Trifluridine | Trifluorothymidine;TFT;2-Deoxy-5-trifluoromethyluridine;FTD ;Viroptic;NSC 529182;NSC 75520;5-Trifluorothymidine | 曲氟尿苷 | Antivirus | Apoptosis | Thymidylate Synthase

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三氟胸苷 /Trifluridine {[allProObj[0].p_purity_real_show]}

货号：A179915 同义名： 曲氟尿苷 / Trifluorothymidine;TFT

Trifluorothymidine is a derivative of thymidine that can inhibit thymidylate synthase and lead to DNA damage and apoptosis. It could be used to treat colorectal cancer.

Trifluridine 化学结构
CAS号：70-00-8

Trifluridine 3D分子结构
CAS号：70-00-8

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Trifluridine 纯度/质量文件产品仅供科研

货号：A179915 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

Trifluridine 生物活性

靶点

DNA synthesis

描述

Trifluridine is a nucleoside metabolic inhibitor used to treat keratoconjunctivitis and epithelial keratitis caused by simplex virus, and as a part of chemotherapy for certain types of metastatic gastrointestinal cancers^[3]. Phase III trial of trifluridine showed significant improvement of overall survival and progression-free survival in refractory gastric cancer and gastroesophageal junction cancer^[4].

Trifluridine 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02943733	Neuroendocrine Tumors ... 展开 >> Neoplasms Cancer Tumors 收起 <<	Phase 1	Recruiting	August 2020	United States, Wisconsin ... 展开 >> University of Wisconsin Carbone Cancer Center Recruiting Madison, Wisconsin, United States, 53792 Contact: Cancer Connect 800-622-8922 cancerconnect@uwcarbone.wisc.edu Principal Investigator: Nataliya Uboha 收起 <<
NCT01916447	Advanced Gastrointestinal Tumo... 展开 >>rs 收起 <<	Phase 1	Completed	-	United States, California ... 展开 >> Los Angeles Clinical Site Los Angeles, California, United States, 90095 United States, Illinois Chicago Clinical Site Chicago, Illinois, United States, 60611 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Tennessee Vanderbilt Ingram Cancer Center Nashville, Tennessee, United States, 37212 收起 <<
NCT01904253	Small Cell Lung Cancer (SCLC)	Phase 2	Terminated(The preliminary dat... 展开 >>a does not suggest any safety signal, but an ad hoc interim analysis showed an imbalance of PFS between the two arms) 收起 <<	-	Germany ... 展开 >> Klinikum Mannheim GmbH Universitaetsklinikum Mannheim, Baden-Württemberg, Germany Lungenklinik Heckeshorn- HELIOS Kliniken GmbH Berlin, Germany LungenClinic Grosshansdorf Grosshansdorf, Germany Klinikum Koeln-Merheim Koplin, Germany St. Hildegardis-Krankenhaus- Katholisches Klinikum Mainz Mainz, Germany LMU-Campus Innenstadt Muenchen, Germany Italy Azienda Ospedaliero-Universitaria S. Luigi Gonzaga Orbassano, Turin, Italy IRCCS Centro di Riferimento Oncologico di Aviano, Divisione Oncologia Medica A Aviano, Italy Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico Bari Bari, Italy Azienda Ospedaliera Univ. Policlinico Gaspare Rodolico Catania, Italy Azienda Ospedaliera Instituti Ospitalieri di Cremona Cremona, Italy Azienda Ospedaliera Universitaria Careggi Firenze, Italy IEO Istituto Europeo di Oncologia Milano, Italy Azienda Ospedaliera San Gerardo U.O Oncologia Medica Monza, Italy Arcispedale S. Maria Nuova Azienda Ospedaliera di Reggio Emilia Reggio Emilia, Italy A.O.V.V. Ospedale Eugenio Morelli-Sondalo Sondalo, Italy Japan National Cancer Center Hospital East Chiba, Japan, 277-8577 National Kyushi Cancer Center Fukuoka, Japan, 811-1395 Hyogo Cancer Center Hyogo, Japan, 673-8588 Saitama Cancer Center Saitama, Japan, 362-0806 Shizuoka Cancer Center Shizuoka, Japan, 411-8777 Nippon Medical School Hospital Tokyo, Japan, 113-8603 Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo, Japan, 135-8550 收起 <<

Trifluridine 参考文献

[1]Sakamoto K, Yokogawa T, et al. Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2'-deoxy-5-fluorouridine into DNA. Int J Oncol. 2015;46(6):2327-34.

