Meclizine dihydrochloride, is a piperazine-derived histamine H1 antagonist, and has been frequently used for prevention and treatment of vomiting and nausea. In primary bone marrow-derived macrophages (BMMs), meclizine reduced osteoclast formation and bone resorption in a dose-dependent manner[3]. Meclizine is also an agonist of human pregnane X receptor (PXR). The inhibition of human liver microsomal testosterone 6β-hydroxylation by meclizine occurred by a mixed mode and with an apparent Ki of 31 ± 6μM[4]. Meclizine is a first generation antihistamine that is used largely to treat vertigo and motion sickness. It has not been linked to instances of clinically apparent acute liver injury[5]. Meclizine protected against 6-hydroxydopamine-induced apoptosis and cell death in both SH-SY5Y cells and rat primary cortical cultures. It increases the level of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), which activates phosphofructokinase, a rate-determining enzyme of glycolysis[6].
Israel
... 展开 >> Israeli Navy Medical Institute
Recruiting
Haifa, Israel
Contact: Dror Tal, PhD +972549096080 tldror1@gmail.com
Sub-Investigator: Daniel Lagami, BSc 收起 <<
Brazil
... 展开 >> Clinilive
Not yet recruiting
Maringá, Paraná, Brazil
Contact: Antonio Carlos da Silva 55 44 30293004
Principal Investigator: Antonio Carolos da Silva
Irmandade da Santa Casa de Misericórdia de São Paulo
Recruiting
São Paulo, SP, Brazil
Contact: Monica Alcantra 55 11 21767235
Principal Investigator: José Eduardo Lutaif Dolci
Alergoalpha
Not yet recruiting
Barueri, São Paulo, Brazil, 06454010
Contact: Thainara Bisognini 55 11 46882251
Principal Investigator: Karina Tavares
Pesquisare Saude S/S Ltda
Not yet recruiting
Santo André, São Paulo, Brazil, 09080110
Contact: Amanda Faulhaber 55 11 44273339
Principal Investigator: Amanda Faulhaber
Clinica de Alergia MarttiAntila
Not yet recruiting
Sorocaba, São Paulo, Brazil, 18040425
Contact: Simone Fernandes 55 15 35194909
Principal Investigator: Martti Anton Antila
ISPEM
Not yet recruiting
São José dos Campos, São Paulo, Brazil, 12243280
Contact: Renata Bolsolani 55 12 39131789
Principal Investigator: Marcio Antonio Pereira
CCBR SP
Not yet recruiting
São Paulo, Brazil, 04063001
Contact: Norton Sayeg, PhD 5511 43064691
Principal Investigator: Norton Sayeg, PhD 收起 <<
United States, North Carolina
... 展开 >>
Duke Center for Nicotine and Smoking Cessation Research
Charlotte, North Carolina, United States, 28210
Duke Center for Nicotine and Smoking Cessation Research
Durham, North Carolina, United States, 27705
Duke Center for Nicotine and Smoking Cessation Research
Raleigh, North Carolina, United States, 27609
Duke Center for Nicotine and Smoking Cessation Research
Winston-Salem, North Carolina, United States, 27103 收起 <<
United States, Texas
... 展开 >>
Baylor Clinic
Recruiting
Houston, Texas, United States, 77030
Contact: Brandon Smaglo, MD 713-798-3750 smaglo@bcm.edu
Baylor St. Luke's Medical Center
Recruiting
Houston, Texas, United States, 77030
Contact: Brando Smaglo, MD 713-798-3750 smaglo@bcm.edu
Dan L. Duncan Cancer Center at Baylor College of Medicine
Recruiting
Houston, Texas, United States, 77030
Contact: Clinical Trials Office - Dan L. Duncan Cancer Center at Baylor 713-798-1297 收起 <<
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