Cidofovir | GS 0504;HPMPC;(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine;(S)-HPMPC | CMV | DNA/RNA Synthesis

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西多福韦 /Cidofovir 99%

货号：A370831 同义名： GS 0504;HPMPC

Cidofovir is an anti-CMV drug which can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Cidofovir 化学结构
CAS号：113852-37-2

Cidofovir 3D分子结构
CAS号：113852-37-2

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Cidofovir 纯度/质量文件产品仅供科研

货号：A370831 标准纯度： 99% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024, 67(17): 14974-14985. Ambeed. [ A288696 ]; • JMC, 2024, 67(17): 15061-15079. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

DNA 亚型比较

产品名称	DNA synthesis ↓ ↑	helicase ↓ ↑	RdRp ↓ ↑	ribonucleotide reductase ↓ ↑	tRNA synthetase ↓ ↑	YB-1 ↓ ↑	其他靶点	纯度
Fexinidazole	✔							98%
Daptomycin	✔							98%
Blasticidin S·HCl	✔							98%
Metronidazole	✔							98%
Daunorubicin HCl	+++ DNA synthesis, Ki: 20 nM							98%
Triglycidyl isocyanurate	✔						p53	98+%
Nedaplatin	✔							99%+
Bendamustine	✔							98+%
Trifluridine	✔							98%
Robinetin	✔							99%+
Carboplatin	✔							99%
Cidofovir	✔							99%
Cisplatin	✔							99%
Cytarabine	++++ DNA synthesis, IC50: 16 nM							98%
Acelarin	++++ DNA synthesis, EC50: 0.2 nM							99%+
Oxaliplatin	✔							98%
YK-4-279		✔						99%+
ML216		+ BLM^full-length, IC50: 2.98 μM BLM^636-1298, IC50: 0.97 μM						99%+
RK-33		✔						98%
Brr2-IN-3		✔						99%+
Phen-DC3 Trifluoromethanesulfonate		✔						98%
Favipiravir			✔					97%
Suramin sodium salt			++ RdRp, IC50: 0.26 μM					99%+
Clofarabine				++ Ribonucleotide reductase, IC50: 65 nM				97%
Didox				✔				98%
(E)-3-AP				✔				97%
Halofuginone					+++ prolyl-tRNA synthetase, Ki: 18.3nM			99%+
BC-LI-0186					+++ Leucyl-tRNA synthetase, IC50: 46.11 nM Leucyl-tRNA synthetase, Kd: 42.1 nM			98%
SU056						+ YB-1, IC50: 1.73 μM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Cidofovir 生物活性

靶点

DNA synthesis

描述

Cidofovir is a synthetic nucleotide analog with potent antiviral activity against a wide range of herpes viruses. In A549 cells, the analysis of 50% inhibitory dose (ID50) of cidofovir dihydrate in different strains and serotypes of adenovirus showed that the mean ID50 values for Ad5 wide-type, Ad5 McEwen, Ad14 and Ad8 are 9.5, 7.3, 5.4, and 4.7 μg/mL, respectively[2]. In MRC-5 cells, the ED50 values of cidofovir dihydrate against Hmc wild type, SC16, BW-S, BW-R, MS wild type are 6.5 ± 2.5, 9.3 ± 1.8, 8.5 ± 1.0, 1.1 ± 0.9, and 9.1 ± 1.8 μM, respectively[3].. A graded decrease in the severity of acute conjunctivitis was observed in rabbits received the treatment of 0.1% cidofovir dihydrate, whereas the concentrations at 0.5% and 1% caused a moderate grade of acute conjunctivitis. A significantly reduction in Ad5 ocular titers was shown in 0.5% and 1% cidofovir dihydrate-treated groups compared to the placebo group. The duration of viral ocular shedding in 0.1%, 0.5%, and 1% cidofovir dihydrate-treated groups were 6, 4, and 4 days, compared to 7-day duration in placebo group. The mean ELISA antibody titer was decreased by 0.5% and 1% cidofovir dihydrate 21 days post the inoculation^[3].

