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甲硝唑 /Metronidazole {[allProObj[0].p_purity_real_show]}

货号：A114755 同义名： MNZ;NSC 69587

Metronidazole is an inhibitor of OAT3 and can inhibit the transport activity of OAT3 with IC50 and Ki of 6.51 ± 0.99 μM, 6.48 μM, respectively. It is also an antibacterial agent for anaerobic bacteria and protozoa.

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Metronidazole 化学结构 CAS号：443-48-1
Metronidazole 化学结构
CAS号：443-48-1
Metronidazole 3D分子结构
CAS号：443-48-1
Metronidazole 化学结构 CAS号：443-48-1
Metronidazole 3D分子结构 CAS号：443-48-1
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Metronidazole 纯度/质量文件 产品仅供科研

货号：A114755 标准纯度： {[allProObj[0].p_purity_real_show]}
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Metronidazole 生物活性

靶点

  • DNA synthesis
描述 Metronidazole is an orally active nitroimidazole antibiotic known for its ability to cross the blood-brain barrier. It is primarily used in the research of anaerobic infections due to its efficacy against a range of anaerobic bacteria and protozoa[1].[2].[3].[4].
体内研究

In animal models, prolonged administration of Metronidazole at a dosage of 135 mg/kg/day orally for 28 days can penetrate the blood-brain barrier, where it has been shown to cause neurotoxicity in rats, indicating potential side effects associated with long-term use[3].

Additionally, when administered at 1 g/L orally for four weeks, Metronidazole results in skeletal muscle atrophy and alters the expression of genes involved in muscle peripheral circadian rhythm machinery and metabolic regulation, further demonstrating the systemic effects of this antibiotic under chronic exposure conditions[4].
体外研究

Metronidazole is effective against anaerobic protozoa including Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia, and Balantidium coli, demonstrating its broad spectrum of anti-protozoal activity[1].

Metronidazole also exhibits good bactericidal activity against anaerobic bacteria, with effective inhibitory concentrations ranging from 4 to 8 μg/mL[1].

At concentrations between 0.1 μg/mL and 0.01 mg/mL over periods from 12 to 96 hours, Metronidazole induces granular formation and triggers apoptosis in Blastocystis species, highlighting its impact on cellular structures and viability[2].

Metronidazole 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02735395 Chronic Periodontitis Phase 4 Active, not recruiting September 2018 Brazil ... 展开 >> Guarulhos University Guarulhos, São Paulo, Brazil, 07023-070 收起 <<
NCT03169946 Periodontal and Endodontic Les... 展开 >>ion 收起 << Not Applicable Active, not recruiting September 2017 -
NCT02736682 Post Operative Infections Phase 4 Completed - Uganda ... 展开 >> Mulago National Refferal Hospital Kampala, Uganda, 00256 收起 <<

Metronidazole 参考文献

[1]Scully BE. Metronidazole. Med Clin North Am. 1988 May;72(3):613-21.

[2]Dhurga DB, et al. Granular Formation during Apoptosis in Blastocystis sp. Exposed to Metronidazole (MTZ). PLoS One. 2016 Jul 29;11(7):e0155390.

[3]Chaturvedi S, et al. Mechanistic exploration of quercetin against metronidazole induced neurotoxicity in rats: Possible role of nitric oxide isoforms and inflammatory cytokines. Neurotoxicology. 2020 Jul;79:1-10.

[4]Manickam R, et al. Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism. Int J Mol Sci. 2018 Aug 16;19(8):2418.

Metronidazole 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.84mL

1.17mL

0.58mL

29.21mL

5.84mL

2.92mL

58.43mL

11.69mL

5.84mL

Metronidazole 技术信息

CAS号443-48-1
分子式C6H9N3O3
分子量 171.15
别名 MNZ;NSC 69587;NSC 50364
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C
溶解度

DMSO: 35 mg/mL(204.49 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 15 mg/mL(87.64 mM)，配合低频超声助溶
动物实验配方

Tags: Metronidazole |甲硝唑 | MNZ | NSC 69587 | NSC 50364 | 443-48-1 | 药物标准品 | Antiparasitic | URAT1 | 咪唑类 | 驱虫剂 | Antibacterial | 其他化合物 | Metronidazole 纯度/质量文件 | Metronidazole 生物活性 | Metronidazole 临床数据 | Metronidazole 参考文献 | Metronidazole 实验方案 | Metronidazole 技术信息

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