Levofloxacin Hemihydrate is antibiotic against gram-negative organisms, working by inhibiting the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Levofloxacin (Hemihydrate) is a fluoroquinolone antibiotic and is the optical S-(-) isomer of the racemic drug substance ofloxacin. It has a broad spectrum of in vitro activity against Gram-positive and Gram-negative bacteria, as well as certain other pathogens such as Mycoplasma, Chlamydia, Legionella and Mycobacteria spp. Plasma concentrations in healthy volunteers reach a mean peak drug plasma concentration (Cmax) of approximately 2.8 and 5.2 mg/L within 1 to 2 hours after oral administration of levofloxacin 250 and 500 mg tablets, respectively[3]. In stable COPD (chronic obstructive pulmonary disease), levofloxacin treatment causes a short-term reduction in bacterial load[4]. Levofloxacin was found to significantly improve the clinical and microbiological parameters in CP (chronic periodontitis) individuals[5]. A 30-day course of levofloxacin does not significantly improve BK viral load reduction or allograft function when used in addition to overall reduction of immunosuppression[6].
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