Cidofovir 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
A549 cells		Function assay		Antiviral activity against Human adenovirus type 11p slobitski infected in A549 cells assessed as inhibition of DNA replication by QPCR assay, EC50=16.5 μM	20585112
african green monkey Vero cells		Function assay		Antiviral activity against Herpes simplex virus 1 F infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs, EC50=14.4 μM	17438061
bone marrow cells		Cytotoxicity assay		Cytotoxicity against human bone marrow cells assessed as inhibition of colony forming unit of granulocyte/macrophage, IC50=10 μM	16814545
HEL cells		Function assay		Compound was tested for anti-viral activity against HSV-1(KOS) in HEL cells, EC50=0.57 μM	14643328

Cidofovir 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02227641	Patients Undergoing Allogeneic... 展开 >> Stem Cell Transplantation 收起 <<	Phase 1 Phase 2	Unknown	March 2017	Germany ... 展开 >> Medical Center Augsburg Recruiting Augsburg, Germany, 86156 Contact: Christoph Schmid, MD, PhD 0049 821 4002736 Principal Investigator: Christoph Schmid, MD, PhD Charité University Hospital Berlin Recruiting Berlin, Germany, 13353 Contact: Armin H Gerbitz, MD, PhD ++49 30 450565256 armin.gerbitz@charite.de Contact: Lutz Uharek, MD, PhD lutz.uharek@charite.de Sub-Investigator: Lutz Uharek, MD, PhD Principal Investigator: Armin Gerbitz, MD, PhD Universitiy Hospital Erlangen Recruiting Erlangen, Germany, 91054 Contact: Anita Kremer, MD, PhD ++49 9131 8543183 anita.kremer@uk-erlangen.de Contact: Bernd Spriewald, MD, PhD ++49 9131 8543116 bernd.spriewald@uk-erlangen.de Sub-Investigator: Katja San Niccolo, MD University of Mainz Recruiting Mainz, Germany, 55131 Contact: Eva Wagner, MD Principal Investigator: Eva Wagner, MD University of Munich LMU Recruiting Munich, Germany, 81377 Contact: Johanna Tischer, MD 0049 89 70954240 Principal Investigator: Johanna Tischer, MD University of Regensburg Not yet recruiting Regensburg, Germany, 93053 Contact: Ernst Holler, MD, PhD 0049 941 9445570 Principal Investigator: Ernst Holler, MD, PhD 收起 <<
NCT03532035	Adenovirus	Phase 2	Not yet recruiting	December 20, 2019	-
NCT00078533	Cytomegalovirus Infections	Phase 1	Completed	-	United States, Texas ... 展开 >> Houston Methodist Hospital Houston, Texas, United States, 77030 Texas Children's Hospital Houston, Texas, United States, 77030 收起 <<

Cidofovir 参考文献

[1]Li SB, Yang ZH, et al. Activity of(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) against guinea pig cytomegalovirus infection in cultured cells and in guinea pigs. Antiviral Res. 1990 May;13(5):237-52.

[2]Snoeck R, Sakuma T, et al.(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication. Antimicrob Agents Chemother. 1988 Dec;32(12):1839-44.

[3]de Oliveira CB, Stevenson D, LaBree L, McDonnell PJ, Trousdale MD. Evaluation of Cidofovir (HPMPC, GS-504) against adenovirus type 5 infection in vitro and in a New Zealand rabbit ocular model. Antiviral Res. 1996 Jul;31(3):165-72. doi: 10.1016/0166-3542(95)00962-0. PMID: 8811201.

Cidofovir 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.58mL

0.72mL

0.36mL

17.91mL

3.58mL

1.79mL

35.82mL

7.16mL

3.58mL

Cidofovir 技术信息

CAS号	113852-37-2
分子式	C₈H₁₄N₃O₆P
分子量	279.187

别名	GS 0504;HPMPC;(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine;(S)-HPMPC
运输	蓝冰

