Suramin sodium salt | 苏拉明钠盐 | Suramin hexasodium salt | PTPases Inhibitor

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苏拉明钠 /Suramin sodium salt {[allProObj[0].p_purity_real_show]}

货号：A397022 同义名： 苏拉明钠盐 / Suramin hexasodium salt;Suramin Sodium

Suramin sodium salt (Suramin hexasodium salt) 是一种可逆的、竞争性的蛋白酪氨酸磷酸酶（PTPases）抑制剂。它是一种有效的sirtuins抑制剂：SirT1（IC50=297 nM）、SirT2（IC50=1.15 μM）和SirT5（IC50=22 μM），并且还作为一种逆转录酶的竞争性抑制剂（DNA拓扑异构酶II：IC50=5 μM）。苏拉明钠盐是一种有效的SARS-CoV-2 RNA依赖的RNA聚合酶（RdRp）抑制剂，并有效抑制IP5K。此外，它具有抗寄生虫、抗肿瘤和抗血管生成特性。

Suramin sodium salt 化学结构
CAS号：129-46-4

Suramin sodium salt 3D分子结构
CAS号：129-46-4

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Suramin sodium salt 纯度/质量文件产品仅供科研

货号：A397022 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

Suramin sodium salt 生物活性

靶点	SIRT1 SirT1, IC50:297 nM SIRT5 SirT5, IC50:22 μM RdRp RdRp, IC50:0.26 μM
描述	Suramin sodium salt is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors(10-100 μM).

Suramin sodium salt 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00001230	-		Recruiting	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-441-1222 ext TTY8864111010 prpl@cc.nih.gov 收起 <<
NCT02347332	Recurrent or Metastatic Head a... 展开 >>nd Neck Carcinoma 收起 <<	Phase 3	Active, not recruiting	June 2018	-
NCT02871284	Exercise Chem... 展开 >>otherapy-induced Polyneuropathy 收起 <<	Phase 2 Phase 3	Recruiting	December 2019	Germany ... 展开 >> National Center for Tumor Diseases Recruiting Heidelberg, Germany, 69120 Contact: Joachim Wiskemann, Dr. joachim.wiskemann@nct-heidelberg.de Contact: Jana Müller jana.mueller@nct-heidelberg.de 收起 <<

Suramin sodium salt 参考文献

[1]Nautiyal A, Patil KN, et al. Suramin is a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery. J Antimicrob Chemother. 2014 Jul;69(7):1834-43.

[2]Jindal HK, Anderson CW, et al. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Cancer Res. 1990 Dec 15;50(24):7754-7.

Suramin sodium salt 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

0.70mL

0.14mL

0.07mL

3.50mL

0.70mL

0.35mL

7.00mL

1.40mL

0.70mL

Suramin sodium salt 技术信息

CAS号	129-46-4
分子式	C₅₁H₃₄N₆Na₆O₂₃S₆
分子量	1429.171

别名	苏拉明钠盐 ;Suramin hexasodium salt;Suramin Sodium;NF 060;Germanin;BAY 205;Suramin (sodium salt)
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C

溶解度

DMSO: 85 mg/mL(59.48 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 50 mg/mL(34.99 mM)，配合低频超声助溶

