applicable	Withdrawn(We do not have the f... 展开 >>unding or resources to complete the study at this time) 收起 <<	February 2014	United States, Pennsylvania ... 展开 >> The Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania, United States, 15210 收起 <<
NCT01243736	Gastrointestinal Hemorrhage	Phase 1	Completed	-	United States, Minnesota ... 展开 >> Mayo Clinic Rochester, Minnesota, United States, 55905 收起 <<
NCT02847494	Migraine	Phase 4	Completed	-	United States, New York ... 展开 >> Montefiore Medical Center--Einstein Bronx, New York, United States, 10461 Montefiore Medical Center-Moses Bronx, New York, United States, 10467 收起 <<
NCT02282852	Patients Attending Hospital fo... 展开 >>r Small Bowel Endoscopy 收起 <<	Not Applicable	Completed	-	United Kingdom ... 展开 >> Royal Hallamshire Hospital Sheffield, South Yorkshire, United Kingdom, S10 2JF 收起 <<
NCT00147355	HIV Infections	Phase 3	Terminated(28 of 168 patients ... 展开 >>only were enrolled, numbers too low to be conclusive) 收起 <<	-	Argentina ... 展开 >> Hospital General de Agudos JM Ramos Mejia Buenos Aires, Argentina, C221 FUNCEI Buenos Aires, Argentina Hospital Italiano de Buenos Aires Buenos Aires, Argentina Hospital Prof. Alejandro Posadas Buenos Aires, Argentina Hospital Interzonal de Agudos San Juan de Dios La Plata, Argentina Hospital Interzonal General de Agudos Oscar Alende Mar del Plata, Argentina Hospital Central Mendoza, Argentina CAICI Rosario, Argentina Australia, New South Wales St. Vincent's Hospital Sydney, New South Wales, Australia, 2010 Australia, Queensland AIDS Medical Unit Brisbane, Queensland, Australia, 4002 Cairns Base Hospital Cairns, Queensland, Australia, 4870 Gold Coast Sexual Health Clinic Gold Coast, Queensland, Australia, 4220 Nambour Hospital Nambour, Queensland, Australia, 4560 Australia, Victoria Carlton Clinic Melbourne, Victoria, Australia, 3000 The Alfred Hospital Melbourne, Victoria, Australia, 3000 Israel Kaplan Medical Center Rehovot, Israel 收起 <<
NCT02017379	Upper Gastrointestinal Bleedin... 展开 >>g 收起 <<	Not Applicable	Terminated(Could not recruit a... 展开 >>ny subjects) 收起 <<	-	United States, Texas ... 展开 >> Texas Tech University Health Science Center El Paso, Texas, United States, 79905 收起 <<
NCT01984931	Nausea Vomiti... 展开 >>ng 收起 <<	Phase 3	Unknown	December 2013	Korea, Republic of ... 展开 >> Chungmu General Hopsital Recruiting Seoul, Yeongdeungpo-gu, Korea, Republic of, 150-034 Contact: Sang Hoon Lhee, MD, Phd +82 (2) 2068/4525 cmirb@naver.com Principal Investigator: Paolo Alan B Tabar, MD 收起 <<
NCT00892996	Pregnancy PON... 展开 >>V 收起 <<	Not Applicable	Unknown	April 2011	Thailand ... 展开 >> Anesthesiology department, Siriraj hospital, Mahidol University Bangkok, Thailand, 10700 收起 <<
NCT02784392	Enteral Feeding Intolerance (E... 展开 >>FI) 收起 <<	Phase 2	Completed	-	United States, Louisiana ... 展开 >> New Orleans, Louisiana, United States United States, Ohio Columbus, Ohio, United States Netherlands Amsterdam, Netherlands Spain Barcelona, Spain Madrid, Spain 收起 <<
NCT01191645	Opioid Induced Pharyngeal and ... 展开 >>Esophageal Dysfunction 收起 <<	Phase 4	Completed	-	Sweden ... 展开 >> Örebro University Hospital Örebro, Sweden, 70185 收起 <<