存储条件

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

H₂O: 3 mg/mL(10.75 mM)，配合低频超声助溶

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02227641	Patients Undergoing Allogeneic... 展开 >> Stem Cell Transplantation 收起 <<	Phase 1 Phase 2	Unknown	March 2017	Germany ... 展开 >> Medical Center Augsburg Recruiting Augsburg, Germany, 86156 Contact: Christoph Schmid, MD, PhD 0049 821 4002736 Principal Investigator: Christoph Schmid, MD, PhD Charité University Hospital Berlin Recruiting Berlin, Germany, 13353 Contact: Armin H Gerbitz, MD, PhD ++49 30 450565256 armin.gerbitz@charite.de Contact: Lutz Uharek, MD, PhD lutz.uharek@charite.de Sub-Investigator: Lutz Uharek, MD, PhD Principal Investigator: Armin Gerbitz, MD, PhD Universitiy Hospital Erlangen Recruiting Erlangen, Germany, 91054 Contact: Anita Kremer, MD, PhD ++49 9131 8543183 anita.kremer@uk-erlangen.de Contact: Bernd Spriewald, MD, PhD ++49 9131 8543116 bernd.spriewald@uk-erlangen.de Sub-Investigator: Katja San Niccolo, MD University of Mainz Recruiting Mainz, Germany, 55131 Contact: Eva Wagner, MD Principal Investigator: Eva Wagner, MD University of Munich LMU Recruiting Munich, Germany, 81377 Contact: Johanna Tischer, MD 0049 89 70954240 Principal Investigator: Johanna Tischer, MD University of Regensburg Not yet recruiting Regensburg, Germany, 93053 Contact: Ernst Holler, MD, PhD 0049 941 9445570 Principal Investigator: Ernst Holler, MD, PhD 收起 <<
NCT03532035	Adenovirus	Phase 2	Not yet recruiting	December 20, 2019	-
NCT00078533	Cytomegalovirus Infections	Phase 1	Completed	-	United States, Texas ... 展开 >> Houston Methodist Hospital Houston, Texas, United States, 77030 Texas Children's Hospital Houston, Texas, United States, 77030 收起 <<
NCT01143181	Male or Female Patients With a... 展开 >> Serious or Immediately Life-threatening Disease or Condition Caused by CMV, ADV, HSV, VAVC, VARV or Monkeypox Viruses(s) Who Have a Life Expectancy of ≥ 2 Weeks and for Whom no Comparable or Satisfactory Alternative Therapy is Available 收起 <<	Phase 2 Phase 3	Completed	-	-
NCT00284687	Cytomegalovirus Infections	Phase 3	Completed	-	Israel ... 展开 >> Hadassah Medical Organization Jerusalem,, Israel, 91120 收起 <<
NCT03481244	-		Not yet recruiting	December 2022	-
NCT01431326	-		Recruiting	February 2020	-
NCT01610765	Herpes Simplex Virus	Phase 1 Phase 2	Withdrawn(Study terminated bec... 展开 >>ause unable to obtain access to study drug for study population.) 收起 <<	June 2017	-
NCT00780182	Healthy	Phase 1	Completed	-	United States, North Carolina ... 展开 >> AAI Pharma Rtp, North Carolina, United States, 27709 收起 <<
NCT03216967	BK Virus Nephropathy After Kid... 展开 >>ney Transplantation 收起 <<	Phase 4	Recruiting	December 1, 2022	France ... 展开 >> CHU - Hôpital Sud Not yet recruiting Amiens, France, 80054 Contact: Maité JAUREGUY, MD CHRU d'Angers Not yet recruiting Angers, France, 49033 Contact: Johnny SAYEGH, MD CHU - Hôpital de la Cavale Blanche Recruiting Bois-guillaume, France, 76230 Contact: Dominique BERTRAND, MD CHU - Hôpital de la Cavale Blanche Recruiting Brest, France, 29609 Contact: Yannick LE MEUR, MD CHU Côte de Nacre Recruiting Caen, France, 14033 Contact: Nicolas BOUVIER, MD CHU Hôpital Gabriel Montpied Not yet recruiting Clermont-Ferrand, France, 63000 Contact: Anne Elisabeth HENG, MD CHU - Hôpital Dupuytren Recruiting Limoges, France, 87042 Contact: Jean Philippe REROLLE, MD AP-HP Hôpital Necker Recruiting Paris, France, 75743 Contact: Dany ANGLICHEAU, MD AP-HP - Hôpital Georges Pompidou Not yet recruiting Paris, France, 75908 Contact: Eric THERVET, MD CHU Poitiers - Hôpital Jean Bernard Not yet recruiting Poitiers, France, 86021 Contact: Laure ECOTIERE, MD CHU - Hôpital Maison Blanche Not yet recruiting Reims, France, 51092 Contact: Betoul SCHVARTZ, MD CHU Rennes - Hôpital Pontchaillou Not yet recruiting Rennes, France, 35033 Contact: Léonard GOLBIN, MD Les Hôpitaux Universitaires Recruiting Strasbourg, France, 67000 Contact: Sophie CAILLARD, MD CHRU - Hôpital Bretonneau Recruiting Tours, France, 37044 Contact: Matthias BUCHLER, MD 收起 <<