[2]Germano A, Rapa I, et al. Cytotoxic activity of gemcitabine, alone or in combination with mitotane, in adrenocortical carcinoma cell lines. Mol Cell Endocrinol. 2014 Jan 25;382(1):1-7.

[3]Carmine AA, Brogden RN, Heel RC, Speight TM, Avery GS. Trifluridine: a review of its antiviral activity and therapeutic use in the topical treatment of viral eye infections. Drugs. 1982;23(5):329-353.

[4] Fostea RM, Arkenau HT. Trifluridine/tipiracil in the treatment of gastric cancer. Future Oncol. 2022;18(12):1511-1517.

Trifluridine 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.38mL

0.68mL

0.34mL

16.88mL

3.38mL

1.69mL

33.76mL

6.75mL

3.38mL

Trifluridine 技术信息

CAS号	70-00-8
分子式	C₁₀H₁₁F₃N₂O₅
分子量	296.2

别名	曲氟尿苷 ;Trifluorothymidine;TFT;2-Deoxy-5-trifluoromethyluridine;FTD ;Viroptic;NSC 529182;NSC 75520;5-Trifluorothymidine
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 105 mg/mL(354.49 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 30 mg/mL(101.28 mM)，配合低频超声，并水浴加热至45℃助溶

动物实验配方

PO 0.5% CMC-Na 36 mg/mL suspension

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02943733	Neuroendocrine Tumors ... 展开 >> Neoplasms Cancer Tumors 收起 <<	Phase 1	Recruiting	August 2020	United States, Wisconsin ... 展开 >> University of Wisconsin Carbone Cancer Center Recruiting Madison, Wisconsin, United States, 53792 Contact: Cancer Connect 800-622-8922 cancerconnect@uwcarbone.wisc.edu Principal Investigator: Nataliya Uboha 收起 <<
NCT01916447	Advanced Gastrointestinal Tumo... 展开 >>rs 收起 <<	Phase 1	Completed	-	United States, California ... 展开 >> Los Angeles Clinical Site Los Angeles, California, United States, 90095 United States, Illinois Chicago Clinical Site Chicago, Illinois, United States, 60611 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Tennessee Vanderbilt Ingram Cancer Center Nashville, Tennessee, United States, 37212 收起 <<
NCT01904253	Small Cell Lung Cancer (SCLC)	Phase 2	Terminated(The preliminary dat... 展开 >>a does not suggest any safety signal, but an ad hoc interim analysis showed an imbalance of PFS between the two arms) 收起 <<	-	Germany ... 展开 >> Klinikum Mannheim GmbH Universitaetsklinikum Mannheim, Baden-Württemberg, Germany Lungenklinik Heckeshorn- HELIOS Kliniken GmbH Berlin, Germany LungenClinic Grosshansdorf Grosshansdorf, Germany Klinikum Koeln-Merheim Koplin, Germany St. Hildegardis-Krankenhaus- Katholisches Klinikum Mainz Mainz, Germany LMU-Campus Innenstadt Muenchen, Germany Italy Azienda Ospedaliero-Universitaria S. Luigi Gonzaga Orbassano, Turin, Italy IRCCS Centro di Riferimento Oncologico di Aviano, Divisione Oncologia Medica A Aviano, Italy Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico Bari Bari, Italy Azienda Ospedaliera Univ. Policlinico Gaspare Rodolico Catania, Italy Azienda Ospedaliera Instituti Ospitalieri di Cremona Cremona, Italy Azienda Ospedaliera Universitaria Careggi Firenze, Italy IEO Istituto Europeo di Oncologia Milano, Italy Azienda Ospedaliera San Gerardo U.O Oncologia Medica Monza, Italy Arcispedale S. Maria Nuova Azienda Ospedaliera di Reggio Emilia Reggio Emilia, Italy A.O.V.V. Ospedale Eugenio Morelli-Sondalo Sondalo, Italy Japan National Cancer Center Hospital East Chiba, Japan, 277-8577 National Kyushi Cancer Center Fukuoka, Japan, 811-1395 Hyogo Cancer Center Hyogo, Japan, 673-8588 Saitama Cancer Center Saitama, Japan, 362-0806 Shizuoka Cancer Center Shizuoka, Japan, 411-8777 Nippon Medical School Hospital Tokyo, Japan, 113-8603 Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo, Japan, 135-8550 收起 <<
