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/ 5-羟色胺受体 / Ondansetron hydrochloride dihydrate

盐酸昂丹司琼二水物 /Ondansetron hydrochloride dihydrate {[allProObj[0].p_purity_real_show]}

货号：A344767 同义名： 昂丹司琼盐酸盐 二水合物 / GR 38032 hydrochloride dihydrate;SN 307 hydrochloride dihydrate

Ondansetron HCl 2H2O is a competitive 5-HT3 receptor antagonist.

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Type HazMat fee for 500 gram (Estimated)
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Ondansetron hydrochloride dihydrate 化学结构 CAS号：103639-04-9
Ondansetron hydrochloride dihydrate 化学结构
CAS号：103639-04-9
Ondansetron hydrochloride dihydrate 3D分子结构
CAS号：103639-04-9
Ondansetron hydrochloride dihydrate 化学结构 CAS号：103639-04-9
Ondansetron hydrochloride dihydrate 3D分子结构 CAS号：103639-04-9
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Ondansetron hydrochloride dihydrate 纯度/质量文件 产品仅供科研

货号：A344767 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]
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更多 >
产品名称 5-HT ↓ 5-HT1 ↓ 5-HT2 ↓ 5-HT3 ↓ 5-HT5 ↓ 5-HT6 ↓ 5-HT7 ↓ 其他靶点 纯度
Desvenlafaxine ++

5-HT, Ki: 40.2 nM

 		98%
Lamotrigine +

5-HT (human platelets), IC50: 240 μM

5-HT (rat brain synaptosomes), IC50: 474 μM

 		98%
Venlafaxine ✔ 98%
Fluvoxamine maleate ✔ 99%
Iloperidone ✔ 98%
Ziprasidone HCl ✔ 98+%
Atomoxetine HCI +

5-HT, Ki: 77 nM

 		98%
Dapoxetine HCl ✔ 97%
Trazodone ✔ 98+%
Clomipramine HCl ✔ 98%
Mirtazapine ✔ 99+%
Escitalopram oxalate +++

5-HT, Ki: 0.89 nM

 		97%
Duloxetine ✔ 98+%
Sertraline HCl ++

5-HT, Ki: 13 nM

 		98%
Citalopram HBr +++

serotonin reuptake, IC50: 1.8 nM

 		98%
Latrepirdine 2HCl ✔ GluR 98%
Fluoxetine HCl ✔ 99.5%
Paroxetine hydrochloride ✔ AChR 97%
BMY 7378 ++

5-HT1A, pIC50: 6.4

5-HT1D, pIC50: 5.9

 		+

5-HT2, pIC50: 5.5

 		97%
Flibanserin +++

5-HT1A, Ki: 1 nM

 		+

5-HT2A, Ki: 49 nM

 		98%
LY310762 +

5-HT1D, Ki: 249 nM

 		99%+
Cyclobenzaprine HCI ✔ 99%
Blonanserin +++

5-HT2, Ki: 3.98 nM

 		98% HPLC
Cyproheptadine HCl ++++

5-HT2, IC50: 0.6 nM

 		99+%
Olanzapine ✔ 99+%
Pimavanserin hemitartrate +++

5-HT2A, pIC50: 8.7

 		99%
Ketanserin +++

5-HT2C (Human), Ki: 2.5 nM

5-HT2C (Rat), Ki: 50 nM

 		99%+
Loxapine succinate ++

5-HT2 (human), Ki: 6.8 nM

5-HT2 (bovine), Ki: 6.6 nM

 		99%
Agomelatine ✔ 98%
Clozapine ✔ 98%
Amitriptyline +

5-HT2, Ki: 235 nM

 		SERT 98%
PRX-08066 maleate +++

5-HT2B, IC50: 3.4 nM

 		98+%
RS-127445 ++++

5-HT2B, pKi: 9.5

5-HT2B, pIC50: 10.4

 		99%+
Sarpogrelate HCl ++++

5-HT2C, Kd: 1.1 nM

5-HT2A, Kd: 2.1 nM

 		98%
Tropisetron ✔ 99%
Palonosetron ✔ 98+%
Ramosetron HCl ++++

5-HT3 receptor, Ki: 0.091 nM

 		98%
Ondansetron ✔ 99%
Granisetron ✔ 98%
Alosetron HCl ✔ 98%
Ondansetron hydrochloride dihydrate ✔ 98%
VUF10166 ++++