NCT01934192	Gastroparesis	Phase 2	Terminated	-	United States, Colorado ... 展开 >> GSK Investigational Site Aurora, Colorado, United States, 80045 United States, Georgia GSK Investigational Site Augusta, Georgia, United States, 30909 United States, Kentucky GSK Investigational Site Louisville, Kentucky, United States, 40202 United States, Pennsylvania GSK Investigational Site Philadelphia, Pennsylvania, United States, 19104 Australia, New South Wales GSK Investigational Site Randwick, New South Wales, Australia, 2031 Australia, Queensland GSK Investigational Site Southport, Queensland, Australia, 4215 Australia, South Australia GSK Investigational Site Adelaide, South Australia, Australia, 5000 GSK Investigational Site Woodville, South Australia, Australia, 5011 Canada, Alberta GSK Investigational Site Calgary, Alberta, Canada, T1Y 6J4 GSK Investigational Site Calgary, Alberta, Canada, T2N 2T9 Canada, Ontario GSK Investigational Site Hamilton, Ontario, Canada, L8L 2X2 GSK Investigational Site Kingston, Ontario, Canada, K7L 2V7 GSK Investigational Site Ottawa, Ontario, Canada, K1H 8L6 GSK Investigational Site Ottawa, Ontario, Canada, K1Y 4E9 GSK Investigational Site Toronto, Ontario, Canada, M5G 1X5 Canada, Quebec GSK Investigational Site Montreal, Quebec, Canada, H2X 3J4 GSK Investigational Site Sainte-Foy, Quebec, Canada, G1V 4G5 GSK Investigational Site Sherbrooke, Quebec, Canada, J1H 5N4 Canada GSK Investigational Site Quebec, Canada, G1J 1Z4 收起 <<
NCT00869310	Emesis	Phase 3	Terminated(we terminated the s... 展开 >>tudy before enrolling 303/560 due to a slow accrual) 收起 <<	-	Italy ... 展开 >> Fausto Roila Terni, Italy, 05100 收起 <<
NCT00395161	Sepsis	Phase 3	Terminated(Terminated for futi... 展开 >>lity on 11/30/09 based on the recommendation of the DSMB) 收起 <<	-	United States, Arkansas ... 展开 >> Arkansas Children's Hospital Little Rock, Arkansas, United States, 72202 United States, California Childrens Hospital of Los Angeles Los Angeles, California, United States, 90027 University of California Los Angeles Medical Center Los Angeles, California, United States, 90095 United States, District of Columbia Children's National Medical Center Washington, District of Columbia, United States, 20010 United States, Michigan Children's Hospital of Michigan Detroit, Michigan, United States, 48201 United States, Pennsylvania University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15213 United States, Washington Seattle Children's Hospital Seattle, Washington, United States, 98105 收起 <<
NCT01051271	Akathisia	Not Applicable	Completed	-	-
NCT01934192	-		Terminated	-	-
NCT03017391	Nausea Vomiti... 展开 >>ng Cancer 收起 <<	Phase 4	Unknown	-	-
NCT02913469	ST-segment Elevation Myocardia... 展开 >>l Infarction 收起 <<	Phase 4	Unknown	December 2016	China ... 展开 >> Cardiology Department, Chinese Armed Police Force Genral Hospital, Beijing China Recruiting Beijing, China, 100039 Contact: HUILIANG LIU, MD +8610-57976531 liuhuiliang1961@163.com Contact: JIAO ZHANG, MD +8615011558161 15011558161@163.com 收起 <<
