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盐酸达泊西汀 /Dapoxetine HCl {[allProObj[0].p_purity_real_show]}

货号:A151531 同义名: 达泊西汀 盐酸盐 / LY-210448 hydrochloride;Dapoxetine (hydrochloride)

Dapoxetine HCl is an inhibitor of serotonin reuptake. It can treat premature ejaculation.

Dapoxetine HCl 化学结构 CAS号:129938-20-1
Dapoxetine HCl 化学结构
CAS号:129938-20-1
Dapoxetine HCl 3D分子结构
CAS号:129938-20-1
Dapoxetine HCl 化学结构 CAS号:129938-20-1
Dapoxetine HCl 3D分子结构 CAS号:129938-20-1
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Dapoxetine HCl 纯度/质量文件 产品仅供科研

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Dapoxetine HCl 生物活性

靶点
  • 5-HT

描述 Dapoxetine hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI) known primarily for its use in the study of premature ejaculation (PE)[1].
体内研究

Furthermore, when administered via oral gavage at doses ranging from 1 to 10 mg/kg daily, dapoxetine hydrochloride significantly mitigates the increase in prostate weight and relative prostate weight induced by testosterone, thereby attenuating testosterone-induced prostatic hyperplasia in rats[2].

体外研究

Dapoxetine hydrochloride functions by binding to serotonin (5-HT), norepinephrine, and dopamine reuptake transporters, inhibiting their uptake. The potency of dapoxetine in inhibiting these neurotransmitters is greatest for 5-HT, followed by norepinephrine, and considerably less so for dopamine. Specifically, dapoxetine hydrochloride inhibits serotonin uptake by the 5-HT reuptake transporter with a highly potent value of 1.12 nM. It also inhibits the uptake of norepinephrine and dopamine through their respective transporters with IC50 values of 202 nM and 1720 nM[1].

Dapoxetine HCl 参考文献

[1]Muammer Kendirci, et al. Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation. Ther Clin Risk Manag. 2007 Jun;3(2):277-89.

[2]Rabab H Sayed, et al. Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins. Toxicol Appl Pharmacol. 2016 Nov 15;311:52-60.

Dapoxetine HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.93mL

0.59mL

0.29mL

14.63mL

2.93mL

1.46mL

29.25mL

5.85mL

2.93mL

Dapoxetine HCl 技术信息

CAS号129938-20-1
分子式C21H24ClNO
分子量 341.874
别名 达泊西汀 盐酸盐 ;LY-210448 hydrochloride;Dapoxetine (hydrochloride);​(S)-(+)-Dapoxetine;LY-210448;Dapoxetine hydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C

溶解度

DMSO: 30 mg/mL(87.75 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(292.51 mM),配合低频超声助溶

动物实验配方
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