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Betulinic acid
白桦脂酸 /Betulinic acid
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货号：A200416
同义名：
桦木酸
/ Lupatic acid;Betulic acid
Bet ulinic ac id 是一种天然的五环三萜类 化合物，为真核细胞拓扑异构酶 I (topoisomeras e I) 的抑制剂，IC50 值为 5 μM，具有抗炎 、抗疟疾、抗艾滋病和抗肿瘤 等活性。
Betulinic acid 化学结构
Betulinic acid 3D分子结构
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Betulinic acid 纯度/质量文件 产品仅供科研
货号：A200416
标准纯度：
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Betulinic acid 质控信息
Betulinic acid 生物活性
靶点
描述
Betulinic Acid is a natural pentacyclic triterpenoid compound and a eukaryotic topoisomerase I inhibitor with IC50 value of 0.5 mM. It has anti-inflammatory, anti malaria, anti AIDS and anti-tumor activities[3] [4] [5] [6] [7]
Betulinic acid 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT00346502
Dysplastic Nevus Syndrome
Phase 1
Phase 2
Suspended(The study has been t... 展开 >> emporarily suspended due to funding issues) 收起 <<
December 2015
United States, Illinois
... 展开 >>
University of Illinois at Chicago Medical Center
Chicago, Illinois, United States, 60612 收起 <<
Betulinic acid 参考文献
[1] Melzig MF, Bormann H. Betulinic acid inhibits aminopeptidase N activity. Planta Med. 1998 Oct;64(7):655-7.
[2] Fujioka T, Kashiwada Y, et al. Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. J Nat Prod. 1994 Feb;57(2):243-7.
[3] Chowdhury AR, Mandal S, Mittra B, Sharma S, Mukhopadhyay S, Majumder HK. Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives. Med Sci Monit. 2002 Jul;8(7):BR254-65. PMID: 12118187.
[4] Kasperczyk H, La Ferla-Brühl K, Westhoff MA, Behrend L, Zwacka RM, Debatin KM, Fulda S. Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. Oncogene. 2005 Oct 20;24(46):6945-56. doi: 10.1038/sj.onc.1208842. PMID: 16007147.
[5] Gao Y, Ma Q, Ma YB, Ding L, Xu XL, Wei DF, Wei L, Zhang JW. Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. 2018 Jan-Feb;42(1):49-54. doi: 10.1080/01913123.2017.1383548. Epub 2017 Dec 1. PMID: 29192840.
[6] Hashimoto F, Kashiwada Y, Cosentino LM, Chen CH, Garrett PE, Lee KH. Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. Bioorg Med Chem. 1997 Dec;5(12):2133-43. doi: 10.1016/s0968-0896(97)00158-2. PMID: 9459011.
[7] Kalra J, Lingaraju MC, Mathesh K, Kumar D, Parida S, Singh TU, Sharma AK, Kumar D, Tandan SK. Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Mar;391(3):285-297. doi: 10.1007/s00210-017-1455-3. Epub 2017 Dec 26. PMID: 29279966.
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Betulinic acid 实验方案
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.19mL
0.44mL
0.22mL
10.95mL
2.19mL
1.09mL
21.90mL
4.38mL
2.19mL
Betulinic acid 技术信息
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