货号:A151531 同义名: 达泊西汀 盐酸盐 / LY-210448 hydrochloride;Dapoxetine (hydrochloride)
Dapoxetine HCl is an inhibitor of serotonin reuptake. It can treat premature ejaculation.
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描述 | Dapoxetine hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI) known primarily for its use in the study of premature ejaculation (PE)[1]. |
体内研究 | Furthermore, when administered via oral gavage at doses ranging from 1 to 10 mg/kg daily, dapoxetine hydrochloride significantly mitigates the increase in prostate weight and relative prostate weight induced by testosterone, thereby attenuating testosterone-induced prostatic hyperplasia in rats[2]. |
体外研究 | Dapoxetine hydrochloride functions by binding to serotonin (5-HT), norepinephrine, and dopamine reuptake transporters, inhibiting their uptake. The potency of dapoxetine in inhibiting these neurotransmitters is greatest for 5-HT, followed by norepinephrine, and considerably less so for dopamine. Specifically, dapoxetine hydrochloride inhibits serotonin uptake by the 5-HT reuptake transporter with a highly potent value of 1.12 nM. It also inhibits the uptake of norepinephrine and dopamine through their respective transporters with IC50 values of 202 nM and 1720 nM[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.93mL 0.59mL 0.29mL |
14.63mL 2.93mL 1.46mL |
29.25mL 5.85mL 2.93mL |
CAS号 | 129938-20-1 |
分子式 | C21H24ClNO |
分子量 | 341.874 |
别名 | 达泊西汀 盐酸盐 ;LY-210448 hydrochloride;Dapoxetine (hydrochloride);(S)-(+)-Dapoxetine;LY-210448;Dapoxetine hydrochloride |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Inert atmosphere,2-8°C |
溶解度 |
DMSO: 30 mg/mL(87.75 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 100 mg/mL(292.51 mM),配合低频超声助溶 |
动物实验配方 |