NCT00004794	Cytomegalovirus Retinitis ... 展开 >> Acquired Immunodeficiency Syndrome 收起 <<	Phase 2	Completed	-	-
NCT00001611	-		Completed	-	United States, Maryland ... 展开 >> National Eye Institute (NEI) Bethesda, Maryland, United States, 20892 收起 <<
NCT02515877	Cervical Cancer	Phase 1	Completed	-	France ... 展开 >> Gustave Roussy Cancer Campus Grand Paris Villejuif, Val de Marne, France, 94805 收起 <<
NCT00000945	HIV Infections ... 展开 >> Leukoencephalopathy, Progressive Multifocal 收起 <<	Not Applicable	Completed	-	United States, Alabama ... 展开 >> Univ of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, California San Francisco AIDS Clinic / San Francisco Gen Hosp San Francisco, California, United States, 941102859 San Francisco Gen Hosp San Francisco, California, United States, 941102859 United States, Colorado Univ of Colorado Health Sciences Ctr Denver, Colorado, United States, 80262 United States, District of Columbia Howard Univ Washington, District of Columbia, United States, 20059 United States, Illinois Northwestern Univ Med School Chicago, Illinois, United States, 60611 Cook County Hosp Chicago, Illinois, United States, 60612 Rush Presbyterian - Saint Luke's Med Ctr Chicago, Illinois, United States, 60612 Louis A Weiss Memorial Hosp Chicago, Illinois, United States, 60640 United States, Maryland Johns Hopkins Hosp Baltimore, Maryland, United States, 21287 United States, New York SUNY / Erie County Med Ctr at Buffalo Buffalo, New York, United States, 14215 Beth Israel Med Ctr New York, New York, United States, 10003 Bellevue Hosp / New York Univ Med Ctr New York, New York, United States, 10016 Mount Sinai Med Ctr New York, New York, United States, 10029 Univ of Rochester Medical Center Rochester, New York, United States, 14642 United States, North Carolina Univ of North Carolina Chapel Hill, North Carolina, United States, 275997215 United States, Ohio Univ of Kentucky Lexington Cincinnati, Ohio, United States, 45267 United States, South Carolina Julio Arroyo West Columbia, South Carolina, United States, 29169 United States, Washington Univ of Washington Seattle, Washington, United States, 98104 收起 <<
NCT00002384	Cytomegalovirus Retinitis ... 展开 >> HIV Infections 收起 <<	Not Applicable	Unknown	-	-
NCT00019240	Sarcoma	Phase 2	Completed	-	United States, Maryland ... 展开 >> Medicine Branch Bethesda, Maryland, United States, 20892 收起 <<
NCT00002142	Cytomegalovirus Retinitis ... 展开 >> HIV Infections 收起 <<	Not Applicable	Completed	-	United States, New Jersey ... 展开 >> Besselaar Associates Princeton, New Jersey, United States, 085406681 收起 <<
NCT02931539	Cytomegalovirus (CMV)	Phase 3	Recruiting	May 6, 2019	-
NCT00000142	HIV Infections ... 展开 >> CMV Cytomegalovirus Retinitis 收起 <<	Phase 2 Phase 3	Completed	-	-
NCT00002437	Cytomegalovirus Retinitis ... 展开 >> HIV Infections 收起 <<	Phase 2	Completed	-	United States, California ... 展开 >> Los Angeles County - USC Med Ctr Los Angeles, California, United States, 90033 UCI Med Ctr Orange, California, United States, 92668 Mount Zion Med Ctr San Francisco, California, United States, 94115 United States, Massachusetts Beth Israel Hosp Boston, Massachusetts, United States, 02215 United States, New Jersey Besselaar Associates Princeton, New Jersey, United States, 085406681 United States, New York Univ of Rochester Med Ctr Rochester, New York, United States, 14607 United States, North Carolina Univ of North Carolina Hosps Chapel Hill, North Carolina, United States, 27599 United States, Texas Audie L Murphy Veterans Administration Hosp San Antonio, Texas, United States, 78284 United Kingdom Charing Cross and Westminster Med School London SW 10, United Kingdom 收起 <<
