There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Camptothecin (CPT), an alkaloid, acts as an inhibitor for DNA topoisomerase I (Topo I) with an IC50 value of 679 nM[1]. Demonstrating significant antitumor effects on colorectal, breast, lung, and ovarian cancers, CPT also affects the activity of hypoxia-inducible factor-1α (HIF-1α) by altering the patterns of microRNAs (miRNA) expression in human cancer cells[2].[3].
体内研究
Administering Camptothecin (2 mg/kg every other day) to mice presenting extensive pulmonary metastases resulted in a significant reduction of these metastases when combined with the kinase inhibitor of nuclear factor-kappaB-1 (KINK-1)[5].
体外研究
MCF7 (Luminal subtype) and HCC1419 (HER2 subtype) cells, characterized by elevated TOP1 enzyme activity, are particularly susceptible to Camptothecin treatment (ranging from 0.1 μM to 5 μM over 72 hours), showing IC50 values of 0.089 μM and 0.067 μM, respectively[4].
A dosage of Camptothecin at 0.5 μM for 6 and 24 hours notably decreases the expression of VEGF activated by desferrioxamine. Furthermore, Camptothecin administration (0.5 μM; 8 to 24 hours) effectively inhibits the accumulation of HIF-1α induced by desferrioxamine[2].
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