Dexrazoxane | ICRF-187 | Cardioprotective Agent | AmBeed-信号通路专用抑制剂

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右雷佐生 /Dexrazoxane {[allProObj[0].p_purity_real_show]}

货号：A170417 同义名： ICRF-187;ADR-529

Dexrazoxane is both an antimitotic agent with immunosuppressive properties and a cardioprotective agent.

Dexrazoxane 化学结构
CAS号：24584-09-6

Dexrazoxane 3D分子结构
CAS号：24584-09-6

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Dexrazoxane 纯度/质量文件产品仅供科研

货号：A170417 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

Dexrazoxane 生物活性

靶点

Topo II

描述

Dexrazoxane, a derivative of the powerful metal-chelating agent ethyl enediamine tetra acetic acid, is a cardioprotective agent. Dexrazoxane is well-tolerated, with myelosuppression being the dose-limiting toxicity in Phase I trials^[3]. As a single agent, dexrazoxane inhibited synchronized cultures of P. falciparum in human erythrocytes only at suprapharmacologic concentrations (> 200 microM). In combination with desferrioxamine B, dexrazoxane in pharmacologic concentrations (100-200 microM) moderately potentiated inhibition by approximately 20%. In contrast, pharmacologic concentrations of dexrazoxane (50-200 microM) as a single agent inhibited the progression of P. yoelli from sporozoites to schizonts in cultured mouse hepatocytes by 45 to 69%^[4]. Dexrazoxane preserved cardiac function without compromising EFS (event-free survival) and OS (overall survival) or increasing noncardiac toxicities^[5]. Dexrazoxane might exert a cardioprotective effect against doxorubicin-induced cardiomyocyte apoptosis by regulating the expression of miR-17-5p/PTEN cascade^[6]. Dexrazoxane may protect against RIHD (radiation-induced heart disease) by suppressing apoptosis and oxidative stress in cardiomyocytes^[7].

Dexrazoxane 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02786719	Neuroblastoma	Not Applicable	Recruiting	June 2019	United States, California ... 展开 >> Rady Children's Hospital Recruiting San Diego, California, United States, 92123 Contact: Laura Conner 858-966-5983 LConner@rchsd.org Principal Investigator: Peter Zage, MD United States, Texas Texas Children's Hospital Recruiting Houston, Texas, United States, 77030 Contact: Sarah Whittle, MD, BA 832-822-4242 sbwhittl@txch.org 收起 <<
NCT00077285	Sarcoma	Phase 2	Active, not recruiting	October 2019	United States, New York ... 展开 >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 收起 <<
NCT00400946	Drug/Agent Toxicity by Tissue/... 展开 >>Organ Leukemia 收起 <<	Phase 3	Active, not recruiting	June 2019	United States, Massachusetts ... 展开 >> Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, New York Albert Einstein Cancer Center at Albert Einstein College of Medicine Bronx, New York, United States, 10461 Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center New York, New York, United States, 10032 James P. Wilmot Cancer Center at University of Rochester Medical Center Rochester, New York, United States, 14642 United States, Rhode Island Hasbro Children's Hospital Providence, Rhode Island, United States, 02903 United States, Virginia INOVA Fairfax Hospital Fairfax, Virginia, United States, 22031 Canada, Ontario McMaster Children's Hospital at Hamilton Health Sciences Hamilton, Ontario, Canada, L8N 3Z5 Canada, Quebec Hopital Sainte Justine Montreal, Quebec, Canada, H3T 1C5 Centre de Recherche du Centre Hospitalier de l'Universite Laval Sainte Foy, Quebec, Canada, GIV 4G2 Puerto Rico San Jorge Children's Hospital Santurce, Puerto Rico, 00912 收起 <<

Dexrazoxane 参考文献

[1]Shaikh F, Dupuis LL, et al. Cardioprotection and Second Malignant Neoplasms Associated With Dexrazoxane in Children Receiving Anthracycline Chemotherapy: A Systematic Review and Meta-Analysis. J Natl Cancer Inst. 2015 Nov 23;108(4). pii: djv357.

[2]Jones, R.L. Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther, 2008. 6(10): p. 1311-7.

