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/ Trifluridine

三氟胸苷 /Trifluridine {[allProObj[0].p_purity_real_show]}

货号：A179915 同义名： 曲氟尿苷 / Trifluorothymidine;TFT

Trifluridine是一种胸苷酸合酶抑制剂，具有抗病毒作用，能够诱导细胞凋亡和自噬，常用于治疗结直肠癌、疱疹病毒感染等。

Trifluridine 化学结构 CAS号：70-00-8
Trifluridine 化学结构
CAS号：70-00-8
Trifluridine 3D分子结构
CAS号：70-00-8
Trifluridine 化学结构 CAS号：70-00-8
Trifluridine 3D分子结构 CAS号：70-00-8
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Trifluridine 纯度/质量文件 产品仅供科研

货号：A179915 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Neuron, 2025. Ambeed. [ A1440350 ]
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• JACS, 2025. Ambeed. [ A349578 , A2270125 ]
• PLoS Biol., 2025, 23(2): e3002961. Ambeed. [ A181909 ]
• Redox Rep., 2025, 30(1): 2454887. Ambeed. [ A1155014 ]
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Trifluridine 生物活性

靶点

  • DNA synthesis
描述 Trifluridine is a nucleoside metabolic inhibitor used to treat keratoconjunctivitis and epithelial keratitis caused by simplex virus, and as a part of chemotherapy for certain types of metastatic gastrointestinal cancers[3]. Phase III trial of trifluridine showed significant improvement of overall survival and progression-free survival in refractory gastric cancer and gastroesophageal junction cancer[4].

Trifluridine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02943733 Neuroendocrine Tumors ... 展开 >> Neoplasms Cancer Tumors 收起 << Phase 1 Recruiting August 2020 United States, Wisconsin ... 展开 >> University of Wisconsin Carbone Cancer Center Recruiting Madison, Wisconsin, United States, 53792 Contact: Cancer Connect    800-622-8922    cancerconnect@uwcarbone.wisc.edu    Principal Investigator: Nataliya Uboha 收起 <<
NCT01916447 Advanced Gastrointestinal Tumo... 展开 >>rs 收起 << Phase 1 Completed - United States, California ... 展开 >> Los Angeles Clinical Site Los Angeles, California, United States, 90095 United States, Illinois Chicago Clinical Site Chicago, Illinois, United States, 60611 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Tennessee Vanderbilt Ingram Cancer Center Nashville, Tennessee, United States, 37212 收起 <<
NCT01904253 Small Cell Lung Cancer (SCLC) Phase 2 Terminated(The preliminary dat... 展开 >>a does not suggest any safety signal, but an ad hoc interim analysis showed an imbalance of PFS between the two arms) 收起 << - Germany ... 展开 >> Klinikum Mannheim GmbH Universitaetsklinikum Mannheim, Baden-Württemberg, Germany Lungenklinik Heckeshorn- HELIOS Kliniken GmbH Berlin, Germany LungenClinic Grosshansdorf Grosshansdorf, Germany Klinikum Koeln-Merheim Koplin, Germany St. Hildegardis-Krankenhaus- Katholisches Klinikum Mainz Mainz, Germany LMU-Campus Innenstadt Muenchen, Germany Italy Azienda Ospedaliero-Universitaria S. Luigi Gonzaga Orbassano, Turin, Italy IRCCS Centro di Riferimento Oncologico di Aviano, Divisione Oncologia Medica A Aviano, Italy Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico Bari Bari, Italy Azienda Ospedaliera Univ. Policlinico Gaspare Rodolico Catania, Italy Azienda Ospedaliera Instituti Ospitalieri di Cremona Cremona, Italy Azienda Ospedaliera Universitaria Careggi Firenze, Italy IEO Istituto Europeo di Oncologia Milano, Italy Azienda Ospedaliera San Gerardo U.O Oncologia Medica Monza, Italy Arcispedale S. Maria Nuova Azienda Ospedaliera di Reggio Emilia Reggio Emilia, Italy A.O.V.V. Ospedale Eugenio Morelli-Sondalo Sondalo, Italy Japan National Cancer Center Hospital East Chiba, Japan, 277-8577 National Kyushi Cancer Center Fukuoka, Japan, 811-1395 Hyogo Cancer Center Hyogo, Japan, 673-8588 Saitama Cancer Center Saitama, Japan, 362-0806 Shizuoka Cancer Center Shizuoka, Japan, 411-8777 Nippon Medical School Hospital Tokyo, Japan, 113-8603 Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo, Japan, 135-8550 收起 <<

Trifluridine 参考文献

[1]Sakamoto K, Yokogawa T, et al. Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2'-deoxy-5-fluorouridine into DNA. Int J Oncol. 2015;46(6):2327-34.

[2]Germano A, Rapa I, et al. Cytotoxic activity of gemcitabine, alone or in combination with mitotane, in adrenocortical carcinoma cell lines. Mol Cell Endocrinol. 2014 Jan 25;382(1):1-7.

[3]Carmine AA, Brogden RN, Heel RC, Speight TM, Avery GS. Trifluridine: a review of its antiviral activity and therapeutic use in the topical treatment of viral eye infections. Drugs. 1982;23(5):329-353.

[4] Fostea RM, Arkenau HT. Trifluridine/tipiracil in the treatment of gastric cancer. Future Oncol. 2022;18(12):1511-1517.

Trifluridine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.38mL

0.68mL

0.34mL

16.88mL

3.38mL

1.69mL

33.76mL

6.75mL

3.38mL

Trifluridine 技术信息

CAS号70-00-8
分子式C10H11F3N2O5
分子量 296.2
别名 曲氟尿苷 ;Trifluorothymidine;TFT;2-Deoxy-5-trifluoromethyluridine;FTD ;Viroptic;NSC 529182;NSC 75520;5-Trifluorothymidine
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Store in freezer, under -20°C
溶解方案

DMSO: 105 mg/mL(354.49 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(101.28 mM)，配合低频超声，并水浴加热至45℃助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方

PO 0.5% CMC-Na 36 mg/mL suspension

Tags: Trifluridine | Trifluorothymidine;TFT;2-Deoxy-5-trifluoromethyluridine;FTD ;Viroptic;NSC 529182;NSC 75520;5-Trifluorothymidine | 曲氟尿苷 | Antivirus | Apoptosis | Thymidylate Synthase | AmBeed-信号通路专用抑制剂 | Trifluridine 纯度/质量文件 | Trifluridine 生物活性 | Trifluridine 临床数据 | Trifluridine 参考文献 | Trifluridine 实验方案 | Trifluridine 技术信息

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