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00001230	-		Recruiting	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-441-1222 ext TTY8864111010 prpl@cc.nih.gov 收起 <<
NCT02347332	Recurrent or Metastatic Head a... 展开 >>nd Neck Carcinoma 收起 <<	Phase 3	Active, not recruiting	June 2018	-
NCT02871284	Exercise Chem... 展开 >>otherapy-induced Polyneuropathy 收起 <<	Phase 2 Phase 3	Recruiting	December 2019	Germany ... 展开 >> National Center for Tumor Diseases Recruiting Heidelberg, Germany, 69120 Contact: Joachim Wiskemann, Dr. joachim.wiskemann@nct-heidelberg.de Contact: Jana Müller jana.mueller@nct-heidelberg.de 收起 <<
NCT00003038	Adrenocortical Carcinoma ... 展开 >> Breast Cancer Colorectal Cancer Prostate Cancer Unspecified Adult Solid Tumor, Protocol Specific 收起 <<	Phase 1	Completed	-	United States, Minnesota ... 展开 >> Mayo Clinic Cancer Center Rochester, Minnesota, United States, 55905 收起 <<
NCT00001266	Prostatic Neoplasm	Phase 2	Completed	-	United States, Maryland ... 展开 >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 收起 <<
NCT00006476	Bladder Cancer	Phase 1	Completed	-	United Kingdom ... 展开 >> Oxford Radcliffe Hospital Oxford, England, United Kingdom, 0X3 9DU 收起 <<
NCT00004073	Brain and Central Nervous Syst... 展开 >>em Tumors 收起 <<	Phase 2	Completed	-	United States, Alabama ... 展开 >> University of Alabama Comprehensive Cancer Center Birmingham, Alabama, United States, 35294 United States, Florida H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 United States, Georgia Emory University Hospital - Atlanta Atlanta, Georgia, United States, 30322 United States, Maryland Johns Hopkins Oncology Center Baltimore, Maryland, United States, 21231 United States, Massachusetts Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 United States, Michigan Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, North Carolina Comprehensive Cancer Center of Wake Forest University Baptist Medical Center Winston-Salem, North Carolina, United States, 27157-1082 United States, Pennsylvania University of Pennsylvania Cancer Center Philadelphia, Pennsylvania, United States, 19104 United States, Texas University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78284-7811 收起 <<
NCT00001381	Bladder Neoplasms ... 展开 >> Carcinoma, Transitional Cell 收起 <<	Phase 1	Completed	-	United States, Maryland ... 展开 >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 收起 <<
NCT00002881	Prostate Cancer	Phase 3	Completed	-	United States, District of Col... 展开 >>umbia Walter Reed Army Medical Center Washington, District of Columbia, United States, 20307-5000 收起 <<
NCT00006929	Recurrent Non-small Cell Lung ... 展开 >>Cancer Stage IIIB Non-small Cell Lung Cancer Stage IV Non-small Cell Lung Cancer 收起 <<	Phase 2	Completed	-	United States, Ohio ... 展开 >> Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Columbus, Ohio, United States, 43210 收起 <<
NCT00002639	Brain and Central Nervous Syst... 展开 >>em Tumors 收起 <<	Phase 2	Completed	-	United States, Georgia ... 展开 >> Department of Neurosurgery - Emory Atlanta, Georgia, United States, 30322 收起 <<
NCT01671332	Carcinoma, Non Small Cell Lung	Phase 2	Unknown	December 2016	United States, Wisconsin ... 展开 >> University of Wisconsin Carbone Comprehensive Cancer Center Madison, Wisconsin, United States, 53792 Medical College of Wisconsin Milwaukee, Wisconsin, United States 收起 <<
NCT00002652	Multiple Myeloma and Plasma Ce... 展开 >>ll Neoplasm 收起 <<	Phase 2	Completed	-	United States, Arkansas ... 展开 >> University of Arkansas for Medical Sciences Little Rock, Arkansas, United States, 72205 收起 <<
NCT00083109	Recurrent Renal Cell Carcinoma... 展开 >> Stage IV Renal Cell Cancer 收起 <<	Phase 1 Phase 2	Completed	-	United States, Ohio ... 展开 >> Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 收起 <<
NCT00054028	Recurrent Breast Cancer ... 展开 >> Stage IIIB Breast Cancer Stage IV Breast Cancer 收起 <<	Phase 1 Phase 2	Completed	-	United States, Ohio ... 展开 >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 收起 <<
NCT00066768	Recurrent Non-small Cell Lung ... 展开 >>Cancer Stage IIIB Non-small Cell Lung Cancer Stage IV Non-small Cell Lung Cancer 收起 <<	Phase 1	Completed	-	United States, Ohio ... 展开 >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 收起 <<
NCT01038752	Non-small Cell Lung Cancer	Phase 2	Terminated	-	United States, Illinois ... 展开 >> John H Stroger Jr Hospital of Cook County Chicago, Illinois, United States, 60612 United States, Virginia Virginia Commonwealth University Massey Cancer Center Richmond, Virginia, United States, 23298 收起 <<
NCT00054028	-		Completed	-	-
NCT02508259	Autism Spectrum Disorders	Phase 1 Phase 2	Completed	-	United States, California ... 展开 >> University of California, San Diego School of Medicine La Jolla, California, United States, 92093 收起 <<
NCT01038752	-		Terminated	-	-
NCT00002921	Adrenocortical Carcinoma	Phase 2	Terminated(Permanently Closed ... 展开 >>Due to Lack of Accrual) 收起 <<	-	-
NCT00002723	Prostate Cancer	Phase 3	Completed	-	-

苏拉明钠 /Suramin sodium salt {[allProObj[0].p_purity_real_show]}

Suramin sodium salt 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Suramin sodium salt 质控信息

Suramin sodium salt 生物活性

Suramin sodium salt 临床研究

Suramin sodium salt 参考文献

Suramin sodium salt 实验方案

Suramin sodium salt 技术信息

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SIRT1	SirT1, IC50:297 nM
SIRT5	SirT5, IC50:22 μM
RdRp	RdRp, IC50:0.26 μM

苏拉明钠 /Suramin sodium salt {[allProObj[0].p_purity_real_show]}

Suramin sodium salt 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Suramin sodium salt 质控信息

Suramin sodium salt 生物活性

Suramin sodium salt 临床研究

Suramin sodium salt 参考文献

Suramin sodium salt 实验方案

Suramin sodium salt 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Suramin sodium salt 纯度/质量文件产品仅供科研