[3]Jones RL. Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther. 2008 Nov;6(10):1311-7

[4]Loyevsky M, Sacci JB Jr, Boehme P, Weglicki W, John C, Gordeuk VR. Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures. Exp Parasitol. 1999 Feb;91(2):105-14

[5]Getz KD, Sung L, Alonzo TA, Leger KJ, Gerbing RB, Pollard JA, Cooper T, Kolb EA, Gamis AS, Ky B, Aplenc R. Effect of Dexrazoxane on Left Ventricular Systolic Function and Treatment Outcomes in Patients With Acute Myeloid Leukemia: A Report From the Children's Oncology Group. J Clin Oncol. 2020 Jul 20;38(21):2398-2406

[6]Yu X, Ruan Y, Shen T, Qiu Q, Yan M, Sun S, Dou L, Huang X, Wang Q, Zhang X, Man Y, Tang W, Jin Z, Li J. Dexrazoxane Protects Cardiomyocyte from Doxorubicin-Induced Apoptosis by Modulating miR-17-5p. Biomed Res Int. 2020 Mar 1;2020:5107193

[7]Li L, Nie X, Zhang P, Huang Y, Ma L, Li F, Yi M, Qin W, Yuan X. Dexrazoxane ameliorates radiation-induced heart disease in a rat model. Aging (Albany NY). 2021 Jan 2;13(3):3699-3711

Dexrazoxane 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.73mL

0.75mL

0.37mL

18.64mL

3.73mL

1.86mL

37.28mL

7.46mL

3.73mL

Dexrazoxane 技术信息

CAS号	24584-09-6
分子式	C₁₁H₁₆N₄O₄
分子量	268.269

别名	ICRF-187;ADR-529;Zinecard. Foreign brand names: Cardioxane Savene.;US brand names: Totect;Cardioxane;Cardioxan;Zinecard;Totect®;NSC-169780
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度

