Ellagic acid | Gallogen;Elagostasine;HSDB 7574;CCRIS 774;Benzoaric acid;Alizarine Yellow;TBBD;Lagistase | Plant Standard | Casein Kinase

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鞣花酸 /Ellagic acid {[allProObj[0].p_purity_real_show]}

货号：A106247 同义名： Gallogen;Elagostasine

Ellagic acid is a potent and cell permeable casein kinase 2 (CK2) inhibitor with Ki of 20 nM, acts as a potent antioxidant and anti-mutagenic.

Ellagic acid 化学结构
CAS号：476-66-4

Ellagic acid 3D分子结构
CAS号：476-66-4

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Ellagic acid 纯度/质量文件产品仅供科研

货号：A106247 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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Casein Kinase 亚型比较

产品名称	CK1 ↓ ↑	CK2 ↓ ↑	其他靶点	纯度
PF-670462 2HCl	++++ CK1ε, IC50: 90 nM CK1δ, IC50: 13 nM			99%+
D4476	++ CK1 from Schizosaccharomyces pombe, IC50: 200 nM CK1δ, IC50: 300 nM			98%
SR-3029	+++ CK1ε, IC50: 260 nM CK1δ, IC50: 44 nM			99%+
IWP-2	+++ ^M82FCK1δ, IC50: 40 nM		Wnt	98%
LY364947	++ CK1δ, IC50: 0.22 μM			98%
TA-01	++++ CK1ε, IC50: 6.4 nM CK1δ, IC50: 6.8 nM		p38 MAPK	99%+
IC261	+ CK1, IC50: 16 μM			98%
PF-4800567	+++ casein kinase 1 epsilon, IC50: 32 nM casein kinase 1 delta, IC50: 711 nM			99%+
CK1-IN-1	++++ CK1ε, IC50: 16 nM CK1δ, IC50: 15 nM			98%
Longdaysin	+ CKIα, IC50: 5.6 μM CKIδ, IC50: 8.8 μM			99%+
Silmitasertib		++++ CK2, IC50: 1 nM		99%+
Ellagic acid (hydrate)		+++ CK2, IC50: 0.04 μM	PKA	95+%
DMAT		+++ CK2, Ki: ~40 nM		98%
Hematein		++ CK2, IC50: 0.55 μM		98+%
Silmitasertib sodium salt		++++ CK2α', IC50: 1 nM CK2α, IC50: 1 nM		99%+
LY294002		+++ CK2, IC50: 98 nM		99%+
A-3 HCl	+ CK1, Ki: 80 μM	++ CK2, Ki: 5.1 μM	PKC,PKA,MLCK	98+%
TBB	+ CK1, Ki: 47 μM	++ CK2, Ki: 0.4 μM		98%
TTP 22		++ CK2, IC50: 100 nM		98%+
DRB		✔		99%+
BioE-1115		+ CK2α, IC50: 10 μM		99%+
(E/Z)-GO289		++++ CK2, IC50: 7 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ellagic acid 生物活性

靶点

Topo I

描述

Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive CK2 (Casein kinase 2) inhibitor, with an IC50 of 40 nM and a Ki of 20 nM^[3]. Ellagic acid (EA; 10 mg/kg/day; p.o., 14 days) strongly decreases MDA brain content by 17%, and reduces the levels of brain TNF-α by 42% in rats. Ellagic acid markedly increases the reduced brain contents of 5-HT (39%), dopamine (DA, 71%), and norepinephrine (NE, 77%). Ellagic acid (10 mg/kg, p.o., 14 days) causes decreased histopathological changes induced by Doxorubicin in rats^[4]. Ellagic acid (10 μM) exhibits cytotoxic effects on MCF-7 cells after treatment of radiation. Ellagic acid (10 μM) in combination with Irradiation (IR) significantly abridges the capacity of MCF-7 cells to form colonies equated with individual treatments. Ellagic acid with IR also induces cell apoptosis, and facilitates the upregulation of pro-apopttotic Bax and downregulation of Bcl-2 in MCF-7 cells^[5]. The antitumor activity of EA has been mostly attributed to direct antiproliferative and apoptotic effects. Moreover, EA can inhibit tumour cell migration, extra-cellular matrix invasion and angiogenesis^[6].