NCT00000799	Cytomegalovirus Retinitis ... 展开 >> HIV Infections 收起 <<	Not Applicable	Completed	-	United States, California ... 展开 >> UCSD - Shiley Eye Ctr / SOCA La Jolla, California, United States, 920930946 UCLA - Jules Stein Eye Institute / SOCA Los Angeles, California, United States, 900957003 UCSF - San Francisco Gen Hosp San Francisco, California, United States, 94143 United States, Illinois Northwestern Univ / SOCA Chicago, Illinois, United States, 60611 United States, Maryland Johns Hopkins Hosp / SOCA Baltimore, Maryland, United States, 212879217 United States, New York New York Univ Med Ctr / SOCA New York, New York, United States, 10016 United States, North Carolina Univ of North Carolina / SOCA Chapel Hill, North Carolina, United States, 275997030 收起 <<
NCT00811408	Cervical Cancer ... 展开 >> Precancerous Condition 收起 <<	Phase 1	Unknown	-	France ... 展开 >> Institut Gustave Roussy Recruiting Villejuif, France, F-94805 Contact: Eric Deutsch, MD 33-1-4211-4339 收起 <<
NCT00000881	Cytomegalovirus Infections ... 展开 >> Cytomegalovirus Retinitis HIV Infections 收起 <<	Phase 1	Withdrawn	-	-
NCT00000142	-		Completed	-	-
NCT00000894	Cytomegalovirus Retinitis ... 展开 >> HIV Infections 收起 <<	Phase 4	Completed	-	United States, California ... 展开 >> Univ of Southern California / LA County USC Med Ctr Los Angeles, California, United States, 900331079 UCLA CARE Ctr Los Angeles, California, United States, 90095 United States, Florida Univ of Miami / Bascom Palmer Eye Institute Miami, Florida, United States, 33136 United States, Georgia Emory Eye Clinic Atlanta, Georgia, United States, 30322 United States, Illinois Northwestern Univ / SOCA Chicago, Illinois, United States, 60611 United States, Louisiana Charity Hosp / Tulane Univ Med School New Orleans, Louisiana, United States, 70112 United States, Maryland Johns Hopkins Hosp Baltimore, Maryland, United States, 21287 United States, New York Cornell Univ Med Ctr New York, New York, United States, 10021 New York Hosp / Cornell Med Ctr New York, New York, United States, 10021 United States, North Carolina Univ of North Carolina Chapel Hill, North Carolina, United States, 275997215 United States, South Carolina Julio Arroyo West Columbia, South Carolina, United States, 29169 United States, Texas Univ of Texas Galveston Galveston, Texas, United States, 775550435 收起 <<
NCT00002327	HIV Infections ... 展开 >> Condyloma Acuminata 收起 <<	Phase 1	Completed	-	United States, California ... 展开 >> East Bay AIDS Ctr Berkeley, California, United States, 94705 Univ California San Francisco San Francisco, California, United States, 941430316 United States, Colorado City and County of Denver / Dept of Health & Hosps Denver, Colorado, United States, 802044507 United States, New York Bronx-Lebanon Hosp Ctr Bronx, New York, United States, 10453 Univ of Rochester Med Ctr Rochester, New York, United States, 14642 United States, Texas Houston Clinical Research Network Houston, Texas, United States, 77006 Dr Brad Bowden Houston, Texas, United States, 77027 Dr Stephen Tyring Nassau Bay, Texas, United States, 77058 United States, Utah Univ of Utah School of Medicine Salt Lake City, Utah, United States, 84132 United States, Washington Univ of Washington / Viral Disease Clinic Seattle, Washington, United States, 98122 Pacific Med Ctr Seattle, Washington, United States, 98144 收起 <<
NCT00002116	Herpes Simplex ... 展开 >> HIV Infections 收起 <<	Phase 1	Completed	-	United States, California ... 展开 >> Los Angeles County - USC Med Ctr Los Angeles, California, United States, 90033 UCSF - San Francisco Gen Hosp San Francisco, California, United States, 94110 Mount Zion Med Ctr / UCSF San Francisco, California, United States, 94115 United States, Illinois Rush Presbyterian - Saint Luke's Med Ctr Chicago, Illinois, United States, 60612 United States, Maryland Johns Hopkins Hosp Baltimore, Maryland, United States, 21205 United States, North Carolina Univ of North Carolina Hosps Chapel Hill, North Carolina, United States, 27599 United States, Texas Park Plaza Hosp Houston, Texas, United States, 77004 United States, Washington Univ of Washington / Viral Disease Clinic Seattle, Washington, United States, 98122 Canada, British Columbia Univ of British Columbia / Univ Hosp Vancouver, British Columbia, Canada 收起 <<