DMSO: 25 mg/mL(93.19 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02786719	Neuroblastoma	Not Applicable	Recruiting	June 2019	United States, California ... 展开 >> Rady Children's Hospital Recruiting San Diego, California, United States, 92123 Contact: Laura Conner 858-966-5983 LConner@rchsd.org Principal Investigator: Peter Zage, MD United States, Texas Texas Children's Hospital Recruiting Houston, Texas, United States, 77030 Contact: Sarah Whittle, MD, BA 832-822-4242 sbwhittl@txch.org 收起 <<
NCT00077285	Sarcoma	Phase 2	Active, not recruiting	October 2019	United States, New York ... 展开 >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 收起 <<
NCT00400946	Drug/Agent Toxicity by Tissue/... 展开 >>Organ Leukemia 收起 <<	Phase 3	Active, not recruiting	June 2019	United States, Massachusetts ... 展开 >> Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, New York Albert Einstein Cancer Center at Albert Einstein College of Medicine Bronx, New York, United States, 10461 Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center New York, New York, United States, 10032 James P. Wilmot Cancer Center at University of Rochester Medical Center Rochester, New York, United States, 14642 United States, Rhode Island Hasbro Children's Hospital Providence, Rhode Island, United States, 02903 United States, Virginia INOVA Fairfax Hospital Fairfax, Virginia, United States, 22031 Canada, Ontario McMaster Children's Hospital at Hamilton Health Sciences Hamilton, Ontario, Canada, L8N 3Z5 Canada, Quebec Hopital Sainte Justine Montreal, Quebec, Canada, H3T 1C5 Centre de Recherche du Centre Hospitalier de l'Universite Laval Sainte Foy, Quebec, Canada, GIV 4G2 Puerto Rico San Jorge Children's Hospital Santurce, Puerto Rico, 00912 收起 <<
NCT03063983	Osteosarcoma	Phase 2	Recruiting	January 31, 2022	Brazil ... 展开 >> Grupo de Apoio ao Adolescente e a Criança com Câncer Recruiting Sao Paulo, Brazil, 04039001 Contact: Antonio S Petrilli +55 (11) 5080-8400 sergiopetrilli@graacc.org.br Contact: Andreza A Senerchia +55 (11) 5080-8400 andrezasenerchia@graacc.org.br 收起 <<
NCT00019864	Cardiac Toxicity ... 展开 >> Sarcoma 收起 <<	Phase 2	Terminated	-	United States, Maryland ... 展开 >> Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office Bethesda, Maryland, United States, 20892-1182 United States, Oklahoma Oklahoma University Cancer Institute Oklahoma City, Oklahoma, United States, 73104 United States, Texas Cook Children's Medical Center - Fort Worth Fort Worth, Texas, United States, 76104 Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital Houston, Texas, United States, 77030-2399 收起 <<
NCT00334867	Sarcoma	Phase 3	Withdrawn(withdrawn)	-	-
NCT00581360	Adenoid Cystic Carcinoma	Phase 2	Completed	-	United States, Ohio ... 展开 >> UPMC Cancer Center - Teramana Cancer Center - Steubenville Steubenville, Ohio, United States, 43952 United States, Pennsylvania UPMC Cancer Center - Beaver Beaver, Pennsylvania, United States, 15009 UPMC Cancer Center - Clairton Clairton, Pennsylvania, United States, 15025 UPMC Cancer Center - Arnold Palmer Pavilion - Greensburg Greensburg, Pennsylvania, United States, 15601 UPMC Cancer Center - Oakbrook Commons - Greensburg Greensburg, Pennsylvania, United States, 15601 UPMC Cancer Center - Indiana Indiana, Pennsylvania, United States, 15701 UPMC Cancer Center - John P. Murtha Pavilion - Johnstown Johnstown, Pennsylvania, United States, 15901 UPMC Cancer Center - McKeesport McKeesport, Pennsylvania, United States, 15132 UPMC Cancer Center -Haymaker Rd. Monroeville, Pennsylvania, United States, 15146 UPMC Cancer Center -Mosside Blvd. Monroeville, Pennsylvania, United States, 15146 UPMC Cancer Center - Sewickley Medical Oncology/Hematology Group Moon Township, Pennsylvania, United States, 15108 UPMC Cancer Center -Mt. Pleasant Mt. Pleasant, Pennsylvania, United States, 15666 UPMC Cancer Center -New Castle New Castle, Pennsylvania, United States, 16105 UPMC Cancer Center -Delafield Rd. Pittsburgh, Pennsylvania, United