NCT02979548	Chemotherapy Induced Vomiting ... 展开 >> Acute Myeloid Leukemia 收起 <<	Phase 3	Recruiting	December 2018	India ... 展开 >> Irch, Aiims , New Delhi , India Recruiting New Delhi, DEL, India, 110029 Contact: ATUL SHARMA, MD 9968859779 dratulsharma@hotmail.com 收起 <<
NCT00395161	-		Terminated(Terminated for futi... 展开 >>lity on 11/30/09 based on the recommendation of the DSMB) 收起 <<	-	-
NCT02262923	in Vitro Fertilization ... 展开 >> Poor Responder 收起 <<	Not Applicable	Unknown	March 2018	Canada, Ontario ... 展开 >> Mount Sinai Hospital Not yet recruiting Toronto, Ontario, Canada, M5T 3H7 Contact: Crystal Chan, MD, FRCSC Principal Investigator: Robert Casper, MD, FRCSC Sub-Investigator: Crystal Chan, MD, FRCSC 收起 <<
NCT03477903	Critical Illness ... 展开 >> Enteral Nutrition Enteral Feeding Intolerance 收起 <<	Phase 2	Terminated(Insufficient enroll... 展开 >>ment; No safety concerns) 收起 <<	-	-
NCT02959840	Nausea Vomiti... 展开 >>ng Satisfaction 收起 <<	Phase 4	Completed	-	United States, New Jersey ... 展开 >> Robert Wood Johnson University Hospital New Brunswick, New Jersey, United States, 08901 收起 <<
NCT03698292	Critically-ill Patients	Not Applicable	Recruiting	September 2019	Egypt ... 展开 >> Kasr Al Ainy Hospital Recruiting Cairo, Egypt Contact: Maha Hanna, MD 01227342966 mahagamil@hotmail.com 收起 <<
NCT01569633	Feeding Disorder ... 展开 >> Nutrition Disorder Infant,Premature 收起 <<	Not Applicable	Terminated(very poor enrollmen... 展开 >>t) 收起 <<	December 2015	United States, Tennessee ... 展开 >> East Tennessee State University Johnson City, Tennessee, United States, 37604 收起 <<
NCT00008736	Infant, Newborn, Diseases	Phase 2	Completed	-	United States, Pennsylvania ... 展开 >> Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 收起 <<
NCT02959840	-		Completed	-	-
NCT00364806	Migraine	Phase 4	Completed	-	United States, New York ... 展开 >> Montefiore Medical Center Bronx, New York, United States, 10467 收起 <<
NCT01825941	Migraine	Phase 4	Completed	-	United States, New York ... 展开 >> Montefiore Medical Center Bronx, New York, United States, 10467 收起 <<
NCT01069536	Akathisia Nau... 展开 >>sea 收起 <<	Not Applicable	Completed	-	-
NCT01825941	-		Completed	-	-
NCT01781377	PREGNANCY	Phase 4	Completed	-	Italy ... 展开 >> A.O. SS.ma Annunziata Chieti, Italy, 60100 收起 <<
NCT00139893	Diabetic Gastroparesis	Not Applicable	Completed	-	United States, Wisconsin ... 展开 >> Schwarz Milwaukee, Wisconsin, United States 收起 <<
NCT01937234	Prolonged First Stage of Labor	Phase 4	Completed	-	Saudi Arabia ... 展开 >> Labor and delivery ward of Armed Forces Hospital, Southern Region. Khamis Mushait, Saudi Arabia, 101 收起 <<
NCT00237705	Post Concussive Headache ... 展开 >> Post Concussive Syndrome 收起 <<	Not Applicable	Unknown	-	Canada, British Columbia ... 展开 >> Vancouver General Hospital Recruiting Vancouver, British Columbia, Canada, V5Z 1M9 Contact: David W Harrison, MD 604 875-4033 david.harrison@vch.ca Principal Investigator: David W Harrison, MD 收起 <<
NCT00778011	Nausea Vomiti... 展开 >>ng 收起 <<	Phase 4	Completed	-	United States, Pennsylvania ... 展开 >> York Hospital York, Pennsylvania, United States, 17405 收起 <<