NCT00002181	Herpes Simplex ... 展开 >> HIV Infections 收起 <<	Not Applicable	Completed	-	United States, California ... 展开 >> Mem Med Group Inc Long Beach, California, United States, 90806 AIDS Healthcare Foundation Labs Los Angeles, California, United States, 90027 Sharp Mission Park / Med Group Oceanside, California, United States, 92054 Park Ctr for Health / Keith Vrhel San Diego, California, United States, 92103 Potrero Hill Med Ctr San Francisco, California, United States, 94107 HIV Primary Care & Consult Santa Rosa, California, United States, 95404 United States, Florida Central Florida Research Initiative Maitland, Florida, United States, 32751 United States, Georgia Braude Mermin Spivey MD PC Atlanta, Georgia, United States, 30309 United States, Illinois Christie Clinic / Urbana Campus Urbana, Illinois, United States, 61801 United States, Massachusetts Heywood Memorial Hosp Gardner, Massachusetts, United States, 01440 United States, New York Gouverneur Hosp New York, New York, United States, 10002 United States, Texas Central Texas Med Foundation Austin, Texas, United States, 78751 Dr Nicholaos Bellos Dallas, Texas, United States, 75225 Dr Susan M Diamond Dallas, Texas, United States, 75225 ID Associates Dallas, Texas, United States, 75231 收起 <<
NCT00000143	Cytomegalovirus Retinitis ... 展开 >> HIV Infections 收起 <<	Phase 3	Completed	-	United States, California ... 展开 >> Department of Ophthalmology, University of California, Irvine Irvine, California, United States, 92697-4375 Shiley Eye Center Center, 0946, University of California, San Diego La Jolla, California, United States, 92093-0946 LAC/USC Medical Center, 5P21 Rand Schrader Clinic Los Angeles, California, United States, 90033 Jules Stein Eye Institute, University of California, Los Angeles Los Angeles, California, United States, 90095-7003 Beckman Vision Center, University of California, San Francisco San Francisco, California, United States, 94143 United States, Florida Bascom Palmer Eye Institute, University of Miami Miami, Florida, United States, 33136 University of South Florida, MDC Box 21 Tampa, Florida, United States, 33612-4799 United States, Georgia The Emory Clinic, Emory University Atlanta, Georgia, United States, 30322 United States, Illinois Department of Ophthalmology, Northwestern University Chicago, Illinois, United States, 60611 United States, Indiana Division of Infectious Diseases, Indiana University, Indianapolis Indianapolis, Indiana, United States, 46202-2879 United States, Louisiana LSU Eye Center, Louisiana State University Medical Center New Orleans, Louisiana, United States, 70112 United States, Maryland The Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine Baltimore, Maryland, United States, 21287-9217 United States, Massachusetts Harvard/BCH AIDS Clinical Trials Unit, Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, New Jersey UMDNJ-New Jersey Medical School Newark, New Jersey, United States, 07103-2499 United States, New York Department of Ophthalmology, New York University Medical Center New York, New York, United States, 10016 Department of Ophthalmology, New York Hospital-Cornell Medical Center New York, New York, United States, 10021 Department of Ophthalmology, Mount Sinai School of Medicine New York, New York, United States, 10029-6574 United States, North Carolina University of North Carolina at Chapel Hill Chapel Hill, North Carolina, United States, 27599-7030 United States, Texas Cullen Eye Institute, Baylor College of Medicine Houston, Texas, United States, 77030 收起 <<
NCT00001126	Papilloma	Phase 1	Completed	-	United States, Alabama ... 展开 >> NIAID/DMID/CASG Central Unit Birmingham, Alabama, United States, 35294 收起 <<
NCT00000143	-		Completed	-	-
NCT00550589	Anal Cancer P... 展开 >>recancerous Condition 收起 <<	Phase 2	Completed	-	United States, California ... 展开 >> UCLA Clinical AIDS Research and Education (CARE) Center Los Angeles, California, United States, 90095-1793 UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94115 United States, Massachusetts Boston University Cancer Research Center Boston, Massachusetts, United States, 02118 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, New York Montefiore Medical Center Bronx, New York, United States, 10461 Laser Surgery Care New York, New York, United States, 10010 New York Weill Cornell Cancer Center at Cornell University New York, New York, United States, 10021 United States, Washington Benaroya Research Institute at Virginia Mason Medical Center Seattle, Washington, United States, 98101 收起 <<
