There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Bendamustine (SDX-105 free base), a purine analogue, acts as a DNA cross-linking agent, activating DNA-damage stress response and apoptosis. It possesses potent alkylating, anticancer, and antimetabolite properties [1].
体内研究
Bendamustine (25 mg/kg, i.v.) exhibits significant inhibition of tumor cell growth, reducing it by 91%, 99%, and 95% in the DoHH-2, Granta 519, and RAMOS models, respectively. Additionally, the combination of bendamustine with rituximab enhances its antitumor effect in the DoHH-2 and RAMOS models, but not in the Granta 519 model [3].
体外研究
Bendamustine acts as a DNA cross-linking agent, inducing DNA breaks, and possesses alkylating and antimetabolite properties. It uniquely modulates apoptosis and DNA repair pathways in non-Hodgkin's lymphoma cells. At a concentration of 50 μM, bendamustine induces the expression of p21 (Cip1/Waf1) and NOXA genes, while also increasing p53 expression in SU-DHL-1 cells. Additionally, at 25 μM, bendamustine disrupts mitotic checkpoints, leading to mitotic catastrophe [1].
Bendamustine decreases the viability of multiple myeloma (MM) cell lines, including RPMI-8226 and 8226-LR5 cells, with IC25 values of 101.8 μM and 585.5 μM after 24 hours of incubation, and 51.7 μM and 374.3 μM after 48 hours of incubation, respectively. It triggers a caspase-dependent cell death pathway specific to MM cells and inhibits the spindle-assembly checkpoint [2].
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