NCT00003213	Nausea and Vomiting ... 展开 >> Unspecified Adult Solid Tumor, Protocol Specific 收起 <<	Phase 3	Completed	-	Italy ... 展开 >> Istituto Europeo Di Oncologia Milano, Italy, 20141 Switzerland Kantonspital Aarau Aarau, Switzerland, 5001 Office of Walter Weber-Stadelman Basel, Switzerland, CH 4051 University Hospital Basel, Switzerland, CH-4031 Inselspital, Bern Bern, Switzerland, CH-3010 Hopital Cantonal Universitaire de Geneva Geneva, Switzerland, CH-1211 Istituto Oncologico della Svizzera Italiana Lugano, Switzerland, CH-6900 Burgerspital, Solothurn Solothurn, Switzerland, 4500 City Hospital Triemli Zurich, Switzerland, 8063 Klinik Hirslanden Zurich, Switzerland, CH-8008 收起 <<
NCT00655642	-		Terminated(Conditional analysi... 展开 >>s showed observed differences were significantly less than power calculations) 收起 <<	-	-
NCT00355394	Migrainous Headache	Phase 2	Completed	-	United States, Pennsylvania ... 展开 >> Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 收起 <<
NCT00275184	Small Bowel Disease ... 展开 >> Gastrointestinal Hemorrhage Refractory Anemia 收起 <<	Phase 3	Unknown	-	United Kingdom ... 展开 >> St Mark's Hospital, North West London Hospitals NHS Trust Recruiting London, United Kingdom, HA1 3UJ Contact: Alan Warnes, PhD alan.warnes@nwlh.nhs.ul Contact: Iva Hauptmannova, BSc, MA iva.hauptmannova@nwlh.nhs.uk Sub-Investigator: Neil Patterson, MB BCH, MD, MRCP 收起 <<
NCT01216410	Cesarean Delivery	Not Applicable	Completed	-	United States, North Carolina ... 展开 >> Duke University Medical Center Durham, North Carolina, United States, 27710 收起 <<
NCT03459248	Postoperative Nausea and Vomit... 展开 >>ing 收起 <<	Not Applicable	Recruiting	February 2019	Lebanon ... 展开 >> Makassed General Hospital Recruiting Beirut, Lebanon Contact: Zoher Naja, MD +9611636000 ext 6405 zouhnaja@yahoo.com 收起 <<
NCT00477776	Breastfeeding	Phase 3	Completed	-	Singapore ... 展开 >> National University Hospital Singapore, Singapore, 119074 收起 <<
NCT00355394	-		Completed	-	-
NCT02135510	Solid Tumors	Phase 3	Recruiting	July 2019	Netherlands ... 展开 >> Gemini Ziekenhuis Recruiting Den Helder, Noord Holland, Netherlands, 1782 GZ Contact: S.C.S. Tromp-van Driel (0223) 69 69 69 Tergooiziekenhuizen Recruiting Hilversum, Noord Holland, Netherlands, 1213 XZ Contact: H.P. van den Berg 088 753 17 53 Medisch Centrum Alkmaar Recruiting Alkmaar, Noord-Holland, Netherlands, 1815 JD Contact: S Vrijaldenhoven (072) 548 2870 Ziekenhuis Amstelland Recruiting Amstelveen, Noord-Holland, Netherlands, 1186 AM Contact: A. van Zweeden (020) 755 7000 Waterland Ziekenhuis Not yet recruiting Purmerend, Noord-Holland, Netherlands, 1441 RN Contact: J Brakenhoff 0299 457 457 De Heel - Zaans Medisch Centrum Not yet recruiting Zaandam, Noord-Holland, Netherlands, 1502 DV Contact: A. van Bochove (075) 650 29 11 Rijnstate Recruiting Arnhem, Netherlands Contact: T van Voorthuizen +31(0)88 005 8888 收起 <<
NCT00655642	Nausea	Not Applicable	Terminated(Conditional analysi... 展开 >>s showed observed differences were significantly less than power calculations) 收起 <<	-	United States, Tennessee ... 展开 >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37240 收起 <<
