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左氧氟沙星 /Levofloxacin {[allProObj[0].p_purity_real_show]}

货号:A105051 同义名: (-)-Ofloxacin;MP-376

Levofloxacin is an inhibitor of type II topoisomerases. It can inhibit DNA gyrase and topoisomerase IV with IC50 of 8.06 µg/ml and 9.81 µg/ml. It is an antibacterial agent.

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Levofloxacin 化学结构 CAS号:100986-85-4
Levofloxacin 化学结构
CAS号:100986-85-4
Levofloxacin 3D分子结构
CAS号:100986-85-4
Levofloxacin 化学结构 CAS号:100986-85-4
Levofloxacin 3D分子结构 CAS号:100986-85-4
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Levofloxacin 纯度/质量文件 产品仅供科研

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产品名称 Topo I Topo II Topo IV Topoisomerase 其他靶点 纯度
Ellagic acid 98%
β-Lapachone 99%+
(s)-10-hydroxycamptothecin 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

98%
Topotecan ++++

Topo I (MCF-7 Luc cells), IC50: 13 nM

Topo I (DU-145 Luc cells), IC50: 2 nM

98%
Irinotecan HCl Trihydrate 98%
SN-38 98%
Levofloxacin hydrate 98%
Dexrazoxane 99%+
Ofloxacin 98+%
Enoxacin 99%+
Flumequine +

Topo II, IC50: 15 μM

98%
Levofloxacin 97%
Etoposide 98%
Pefloxacin mesylate dihydrate 99+%
Marbofloxacin 98+%
Voreloxin HCl 98%
Mitoxantrone dihydrochloride PKC 98%
Nalidixic acid 98%
Doxorubicin 98%
Novobiocin sodium 95%
Amonafide 99%+
Pirarubicin 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

99%+
Genistein EGFR 98%
Teniposide 98%
Moxifloxacin 98%
Ciprofloxacin 98%
Clinafloxacin 97%
Gatifloxacin 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

98%
Epirubicin HCl 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Levofloxacin 生物活性

靶点
  • Topo II

描述 Levofloxacin is a new fluoroquinolone antibiotic which is the active isomer of ofloxacin[3]. It is active against S. aureus, S. epidermidis, B. subtilis, E. coli, P. aeruginosa, and K. pneumoniae (MICs = 0.25, 0.25, 0.5, 0.03, 4, and 0.25 μg/ml, respectively)[4]. In stable chronic obstructive pulmonary disease, levofloxacin treatment (500mg/day) causes a short term reduction in bacterial load among patients[5].

Levofloxacin 细胞研究

细胞系 浓度 检测类型 检测时间 活动说明 数据源
HEK293 cells Function assay 1.5 mins Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay, IC50=17.9 μM 23241029
human 5637 cells 200 to 300 ug/ml Function assay 12 h Antibacterial activity against uropathogenic Escherichia coli UTI89 infected in human 5637 cells assessed as decrease in intracellular bacterial level at 200 to 300 ug/ml after 12 hrs by serial dilution method 20231390

Levofloxacin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00020865 Fever, Sweats, and Hot Flashes... 展开 >> Infection Leukemia Lymphoma Neutropenia Unspecified Adult Solid Tumor, Protocol Specific 收起 << Phase 3 Unknown - United States, California ... 展开 >> Jonsson Comprehensive Cancer Center, UCLA Los Angeles, California, United States, 90095-1781 收起 <<
NCT01131026 Helicobacter Pylori Infection Phase 3 Completed - Turkey ... 展开 >> Erciyes University School of Medicine Hospital, Department of Internal Medicine and Gastroenterology Kayseri, Turkey, 38039 收起 <<
NCT02975570 Tuberculosis Multi Drug Resist... 展开 >>ant Active 收起 << Phase 3 Withdrawn(The study could not ... 展开 >>be conducted since funding was not obtained.) 收起 << August 2022 -

Levofloxacin 参考文献

[1]Davis R, Bryson HM. Levofloxacin. A review of its antibacterial activity, pharmacokinetics and therapeutic efficacy. Drugs. 1994 Apr;47(4):677-700.

[2]Fu KP, Lafredo SC, et al. In vitro and in vivo antibacterial activities of levofloxacin (l-ofloxacin), an optically active ofloxacin. Antimicrob Agents Chemother. 1992 Apr;36(4):860-6.

[3]S Ragnar Norrby. Levofloxacin. Expert Opinion on Pharmacotherapy. 1999;1(1): 109-119.

[4]Mohammadhosseini N, Alipanahi Z, Alipour E, et al. Synthesis and antibacterial activity of novel levofloxacin derivatives containing a substituted thienylethyl moiety. Daru. 2012;20(1):16.

[5]Siva R, Bafadhel M, Monteiro W, Brightling CE, Pavord ID. Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial. Int J Chron Obstruct Pulmon Dis. 2014;9:179-186.

Levofloxacin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.84mL

2.77mL

1.38mL

27.67mL

5.53mL

2.77mL

Levofloxacin 技术信息

CAS号100986-85-4
分子式C18H20FN3O4
分子量 361.368
别名 (-)-Ofloxacin;MP-376;Levofloxacin, Levaquin, Tavanic, Iquix, Quixin;Fluoroquinolone
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度

DMSO: 9 mg/mL(24.91 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 5 mg/mL(13.84 mM)

动物实验配方
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