ONC206
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货号：A1155605
ONC206 是 ONC201 的类似物。ONC206 是一种选择性拮抗剂，对多巴胺 D2 类受体 (DRD2/3/4) 具有纳摩尔效力。ONC206 表现出广谱抗肿瘤 活性。
ONC206 化学结构
ONC206 3D分子结构
规格
价格
会员价
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数量
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ONC206 纯度/质量文件 产品仅供科研
货号：A1155605
标准纯度：
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产品说明书
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ONC206 质控信息
Penfluridol
+
Dopamine receptor, Ki: 1.6 μM
98%
Ansofaxine HCl
++
Dopamine receptor, IC50: 491 nM
98%
Tetrahydroberberine,THB
+
98+%
Prochlorperazine Maleate
✔
95%
Olanzapine
✔
99+%
Trifluoperazine
++++
Dopamine D2 receptor, IC50: 1.1 nM
98%
Ropinirole hydrochloride
++
99%
Lurasidone
++++
98%
Levosulpiride
✔
99+%
Pridopidine
✔
95%
Metoclopramide
✔
✔
99+%
Molindone HCl
✔
98%
Sulpiride
✔
99+%
Perospirone
++++
99%
Perospirone HCl
++++
98+%
Phenothiazine
✔
98%
Pimozide
+
Dopamine D1 receptor, Ki: 6600 nM
+++
Dopamine D2 receptor, Ki: 3.0 nM
++++
Dopamine D3 receptor, Ki: 0.83 nM
98%
Rotundine
++
D1 receptor, IC50: 166 nM
+
D2 receptor, IC50: 1.47 μM
+
D3 receptor, IC50: 3.25 μM
98%
Domperidone
✔
99+%
ONC206
✔
97%
Pimethixene maleate
++
Dopamine D1 Receptor, pKi: 6.37
+++
Dopamine D2 Receptor, pKi: 8.19
++
Dopamine D4.4 Receptor, pKi: 7.54
97%
Loxapine succinate
++
D2 receptor (Human), Ki: 62 nM
D1 receptor (human), Ki: 26 nM
++
D2 receptor (bovine), Ki: 26 nM
D2 receptor (human), Ki: 24 nM
+++
D4 receptor (human), Ki: 7.5 nM
99%
Chlorprothixene
+++
+++
+++
+++
98%
SCH-23390 HCl
++++
D1 dopamine receptor, Ki: 0.2 nM
++++
D5 dopamine receptor, Ki: 0.3 nM
98%
MPP+ iodide
✔
97%
σ1 Receptor antagonist-1
+
97%
Benztropine mesylate
++
98%
Azaperone
✔
98%
Ziprasidone HCl
✔
98+%
Paliperidone
✔
98%
Alizapride HCl
✔
99+%
Amisulpride
✔
98%
Quetiapine hemifumarate
✔
Adrenergic Receptor
98%
Clozapine N-oxide
✔
99%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
ONC206 生物活性
靶点
描述
ONC206 is a derivative of the TRAIL inducer ONC201[1] [2]
体内研究
ONC206 (100 mg/kg;pO.; every 10 days) results in notable inhibition of tumor growth[2]
体外研究
ONC206 exhibits selective antagonism towards the D2-like (DRD2/3/4), rather than the D1-like (DRD1/5), subfamily of dopamine receptors[2]
ONC206 markedly suppresses tumor cell migration and invasion in vitro [1]
ONC206 (0.05 μM; for 48 hours) impedes the migration of ONC201- and TRAIL-resistant HCT116 Bax cells without eliciting cell death or hindering cell proliferation[1]
ONC206 activates the ISR and TRAIL pathway, resulting in tumor growth arrest and cell death[1]
ONC206 does not cause cell cycle arrest in a colorectal cell line that has developed resistance to ONC201[1]
ONC206 参考文献
ONC206 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.45mL
0.49mL
0.24mL
12.24mL
2.45mL
1.22mL
24.48mL
4.90mL
2.45mL
ONC206 技术信息
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