NCT02860546	Refractory Metastatic Colorect... 展开 >>al Cancer 收起 <<	Phase 2	Completed	-	United States, Colorado ... 展开 >> Sarah Cannon Research Institute at HealthONE Denver, Colorado, United States, 80218 United States, Florida Florida Cancer Specialists Sarasota, Florida, United States, 34232 United States, Tennessee Sarah Cannon Research Institute Nashville, Tennessee, United States, 37203 收起 <<
NCT03686488	Gastric Adenocarcinoma ... 展开 >> Gastroesophageal Junction Adenocarcinoma Gastric Cancer 收起 <<	Phase 2	Recruiting	January 1, 2023	United States, Florida ... 展开 >> H. Lee Moffitt Cancer Center and Research Institute Recruiting Tampa, Florida, United States, 33612 Contact: Neal Shah 813-745-1393 Neal.Shah@moffitt.org 收起 <<
NCT01896856	Previously Treated Metastatic ... 展开 >>Colorectal Cancer 收起 <<	Phase 2	Recruiting	September 2019	United States, California ... 展开 >> USC / Norris Comprehensive Cancer Center Recruiting Los Angeles, California, United States, 90033 Contact: Anthony El-Khoueiry, MD 323-865-3967 elkhouei@med.usc.edu United States, Maryland Sidney Kimmel Comprehensive Cancer Center Recruiting Baltimore, Maryland, United States, 21231 Contact: Ellen Lilly-Foreman, RN 443-287-4961 lillyel@jhmi.edu Contact: Tearra Miles tlawre18@jhmi.edu Principal Investigator: Nilo Azad, MD United States, New York Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Derek Alexander 646-888-1381 alexandd@mskcc.org Principal Investigator: Andrea Cercek, MD Netherlands VU Medisch Centrum Recruiting Amsterdam, Netherlands, 1081 HV Contact: Henk Verheul, MD h.verheul@vumc.nl Contact: Elske Gootjes, MD e.gootjes@vumc.nl 收起 <<
NCT01874522	Advanced Solid Tumors (Excludi... 展开 >>ng Breast Cancer) 收起 <<	Phase 1	Completed	-	United States, Arizona ... 展开 >> Scottsdale Healthcare Scottsdale, Arizona, United States, 85258 收起 <<
NCT02031055	Advanced Solid Tumors	Phase 1	Completed	-	United States, Pennsylvania ... 展开 >> University of Pittsbutgh Cancer Institute Pittsburgh, Pennsylvania, United States, 15232 收起 <<
NCT02613221	Colorectal Cancer	Phase 1 Phase 2	Completed	-	Japan ... 展开 >> Nagoya, Aichi, Japan Kashiwa, Chiba, Japan Matsuyama, Ehime, Japan Kitakyushu, Fukuoka, Japan Kurume, Fukuoka, Japan Hakodate, Hokkaido, Japan Kushiro, Hokkaido, Japan Sapporo, Hokkaido, Japan Amagasaki, Hyogo, Japan Kobe, Hyogo, Japan Tsukuba, Ibaragi, Japan Kasama, Ibaraki, Japan Miki-cho, Kagawa, Japan Sagamihara, Kanagawa, Japan Osaki, Miyagi, Japan Matsumoto, Nagano, Japan Sasebo, Nagasaki, Japan Yamatotakada, Nara, Japan Takatsuki, Osaka, Japan Ina, Saitama, Japan Shizuoka, Shizioka, Japan Nagaizumi, Shizuoka, Japan Kouto-ku, Tokyo, Japan Minato-ku, Tokyo, Japan Chiba, Japan Fukui, Japan Fukuoka, Japan Kumamoto, Japan Okayama, Japan Okinawa, Japan Osaka, Japan Toyama, Japan 收起 <<
NCT02848079	Colorectal Neoplasms	Phase 1 Phase 2	Recruiting	December 2020	United States, Connecticut ... 展开 >> Yale Cancer Center Recruiting New Haven, Connecticut, United States, 06510 Contact: Jeremy Kortansky, MD Jeremy.kortmansky@yale.edu Contact: Kamil Sadowski kamil.sadowski@yale.edu 收起 <<
NCT02654639	-		Terminated(Principal investiga... 展开 >>tor left the institution) 收起 <<	-	-