5-HT3A, Ki: 0.04 nM

5-HT3AB, Ki: 22 nM

 		99%+
Azasetron hydrochloride ++++

5-HT3, IC50: 0.33 nM

 		98%
Asenapine maleate +++

5-HT1A, pKi: 8.6

5-HT1B, pKi: 8.4

 		++++

5-HT2A, pKi: 9.75

5-HT2C, pKi: 10.46

 		+++

5-HT5A, pKi: 8.84

 		++++

5-HT6, pKi: 9.6

 		++++

5-HT7, pKi: 9.94

 		97%
Risperidone ++

5-HT1B, Ki: 14.9 nM

5-HT1D, Ki: 84.6 nM

 		++++

5-HT2A, Ki: 61.9 nM

5-HT2C, Ki: 12 nM

 		+

5-HT5A, Ki: 206 nM

 		++

5-HT7, Ki: 6.6 nM

 		98%
SB 271046 HCl +++

5-HT6, pKi: 8.92

 		99%+
Intepirdine ++++

5-HT6, pKi: 9.63

 		99%+
SB-269970 HCl ++

5-HT7, pKi: 8.3

 		98+%
BRL 15572 ++

5-HT1D, pKi: 6

5-HT1B, pKi: 6.1

 		++

5-HT2A, pKi: 6.6

5-HT2B, pKi: 6.2

 		+

5-HT6, pKi: 5.9

 		+

5-HT7, pKi: 6.3

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ondansetron hydrochloride dihydrate 生物活性

靶点

  • 5-HT3

    5-HT3 receptor, IC50:810 nM

  • 5-HT3
描述 Ondansetron Hydrochloride Dihydrate is the hydrated state of Ondansetron hydrochloride. Ondansetron is a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist as an antiemetic for cancer treatment-induced and anesthesia-related nausea and vomiting[3]. 5-HT evoked transient inward currents (EC50 = 3.4 mM; Hill coefficient = 1.8) that were blocked by the 5-HT3 receptor antagonist ondansetron (IC50 = 103 pM)[4]. Indirect stimulation of nicotinic acetylcholine receptor by ondansetron can improve the auditory gating parameters of DBA/2 mice[5]. Different doses of ondansetron were injected intraperitoneally (i.p.) at fixed times during the day to determine both the sublethal (TD50) and lethal (LD50) doses, which were, 3.7 +/- 0.6 mg/kg and 4.6 +/- 0.5 mg/kg, respectively[6].

Ondansetron hydrochloride dihydrate 细胞研究

细胞系 浓度 检测类型 检测时间 活动说明 数据源
CHO cells Function assay Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique, IC50=0.81283 μM 18448342
HEK cells Function assay Inhibition of human ERG expressed in HEK cells by patch clamp technique, IC50=0.4 μM 20889341
HEK293 cells Function assay Displacement of [3H]granisetron from human 5HT3A receptor expressed in HEK293 cells by filter binding assay, Ki=0.0028 μM 21486038
MDCK2 cells Function assay Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis, IC50=0.01 μM 23241029

Ondansetron hydrochloride dihydrate 参考文献

[1]Wildeboer KM, Zheng L, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 1;1300:41-50.

[2]Brown AM, Hope AG, et al. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol. 1998 Mar 15;507 ( Pt 3):653-65.

[3]Ye JH, Ponnudurai R, Schaefer R. Ondansetron: a selective 5-HT(3) receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 2001 Summer;7(2):199-213. doi: 10.1111/j.1527-3458.2001.tb00195.x. PMID: 11474424; PMCID: PMC6741689.

[4]Brown AM, Hope AG, Lambert JJ, Peters JA. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol. 1998 Mar 15;507 ( Pt 3)(Pt 3):653-65. doi: 10.1111/j.1469-7793.1998.653bs.x. PMID: 9508827; PMCID: PMC2230823.

[5]Wildeboer KM, Zheng L, Choo KS, Stevens KE. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 1;1300:41-50. doi: 10.1016/j.brainres.2009.08.075. Epub 2009 Sep 1. PMID: 19728991; PMCID: PMC2784252.

[6]Khedhaier A, Ben Attia M, Gadacha W, Sani M, Bouzouita K, Chouchane L, Mechkouri M, Reinberg A, Boughattas NA. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov;20(6):1103-16. doi: 10.1081/cbi-120025532. PMID: 14680146.

Ondansetron hydrochloride dihydrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.73mL

0.55mL

0.27mL

13.67mL

2.73mL

1.37mL

27.33mL

5.47mL

2.73mL

Ondansetron hydrochloride dihydrate 技术信息

CAS号103639-04-9
分子式C18H24ClN3O3
分子量 365.854
别名 昂丹司琼盐酸盐 二水合物 ;GR 38032 hydrochloride dihydrate;SN 307 hydrochloride dihydrate;Ondansetron (hydrochloride hydrate)
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C
溶解度

DMSO: 105 mg/mL(287 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 15 mg/mL(41 mM)，配合低频超声助溶
动物实验配方

PO 0.5% CMC-Na 52 mg/mL suspension

Tags: Ondansetron hydrochloride dihydrate | GR 38032 hydrochloride dihydrate;SN 307 hydrochloride dihydrate;Ondansetron (hydrochloride hydrate) | 昂丹司琼盐酸盐 二水合物 | 5-HT Receptor | AmBeed-信号通路专用抑制剂 | Ondansetron hydrochloride dihydrate 纯度/质量文件 | Ondansetron hydrochloride dihydrate 亚型比较 | Ondansetron hydrochloride dihydrate 生物活性 | Ondansetron hydrochloride dihydrate 细胞研究 | Ondansetron hydrochloride dihydrate 参考文献 | Ondansetron hydrochloride dihydrate 实验方案 | Ondansetron hydrochloride dihydrate 技术信息

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