Ellagic acid 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00788866	Intrauterine Growth Restrictio... 展开 >>n 收起 <<	Not Applicable	Completed	-	United States, Missouri ... 展开 >> St Louis Children's Hospital St Louis, Missouri, United States, 63110 收起 <<
NCT02333461	Overweight Ob... 展开 >>esity 收起 <<	Not Applicable	Completed	-	-
NCT03140280	Myelodysplastic Syndromes	Phase 2	Recruiting	April 1, 2020	United States, Wisconsin ... 展开 >> Froedtert & the Medical College of Wisconsin Recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Ehab Atallah, MD 414-805-4600 eatallah@mcw.edu Contact: Medical College of Wisconsin Cancer Center Clinical Trials Office 414-805-8900 cccto@mcw.edu 收起 <<

Ellagic acid 参考文献

[1]Narayanan BA, Geoffroy O, et al. p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett. 1999 Mar 1;136(2):215-21.

[2]Mandal S, Shivapurkar NM, et al. Inhibition of N-nitrosobenzylmethylamine metabolism and DNA binding in cultured rat esophagus by ellagic acid. Carcinogenesis. 1988 Jul;9(7):1313-6.

[3]Cozza G, Bonvini P, Zorzi E, Poletto G, Pagano MA, Sarno S, Donella-Deana A, Zagotto G, Rosolen A, Pinna LA, Meggio F, Moro S. Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. J Med Chem. 2006 Apr 20;49(8):2363-6

[4]Rizk HA, Masoud MA, Maher OW. Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats. J Biochem Mol Toxicol. 2017 Dec;31(12)

[5]Ahire V, Kumar A, Mishra KP, Kulkarni G. Ellagic Acid Enhances Apoptotic Sensitivity of Breast Cancer Cells to γ-Radiation. Nutr Cancer. 2017 Aug-Sep;69(6):904-910

[6]Ceci C, Lacal PM, Tentori L, De Martino MG, Miano R, Graziani G. Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid. Nutrients. 2018 Nov 14;10(11):1756