States, 15215 UPMC Cancer Center - Mercy Pittsburgh, Pennsylvania, United States, 15219 University of Pittsburgh Cancer Institute-Hillman Cancer Center Pittsburgh, Pennsylvania, United States, 15232 UPMC Cancer Center - Passavant Pittsburgh, Pennsylvania, United States, 15237 UPMC Cancer Center -Drake Pittsburgh, Pennsylvania, United States, 15241 UPMC Cancer Center - Uniontown Uniontown, Pennsylvania, United States, 15401 UPMC Cancer Center - Washington Washington, Pennsylvania, United States, 15301 UPMC Cancer Center -Wexford Wexford, Pennsylvania, United States, 15090 收起 <<
NCT03007147	B Acute Lymphoblastic Leukemia... 展开 >> BCR-ABL1 Fusion Protein Expression Minimal Residual Disease Philadelphia Chromosome Positive T Acute Lymphoblastic Leukemia Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia 收起 <<	Phase 3	Recruiting	June 30, 2026	-
NCT03126916	Childhood Ganglioneuroblastoma... 展开 >> Childhood Neuroblastoma INRG Stage L2 INRG Stage M INRG Stage MS NMYC Gene Amplification Recurrent Neuroblastoma 收起 <<	Phase 3	Recruiting	June 30, 2026	-
NCT00581360	-		Completed	-	-
NCT01864109	Newly Diagnosed Ewing Sarcoma	Phase 2	Recruiting	May 2020	United States, New Jersey ... 展开 >> Memoral Sloan Kettering Cancer Center Recruiting Basking Ridge, New Jersey, United States, 07920 Contact: Paul Meyers, MD 212-639-5952 Memorial Sloan Kettering Monmouth Recruiting Middletown, New Jersey, United States, 07748 Contact: Paul Meyers, MD 212-639-5952 United States, New York Memorial Sloan Kettering Commack Recruiting Commack, New York, United States, 11725 Contact: Paul Meyers, MD 212-639-5952 Memorial Sloan Kettering Westchester Recruiting Harrison, New York, United States, 10604 Contact: Paul Meyers, MD 212-639-5952 Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Paul Meyers, MD 212-639-5952 Contact: Emily Slotkin, MD 212-639-8856 Principal Investigator: Paul Meyers, MD Memorial Sloan Kettering Rockville Centre Recruiting Rockville Centre, New York, United States, 11570 Contact: Paul Meyers, MD 212-639-5952 收起 <<
NCT00004853	Ewing's Sarcoma ... 展开 >> Rhabdomyosarcoma MPNST Synovial Sarcoma High-risk Sarcoma 收起 <<	Phase 1	Completed	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT03166813	Cardiotoxicity	Not Applicable	Recruiting	December 31, 2020	Hong Kong ... 展开 >> Queen Mary Hospital Recruiting Hong Kong, Hong Kong Contact: Yiu-fai Cheung, MD 852-22554091 xfcheung@hkucc.hku.hk Principal Investigator: Yiu-fai Cheung, MD Sub-Investigator: Daniel KL Cheuk, MBBS Sub-Investigator: Vivian WY Li, PhD 收起 <<
NCT00084838	-		Completed	-	-
NCT00400946	-		Active, not recruiting	-	-
NCT03164057	Acute Myeloid Leukemia ... 展开 >> Myelodysplastic Syndromes 收起 <<	Phase 2	Recruiting	June 2027	United States, California ... 展开 >> City of Hope Comprehensive Cancer Center Recruiting Duarte, California, United States, 91010 Contact: Weili Sun, MD,PhD 800-826-4673 weilisun@coh.org Principal Investigator: Weili Sun, MD,PhD Children's Hospital of Central California Recruiting Madera, California, United States, 93636 Contact: Faisal Razzaqi, MD 866-353-5437 frazzaqi@valleychildrens.org Principal Investigator: Faisal Razzaqi, MD Children's Hospital of Orange County Recruiting Orange, California, United States, 92968 Contact: Jamie Frediani, MD 714-509-4348 jfrediani@choc.org Principal Investigator: Jamie Frediani, MD Lucile Packard Children's Hospital Stanford University Recruiting Palo Alto, California, United States, 94304 Contact: Norman J. Lacayo, MD 650-497-8953 lacayon@stanford.edu Principal Investigator: Norman J. Lacayo, MD Rady Children's Hospital and Health Center Recruiting San Diego, California, United States, 92123 Contact: Deborah Schiff, MD 858-966-5983 dschiff@chsd.org Principal Investigator: Deborah Schiff, MD United States, Tennessee St. Jude Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Contact: Tanja A. Gruber, MD, PhD 866-278-5833 tanja.gruber@stjude.org Contact: Referral Office 866-278-5833 referralinfo@stjude.org Principal Investigator: Tanja A. Gruber, MD, PhD United States, Texas Cook Children's Medical Center Recruiting Fort Worth, Texas, United States, 76104 Contact: Kenneth M. Heym, MD 682-885-4007 kenneth.heym@cookchildrens.org Principal Investigator: Kenneth M. Heym, MD 收起 <<