NCT03520946	Colorectal Cancer	Phase 2	Not yet recruiting	June 1, 2021	Germany ... 展开 >> Klinikum Altenburger Land GmbH Not yet recruiting Altenburg, Germany, 04600 Contact: Armin Schulz-Abelius, Dr. MVZ Gesundheitszentrum St. Marien GmbH Not yet recruiting Amberg, Germany, 922241 Contact: Ludwig Fischer von Weikersthal, Dr. HELIOS Klinikum Bad Saarow Not yet recruiting Bad Saarow, Germany, 15526 Contact: Daniel Pink, Dr. Charité - Universitätsmedizin Berlin Campus Mitte Not yet recruiting Berlin, Germany, 10115 Contact: Susen Burock, Dr. MVZ Seestrasse Not yet recruiting Berlin, Germany, 13347 Contact: Alexander Schmittel, Dr. St.-Johannes-Hospital Not yet recruiting Dortmund, Germany, 44137 Contact: Volker Hagen, Dr. Universitätsklinikum Düsseldorf Not yet recruiting Düsseldorf, Germany, 40225 Contact: Dirk Graf, Prof. Dr. Universitätsklinikum Essen Not yet recruiting Essen, Germany, 45147 Contact: Stefan Kasper, Prof. Dr. Krankenhaus Nordwest GmbH Not yet recruiting Frankfurt, Germany, 60488 Contact: Thorsten O Goetze, PD Dr. Universitätsklinikum Hamburg-Eppendorf Not yet recruiting Hamburg, Germany, 20246 Contact: Alexander Stein, Prof. Dr. Medizinische Hochschule Hannover Not yet recruiting Hannover, Germany, 30625 Contact: Arndt Vogel, Prof. Dr. Vincentius-Diakonissen-Kliniken gAG Not yet recruiting Karlsruhe, Germany, 76137 Contact: Alexander Kolov, Dr. Universitätsklinikum Leipzig Not yet recruiting Leipzig, Germany, 04103 Contact: Albrecht Hoffmeister, Prof. Dr. Klinikum Ludwigsburg Not yet recruiting Ludwigsburg, Germany, 71640 Contact: Stefan Angermeier, Dr. Tagestherapiezentrum am ITM Universitätsmedizin Mannheim Not yet recruiting Mannheim, Germany, 68167 Contact: Ralf D Hofheinz, Prof. Dr. Johannes Weslin Klinikum Minden Not yet recruiting Minden, Germany, 32429 Contact: Hans J Tischler, Dr. Kliniken Maria Hilf GmbH Not yet recruiting Mönchengladbach, Germany, 41063 Contact: Ullrich Graeven, Prof. Dr. Klinikum der Universität München-Großhadern Not yet recruiting München, Germany, 81377 Contact: Volker Heinemann, Prof. Dr. Klinikum Nürnberg Not yet recruiting Nürnberg, Germany, 90419 Contact: Gabriele Siegler, Dr. Studienzentrum Onkologie Ravensburg Not yet recruiting Ravensburg, Germany, 88212 Contact: Tobias Dechow, Prof. Dr. Leopoldina Krankenhaus Not yet recruiting Schweinfurt, Germany, 97422 Contact: Stephan Kanzler, Prof. Dr. MVZ Klinik Dr. Hancken GmbH Not yet recruiting Stade, Germany, 21680 Contact: Johannes Meiler, Dr. Klinikum Wilhelmshaven Not yet recruiting Wilhelmshaven, Germany, 26389 Contact: Tanja Trarbach, Dr. Hämatologisch-Onkologische Praxis Not yet recruiting Würselen, Germany, 52146 Contact: Christoph Maintz, Dr. 收起 <<
NCT01867879	Advanced Solid Tumors (Excludi... 展开 >>ng Breast Cancer) 收起 <<	Phase 1	Completed	-	United States, Tennessee ... 展开 >> Sarah Cannon Research Institute Nashville, Tennessee, United States, 37203 收起 <<
NCT02261532	Advanced or Metastatic Solid T... 展开 >>umors 收起 <<	Phase 1	Completed	-	China ... 展开 >> Taiho Pharmaceutical Co., Ltd selected site Beijing, China 收起 <<
NCT02654639	Metastatic Colorectal Cancer	Phase 2	Terminated(Principal investiga... 展开 >>tor left the institution) 收起 <<	-	United States, District of Col... 展开 >>umbia Georgetown University Washington, District of Columbia, United States, 20007 收起 <<
NCT02301104	Advanced Solid Tumors	Phase 1	Completed	-	United States, Arizona ... 展开 >> Mayo Clinic Scottsdale, Arizona, United States, 85259 United States, California Duarte Clinical Site Duarte, California, United States, 91010 Santa Monica Clinical Site Santa Monica, California, United States, 90404 United States, Maryland Baltimore Clinical Site Baltimore, Maryland, United States, 21231 United States, Massachusetts Boston Clinical Site Boston, Massachusetts, United States, 02111 United States, Ohio Cleveland Clinical Site Cleveland, Ohio, United States, 44195 United States, Pennsylvania Pittsburgh Clinical Site Pittsburgh, Pennsylvania, United States, 15232 United States, Texas Dallas Clinical Site Dallas, Texas, United States, 75246 收起 <<
