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/ Atomoxetine HCI

盐酸托莫西汀 /Atomoxetine HCI {[allProObj[0].p_purity_real_show]}

货号：A258704 同义名： Tomoxetine hydrochloride;(R)-Tomoxetine hydrochloride

Atomoxetine HCI是一种选择性的非兴奋性去甲肾上腺素再摄取抑制剂，具有认知增强作用，Ki 值分别为去甲肾上腺素 5 nM、5-羟色胺 77 nM、多巴胺 1451 nM。

Atomoxetine HCI 化学结构 CAS号：82248-59-7
Atomoxetine HCI 化学结构
CAS号：82248-59-7
Atomoxetine HCI 3D分子结构
CAS号：82248-59-7
Atomoxetine HCI 化学结构 CAS号：82248-59-7
Atomoxetine HCI 3D分子结构 CAS号：82248-59-7
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Atomoxetine HCI 纯度/质量文件 产品仅供科研

货号：A258704 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Adrenergic Receptor ↓ α-adrenergic receptor ↓ β-adrenergic receptor ↓ 其他靶点 纯度
Ivabradine HCl ✔ 98%
Maprotiline hydrochloride ✔ 98%
Cisatracurium besylate ✔ 96%
Yohimbine HCI ✔ 99+%
BMY 7378 ++

α1D-adrenoceptor, pKi: 5.1

α2C-adrenoceptor, pKi: 6.54

 		+

β1-adrenoceptor, pIC50: 5.1

 		97%
Asenapine maleate ++++

α2A-adrenergic receptor, pKi: 8.9

α2B-adrenergic receptor, pKi: 8.9

 		97%
Piribedil ++

adrenoceptor α2A, pKi: 7.1

adrenoceptor α2C, pKi: 7.2

 		98%
Prazosin HCl ✔ 95%
Silodosin ✔ 98%
Phenoxybenzamine HCl ✔ 98%
Naftopidil +++

α1D-adrenergic receptor, Ki: 20 nM

α1A-adrenergic receptor, Ki: 3.7 nM

 		98%
Naftopidil 2HCl +

α1-adrenergic receptor, IC50: 0.2 μM

 		99%
Alfuzosin HCl ✔ 98%
Terazosin HCl ✔ 99%
Atipamezole ✔ 95%
Phentolamine methanesulfonate salt ✔ 99%
Doxazosin mesylate ✔ 99%
Tolazoline HCl ✔ 98%
Zenidolol hydrochloride ++++

β2-adrenergic receptor, Ki: 0.7nM

β1-adrenergic receptor, Ki: 611nM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Atomoxetine HCI 生物活性

靶点

  • 5-HT

    5-HT, Ki:77 nM
描述 Atomoxetine hydrochloride is a norepinephrine transporter (NET) inhibitor and also acts as an N-methyl-D-aspartate receptor (NMDAR) antagonist. In vivo, atomoxetine (3 mg/kg, intraperitoneal injection) seems to decrease glutamatergic transmission in a brain region-specific manner[3]. ICV (intracerebroventricularly) administration of atomoxetine at 200 – 250 nmol significantly reduced S-IRA (seizure-induced respiratory arrest) evoked by acoustic stimulation in DBA/1 mice. Peripheral atomoxetine administration at a dosage that reduces S-IRA (15 mg/kg, IP) slightly increased basal ventilation and the ventilatory response to 7% CO2[4].

Atomoxetine HCI 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00191880 Attention Deficit Hyperactivit... 展开 >>y Disorder 收起 << Phase 3 Completed - Canada ... 展开 >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Calgary, Canada For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Edmonton, Canada For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician London, Canada For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Montreal, Canada For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Saskatoon, Canada For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Scarborough, Canada For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician St. Johns, Canada For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Monday-Friday from 9:00 AM to 5:00 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Toronto, Canada 收起 <<
NCT00286949 Parkinson's Disease Not Applicable Completed - United States, Maryland ... 展开 >> Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 收起 <<
NCT00286949 - Completed - -

Atomoxetine HCI 参考文献

[1]Bymaster FP, Katner JS, et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711.

[2]Zerbe RL, Rowe H, et al. Clinical pharmacology of tomoxetine, a potential antidepressant. J Pharmacol Exp Ther. 1985 Jan;232(1):139-43.

[3]Udvardi PT, Föhr KJ, Henes C, Liebau S, Dreyhaupt J, Boeckers TM, Ludolph AG. Atomoxetine affects transcription/translation of the NMDA receptor and the norepinephrine transporter in the rat brain--an in vivo study. Drug Des Devel Ther. 2013 Dec 4;7:1433-46.

[4]Zhao H, Cotten JF, Long X, Feng HJ. The effect of atomoxetine, a selective norepinephrine reuptake inhibitor, on respiratory arrest and cardiorespiratory function in the DBA/1 mouse model of SUDEP. Epilepsy Res. 2017 Nov;137:139-144.

Atomoxetine HCI 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.43mL

0.69mL

0.34mL

17.13mL

3.43mL

1.71mL

34.27mL

6.85mL

3.43mL

Atomoxetine HCI 技术信息

CAS号82248-59-7
分子式C17H22ClNO
分子量 291.816
别名 Tomoxetine hydrochloride;(R)-Tomoxetine hydrochloride;Atomoxetine (hydrochloride);LY 139603 HCl;Atomoxetine HCl;LY 139603
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Store in freezer, under -20°C
溶解度

DMSO: 105 mg/mL(359.82 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(171.34 mM)，配合低频超声助溶
动物实验配方

Tags: Atomoxetine HCI | Tomoxetine hydrochloride;(R)-Tomoxetine hydrochloride;Atomoxetine (hydrochloride);LY 139603 HCl;Atomoxetine HCl;LY 139603 | Neurotransmitter | Other Compounds | Adrenergic Receptor | AmBeed-信号通路专用抑制剂 | Atomoxetine HCI 纯度/质量文件 | Atomoxetine HCI 亚型比较 | Atomoxetine HCI 生物活性 | Atomoxetine HCI 临床数据 | Atomoxetine HCI 参考文献 | Atomoxetine HCI 实验方案 | Atomoxetine HCI 技术信息

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