NCT03020030	Acute Lymphoblastic Leukemia, ... 展开 >>Pediatric 收起 <<	Phase 3	Recruiting	December 2026	United States, Massachusetts ... 展开 >> Boston Children's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Lewis Silverman, MD 617-632-6191 lewis_silverman@dfci.harvard.edu Principal Investigator: Lewis Silverman, MD Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Lewis Silverman, MD 617-632-6191 lewis_silverman@dfci.harvard.edu Principal Investigator: Lewis Silverman, MD United States, New York Montefiore Medical Center Recruiting Bronx, New York, United States, 104617 Contact: Lisa Gennarini, MD lfigueir@montefiore.org Roswell Park Cancer Institute Recruiting Buffalo, New York, United States, 14263 Contact: Kara Kelly, MD Kara.Kelly@RoswellPark.org Columbia University Medical Center, Morgan Stanley Children's Hospital of New York-Presbyterian Recruiting New York, New York, United States, 10032 Contact: Justine Kahn, MD jk2034@cumc.columbia.edu Principal Investigator: Justine Kahn, MD United States, Rhode Island Hasbro Children's Hospital / Rhode Island Hospital Recruiting Providence, Rhode Island, United States, 02903 Contact: Jennifer Welch, MD jwelch@lifespan.org Canada, Quebec Hospital Sainte Justine, University of Montreal Recruiting Montreal, Quebec, Canada Contact: Jean-Marie LeClerc, MD jean-marie.leclerc@umontreal.ca Principal Investigator: Jean-Marie LeClerc, MD Centre Hospitalier U. de Quebec Recruiting Quebec City, Quebec, Canada Contact: Bruno Michon, MD bruno.michon@mail.chuq.qc.ca Principal Investigator: Bruno Michon, MD 收起 <<
NCT00980460	Alpha Fetoprotein Increased ... 展开 >> PRETEXT Stage 1 Hepatoblastoma PRETEXT Stage 2 Hepatoblastoma PRETEXT Stage 3 Hepatoblastoma PRETEXT Stage 4 Hepatoblastoma 收起 <<	Phase 3	Active, not recruiting	December 31, 2018	-
NCT02953184	Antineoplastic Combined Chemot... 展开 >>herapy Protocols 收起 <<	Phase 2	Recruiting	November 2020	China, Jilin ... 展开 >> First Hospital of Jilin University Recruiting Changchun, Jilin, China, 130021 Contact: Aiping Shi, Doctor 0086-13364308696 13364308696@163.com Contact: Zhimin Fan, Doctor 0086-13756661286 fanzhimn@163.com Sub-Investigator: Di Wu, Doctor Sub-Investigator: Hongyao Jia, Master Sub-Investigator: Xin Guan, Master Principal Investigator: Zhimin Fan, Doctor Principal Investigator: Haibo Wang, Doctor Sub-Investigator: Gang Nie, Doctor 收起 <<
NCT00084838	Central Nervous System Tumor, ... 展开 >>Pediatric 收起 <<	Phase 2	Completed	-	United States, California ... 展开 >> Stanford Cancer Center Stanford, California, United States, 94305-5826 United States, Connecticut Yale Cancer Center New Haven, Connecticut, United States, 06520-8028 United States, Georgia AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus Atlanta, Georgia, United States, 30342 United States, Illinois Children's Memorial Hospital - Chicago Chicago, Illinois, United States, 60614 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231-2410 United States, Massachusetts Children's Hospital Boston Boston, Massachusetts, United States, 02115 Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Minnesota Children's Hospitals and Clinics of Minnesota - Minneapolis Minneapolis, Minnesota, United States, 55404 United States, Nevada Sunrise Hospital and Medical Center Las Vegas, Nevada, United States, 89109 United States, Ohio Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 United States, Texas Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas Dallas, Texas, United States, 75390 收起 <<
