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/ 5-羟色胺受体 / Sarpogrelate HCl

盐酸沙格雷酯 /Sarpogrelate HCl 98%

货号：A166685 同义名： MCI-9042;Sarpogrelate (hydrochloride) Ambeed 开学季，买赠积分，赢豪礼

Sarpogrelate HCl is an antagonist of both 5HT2A and 5-HT2B receptors, which can block serotonin-induced platelet aggregation and treat diabetes mellitus, Buerger's disease, Raynaud's disease, coronary artery disease, angina pectoris and atherosclerosis.

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Sarpogrelate HCl 化学结构 CAS号：135159-51-2
Sarpogrelate HCl 化学结构
CAS号：135159-51-2
Sarpogrelate HCl 3D分子结构
CAS号：135159-51-2
Sarpogrelate HCl 化学结构 CAS号：135159-51-2
Sarpogrelate HCl 3D分子结构 CAS号：135159-51-2
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Sarpogrelate HCl 纯度/质量文件 产品仅供科研

货号：A166685 标准纯度： 98%
批次查询： 批次纯度:

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产品名称 5-HT ↓ 5-HT1 ↓ 5-HT2 ↓ 5-HT3 ↓ 5-HT5 ↓ 5-HT6 ↓ 5-HT7 ↓ 其他靶点 纯度
Desvenlafaxine ++

5-HT, Ki: 40.2 nM

 		98%
Lamotrigine +

5-HT (human platelets), IC50: 240 μM

5-HT (rat brain synaptosomes), IC50: 474 μM

 		99%+
Venlafaxine ✔ 99%+
Fluvoxamine maleate ✔ 99%
Iloperidone ✔ 99%+
Ziprasidone HCl ✔ 98+%
Atomoxetine HCI +

5-HT, Ki: 77 nM

 		98%
Dapoxetine HCl ✔ 99%+
Trazodone ✔ 98+%
Clomipramine HCl ✔ 99%+
Mirtazapine ✔ 99+%
Escitalopram oxalate +++

5-HT, Ki: 0.89 nM

 		99%+
Duloxetine ✔ 98+%
Sertraline HCl ++

5-HT, Ki: 13 nM

 		99%+
Citalopram HBr +++

serotonin reuptake, IC50: 1.8 nM

 		99%+
Latrepirdine 2HCl ✔ GluR 99%+
Fluoxetine hydrochloride ✔ 98%
Paroxetine hydrochloride ✔ AChR 99%+
BMY 7378 ++

5-HT1A, pIC50: 6.4

5-HT1D, pIC50: 5.9

 		+

5-HT2, pIC50: 5.5

 		97%
Flibanserin +++

5-HT1A, Ki: 1 nM

 		+

5-HT2A, Ki: 49 nM

 		98%
LY310762 +

5-HT1D, Ki: 249 nM

 		99%+
Cyclobenzaprine HCI ✔ 99%
Blonanserin +++

5-HT2, Ki: 3.98 nM

 		99%+
Cyproheptadine HCl ++++

5-HT2, IC50: 0.6 nM

 		99+%
Olanzapine ✔ 99+%
Pimavanserin hemitartrate +++

5-HT2A, pIC50: 8.7

 		99%
Ketanserin +++

5-HT2C (Rat), Ki: 50 nM

5-HT2C (Human), Ki: 2.5 nM

 		99%+
Loxapine succinate ++

5-HT2 (human), Ki: 6.8 nM

5-HT2 (bovine), Ki: 6.6 nM

 		99%
Agomelatine ✔ 99%+
Clozapine ✔ 99%+
Amitriptyline +

5-HT2, Ki: 235 nM

 		SERT 98%
PRX-08066 maleate +++

5-HT2B, IC50: 3.4 nM

 		98+%
RS-127445 ++++

5-HT2B, pIC50: 10.4

5-HT2B, pKi: 9.5

 		99%+
Sarpogrelate HCl ++++

5-HT2A, Kd: 2.1 nM

5-HT2C, Kd: 1.1 nM

 		98%
Tropisetron ✔ 99%
Palonosetron ✔ 98+%
Ramosetron HCl ++++

5-HT3 receptor, Ki: 0.091 nM

 		99%+
Ondansetron ✔ 99%
Granisetron ✔ 98%
Alosetron HCl ✔ 98%
Ondansetron hydrochloride dihydrate ✔ 99%+
VUF10166 ++++

