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/ Aclacinomycin A

阿克拉霉素 /Aclacinomycin A 98+%

货号：A682704 同义名： 阿克拉霉素A / Aclarubicin;NSC 208734 Ambeed 开学季，买赠积分，赢豪礼

Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus.

Aclacinomycin A 化学结构 CAS号：57576-44-0
Aclacinomycin A 化学结构
CAS号：57576-44-0
Aclacinomycin A 3D分子结构
CAS号：57576-44-0
Aclacinomycin A 化学结构 CAS号：57576-44-0
Aclacinomycin A 3D分子结构 CAS号：57576-44-0
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Aclacinomycin A 纯度/质量文件 产品仅供科研

货号：A682704 标准纯度： 98+%
批次查询： 批次纯度:

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产品名称 DNA synthesis ↓ helicase ↓ RdRp ↓ ribonucleotide reductase ↓ tRNA synthetase ↓ YB-1 ↓ 其他靶点 纯度
Fexinidazole ✔ 99%+
Daptomycin ✔ 98%
Blasticidin S·HCl ✔ 99%+
Metronidazole ✔ 99%+
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Triglycidyl isocyanurate ✔ p53 98+%
Nedaplatin ✔ 99%+
Bendamustine ✔ 99%+
Trifluridine ✔ 99%+
Robinetin ✔ 99%+
Carboplatin ✔ 99%
Cidofovir ✔ 99%
Cisplatin ✔ 99%
Cytarabine ++++

DNA synthesis, IC50: 16 nM

 		99%+
Acelarin ++++

DNA synthesis, EC50: 0.2 nM

 		99%+
Oxaliplatin ✔ 99%+
YK-4-279 ✔ 99%+
ML216 +

BLM636-1298, IC50: 0.97 μM

BLMfull-length, IC50: 2.98 μM

 		99%+
RK-33 ✔ 99%+
Brr2-IN-3 ✔ 99%+
Phen-DC3 Trifluoromethanesulfonate ✔ 98%
Favipiravir ✔ 97%
Suramin sodium salt ++

RdRp, IC50: 0.26 μM

 		99%+
Clofarabine ++

Ribonucleotide reductase, IC50: 65 nM

 		99%+
Didox ✔ 99%+
(E)-3-AP ✔ 99%+
Halofuginone +++

prolyl-tRNA synthetase, Ki: 18.3nM

 		99%+
BC-LI-0186 +++

Leucyl-tRNA synthetase, IC50: 46.11 nM

Leucyl-tRNA synthetase, Kd: 42.1 nM

 		98%
SU056 +

YB-1, IC50: 1.73 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 Topo I ↓ Topo II ↓ Topo IV ↓ Topoisomerase ↓ 其他靶点 纯度
Ellagic acid ✔ 99%+
β-Lapachone ✔ 99%+
(s)-10-hydroxycamptothecin ✔ 99%+
Camptothecin ++

Topo I, IC50: 0.68 μM

 		98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

 		99%+
Topotecan ++++

Topo I (DU-145 Luc cells), IC50: 2 nM

Topo I (MCF-7 Luc cells), IC50: 13 nM

 		99%+
Irinotecan HCl Trihydrate ✔ 98%
SN-38 ✔ 98%
Levofloxacin hydrate ✔ 99%+
Dexrazoxane ✔ 99%+
Ofloxacin ✔ 98+%
Enoxacin ✔ 99%+
Flumequine +

Topo II, IC50: 15 μM

 		99%+
Levofloxacin ✔ 99%+
Etoposide ✔ 98%
Pefloxacin mesylate dihydrate ✔ 99+%
Marbofloxacin ✔ 99%+
Voreloxin HCl ✔ 98%
Mitoxantrone dihydrochloride ✔ PKC 99%+
Nalidixic acid ✔ 99%+
Doxorubicin ✔ 98%
Novobiocin sodium ✔ 98%+
Amonafide ✔ 99%+
Pirarubicin ✔ 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