NCT00165087	Acute Lymphoblastic Leukemia	Phase 3	Terminated(Terminated by IRB f... 展开 >>or continuing review) 收起 <<	-	United States, Louisiana ... 展开 >> Ochsner Clinic New Orleans, Louisiana, United States, 70121 United States, Maine Maine Medical Center Lewiston, Maine, United States, 04240 United States, Massachusetts Children's Hospital Boston Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, New York Mt. Sinai Medical Center New York, New York, United States, 10029 University of Rochester Rochester, New York, United States, 14627 Canada, Ontario McMaster University Hamilton, Ontario, Canada Canada, Quebec Laval University Montreal, Quebec, Canada Sainte Justine Hosptial Montreal, Quebec, Canada Puerto Rico San Jorge Children's Hospital Santurce, Puerto Rico, 00912 收起 <<
NCT01871766	Rhabdomyosarcoma	Phase 2	Recruiting	June 2024	United States, Florida ... 展开 >> University of Florida Proton Therapy Institute Active, not recruiting Jacksonville, Florida, United States, 32206 Nemours Children's Clinic Active, not recruiting Jacksonville, Florida, United States, 32207 United States, Tennessee St. Jude Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Contact: Matthew J. Krasin, MD 866-278-5833 referralInfo@stjude.org Principal Investigator: Matthew J. Krasin, MD United States, Texas Cook Children's Medical Center Recruiting Fort Worth, Texas, United States, 76104 Contact: Karen Albritton, MD 682-885-2103 karen.albritton@cookchildrens.org Principal Investigator: Karen Albritton, MD 收起 <<
NCT00742924	Sarcoma	Phase 1	Completed	-	-
NCT00410488	Sarcoma Nause... 展开 >>a Vomiting 收起 <<	Not Applicable	Completed	-	United States, Texas ... 展开 >> UT MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT00410488	-		Completed	-	-
NCT00673179	Osteosarcoma	Not Applicable	Terminated(Low accrual.)	-	United States, Texas ... 展开 >> UT MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT00673179	-		Terminated(Low accrual.)	-	-
NCT00098839	Recurrent Childhood Acute Lymp... 展开 >>hoblastic Leukemia 收起 <<	Phase 1 Phase 2	Completed	-	-
NCT00001335	Ewing's Sarcoma ... 展开 >> Neuroblastoma Rhabdomyosarcoma 收起 <<	Phase 2	Completed	-	United States, Maryland ... 展开 >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 收起 <<
NCT00165178	Acute Lymphoblastic Leukemia	Phase 3	Completed	-	United States, Massachusetts ... 展开 >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 收起 <<
NCT00098839	-		Completed	-	-
NCT01258634	Osteosarcoma ... 展开 >>Lung Metastases 收起 <<	Phase 1	Terminated(PI no longer affili... 展开 >>ated with institution; only 2 subjects enrolled) 收起 <<	-	United States, Illinois ... 展开 >> University of Chicago Department of Pediatrics Hematology/Oncology Chicago, Illinois, United States, 60637 收起 <<
NCT01606878	Recurrent Childhood Anaplastic... 展开 >> Large Cell Lymphoma Recurrent Neuroblastoma Unspecified Childhood Solid Tumor, Protocol Specific 收起 <<	Phase 1	Active, not recruiting	-	-
NCT03698227	Advanced Soft Tissue Sarcoma	Phase 2	Not yet recruiting	December 31, 2019	Germany ... 展开 >> Helios Klinikum Bad Saarow Not yet recruiting Bad Saarow, Germany, 15526 Contact: Daniel Pink, MD 收起 <<
NCT00003667	Sarcoma	Phase 2	Completed	-	United States, New York ... 展开 >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 United States, Texas University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT01523977	Acute Lymphoblastic Leukemia	Phase 1	Active, not recruiting	November 2018	United States, California ... 展开 >> UCSF San Francisco, California, United States, 94143 United States, Colorado Children's Hospital Colorado Aurora, Colorado, United States, 80045 United States, Georgia Children's Healthcare of Atlanta Atlanta, Georgia, United States, 30322 United States, Illinois Ann & Robert H. Lurie Children's Hospital of Chicago Chicago, Illinois, United States, 60611 United States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, New York Columbia University Medical Center New York, New York, United States, 12549 United States, Washington Seattle Children's Hospital Seattle, Washington, United States, 98105 收起 <<
