货号:A200416
同义名:
桦木酸
/ Lupatic acid;Betulic acid
Betulinic acid 是一种天然的五环三萜类化合物,为真核细胞拓扑异构酶 I (topoisomerase I) 的抑制剂,IC50 值为 5 μM,具有抗炎、抗疟疾、抗艾滋病和抗肿瘤等活性。
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | NF-κB ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pyrrolidinedithiocarbamate ammonium | ✔ | 98% | |||||||||||||||||
QNZ |
++++
NF-κB, IC50: 11 nM |
99%+ | |||||||||||||||||
Sodium 4-Aminosalicylate Dihydrate | ✔ | 99%+ | |||||||||||||||||
Sodium Salicylate | ✔ | 99%+ | |||||||||||||||||
Parthenolide | ✔ | p53 | 97% HPLC | ||||||||||||||||
JSH-23 |
+
NF-κB, IC50: 7.1 μM |
98% | |||||||||||||||||
Phenethyl caffeate | ✔ | 99%+ | |||||||||||||||||
Andrographolide | ✔ | 99%+ | |||||||||||||||||
Curcumin | ✔ | HDAC,Nrf2 | 98% | ||||||||||||||||
SC75741 |
+++
NF-κB, EC50: 200 nM |
99%+ | |||||||||||||||||
CBL0137 HCl |
++
NF-κB, EC50: 0.47 μM |
p53 | 99%+ | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Betulinic Acid is a natural pentacyclic triterpenoid compound and a eukaryotic topoisomerase I inhibitor with IC50 value of 0.5 mM. It has anti-inflammatory, anti malaria, anti AIDS and anti-tumor activities[3]. Betulinic Acid is also a new activator of NF κB[4]. Betulinic Acid (20, 40 µM) causes decrease in Bcl-2 expression of MDA-MB-231 cells[5]. Betulinic Acid has anti HIV activity. EC50 of H9 lymphocytes infected with Betulinic Acid is 1.4 μ M[6]. Moreover, oral administration of Betulinic Acid reduced the bleeding score at 10 and 30 mg/kg and improved the stool consistency at 30 mg/kg[7]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00346502 | Dysplastic Nevus Syndrome | Phase 1 Phase 2 | Suspended(The study has been t... 展开 >>emporarily suspended due to funding issues) 收起 << | December 2015 | United States, Illinois ... 展开 >> University of Illinois at Chicago Medical Center Chicago, Illinois, United States, 60612 收起 << |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.19mL 0.44mL 0.22mL |
10.95mL 2.19mL 1.09mL |
21.90mL 4.38mL 2.19mL |
CAS号 | 472-15-1 |
分子式 | C30H48O3 |
分子量 | 456.7 |
别名 | 桦木酸 ;Lupatic acid;Betulic acid;Mairin;NSC 113090;ALS-357 |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 35 mg/mL(76.64 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |