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首页 / 抑制剂/激动剂 / 泛素 / 蛋白酶体 / Epoxomicin

环氧酶素 /Epoxomicin {[allProObj[0].p_purity_real_show]}

货号：A509209 同义名： BU-4061T;Aids010837

Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome.

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Epoxomicin 化学结构 CAS号：134381-21-8
Epoxomicin 化学结构
CAS号：134381-21-8
Epoxomicin 3D分子结构
CAS号：134381-21-8
Epoxomicin 化学结构 CAS号：134381-21-8
Epoxomicin 3D分子结构 CAS号：134381-21-8
规格 价格 会员价 库存 数量
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Epoxomicin 纯度/质量文件 产品仅供科研

货号：A509209 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 20S proteasome ↓ Proteasome ↓ 其他靶点 纯度
Ixazomib ++++

20S proteasome, IC50: 3.4 nM

20S proteasome, Ki: 0.93 nM

 		99%+
Delanzomib +++

Chymotrypsin-like proteasome, IC50: 3.8 nM

 		98%
Celastrol +

20S proteasome, IC50: 2.5 μM

 		98%
MLN9708 +++

20S proteasome, IC50: 3.4 nM

20S proteasome, Ki: 0.93 nM

 		99%
Bortezomib ++++

20S proteasome, Ki: 0.6 nM

 		98%
Oprozomib ++

20S proteasome LMP7, IC50: 82 nM

20S proteasome β5, IC50: 36 nM

 		99%+
Epoxomicin ✔ 99%
PI-1840 ++

Chymotrypsin-like proteasome, IC50: 27 nM

 		98%
VR23 +++

Chymotrypsin-like proteasomes, IC50: 3 μM

Trypsin-like proteasomes, IC50: 1 nM

 		98%
Carfilzomib ++

Proteasome, IC50: 5 nM

 		98%
(R)-MG-132 +

Proteasome, IC50: 100 nM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Epoxomicin 生物活性

靶点

  • 20S proteasome
描述 Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome.

Epoxomicin 细胞研究

细胞系 浓度 检测类型 检测时间 活动说明 数据源
HEK293 cells Function assay 2 h Inhibition of chymotrypsin-like activity of proteasome beta-5 subunit in HEK293 cells using Suc-LLVY-Glo as substrate incubated for 2 hrs prior to substrate addition measured after 10 mins by cell-based proteasome-Glo beta5 assay, IC50=0.026 μM 23540790
human DLD1 cells Function assay Inhibition of chymotrypsin-like activity of 20S proteasome in human DLD1 cells transfected with 4Ub-Luc gene using Succinyl-Leu-Leu-Val-Tyr-AMC as substrate after 6 hrs by spectrofluorometric analysis, IC50=0.006 μM 22206869
human LCL cells Function assay 12 h Inhibition of chymotrypsin-like activity of 20S proteasome beta2 in human LCL cells after 12 hrs, IC50=0.005 μM 20687609
lymphoblastoid cells Function assay Inhibition of caspase like 20S proteasome activity in lymphoblastoid cells, IC50=4.56 μM 17996987

Epoxomicin 参考文献

[1]Meng L, Mohan R, et al. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10403-8.

[2]Kim KB, Myung J, et al. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3335-40.

Epoxomicin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.80mL

0.36mL

0.18mL

9.01mL

1.80mL

0.90mL

18.03mL

3.61mL

1.80mL

Epoxomicin 技术信息

CAS号134381-21-8
分子式C28H50N4O7
分子量 554.719
别名 BU-4061T;Aids010837
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C
溶解度

DMSO: 105 mg/mL(189.28 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Epoxomicin | 134381-21-8 | BU-4061T | Proteasome | Proteasome Inhibitor | Metabolic Enzyme/Protease | Apoptosis | Proteasome | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Epoxomicin 纯度/质量文件 | Epoxomicin 亚型比较 | Epoxomicin 生物活性 | Epoxomicin 细胞研究 | Epoxomicin 参考文献 | Epoxomicin 实验方案 | Epoxomicin 技术信息

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