NCT02301117	Advanced Solid Tumors	Phase 1	Recruiting	July 2019	United States, Arizona ... 展开 >> Phoenix Clinical Site Completed Phoenix, Arizona, United States, 85054 United States, California Duarte Clinical Site Recruiting Duarte, California, United States, 91010 Contact: Robert Winkler, MD 855-598-8259 rwinkler@taihooncology.com Santa Monica Clinical Site Recruiting Santa Monica, California, United States, 90095 Contact: Robert Winkler, MD 855-598-8259 rwinkler@taihooncology.com United States, Florida Gainesville Clinical Site Recruiting Gainesville, Florida, United States, 32610 Contact: Robert Winkler, MD 855-598-8259 rwinkler@taihooncology.com United States, Maryland Baltimore Clinical Site Active, not recruiting Baltimore, Maryland, United States, 21231 United States, Massachusetts Boston Clinical Site Recruiting Boston, Massachusetts, United States, 02111 Contact: Robert Winkler, MD 855-598-8259 rwinkler@taihooncology.com United States, Ohio Cleveland Clinical Site Completed Cleveland, Ohio, United States, 44106 Cleveland Clinical Site Completed Cleveland, Ohio, United States, 44195 United States, Pennsylvania Pittsburgh Clinical Site Completed Pittsburgh, Pennsylvania, United States, 15232 United States, Texas Dallas Clinical Site Recruiting Dallas, Texas, United States, 75246 Contact: Robert Winkler, MD 855-598-8259 rwinkler@taihooncology.com Czechia Brno Clinical Site Recruiting Brno, Czechia Contact: Robert Winkler, MD 855-598-8259 rwinkler@taihooncology.com Praha Clinical Site Recruiting Praha, Czechia Contact: Robert Winkler, MD 855-598-8259 rwinkler@taihooncology.com Serbia Belgrade Clinical Site Recruiting Belgrade, Serbia, 11080 Contact: Robert Winkler, MD 855-598-8259 rwinkler@taihooncology.com Sremska Kamenica Clinical Site Recruiting Sremska Kamenica, Serbia, 21204 Contact: Robert Winkler, MD 855-598-8259 rwinkler@taihooncology.com 收起 <<
NCT01955837	Colorectal Cancer	Phase 3	Completed	-	China ... 展开 >> Peking University Cancer Hospital Beijing, China, 100142 Fudan University Shanghai Cancer Center Shanghai, China, 200032 Korea, Republic of Asan Medical Center Seoul, Korea, Republic of, 138-736 Thailand Chulalongkorn University & The King Chulalongkorn Memorial Hospital Bangkok, Thailand, 10330 收起 <<
NCT02500043	Refractory Metastatic Gastric ... 展开 >>Cancer 收起 <<	Phase 3	Completed	-	-
NCT02920476	Squamous Cell Lung Carcinoma	Phase 2	Active, not recruiting	July 30, 2021	United States, Florida ... 展开 >> UF Health Cancer Center Gainesville, Florida, United States, 32608 收起 <<
NCT03305913	Pretreated Metastatic Colorect... 展开 >>al Cancer 收起 <<	Phase 1	Recruiting	June 30, 2019	Germany ... 展开 >> Universitätsmedizin Mainz, I.Medizinische Klinik und Poliklinik Recruiting Mainz, Germany, 55131 Contact: Markus Möhler, Prof. Dr. 收起 <<
NCT01607957	Colorectal Cancer	Phase 3	Completed	-	-
NCT03190616	Colorectal Neoplasms	Phase 2	Recruiting	December 30, 2019	China, Jiangsu ... 展开 >> the second hospital of Changzhou city Not yet recruiting Changzhou, Jiangsu, China, 213000 Contact: Hua Jiang, Dr. 008651981099988 Nanjing 81 Hospital Not yet recruiting Nanjing, Jiangsu, China, 210000 Contact: Yingxia Chen, Dr. the first affiliated hospital with Nanjing Medical University Recruiting Nanjing, Jiangsu, China, 210029 Contact: xiaofeng chen, Dr. Principal Investigator: Yanhong Gu, Dr Jiangnan University affiliated hospital Not yet recruiting Wuxi, Jiangsu, China, 214000 Contact: Dong Hua, Dr. 008651088683114 收起 <<