NCT00989443	Uterine Cervical Neoplasms ... 展开 >> Cervix Intraepithelial Neoplasia 收起 <<	Phase 1	Completed	-	Belgium ... 展开 >> Erasme Hospital Brussels, Belgium, 1070 收起 <<
NCT00205374	Recurrent Respiratory Papillom... 展开 >>atosis 收起 <<	Phase 4	Completed	-	-
NCT00205374	-		Completed	-	-
NCT00948506	Prevention of Hair Growth	Phase 2	Completed	-	United States, Pennsylvania ... 展开 >> Hospital of the University of PA Philadelphia, Pennsylvania, United States, 19104 收起 <<
NCT00948506	-		Completed	-	-
NCT00138424	-		Terminated	-	-
NCT00138424	BK Virus (Nephropathy)	Phase 1 Phase 2	Terminated	-	United States, Alabama ... 展开 >> University of Alabama Hospital - Nephrology Birmingham, Alabama, United States, 35249-0001 United States, California California Pacific Medical Center - Sutter Pacific Medical Foundation - Transplant Nephrology San Francisco, California, United States, 94115-1932 University of California San Francisco Medical Center at Parnassus - Organ Transplant San Francisco, California, United States, 94143-2204 United States, Colorado University of Colorado Denver Aurora, Colorado, United States, 80045-2541 United States, Illinois Northwestern University - Comprehensive Transplant Center Chicago, Illinois, United States, 60611-2927 The University of Chicago Medical Center - Kindney Trasnplant - Nephrology Chicago, Illinois, United States, 60637-1447 United States, Minnesota University of Minnesota Medical Center, Fairview - Infectious Diseases and International Medicine Minneapolis, Minnesota, United States, 55455-0356 Mayo Clinic, Rochester - Infectious Diseases Rochester, Minnesota, United States, 55905-0001 United States, New Hampshire Dartmouth-Hitchcock Medical Center - Infectious Disease Lebanon, New Hampshire, United States, 03756-1000 United States, Texas Dallas Nephrology Associates - Dallas Transplant Institute Dallas, Texas, United States, 75204-6168 United States, Washington University of Washington - Medicine Seattle, Washington, United States, 98195-7110 United States, Wisconsin University of Wisconsin Hospital and Clinics - Clinical Science Center - Nephrology Madison, Wisconsin, United States, 53792-0001 收起 <<
NCT00550589	-		Completed	-	-
NCT02555800	Recurrent Respiratory Papillom... 展开 >>atosis 收起 <<	Phase 2	Unknown	June 2017	Mexico ... 展开 >> Centro de Investigacion en Enfermedades Infecciosas Recruiting Mexico, Mexico, 14080 Contact: Gustavo Reyes-Teran, M.D. +52(55)56667985 Contact: Yuria Ablanedo-Terrazas, M.D. +52(55)56667985 Principal Investigator: Gustavo Reyes-Teran, M.D. Sub-Investigator: Yuria Ablanedo-Terrazas, M.D. Sub-Investigator: Arturo Ramírez-García, M.D. Sub-Investigator: Oscar Estrada-Camacho, M.D. Sub-Investigator: Gabriel Tona-Acedo, M.D. 收起 <<
NCT02976987	High Grade Cervical Epithelial... 展开 >> Neoplasia (CIN2+) 收起 <<	Phase 2	Completed	-	Belgium ... 展开 >> CHU Brugmann Hospital Brussels, Belgium, 1020 收起 <<
NCT01295645	Transplantation Infection	Phase 2	Active, not recruiting	March 2019	United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT00956176	Cystitis Blad... 展开 >>der Diseases 收起 <<	Not Applicable	Withdrawn	-	-
NCT02567149	Warts	Phase 2	Withdrawn(No funding)	-	United States, Minnesota ... 展开 >> University of Minnesota Medical Center Minneapolis, Minnesota, United States, 55455 收起 <<
NCT01866397	Cytomegalovirus Retinitis ... 展开 >> Acute Renal Failure 收起 <<	Phase 4	Completed	-	Austria ... 展开 >> Medical University of Vienna Vienna, Austria, 1190 收起 <<
NCT01946009	HIV	Not Applicable	Completed	-	Spain ... 展开 >> Hospital Universitario La Paz Madrid, Spain 收起 <<
NCT01816646	Blood And Marrow Transplantati... 展开 >>on 收起 <<	Phase 1	Completed	-	United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<

