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/ Favipiravir

法匹拉韦 /Favipiravir {[allProObj[0].p_purity_real_show]}

货号：A265413 同义名： 法维拉韦 / T-705;Favilavir

Favipiravir is an anti-viral compound with activity against many RNA viruses and an RNA-directed RNA polymerase NS5B inhibitor.

Favipiravir 化学结构 CAS号：259793-96-9
Favipiravir 化学结构
CAS号：259793-96-9
Favipiravir 3D分子结构
CAS号：259793-96-9
Favipiravir 化学结构 CAS号：259793-96-9
Favipiravir 3D分子结构 CAS号：259793-96-9
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Favipiravir 纯度/质量文件 产品仅供科研

货号：A265413 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 DNA synthesis ↓ helicase ↓ RdRp ↓ ribonucleotide reductase ↓ tRNA synthetase ↓ YB-1 ↓ 其他靶点 纯度
Fexinidazole ✔ 98%
Daptomycin ✔ 98%
Blasticidin S·HCl ✔ 98%
Metronidazole ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Triglycidyl isocyanurate ✔ p53 98+%
Nedaplatin ✔ 99%+
Bendamustine ✔ 98+%
Trifluridine ✔ 98%
Robinetin ✔ 99%+
Carboplatin ✔ 99%
Cidofovir ✔ 99%
Cisplatin ✔ 99%
Cytarabine ++++

DNA synthesis, IC50: 16 nM

 		98%
Acelarin ++++

DNA synthesis, EC50: 0.2 nM

 		99%+
Oxaliplatin ✔ 98%
YK-4-279 ✔ 99%+
ML216 +

BLMfull-length, IC50: 2.98 μM

BLM636-1298, IC50: 0.97 μM

 		99%+
RK-33 ✔ 98%
Brr2-IN-3 ✔ 99%+
Phen-DC3 Trifluoromethanesulfonate ✔ 98%
Favipiravir ✔ 97%
Suramin sodium salt ++

RdRp, IC50: 0.26 μM

 		99%+
Clofarabine ++

Ribonucleotide reductase, IC50: 65 nM

 		97%
Didox ✔ 98%
(E)-3-AP ✔ 97%
Halofuginone +++

prolyl-tRNA synthetase, Ki: 18.3nM

 		99%+
BC-LI-0186 +++

Leucyl-tRNA synthetase, Kd: 42.1 nM

Leucyl-tRNA synthetase, IC50: 46.11 nM

 		98%
SU056 +

YB-1, IC50: 1.73 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Favipiravir 生物活性

靶点

  • RdRp
描述 Favipiravir (T 705) selectively inhibits the RNA-dependent RNA polymerase of influenza and other RNA viruses, demonstrating much higher selectivity for viral polymerase over human DNA polymerases and RNA polymerase II[1]. Favipiravir (T 705) functions as a pro-drug, with its cytotoxic effects varying by cell line. It dose-dependently inhibits MNV-induced cytopathic effects (CPE) with an EC50 of 250±11 μM and suppresses MNV RNA synthesis in cell culture with an EC50 of 124±42 μM. Although its antiviral efficacy is relatively modest, Favipiravir can fully stop norovirus replication at 100 μg/mL, a dosage that minimally impacts host cell viability (greater than 80%)[2].
体内研究

Favipiravir significantly improves survival and provides protection against H5N1 influenza at doses of 33 mg/kg/day or higher, with optimal effects when administered four times daily[1].
体外研究

Favipiravir (T 705) selectively inhibits the RNA-dependent RNA polymerase of influenza and other RNA viruses, demonstrating much higher selectivity for viral polymerase over human DNA polymerases and RNA polymerase II[1].

Favipiravir (T 705) functions as a pro-drug, with its cytotoxic effects varying by cell line. It dose-dependently inhibits MNV-induced cytopathic effects (CPE) with an EC50 of 250±11 μM and suppresses MNV RNA synthesis in cell culture with an EC50 of 124±42 μM. Although its antiviral efficacy is relatively modest, Favipiravir can fully stop norovirus replication at 100 μg/mL, a dosage that minimally impacts host cell viability (greater than 80%)[2].

Favipiravir 细胞研究

细胞系 浓度 检测类型 检测时间 活动说明 数据源
MDCK cells Function assay Inhibition of viral replication of influenza A virus (A/Hong Kong/213/03(H5N1)) and influenza A virus (A/Ann Arbor/6/60(H2N2)) hybrid virus in MDCK cells by neutral red uptake assay 17194832
MDCK cells Function assay Inhibition of influenza A virus (A/duck/Minnesota/1525/1981 (H5N1)) replication in MDCK cells by neutral red uptake assay 17194832
Vero cells Function assay 7-8 days Antiviral activity against Junin virus Candid-1 in Vero cells assessed as inhibition of virus-induced visual cytopathic effect after 7 to 8 days 17606691

Favipiravir 动物研究

Dose Mice: 37.5 mg/kg - 300 mg/kg[3] (p.o.), 20 mg/kg[4] (p.o.)
Administration p.o.
Pharmacokinetics
Animal Mice[2]
Dose 100 mg/kg
Administration p.o.
Tmax 46.2 min (PICV-infected)
28.5 min (Sham-infected)
T1/2β 53.4 min (PICV-infected)
40.3 min (Sham-infected)
Cmax 40.9 μg/ml (PICV-infected)
81.5 μg/ml (Sham-infected)
T1/2α 20.6 min (PICV-infected)
11.1 min (Sham-infected)
AUC 4339.8 μg·min/ml (PICV-infected)
7740.8 μg·min/ml (Sham-infected)

Favipiravir 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01728753 Influenza Phase 1 Phase 2 Completed - United States, Florida ... 展开 >> Miami Research Associates Miami, Florida, United States, 33143 收起 <<
NCT02662855 Ebola Virus Disease Phase 2 Completed - -
NCT01068912 Influenza Phase 2 Completed - -

Favipiravir 参考文献

[1]Furuta Y, et al. Favipiravir (T-705), a novel viral RNA polymerase inhibitor. Antiviral Res. 2013 Nov;100(2):446-54.

[2]Rocha-Pereira J, et al. Favipiravir (T-705) inhibits in vitro norovirus replication. Biochem Biophys Res Commun. 2012 Aug 10;424(4):777-80.

[3]Gao Y, et al. Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β-arrestin interactions. Pharmacol Res Perspect. 2015 Feb;3(1):e00073.

Favipiravir 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.37mL

1.27mL

0.64mL

31.83mL

6.37mL

3.18mL

63.65mL

12.73mL

6.37mL

Favipiravir 技术信息

CAS号259793-96-9
分子式C5H4FN3O2
分子量 157.103
别名 法维拉韦 ;T-705;Favilavir;Avigan
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

DMSO: 105 mg/mL(668.35 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 6 mg/mL(38.19 mM)，配合低频超声助溶
动物实验配方

Tags: Favipiravir |法匹拉韦 | 法维拉韦 | T-705 | Favilavir | Avigan | 259793-96-9 | DNA | 丙型肝炎病毒 | 抗病毒 | Favipiravir 纯度/质量文件 | Favipiravir 亚型比较 | Favipiravir 生物活性 | Favipiravir 细胞研究 | Favipiravir 动物研究 | Favipiravir 临床数据 | Favipiravir 参考文献 | Favipiravir 实验方案 | Favipiravir 技术信息

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