盐酸沙格雷酯 /Sarpogrelate HCl 货号：A166685 同义名：
MCI-9042;Sarpogrelate (hydrochloride)
Sarpogrelate HCl 是一种 5-HT2A 和 5-HT2B 受体的拮抗剂，能够阻断血清素诱导的血小板聚集，用于治疗糖尿病、Buerger 病、雷诺病、冠状动脉病、心绞痛和动脉粥样硬化。
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Type HazMat fee for 500 gram (Estimated) Excepted Quantity USD 0.00 Limited Quantity USD 15-60 Inaccessible (Haz class 6.1), Domestic USD 80+ Inaccessible (Haz class 6.1), International USD 150+ Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+ Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Sarpogrelate HCl 化学结构 Sarpogrelate HCl 3D分子结构 规格 价格 库存 数量
50μL*10mM(DMSO)
￥99随货￥69
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100μL*10mM(DMSO)
￥99随货￥69
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250μL*10mM(DMSO)
￥129随货￥99
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500μL*10mM(DMSO)
￥239随货￥169
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10mM*1mL(DMSO)
￥336
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5mg
￥295
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10mg
￥473
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50mg
￥1276
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100mg
￥1906
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Sarpogrelate HCl 纯度/质量文件 产品仅供科研 全球学术期刊中引用的产品
• ACS Appl. Nano Mater. , 2025. Ambeed. A188026
]
• Eur. J. Clin. Microbiol. Infect. Dis. , 2025. Ambeed. A151161
]
• JJC , 2025, 20(Special Issue)): 27-39. Ambeed. • bioRxiv , 2025. Ambeed. A538667 ,
A714873 ,
A126729 ,
A126049 ,
A446054
]
• Nature Communications , 2025, 16, 1871. Ambeed. A508148
]
更多 > Sarpogrelate HCl 质控信息
Desvenlafaxine
++
98% Lamotrigine
+
5-HT (human platelets), IC50: 240 μM
5-HT (rat brain synaptosomes), IC50: 474 μM
98% Venlafaxine
✔
99% Fluvoxamine maleate
✔
99% Iloperidone
✔
99% Ziprasidone HCl
✔
98+% Atomoxetine HCI
+
98% Dapoxetine HCl
✔
97% Trazodone
✔
98+% Clomipramine HCl
✔
98% Mirtazapine
✔
99+% Escitalopram oxalate
+++
97% Duloxetine
✔
97% Sertraline HCl
++
98% Citalopram HBr
+++
serotonin reuptake, IC50: 1.8 nM
98% Latrepirdine 2HCl
✔
GluR 99% Fluoxetine HCl
✔
99.5% Paroxetine HCl
✔
AChR 99% BMY 7378
++
5-HT1A, pIC50: 6.4
5-HT1D, pIC50: 5.9
+
97% Flibanserin
+++
+
95% LY310762
+
99%+ Cyclobenzaprine HCI
✔
99% Blonanserin
+++
99% Cyproheptadine HCl
++++
99+% Olanzapine
✔
99+% Pimavanserin hemitartrate
+++
99% Ketanserin
+++
5-HT2C (Human), Ki: 2.5 nM
5-HT2C (Rat), Ki: 50 nM
99%+ Loxapine succinate
++
5-HT2 (human), Ki: 6.8 nM
5-HT2 (bovine), Ki: 6.6 nM
98% Agomelatine
✔
98% Clozapine
✔
98% Amitriptyline
+
SERT 99% PRX-08066 maleate
+++
98+% RS-127445
++++
5-HT2B, pIC50: 10.4
5-HT2B, pKi: 9.5
99%+ Sarpogrelate HCl
++++
5-HT2A, Kd: 2.1 nM
5-HT2C, Kd: 1.1 nM
98% Tropisetron
✔
99% Ramosetron HCl
++++
5-HT3 receptor, Ki: 0.091 nM
98% Ondansetron
✔
99% Granisetron
✔
98% Alosetron HCl
✔
98% Ondansetron HCl dihydrate
✔
98% VUF10166
++++
5-HT3AB, Ki: 22 nM
5-HT3A, Ki: 0.04 nM
99%+ Azasetron HCl
++++
99% Asenapine maleate
+++
5-HT1A, pKi: 8.6
5-HT1B, pKi: 8.4
++++
5-HT2C, pKi: 10.46
5-HT2A, pKi: 9.75
+++
++++
++++
97% Risperidone
++
5-HT1D, Ki: 84.6 nM
5-HT1B, Ki: 14.9 nM
++++
5-HT2C, Ki: 12 nM
5-HT2A, Ki: 61.9 nM
+
++
98% SB 271046 HCl
+++
99%+ Intepirdine
++++
99%+ SB-269970 HCl
++
98+% BRL 15572
++
5-HT1D, pKi: 6
5-HT1B, pKi: 6.1
++
5-HT2A, pKi: 6.6
5-HT2B, pKi: 6.2
+
+
95% 展开 1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Sarpogrelate HCl 生物活性 靶点 5-HT2
5-HT2A, Kd:2.1 nM
5-HT2C, Kd:1.1 nM
描述 Sarpogrelate Hydrochloride is a highly selective serotonin (5-hydroxytryptamine, 5-HT2A) receptor antagonist used as an antiplatelet agent for the treatment of peripheral artery disease. Sarpogrelate hydrochloride might be a weak inhibitor of CYP (cytochrome P450 ) 2D6[3] [4] [5]
Sarpogrelate HCl 参考文献 [1] Nishio H, Inoue A, et al. Binding affinity of sarpogrelate, a new antiplatelet agent, and its metabolite for serotonin receptor subtypes. Arch Int Pharmacodyn Ther. 1996 Mar-Apr;331(2):189-202.
[2] Pertz H, Elz S. In-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-HT2A receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery. J Pharm Pharmacol. 1995 Apr;47(4):310-6.
[3] Min JS, Kim D, Park JB, Heo H, Bae SH, Seo JH, Oh E, Bae SK. Application of physiologically based pharmacokinetic modeling in predicting drug-drug interactions for sarpogrelate hydrochloride in humans. Drug Des Devel Ther. 2016 Sep 14;10:2959-2972. doi: 10.2147/DDDT.S109141. PMID: 27695293; PMCID: PMC5028085.
[4] Lee ES, Lee MY, Kwon MH, Kim HM, Kang JS, Kim YM, Lee EY, Chung CH. Sarpogrelate hydrochloride ameliorates diabetic nephropathy associated with inhibition of macrophage activity and inflammatory reaction in db/db mice. PLoS One. 2017 Jun 22;12(6):e0179221. doi: 10.1371/journal.pone.0179221. PMID: 28640832; PMCID: PMC5480859.
[5] Tullis BE, Ryals RC, Coyner AS, Gale MJ, Nicholson A, Ku C, Regis D, Sinha W, Datta S, Wen Y, Yang P, Pennesi ME. Sarpogrelate, a 5-HT2A Receptor Antagonist, Protects the Retina From Light-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4560-9. doi: 10.1167/iovs.15-16378. PMID: 26200496; PMCID: PMC4515947.
展开 Sarpogrelate HCl 实验方案 计算器 摩尔计算器 总药量计算器 工作液计算器 存储液制备 1mg 5mg 10mg 1 mM
5 mM
10 mM
2.15mL
0.43mL
0.21mL
10.73mL
2.15mL
1.07mL
21.46mL
4.29mL
2.15mL
Sarpogrelate HCl 技术信息
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