NCT02921737	Pancreatic Cancer	Phase 2	Recruiting	November 1, 2020	United States, Florida ... 展开 >> Malcom Randall VA Medical Center Not yet recruiting Gainesville, Florida, United States, 32608 Contact: Allison Trainor, MPH Principal Investigator: Dennie Jones, MD UF Health Cancer Center Recruiting Gainesville, Florida, United States, 32608 Contact: Margaret Veal Principal Investigator: Jennifer Duff, MD 收起 <<
NCT03274882	Metastatic Colorectal Cancer	Phase 2 Phase 3	Active, not recruiting	December 31, 2018	Russian Federation ... 展开 >> Russian Cancer Research Center n.a. NN Blokhin (RCRC), Clinical Pharmacology and Chemotherapy department Moscow, Russian Federation, 115478 Saint Petersburg Clinical Scientific-Practical Center of Special Medical Care (Oncology Center) Saint Petersburg, Russian Federation, 197758 收起 <<
NCT00081835	Vaccinia	Phase 2	Completed	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT03762161	Bladder Cancer	Phase 2	Not yet recruiting	December 2023	United States, Kansas ... 展开 >> University of Kansas Cancer Center - Clinical Research Center Not yet recruiting Fairway, Kansas, United States, 66208 Contact: kerry hepler 913-945-7552 ctnursenav@kumc.edu Principal Investigator: Rahul Parikh, MD University of Kansas Cancer Center, Westwood Campus Not yet recruiting Kansas City, Kansas, United States, 66205 Contact: Clinical Trials Nurse Navigator 913-945-7552 ctnursenav@kumc.edu Principal Investigator: Rahul Parikh, MD 收起 <<
NCT00000138	Keratitis, Herpetic ... 展开 >> Ocular Herpes Simplex 收起 <<	Phase 3	Unknown	-	-
NCT03324113	Neoplasm Malignant	Phase 1	Active, not recruiting	January 2019	Japan ... 展开 >> Investigational Site Number 3920003 Kashiwa-Shi, Japan Investigational Site Number 3920002 Nagoya-Shi, Japan Investigational Site Number 3920001 Sunto-Gun, Japan 收起 <<
NCT02602327	Colon Cancer ... 展开 >>Rectal Cancer Liver Metastases 收起 <<	Phase 1	Recruiting	September 2020	United States, California ... 展开 >> University of California San Francisco Recruiting San Francisco, California, United States, 94143 Contact: Curt Johanson 415-353-2310 curt.johanson@ucsf.edu Principal Investigator: Nicholas Fidelman, MD 收起 <<
NCT03317119	RAS Family Gene Mutation ... 展开 >> Stage III Colon Cancer AJCC v7 Stage III Colorectal Cancer AJCC v7 Stage III Rectal Cancer AJCC v7 Stage IIIA Colon Cancer AJCC v7 Stage IIIA Colorectal Cancer AJCC v7 Stage IIIA Rectal Cancer AJCC v7 Stage IIIB Colon Cancer AJCC v7 Stage IIIB Colorectal Cancer AJCC v7 Stage IIIB Rectal Cancer AJCC v7 Stage IIIC Colon Cancer AJCC v7 Stage IIIC Colorectal Cancer AJCC v7 Stage IIIC Rectal Cancer AJCC v7 Stage IV Colon Cancer AJCC v7 Stage IV Colorectal Cancer AJCC v7 Stage IV Rectal Cancer AJCC v7 Stage IVA Colon Cancer AJCC v7 Stage IVA Colorectal Cancer AJCC v7 Stage IVA Rectal Cancer AJCC v7 Stage IVB Colon Cancer AJCC v7 Stage IVB Colorectal Cancer AJCC v7 Stage IVB Rectal Cancer AJCC v7 收起 <<	Phase 1	Recruiting	December 2019	United States, California ... 展开 >> City of Hope Corona Recruiting Corona, California, United States, 92879 Contact: Cheryl Corpus 626-256-4673 ext 81529 Principal Investigator: Misagh Karimi, MD City of Hope Medical Center Recruiting Duarte, California, United States, 91010 Contact: Marwan Fakih, MD 626-256-4673 mfakih@coh.org Principal Investigator: Marwan Fakih, MD City of Hope Antelope Valley Recruiting Lancaster, California, United States, 93534 Contact: Regan Johnson 626-256-4673 ext 25648 Principal Investigator: Mohammad Fekrazad, MD City of Hope Mission Hills Recruiting Mission Hills, California, United States, 91345 Contact: Amy Shousha 626-256-4673 ext 81865 Principal Investigator: Suzy Melkonian, MD City of Hope Rancho Cucamonga Recruiting Rancho Cucamonga, California, United States, 91730 Contact: Valerie Estala 626-256-4673 ext 81699 Principal Investigator: Behnam Ebrahimi, MD City of Hope South Pasadena Recruiting South Pasadena, California, United States, 91030 Contact: Odessa Rodriguez 626-256-4673 ext 81409 Principal Investigator: Christina Yeon, MD City of Hope West Covina Recruiting West Covina, California, United States, 91790 Contact: Meizi Zheng 626-256-4673 ext 81336 Principal Investigator: Gargi Upadhyaya, MD 收起 <<
