Sulpiride is a typical antipsychotic drug that binds to dopamine D2 receptor. Sulpiride is an effective treatment for schizophrenia and depressive disorder.
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HazMat fee for 500 gram (Estimated)
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Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
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Accessible (Haz class 3, 4, 5 or 8), International
Sulpiride is a substituted benzamide with selective dopaminergic blocking activity. Sulpiride was selective for dopamine (D)2 receptors and also blocks D3 and D4 receptors. Sulpiride does not block D1, adrenergic, cholinergic, gamma-aminobutyric acid-ergic, histaminergic, or serotonergic receptors to an appreciable extent. The oral bioavailability of sulpiride is poor, with estimates approximating 35%. Sulpiride may cause extrapyramidal effects, autonomic effects, tardive dyskinesia, and the neuroleptic malignant syndrome[3]. At low dosages (50 to 150 mg/day), sulpiride produces a disinhibiting and antidepressant effect, which is probably related to its action on D2 presynaptic autoreceptors, thus facilitating dopaminergic neurotransmission[4]. Sulpiride and melatonin reduce tinnitus perception, decreasing dopamine activity[5]. Sulpiride attenuated by 36% the anorexia produced by intrahypothalamic injections of amphetamine[6].
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