5-HT3A, Ki: 0.04 nM

5-HT3AB, Ki: 22 nM

 		99%+
Azasetron hydrochloride ++++

5-HT3, IC50: 0.33 nM

 		98%
Asenapine maleate +++

5-HT1B, pKi: 8.4

5-HT1A, pKi: 8.6

 		++++

5-HT2A, pKi: 9.75

5-HT2C, pKi: 10.46

 		+++

5-HT5A, pKi: 8.84

 		++++

5-HT6, pKi: 9.6

 		++++

5-HT7, pKi: 9.94

 		99%+
Risperidone ++

5-HT1D, Ki: 84.6 nM

5-HT1B, Ki: 14.9 nM

 		++++

5-HT2C, Ki: 12 nM

5-HT2A, Ki: 61.9 nM

 		+

5-HT5A, Ki: 206 nM

 		++

5-HT7, Ki: 6.6 nM

 		99%+
SB 271046 HCl +++

5-HT6, pKi: 8.92

 		99%+
Intepirdine ++++

5-HT6, pKi: 9.63

 		99%+
SB-269970 HCl ++

5-HT7, pKi: 8.3

 		98+%
BRL 15572 ++

5-HT1B, pKi: 6.1

5-HT1D, pKi: 6

 		++

5-HT2A, pKi: 6.6

5-HT2B, pKi: 6.2

 		+

5-HT6, pKi: 5.9

 		+

5-HT7, pKi: 6.3

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Sarpogrelate HCl 生物活性

靶点

  • 5-HT2

    5-HT2A, Kd:2.1 nM

    5-HT2C, Kd:1.1 nM
描述 Sarpogrelate Hydrochloride is a highly selective serotonin (5-hydroxytryptamine, 5-HT2A) receptor antagonist used as an antiplatelet agent for the treatment of peripheral artery disease. Sarpogrelate hydrochloride might be a weak inhibitor of CYP (cytochrome P450 ) 2D6[3]. Moreover, Sarpogrelate Hydrochloride ameliorates diabetic nephropathy not only by suppressing macrophage infiltration, but also by anti-inflammatory and anti-fibrotic effects[4]. A 5- or 1-day treatment with 50 mg/kg sarpogrelate can completely protect the retina of BALB/c mice from light-induced retinopathy[5].

Sarpogrelate HCl 参考文献

[1]Nishio H, Inoue A, et al. Binding affinity of sarpogrelate, a new antiplatelet agent, and its metabolite for serotonin receptor subtypes. Arch Int Pharmacodyn Ther. 1996 Mar-Apr;331(2):189-202.

[2]Pertz H, Elz S. In-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-HT2A receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery. J Pharm Pharmacol. 1995 Apr;47(4):310-6.

[3]Min JS, Kim D, Park JB, Heo H, Bae SH, Seo JH, Oh E, Bae SK. Application of physiologically based pharmacokinetic modeling in predicting drug-drug interactions for sarpogrelate hydrochloride in humans. Drug Des Devel Ther. 2016 Sep 14;10:2959-2972. doi: 10.2147/DDDT.S109141. PMID: 27695293; PMCID: PMC5028085.

[4]Lee ES, Lee MY, Kwon MH, Kim HM, Kang JS, Kim YM, Lee EY, Chung CH. Sarpogrelate hydrochloride ameliorates diabetic nephropathy associated with inhibition of macrophage activity and inflammatory reaction in db/db mice. PLoS One. 2017 Jun 22;12(6):e0179221. doi: 10.1371/journal.pone.0179221. PMID: 28640832; PMCID: PMC5480859.

[5]Tullis BE, Ryals RC, Coyner AS, Gale MJ, Nicholson A, Ku C, Regis D, Sinha W, Datta S, Wen Y, Yang P, Pennesi ME. Sarpogrelate, a 5-HT2A Receptor Antagonist, Protects the Retina From Light-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4560-9. doi: 10.1167/iovs.15-16378. PMID: 26200496; PMCID: PMC4515947.

Sarpogrelate HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.21mL

10.73mL

2.15mL

1.07mL

21.46mL

4.29mL

2.15mL

Sarpogrelate HCl 技术信息

CAS号135159-51-2
分子式C24H32ClNO6
分子量 465.967
别名 MCI-9042;Sarpogrelate (hydrochloride);Sarpogrelate hydrochloride
运输蓝冰
存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 60 mg/mL(128.76 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(64.38 mM)，配合低频超声助溶
动物实验配方

Tags: Sarpogrelate | 135159-51-2 | MCI-9042 | MCI9042 | MCI 9042 | 5-HT2R Antagonist | GPCR/G Protein | Neuronal Signaling | 5-HT Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Sarpogrelate HCl 纯度/质量文件 | Sarpogrelate HCl 亚型比较 | Sarpogrelate HCl 生物活性 | Sarpogrelate HCl 参考文献 | Sarpogrelate HCl 实验方案 | Sarpogrelate HCl 技术信息

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