NCT02295280	Headache	Not Applicable	Completed	-	United States, Missouri ... 展开 >> Saint Louis University Saint Louis, Missouri, United States, 63117 收起 <<
NCT02295280	-		Completed	-	-
NCT01148264	Emesis	Phase 2	Terminated(poor enrolment)	-	Germany ... 展开 >> Martin-Luther-University Halle-Wittenberg, Department for Oncology and Hematology, Ernst-Grube-Strasse 40 Halle (Saale), Sachsen-Anhalt, Germany, 06097 收起 <<
NCT00682734	Migraine	Phase 3	Completed	-	United States, New York ... 展开 >> Montefiore Medical Center Bronx, New York, United States, 10467 收起 <<
NCT01216410	-		Completed	-	-
NCT01267864	-		Completed	-	-
NCT00264719	Breastfeeding	Not Applicable	Completed	-	Singapore ... 展开 >> National University Hospital Singapore, Singapore, 308562 收起 <<
NCT01267864	Acute Migraine	Phase 4	Completed	-	United States, New York ... 展开 >> Montefiore Medical Center Bronx, New York, United States, 10467 收起 <<
NCT00242450	Infant, Premature	Phase 4	Completed	-	Canada, Ontario ... 展开 >> St Joseph's Hospital London, Ontario, Canada, N6A 4V2 收起 <<
NCT01406860	Primary Headaches (Includes Mi... 展开 >>graines, Tension, Cluster Headaches) 收起 <<	Not Applicable	Terminated(lack of enrollment/... 展开 >>drug shortages) 收起 <<	-	United States, Iowa ... 展开 >> University of Iowa Hospitals and Clinics Iowa City, Iowa, United States, 52242 收起 <<
NCT00120653	Myelodysplastic Syndromes	Phase 2	Withdrawn	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 United States, Washington University of Washington Seattle, Washington, United States, 98195 收起 <<
NCT01406860	-		Terminated(lack of enrollment/... 展开 >>drug shortages) 收起 <<	-	-
NCT00557544	Migraine	Phase 3	Withdrawn	June 2010	Italy ... 展开 >> Edoardo Guglia Trieste, Italy, 34100 收起 <<
NCT03383315	Trauma Opioid... 展开 >> Analgesic Adverse Reaction 收起 <<	Phase 2	Completed	-	Malaysia ... 展开 >> Sarawak General Hospital Kuching, Sarawak, Malaysia, 93586 收起 <<
NCT00475306	-		Completed	-	-
NCT00475306	Nausea Extrap... 展开 >>yramidal Symptoms 收起 <<	Phase 4	Completed	-	United States, New York ... 展开 >> Montefiore Medical Center Bronx, New York, United States, 10461 收起 <<
NCT00682734	-		Completed	-	-
NCT02098499	Migraine Headaches ... 展开 >> Nausea Restlessness 收起 <<	Phase 4	Completed	-	United States, Virginia ... 展开 >> Naval Medical Center Portsmouth Portsmouth, Virginia, United States, 23708 收起 <<
NCT02907632	Gastroesophageal Reflux	Phase 4	Recruiting	December 31, 2018	Colombia ... 展开 >> Nathalie Charpak Recruiting Bogotá, Cundinamarca, Colombia, 110231 Contact: Nathalie Charpak, Dr 573002116552 ncharpak@gmail.com Contact: Nathalie Charpak, Dr. ncharpak@gmail.com 收起 <<
NCT01953081	Enteral Feeding Intolerance	Phase 1 Phase 2	Completed	-	Australia, South Australia ... 展开 >> Royal Adelaide Hospital Adelaide, South Australia, Australia 收起 <<
NCT01953081	-		Completed	-	-
NCT01907633	-		Completed	-	-
NCT01165866	Gastroenteritis	Phase 4	Completed	-	Qatar ... 展开 >> Pediatric Emergency Centre, Al-Saad Doha, Qatar 收起 <<
NCT02619201	Acute Gastroenteritis ... 展开 >> Vomiting 收起 <<	Phase 3	Unknown	November 2016	-