NCT01230983	Cardiac Toxicity ... 展开 >> Leukemia Lymphoma 收起 <<	Phase 3	Completed	-	-
NCT00544778	Sarcoma	Phase 2	Terminated(The study was termi... 展开 >>nated prematurely due to withdrawal of support by the sponsor.) 收起 <<	-	-
NCT01696669	Ewing's Sarcoma	Phase 2	Completed	-	Spain ... 展开 >> Hospital Clínic de Barcelona Barcelona, Spain Hospital de la Santa Creu i Sant Pau Barcelona, Spain Hospital Vall d'Hebron Barcelona, Spain Hospital Sant Joan de Déu Esplugues de Llobregat, Spain Institut Català d'Oncologia l'Hospitalet Hospitalet de Llobregat, Spain Hospital Universitario de Canarias La Laguna, Spain Hospital Ramón y Cajal Madrid, Spain, 28034 Hospital Son Espases Palma de Mallorca, Spain Hospital Universitario Miguel Servet Zaragoza, Spain 收起 <<
NCT00039481	Cardiac Toxicity ... 展开 >> Unspecified Childhood Solid Tumor, Protocol Specific 收起 <<	Phase 1	Completed	-	United States, California ... 展开 >> Children's Oncology Group Arcadia, California, United States, 91006-3776 收起 <<
NCT00005578	Cardiac Toxicity ... 展开 >> Lymphoma 收起 <<	Phase 3	Completed	-	-
NCT00011414	Wilms' Tumor ... 展开 >>Sarcoma Adenaocortical Carcinoma Refractory Cancer Coldrhood Cancer 收起 <<	Phase 1	Completed	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT00002827	Cardiac Toxicity ... 展开 >> Lymphoma 收起 <<	Phase 3	Completed	-	-
NCT00003937	Cardiac Toxicity ... 展开 >> Sarcoma 收起 <<	Phase 3	Completed	-	-
NCT00016276	Cardiac Toxicity ... 展开 >> Inflammatory Breast Cancer Stage IIIA Breast Cancer Stage IIIB Breast Cancer Stage IV Breast Cancer 收起 <<	Phase 3	Terminated(Administratively co... 展开 >>mplete.) 收起 <<	-	United States, Illinois ... 展开 >> Cancer and Leukemia Group B Chicago, Illinois, United States, 60606 收起 <<
NCT01790152	-		Recruiting	-	-
NCT00038142	Ewing's Sarcoma	Phase 2	Terminated(Low Accrual)	-	United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT00548561	Anthracycline Extravasation	Phase 2 Phase 3	Completed	-	Denmark ... 展开 >> Aalborg Hospital South Aalborg, Denmark, 9100 Rigshospitalet Copenhagen, Denmark, 2100 Herlev County Hospital Herlev, Denmark, 2730 Herlev Hospital Hematological Department Herlev, Denmark, 2730 Herning District Hospital Herning, Denmark, 7400 Hilleroed Hospital Hilleroed, Denmark, 3400 Odense University Hospital Odense, Denmark, 5000 C Roskilde County Hospital Roskilde, Denmark, 4000 Viborg Hospital Viborg, Denmark, 8800 收起 <<
NCT00550901	Unspecified Adult Solid Tumor,... 展开 >> Protocol Specific 收起 <<	Phase 1	Completed	-	-
NCT00933985	Acute Leukemias of Ambiguous L... 展开 >>ineage Acute Undifferentiated Leukemia Angioimmunoblastic T-cell Lymphoma Blastic Phase Chronic Myelogenous Leukemia Childhood Burkitt Lymphoma Childhood Chronic Myelogenous Leukemia Childhood Diffuse Large Cell Lymphoma Childhood Immunoblastic Large Cell Lymphoma Childhood Nasal Type Extranodal NK/T-cell Lymphoma Cutaneous B-cell Non-Hodgkin Lymphoma Hepatosplenic T-cell Lymphoma Intraocular Lymphoma Noncutaneous Extranodal Lymphoma Peripheral T-cell Lymphoma Recurrent Childhood Acute Lymphoblastic Leukemia Recurrent Childhood Acute Myeloid Leukemia Recurrent Childhood Anaplastic Large Cell Lymphoma Recurrent Childhood Grade III Lymphomatoid Granulomatosis Recurrent Childhood Large Cell Lymphoma Recurrent Childhood Lymphoblastic Lymphoma Recurrent Childhood Small Noncleaved Cell Lymphoma Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma Recurrent Mycosis Fungoides/Sezary Syndrome Recurrent/Refractory Childhood Hodgkin Lymphoma Refractory Chronic Lymphocytic Leukemia Refractory Hairy Cell Leukemia Relapsing Chronic Myelogenous Leukemia Small Intestine Lymphoma Unspecified Childhood Solid Tumor, Protocol Specific 收起 <<	Phase 1	Terminated	-	-
NCT03589729	Acute Myeloid Leukemia ... 展开 >> Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive Blasts 10 Percent or More of Bone Marrow Nucleated Cells High Risk Myelodysplastic Syndrome Myeloid Sarcoma Myeloproliferative Neoplasm Philadelphia Chromosome Positive 收起 <<	Phase 2	Recruiting	December 31, 2020	United States, Texas ... 展开 >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Maro Ohanian 713-792-2631 Principal Investigator: Maro Ohanian 收起 <<