A549 cells	Function assay		Antiviral activity against Human adenovirus type 11p slobitski infected in A549 cells assessed as inhibition of DNA replication by QPCR assay, EC50=16.5 μM	20585112
african green monkey Vero cells	Function assay		Antiviral activity against Herpes simplex virus 1 F infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs, EC50=14.4 μM	17438061
bone marrow cells	Cytotoxicity assay		Cytotoxicity against human bone marrow cells assessed as inhibition of colony forming unit of granulocyte/macrophage, IC50=10 μM	16814545
HEL cells	Function assay		Compound was tested for anti-viral activity against HSV-1(KOS) in HEL cells, EC50=0.57 μM	14643328
HEL cells	Function assay	3 days	Antiviral activity against HCMV AD169 infected in HEL cells assessed as reduction of virus-induced cytopathogenicity after 3 days, EC50=0.41 μM	17961851
HEL cells	Function assay	3 days	Antiviral activity against HCMV Davis infected in HEL cells assessed as reduction of virus-induced cytopathogenicity after 3 days, EC50=0.41 μM	17961851
HEL cells	Function assay		Antiviral activity against ganciclovir-resistant HCMV AD169 clone 4 infected in HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=0.74 μM	19226140
HEL cells	Function assay		Antiviral activity against HCMV Davis infected in human HEL cells assessed inhibition of virus-induced cytopathicity after 7 days postinfection, EC50=0.5 μM	19226140
HEL cells	Function assay		Antiviral activity against HCMV AD169 infected in human HEL cells assessed inhibition of virus-induced cytopathicity after 7 days postinfection, EC50=0.3 μM	19226140
HEL cells	Function assay		Antiviral activity against foscarnet-resistant HCMV AD169 clone C infected in HEL cells assessed as inhibition of virus-induced cytopathicity, IC50=0.045 μM	19226140
HeLaS3 cells	Function assay	3-5 days	Antiviral activity against Vaccinia virus IHD-J ATCC VR-156 infected in HeLaS3 cells after 3 to 5 days by plaque assay, EC50=18.74 μM	18852271
HFF	Proliferation assay	3 days	Antiproliferative activity against HFF after 3 days by coulter counter assay, EC50=1.9 μM	19029322
HFF cells	Function assay		Antiviral activity against Vaccinia virus Copenhagen in HFF cells assessed as reduction in cytopathogenicity, EC50=3.2 μM	16603351
HFF cells	Function assay		Antiviral activity against Cowpox virus Brighton in HFF cells assessed as reduction in cytopathogenicity, EC50=7.1 μM	16603351
HFF cells	Function assay		Antiviral activity against vaccinia virus Copenhagen measured as cytopathogenicity in HFF cells, EC50=6.9 μM	16722657
HFF cells	Function assay		Antiviral activity against Human CMV T2241 in HFF cells by SEAP assay, IC50=0.3 μM	17043128
HFF cells	Function assay		Antiviral activity against Cytomegalovirus CMV T2211 infected in HFF cells by SEAP reporter gene assay, EC50=0.22 μM	17709468
HFF cells	Function assay		Antiviral activity against Cowpox virus (Brighton Red) infected in human HFF cells assessed as reduction in viral-induced cytopathic effect by neutral red uptake assay, EC50=6.7 μM	21376429
HSB2 cells	Function assay	7 days	Antiviral activity against Human herpesvirus 6 GS infected in human HSB2 cells assessed as decrease in viral DNA accumulation after 7 days, EC50=2.7 μM	19770274
MRC5 cells	Function assay		Antiviral activity against Human CMV Towne in MRC5 cells by PRA, IC50=0.3 μM	17043128
MRC-5 cells	Function assay		Inhibitory activity against cytopathic effect of HSV-2(E 194) in MRC-5 cells, IC50=10 μM	8632439
NHDF cells	Function assay		Inhibitory activity against replication of HCMV in NHDF cells, IC50=0.5 μM	8632439
UC1B cells	Function assay		Antiviral activity against Murine polyomavirus MN/RDE Toronto in mouse UC1B cells assessed as reduction of virus-induced cytopathogenicity, EC50=13 μM	17420214

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