NCT02222220	Clozapine-induced Hypersalivat... 展开 >>ion 收起 <<	Phase 3	Completed	-	Israel ... 展开 >> Be'er Sheva Mental Health Center, Be'er Sheva, Israel, 8417000 收起 <<
NCT03588338	Postoperative Nausea and Vomit... 展开 >>ing 收起 <<	Phase 4	Not yet recruiting	August 21, 2018	-
NCT02025751	Diabetic Gastroparesis	Phase 3	Completed	-	-
NCT00845858	Gastroparesis ... 展开 >> Diabetic Gastroparesis Diabetes Diabetes Mellitus Delayed Gastric Emptying 收起 <<	Phase 2	Completed	-	-
NCT01791400	Migraine Disorders	Phase 2	Completed	-	Iran, Islamic Republic of ... 展开 >> Al-zahra university hospital Isfahan, Iran, Islamic Republic of 收起 <<
NCT03220958	Post-Traumatic Headache	Phase 3	Recruiting	August 2019	United States, New York ... 展开 >> Montefiore Medical Center Recruiting Bronx, New York, United States, 10467 Contact: Benjamin W Friedman, MD, MS 718-920-6626 befriedm@montefiore.org 收起 <<
NCT02098915	Gastroschisis	Phase 3	Recruiting	June 2019	Canada, Ontario ... 展开 >> The Hospital for Sick Children Recruiting Toronto, Ontario, Canada, M5G 1X8 Contact: Christopher Tomlinson, MD 416-813-2474 ext 302474 christopher.tomlinson@sickkids.ca Contact: Eveline Lapidus-Krol, Msc 416-813-6542 ext 306542 eveline.lapidus-krol@sickkids.ca Principal Investigator: Jacob C Langer, MD Sub-Investigator: Christopher Tomlinson, MD Sub-Investigator: Eveline Lapidus-Krol, MSc Sub-Investigator: Paul Wales, MD 收起 <<
NCT01093690	Cancer	Not Applicable	Completed	-	Thailand ... 展开 >> Division of medical oncology, department of medicine Siriraj Hospital Bangkok, Thailand, 10700 收起 <<
NCT01093690	-		Completed	-	-
NCT02163434	Hyperemesis Gravidarum	Phase 3	Unknown	May 2018	United States, New York ... 展开 >> University at Buffalo Recruiting Buffalo, New York, United States, 14214 Contact: Rachel LaPorta, RN 716-878-7509 rlaporta@buffalo.edu University of Rochester Recruiting Rochester, New York, United States, 14642 Contact: Heather Fiore 585-275-7480 Heather_Fiore@URMC.Rochester.edu 收起 <<
NCT00845858	-		Completed	-	-
NCT01126034	Gastroesophageal Reflux Diseas... 展开 >>e Diabetic Gastroparesis 收起 <<	Not Applicable	Completed	-	United States, Pennsylvania ... 展开 >> University of Pennsylvania Center for Clinical Epidemiology and Biostatistics Philadelphia, Pennsylvania, United States, 19104 收起 <<
NCT00632606	Headache	Phase 2 Phase 3	Withdrawn	-	United States, Rhode Island ... 展开 >> Women and Infants Hospital of Rhode Island Providence, Rhode Island, United States, 02905 收起 <<
NCT01011673	Headache	Phase 4	Completed	-	United States, New York ... 展开 >> Montefiore Medical Center Bronx, New York, United States, 10467 收起 <<
NCT02025725	Diabetic Gastroparesis	Phase 3	Completed	-	-
NCT01596166	Probable Migraine ... 展开 >> Migraine With Aura Migraine Without Aura 收起 <<	Phase 4	Completed	-	Canada, Alberta ... 展开 >> Alberta Children's Hospital Calgary, Alberta, Canada, T3B 6A8 Stollery Children's Hospital Edmonton, Alberta, Canada, T6G 2C8 收起 <<
NCT03560583	Poor Responders in IVF	Not Applicable	Not yet recruiting	May 2020	-