NCT02848443	Metastatic Colorectal Cancer	Phase 1	Recruiting	December 2019	Austria ... 展开 >> Allgemeines Krankenhaus - Universitätskliniken Klinische Abteilung für Onkologie Recruiting Wien, Austria France CHU Timone Recruiting Marseille, France Hôpital Saint Antoine Recruiting Paris, France Hôpital Universitaire Pitié Salpêtrière - Pavillon Antonin Gosset Recruiting Paris, France Centre Eugène Marquis Recruiting Rennes, France HIA Bégin Recruiting Saint Mandé, France Gustave Roussy Recruiting Villejuif, France Germany St. Josef-Hospital, Klinikum der Ruhr-Universität Bochum Abteilung für Hämatologie und Onkologie Recruiting Bochum, Germany Universitaetsklinikum Hamburg-Eppendorf Hubertus Wald Tumorzentrum - UCCH Recruiting Hamburg, Germany Klinikum der Universität München Campus Großhadern, Medizinische Klinik und Poliklinik III Recruiting Munchen, Germany Universitätsklinikum Ulm, Zentrum für Innere Medizin, Klinik für Innere Medizin I Recruiting Ulm, Germany Klinikum Wolfsburg, Medizinische Klinik II Recruiting Wolfsburg, Germany Hungary Magyar Honvedseg Egeszsegugyi Kozpont Onkologiai Osztaly Recruiting Budapest, Hungary Orszagos Onkologiai Intezet "B" Belgyogyaszati-Onkologiai O. Es Klin. Farmakologiai O. Recruiting Budapest, Hungary Semmelweis Egyetem, I. sz. Belgyogyaszati Klinika - Klin. Farmakologiai Reszleg Recruiting Budapest, Hungary Italy ARNAS - Azienda Ospedaliera Garibaldi - Nesima Struttura Complessa di Oncologia Medica Recruiting Catania, Italy Ist.Scientifico Romagnolo per lo Studio e la Cura dei Tumori Department of Clinical Oncology Recruiting Meldola, Italy Poiclinico G.B. Rossi A.O.U.I. di Verona Recruiting Verona, Italy Spain ICO Badalona. H. Germans Trials y Pujol, Servicio de Oncología médica Recruiting Badalona, Spain Hospital Vall D'Hebron (VHIO) Recruiting Barcelona, Spain HOSPITAL UNIVERSITARIO GREGORIO MARAÑON Oncología Médica Recruiting Madrid, Spain Hospital Universitario Madrid Sanchinarro Recruiting Madrid, Spain Hospital Universitario Ramón y Cajal de Madrid Recruiting Madrid, Spain Hospital Clinico de Valencia Recruiting Valencia, Spain United Kingdom Christie Hospital NHS Foundation Trust GI & Endocrine Recruiting Manchester, United Kingdom 收起 <<
NCT03223779	Colorectal Cancer	Phase 1 Phase 2	Recruiting	January 31, 2025	United States, Massachusetts ... 展开 >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02215 Contact: Theodore S. Hong, MD 617-724-8770 tshong1@mgh.harvard.edu Principal Investigator: Theodore S. Hong, MD 收起 <<
NCT02743221	Metastatic Colorectal Cancer	Phase 2	Active, not recruiting	October 2019	-
NCT01867866	Advanced Solid Tumors	Phase 1	Completed	-	United States, Texas ... 展开 >> South Texas Accelerated Research Therapeutics, LLC San Antonio, Texas, United States, 78229 收起 <<
NCT03031691	Metastatic Colorectal Cancer	Phase 1	Completed	-	United States, Colorado ... 展开 >> Denver Denver, Colorado, United States United States, Florida Miami Miami, Florida, United States Sarasota Sarasota, Florida, United States United States, South Carolina Charleston Charleston, South Carolina, United States United States, Tennessee Nashville Nashville, Tennessee, United States 收起 <<