Ellagic acid 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.55mL

3.31mL

1.65mL

33.09mL

6.62mL

3.31mL

Ellagic acid 技术信息

CAS号	476-66-4
分子式	C₁₄H₆O₈
分子量	302.193

别名	Gallogen;Elagostasine;HSDB 7574;CCRIS 774;Benzoaric acid;Alizarine Yellow;TBBD;Lagistase
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 2 mg/mL(6.62 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00788866	Intrauterine Growth Restrictio... 展开 >>n 收起 <<	Not Applicable	Completed	-	United States, Missouri ... 展开 >> St Louis Children's Hospital St Louis, Missouri, United States, 63110 收起 <<
NCT02333461	Overweight Ob... 展开 >>esity 收起 <<	Not Applicable	Completed	-	-
NCT03140280	Myelodysplastic Syndromes	Phase 2	Recruiting	April 1, 2020	United States, Wisconsin ... 展开 >> Froedtert & the Medical College of Wisconsin Recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Ehab Atallah, MD 414-805-4600 eatallah@mcw.edu Contact: Medical College of Wisconsin Cancer Center Clinical Trials Office 414-805-8900 cccto@mcw.edu 收起 <<
NCT02935777	Mental Processes	Phase 1	Completed	-	United Kingdom ... 展开 >> Queen Margaret University Edinburgh, Scotland, United Kingdom, EH21 6UU 收起 <<
NCT03482401	Breast Cancer	Not Applicable	Active, not recruiting	June 1, 2019	Spain ... 展开 >> Hospital General Universitario Reina Sofía Murcia, Spain, 30003 收起 <<
NCT00455416	Follicular Lymphoma	Phase 2	Unknown	December 2009	Norway ... 展开 >> RRHF RIkshospitalet Radiumhospitalet HF Recruiting Montebello, Oslo, Norway, 0310 Contact: Kjell Magne Russnes, MD +4722934000 k.m.russnes@medisin.uio.no Contact: Harald JR Holte, MD, PhD +4722934000 harald.holte@radiumhospitalet.no Principal Investigator: Harald Jr Holte, Md, PhD Sub-Investigator: Kjell Magne Russnes, MD 收起 <<
NCT03535675	Adenocarcinoma of the Prostate	Phase 3	Recruiting	December 2021	United States, District of Col... 展开 >>umbia Sibley Memorial Hospital Recruiting Washington, District of Columbia, United States, 20016 Contact: Channing Paller, MD 202-660-6500 cpaller1@jhmi.edu United States, Maryland Johns Hopkins Hospital Recruiting Baltimore, Maryland, United States, 21205 Contact: Donna Dowling, RN 410-614-9526 ddowlin1@jhmi.edu Principal Investigator: Channing Paller, MD 收起 <<
NCT01961869	Healthy Volunteers	Phase 1	Active, not recruiting	December 2019	United States, Ohio ... 展开 >> Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Columbus, Ohio, United States, 43210 收起 <<
NCT01249469	Solar Lentigines	Not Applicable	Unknown	June 2011	Taiwan ... 展开 >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Yi-Hua Liao, MD, PhD 886-2-23562141 yihualiao@ntu.edu.tw Principal Investigator: Yi-Hua Liao, MD, PhD 收起 <<
NCT03318042	Genotype, Metabotype and Dieta... 展开 >>ry Habits 收起 <<	Not Applicable	Completed	-	Spain ... 展开 >> Cebas-Csic Murcia, Spain, 30100 收起 <<
NCT01916239	Colorectal Cancer	Phase 1 Phase 2	Completed	-	Spain ... 展开 >> Hospital General Universitario Reina Sofía Murcia, Spain, 30003 收起 <<
NCT01705093	Childhood Obesity ... 展开 >> Cardiovascular Disease 收起 <<	Phase 2	Completed	-	United States, California ... 展开 >> Ragle Human Nutrition Research Center, Academic Surge, UC Davis Davis, California, United States, 95616 收起 <<
NCT03548701	-		Recruiting	May 21, 2020	United States, New York ... 展开 >> Mount Sinai Hospital Recruiting New York, New York, United States, 10029 Contact: Patrick Maher, MD 404-550-9559 patrick.maher@mountsinai.org Contact: Daniel Katz, MD 732-322-6675 daniel.katz@mountsinai.org Principal Investigator: Patrick Maher, MD 收起 <<
NCT02056496	Healthy	Phase 1	Completed	-	Spain ... 展开 >> UCAM (San Antonio Catholic University from Murcia) Murcia, Spain, 30107 收起 <<
NCT02263378	HPV Infection	Not Applicable	Completed	-	-
NCT03713164	Healthy	Phase 1 Phase 2	Completed	-	United States, California ... 展开 >> UCLA Center for Human Nutrition, 900 Veteran Ave. Los Angeles, California, United States, 90095 收起 <<
NCT02370641	Urolith	Not Applicable	Completed	-	-

鞣花酸 /Ellagic acid {[allProObj[0].p_purity_real_show]}

Ellagic acid 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Ellagic acid 质控信息

Ellagic acid 生物活性

Ellagic acid 临床研究

Ellagic acid 参考文献

Ellagic acid 实验方案

Ellagic acid 技术信息

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鞣花酸 /Ellagic acid {[allProObj[0].p_purity_real_show]}

Ellagic acid 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Ellagic acid 质控信息

Ellagic acid 生物活性

Ellagic acid 临床研究

Ellagic acid 参考文献

Ellagic acid 实验方案

Ellagic acid 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Ellagic acid 纯度/质量文件产品仅供科研