 		99%+
Genistein ✔ EGFR 98%
Teniposide ✔ 98%
Moxifloxacin ✔ 98%
Ciprofloxacin ✔ 99%+
Clinafloxacin ✔ 97%
Gatifloxacin ✔ 99%+
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Epirubicin HCl ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 20S proteasome ↓ Proteasome ↓ 其他靶点 纯度
Ixazomib ++++

20S proteasome, Ki: 0.93 nM

20S proteasome, IC50: 3.4 nM

 		99%+
Delanzomib +++

Chymotrypsin-like proteasome, IC50: 3.8 nM

 		98%
Celastrol +

20S proteasome, IC50: 2.5 μM

 		98%
MLN9708 +++

20S proteasome, Ki: 0.93 nM

20S proteasome, IC50: 3.4 nM

 		99%
Bortezomib ++++

20S proteasome, Ki: 0.6 nM

 		99%+
Oprozomib ++

20S proteasome LMP7, IC50: 82 nM

20S proteasome β5, IC50: 36 nM

 		99%+
Epoxomicin ✔ 99%
PI-1840 ++

Chymotrypsin-like proteasome, IC50: 27 nM

 		98%
VR23 +++

Chymotrypsin-like proteasomes, IC50: 3 μM

Trypsin-like proteasomes, IC50: 1 nM

 		99%+
Carfilzomib ++

Proteasome, IC50: 5 nM

 		99%+
(R)-MG-132 +

Proteasome, IC50: 100 nM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Aclacinomycin A 生物活性

描述 Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine.

Aclacinomycin A 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03026842 Acute Myeloid Leukemia Phase 4 Active, not recruiting October 2024 China, Jilin ... 展开 >> First Hospital of Jilin University Changchun, Jilin, China, 130021 收起 <<
NCT02432911 Acute Myeloid Leukemia Not Applicable Recruiting May 2021 China, Tianjin ... 展开 >> Treatment and Diagnosis Center of Leukemia Recruiting Tianjin, Tianjin, China, 300020 Contact: Jianxiang Wang, MD    +862223909120    wangjx@medmail.com.cn    Contact: Chunlin Zhou, MD    +8613820429085    zcl7317@sina.com 收起 <<
NCT03560908 Relapsed AML ... 展开 >>T(8;21) C-KIT Mutation 收起 << Phase 1 Recruiting December 31, 2020 China, Tianjin ... 展开 >> HBDH Recruiting Tianjin, Tianjin, China, 300020 Contact: Hui Wei 收起 <<

Aclacinomycin A 参考文献

[1]Cao J, Feng H, et al. Homoharringtonine combined with aclarubicin and cytarabine synergistically induces apoptosis in t(8;21) leukemia cells and triggers caspase-3-mediated cleavage of the AML1-ETO oncoprotein. Cancer Med. 2016 Nov;5(11):3205-3213.

[2]Traganos F, Staiano-Coico L, et al. Effects of aclacinomycin on cell survival and cell cycle progression of cultured mammalian cells. Cancer Res. 1981 Jul;41(7):2728-37.

Aclacinomycin A 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.23mL

0.25mL

0.12mL

6.16mL

1.23mL

0.62mL

12.32mL

2.46mL

1.23mL

Aclacinomycin A 技术信息

CAS号57576-44-0
分子式C42H53NO15
分子量 811.87
别名 阿克拉霉素A ;Aclarubicin;NSC 208734;MA 144-A1;Antibiotic MA 144A;Aclucinomycin A;Aclarubicine;Aclacur
运输蓝冰
存储条件

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 50 mg/mL(61.59 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Aclacinomycin A | 57576-44-0 | Aclarubicin | Topoisomerase | Topoisomerase Inhibitor | Cell Cycle/DNA Damage | Metabolic Enzyme/Protease | Anti-infection | Topoisomerase | DNA/RNA Synthesis | Proteasome | Antibiotic | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Aclacinomycin A 纯度/质量文件 | Aclacinomycin A 亚型比较 | Aclacinomycin A 生物活性 | Aclacinomycin A 临床数据 | Aclacinomycin A 参考文献 | Aclacinomycin A 实验方案 | Aclacinomycin A 技术信息

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