NCT00002037	Mycobacterium Avium-Intracellu... 展开 >>lare Infection HIV Infections 收起 <<	Not Applicable	Completed	-	United States, New York ... 展开 >> New York Hosp - Cornell Med Ctr New York, New York, United States, 10021 收起 <<
NCT00000635	Herpes Simplex ... 展开 >> HIV Infections 收起 <<	Not Applicable	Completed	-	United States, California ... 展开 >> Ucsf Aids Crs San Francisco, California, United States United States, Colorado University of Colorado Hospital CRS Aurora, Colorado, United States United States, Illinois Cook County Hosp. CORE Ctr. Chicago, Illinois, United States Northwestern University CRS Chicago, Illinois, United States Rush Univ. Med. Ctr. ACTG CRS Chicago, Illinois, United States United States, Maryland Johns Hopkins Adult AIDS CRS Baltimore, Maryland, United States, 21287 United States, Missouri Washington U CRS St. Louis, Missouri, United States United States, New York NY Univ. HIV/AIDS CRS New York, New York, United States, 10016 收起 <<
NCT03278106	Cholangiocarcinoma ... 展开 >> Stage III Gallbladder Cancer AJCC v7 Stage IIIA Gallbladder Cancer AJCC v7 Stage IIIB Gallbladder Cancer AJCC v7 Stage IV Gallbladder Cancer AJCC v7 Stage IVA Gallbladder Cancer AJCC v7 Stage IVB Gallbladder Cancer AJCC v7 收起 <<	Phase 2	Suspended(accrual has been met... 展开 >>) 收起 <<	September 15, 2020	United States, Arizona ... 展开 >> Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 收起 <<
NCT03297710	Rectal Adenocarcinoma ... 展开 >> Recurrent Rectal Carcinoma Stage IV Rectal Cancer AJCC v7 Stage IVA Rectal Cancer AJCC v7 Stage IVB Rectal Cancer AJCC v7 收起 <<	Phase 1	Recruiting	October 31, 2019	United States, Arizona ... 展开 >> Mayo Clinic in Arizona Recruiting Scottsdale, Arizona, United States, 85259 Contact: Clinical Trials Referral Office 855-776-0015 Principal Investigator: Daniel H. Ahn United States, Minnesota Mayo Clinic Recruiting Rochester, Minnesota, United States, 55905 Contact: Clinical Trials Referral Office 855-776-0015 Principal Investigator: Joleen M. Hubbard 收起 <<
NCT03717038	Metastatic Colorectal Cancer ... 展开 >> Colorectal Cancer Metastatic Carcinoma 收起 <<	Phase 3	Not yet recruiting	December 2025	-
NCT03368963	Colorectal Adenocarcinoma ... 展开 >> Gastric Adenocarcinoma Metastatic Pancreatic Adenocarcinoma Non-Resectable Cholangiocarcinoma Stage IV Colorectal Cancer Stage IV Gastric Cancer Stage IV Pancreatic Cancer Stage IVA Colorectal Cancer Stage IVB Colorectal Cancer Unresectable Pancreatic Carcinoma 收起 <<	Phase 1 Phase 2	Recruiting	February 29, 2020	United States, Georgia ... 展开 >> Emory University Hospital Midtown Recruiting Atlanta, Georgia, United States, 30308 Contact: Shabnam Montazeri 404-686-0242 shabnam.montazeri@emory.edu Emory University Hospital/Winship Cancer Institute Recruiting Atlanta, Georgia, United States, 30322 Contact: Sheena Abraham 404-778-2670 sheena.abraham@emory.edu Emory Saint Joseph's Hospital Recruiting Atlanta, Georgia, United States, 30342 Contact: Alicia Escobar 678-843-7029 alicia.m.escobar@emory.edu 收起 <<
NCT03616574	Advanced or Metastatic Solid T... 展开 >>umors Advanced or Metastatic Colorectal Cancer (mCRC) 收起 <<	Phase 1	Not yet recruiting	June 2021	-
NCT03665506	-		Recruiting	June 2021	Germany ... 展开 >> Onkologische Schwerpunktpraxis Kurfürstendamm Recruiting Berlin, Germany, 10707 Contact: Ingo Schwaner, MD +49 30 887742570 ingo.schwaner@onkologie-kurfuerstendamm.de 收起 <<
NCT03306394	Metastatic Colorectal Cancer	Phase 3	Recruiting	May 2019	-

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