NCT00544778	-		Terminated(The study was termi... 展开 >>nated prematurely due to withdrawal of support by the sponsor.) 收起 <<	-	-
NCT01596088	Extravasations of Anthracyclin... 展开 >>e Anti-cancer Agents 收起 <<	Phase 1 Phase 2	Completed	-	Japan ... 展开 >> Japan Tokyo and Other Japanese City, Japan 收起 <<
NCT01596088	-		Completed	-	-
NCT00955890	Breast Cancer	Phase 2	Terminated(Enrolled too slow)	-	China, Shanghai ... 展开 >> Fudan University Cancer Hospital Shanghai, Shanghai, China, 200032 收起 <<
NCT01627938	Multiple Sclerosis	Phase 2	Unknown	April 2016	Germany ... 展开 >> Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum Bochum, Germany, 44791 收起 <<
NCT00548704	Extravasation	Phase 2 Phase 3	Completed	-	Denmark ... 展开 >> Aalborg Hospital South Aalborg, Denmark, 9100 Aarhus County Hospital Aarhus, Denmark, 8000 C Aarhus Municipality Hospital Aarhus, Denmark, 8000 C Rigshospitalet, Haematology Department Copenhagen, Denmark, 2100 Rigshospitalet, Oncology Department Copenhagen, Denmark, 2100 Esbjerg District Hospital Esbjerg, Denmark, 6700 Herlev County Hospital, Haematology Department Herlev, Denmark, 2730 Herlev County Hospital, Oncology Department Herlev, Denmark, 2730 Hilleroed Hospital Hilleroed, Denmark, 3400 Naestved District Hospital Naestved, Denmark, 4700 Odense University Hospital Odense, Denmark, 5000 C Roskilde County Hospital Roskilde, Denmark, 4000 Soenderborg Hospital Soenderborg, Denmark, 6400 Vejle Hospital Vejle, Denmark, 7100 Viborg Hospital Viborg, Denmark, 8800 Germany Evangelisches Bethesda Krankenhaus Essen Borbak Statt, Germany, 45355 Klinik für Gynäkologie und Geburtshilfe Frankfurt am Main, Germany, 60590 Klinik und Poliklinik für Innere Medizin Hamburg, Germany, 20246 Medizinische Hochschule Hannover Hannover, Germany, 30659 Universitäts Frauenklinik Kiel, Germany, 24105 Universitäts Medizinische Klinik Kiel, Germany, 24105 Frauenklinik com Roten Kreuz Munich, Germany, 80637 Universitäts Frauenklinik Rostock, Germany, 18057 Klinik für Gynäkologie und Gynäkologische Onkologie Wiesbaden, Germany, 65199 Italy Ospedale G.B. Morgagni L. Pierantoni Forli, Italy, 47100 Presidio Ospedaliero di Ravenna Ravenna, Italy, 48100 Ospedale degli Infermi Rimini, Italy, 47037 Ospedali Riuniti Trieste, Italy, 34100 Netherlands Netherland Cancer Institute Amsterdam, Netherlands, 1066 CX University Hospital Groningen, Netherlands, 9700 RB Willem Alexander Hospital Hertogenbosch, Netherlands, 5223 GV Poland Centre of Oncology - Krakow Division Krakow, Poland, 31-115 Maria Sklodowska-Curie Memorial Cancer Center Warsaw, Poland, 02-781 Dolnoslaski Centrum Onkologii oddzial Chemoterapii Wroclaw, Poland, 53-413 收起 <<
NCT02519335	Heart Defects, Congenital	Phase 1	Terminated(PI no longer at thi... 展开 >>s facility) 收起 <<	-	United States, Texas ... 展开 >> Medical City Children's Hospital Dallas, Texas, United States, 75230 收起 <<
NCT00742924	-		Completed	-	-
NCT02584309	Sarcoma, Soft Tissue ... 展开 >> Soft Tissue Sarcoma Undifferentiated Pleomorphic Sarcoma Leiomyosarcoma Liposarcoma Synovial Sarcoma Myxofibrosarcoma Angiosarcoma Fibrosarcoma Malignant Peripheral Nerve Sheath Tumor Epithelioid Sarcoma 收起 <<	Phase 2	Recruiting	October 31, 2023	United States, Missouri ... 展开 >> Washington University School of Medicine Recruiting Saint Louis, Missouri, United States, 63110 Contact: Brian A Van Tine, M.D., Ph.D. 314-747-8475 bvantine@wustl.edu Principal Investigator: Brian A Van Tine, M.D., Ph.D. Sub-Investigator: Ashley E Frith, M.D. Sub-Investigator: Douglas R Adkins, M.D. Sub-Investigator: Ronald J Krone, M.D. Sub-Investigator: Justin Vader, M.D. Sub-Investigator: George Heberton, M.D. Sub-Investigator: Peter Oppelt, M.D. Sub-Investigator: Caron Rigden, M.D. Sub-Investigator: Angela Hirbe, M.D. 收起 <<

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