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左氧氟沙星半水合物 /Levofloxacin hydrate {[allProObj[0].p_purity_real_show]}

货号:A126121 同义名: 左氧氟沙星半水合物 / Levofloxacin hemihydrate;Levaquin hydrate

Levofloxacin hydrate是一种抗生素,针对革兰氏阴性菌,通过抑制细菌 DNA 回旋酶的超螺旋活性来阻止 DNA 复制。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Levofloxacin hydrate 化学结构 CAS号:138199-71-0
Levofloxacin hydrate 化学结构
CAS号:138199-71-0
Levofloxacin hydrate 3D分子结构
CAS号:138199-71-0
Levofloxacin hydrate 化学结构 CAS号:138199-71-0
Levofloxacin hydrate 3D分子结构 CAS号:138199-71-0
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Levofloxacin hydrate 纯度/质量文件 产品仅供科研

货号:A126121 标准纯度: {[allProObj[0].p_purity_real_show]}
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DNA synthesis, Ki: 20 nM

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DNA synthesis, IC50: 16 nM

98%
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DNA synthesis, EC50: 0.2 nM

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YK-4-279 99%+
ML216 +

BLMfull-length, IC50: 2.98 μM

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97%
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(E)-3-AP 99%
Halofuginone +++

prolyl-tRNA synthetase, Ki: 18.3nM

99%+
BC-LI-0186 +++

Leucyl-tRNA synthetase, IC50: 46.11 nM

Leucyl-tRNA synthetase, Kd: 42.1 nM

98%
SU056 +

YB-1, IC50: 1.73 μM

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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Ellagic acid 98%
β-Lapachone 99%+
(s)-10-hydroxycamptothecin 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

98%
Topotecan ++++

Topo I (DU-145 Luc cells), IC50: 2 nM

Topo I (MCF-7 Luc cells), IC50: 13 nM

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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Levofloxacin hydrate 生物活性

靶点
  • Topo II

描述 Levofloxacin (Hemihydrate) is a fluoroquinolone antibiotic and is the optical S-(-) isomer of the racemic drug substance ofloxacin. It has a broad spectrum of in vitro activity against Gram-positive and Gram-negative bacteria, as well as certain other pathogens such as Mycoplasma, Chlamydia, Legionella and Mycobacteria spp. Plasma concentrations in healthy volunteers reach a mean peak drug plasma concentration (Cmax) of approximately 2.8 and 5.2 mg/L within 1 to 2 hours after oral administration of levofloxacin 250 and 500 mg tablets, respectively[3]. In stable COPD (chronic obstructive pulmonary disease), levofloxacin treatment causes a short-term reduction in bacterial load[4]. Levofloxacin was found to significantly improve the clinical and microbiological parameters in CP (chronic periodontitis) individuals[5]. A 30-day course of levofloxacin does not significantly improve BK viral load reduction or allograft function when used in addition to overall reduction of immunosuppression[6].

Levofloxacin hydrate 参考文献

[1]Mourelle-Insua A, Lopez-Iglesias M, et al.Stereoselective Access to 1-[2-Bromo(het)aryloxy] propan-2-amines Using Transaminases and Lipases; Development of a Chemoenzymatic Strategy Toward a Levofloxacin Precursor. J Org Chem. 2016 Oct 21;81(20):9765-9774.

[2]Mori K, Maru C, Takasuna K. Characterization of histamine release induced by fluoroquinolone antibacterial agents in-vivo and in-vitro. J Pharm Pharmacol. 2000 May;52(5):577-84.

[3]Fish DN, Chow AT. The clinical pharmacokinetics of levofloxacin. Clin Pharmacokinet. 1997;32(2):101–119

[4]Siva R, Bafadhel M, Monteiro W, Brightling CE, Pavord ID. Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial. Int J Chron Obstruct Pulmon Dis. 2014;9:179–186.

[5]Pradeep AR, Singh SP, Martande SS, et al. Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. J Investig Clin Dent. 2015;6(3):170–178

[6]Lee BT, Gabardi S, Grafals M, et al. Efficacy of levofloxacin in the treatment of BK viremia: a multicenter, double-blinded, randomized, placebo-controlled trial. Clin J Am Soc Nephrol. 2014;9(3):583–589

Levofloxacin hydrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.35mL

0.27mL

0.14mL

6.75mL

1.35mL

0.68mL

13.50mL

2.70mL

1.35mL

Levofloxacin hydrate 技术信息

CAS号138199-71-0
分子式C36H42F2N6O9
分子量 740.75
别名 左氧氟沙星半水合物 ;Levofloxacin hemihydrate;Levaquin hydrate;Cravit hydrate;Iquix hydrate;Quixin hydrate;Tavanic hydrate
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Room Temperature

溶解方案

DMSO: 7 mg/mL(9.45 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(67.5 mM)

动物实验配方
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