NCT02972502	Headache, Migraine	Phase 4	Terminated(PI lapsed instituti... 展开 >>onal training) 收起 <<	-	United States, Ohio ... 展开 >> OhioHealth Doctors Hospital Columbus, Ohio, United States, 43228 收起 <<
NCT01011673	-		Completed	-	-
NCT02939235	Unstable Angina Pectoris	Phase 4	Recruiting	September 2017	Poland ... 展开 >> Cardiology Department, Dr. A. Jurasz University Hospital Recruiting Bydgoszcz, Kujawsko-Pomorskie, Poland, 85-094 Contact: Piotr Niezgoda, M.D. +48525854023 piotr.niezg@gmail.com 收起 <<
NCT01522326	Acute Mountain Sickness ... 展开 >> High Altitude Headache 收起 <<	Not Applicable	Unknown	March 2017	Nepal ... 展开 >> Manang Clinic of the Himalayan Rescue Association Recruiting Manang, District of Manang, Nepal, 33500 Contact: John B Tanner, MD 206-661-1143 JBTANNER@PARTNERS.ORG Sub-Investigator: John B Tanner, MD 收起 <<
NCT03269435	Migraine	Phase 4	Recruiting	October 2020	United States, New York ... 展开 >> Montefiore Medical Center Recruiting Bronx, New York, United States, 10467 Contact: Benjamin W Friedman, MD, MS 718-920-6626 befriedm@montefiore.org 收起 <<
NCT02314351	Migraine Disorders	Phase 4	Completed	-	Turkey ... 展开 >> Kocaeli University, Faculty of Medicine Kocaeli, Turkey, 41000 收起 <<
NCT01631994	Gastric Transit Time	Not Applicable	Completed	-	United States, New York ... 展开 >> Winthrop University Hospital Mineola, New York, United States, 11501 收起 <<
NCT01289938	Drug Metabolism, Poor, CYP2D6-... 展开 >>RELATED 收起 <<	Phase 1	Terminated(To unsuccessful rec... 展开 >>ruitment of rare UM-genotype. All other planned genotype groups are completed (EM, IM and PM).) 收起 <<	-	Germany ... 展开 >> Abteilung Klinische Pharmakologie, UKT Tübingen Tübingen, BW, Germany, 72076 收起 <<
NCT03056352	Post-Traumatic Headache	Phase 1 Phase 2	Completed	-	United States, New York ... 展开 >> Montefiore Medical Center Bronx, New York, United States, 10467 收起 <<
NCT01630109	Pill Capsule Endoscopy Complet... 展开 >>ion Rates 收起 <<	Phase 4	Completed	-	United States, Michigan ... 展开 >> Genesys Regional Medical Center Grand Blanc, Michigan, United States, 48439 收起 <<
NCT03056352	-		Completed	-	-
NCT01630109	-		Completed	-	-
NCT02466984	Nausea Vomiti... 展开 >>ng 收起 <<	Phase 3	Recruiting	March 2018	France ... 展开 >> Centre Hospitalier Universitaire de Bordeaux - St André Recruiting Bordeaux, Aquitaine, France, 33000 Contact: Matthieu FRASCA, Doctor +(33)5 56 79 58 58 matthieu.frasca@chu-bordeaux.fr Principal Investigator: Matthieu FRASCA, Doctor Sub-Investigator: Benoît BURUCOA, Professor Sub-Investigator: Camille SAUSSAC, Doctor Sub-Investigator: Bernard PATERNOSTRE, Doctor Sub-Investigator: Sylvie CHARRAZAC, Doctor Sub-Investigator: Véronique AVEROUS, Doctor 收起 <<
NCT03331965	Radiation Exposure ... 展开 >> Enteral Nutrition 收起 <<	Phase 2	Recruiting	July 2019	United States, North Carolina ... 展开 >> Duke University Hospital Recruiting Durham, North Carolina, United States, 27710 Contact: Clinical Research Coordinator 919-613-5912 stephen.gazda@duke.edu 收起 <<
NCT02972502	-		Terminated(PI lapsed instituti... 展开 >>onal training) 收起 <<	-	-
NCT02253524	Nausea Vomiti... 展开 >>ng Vertigo 收起 <<	Phase 4	Completed	-	-

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