货号:A106247
同义名:
Gallogen;Elagostasine
Ellagic acid is a potent and cell permeable casein kinase 2 (CK2) inhibitor with Ki of 20 nM, acts as a potent antioxidant and anti-mutagenic.
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产品名称 | CK1 ↓ ↑ | CK2 ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PF-670462 2HCl |
++++
CK1δ, IC50: 13 nM CK1ε, IC50: 90 nM |
99%+ | |||||||||||||||||
D4476 |
++
CK1δ, IC50: 300 nM CK1 from Schizosaccharomyces pombe, IC50: 200 nM |
99%+ | |||||||||||||||||
SR-3029 |
+++
CK1δ, IC50: 44 nM CK1ε, IC50: 260 nM |
99%+ | |||||||||||||||||
IWP-2 |
+++
M82FCK1δ, IC50: 40 nM |
Wnt | 99%+ | ||||||||||||||||
LY364947 |
++
CK1δ, IC50: 0.22 μM |
98% | |||||||||||||||||
TA-01 |
++++
CK1δ, IC50: 6.8 nM CK1ε, IC50: 6.4 nM |
p38 MAPK | 99%+ | ||||||||||||||||
IC261 |
+
CK1, IC50: 16 μM |
99%+ | |||||||||||||||||
PF-4800567 |
+++
casein kinase 1 delta, IC50: 711 nM casein kinase 1 epsilon, IC50: 32 nM |
99%+ | |||||||||||||||||
CK1-IN-1 |
++++
CK1δ, IC50: 15 nM CK1ε, IC50: 16 nM |
99%+ | |||||||||||||||||
Longdaysin |
+
CKIα, IC50: 5.6 μM CKIδ, IC50: 8.8 μM |
99%+ | |||||||||||||||||
Silmitasertib |
++++
CK2, IC50: 1 nM |
99%+ | |||||||||||||||||
Ellagic acid (hydrate) |
+++
CK2, IC50: 0.04 μM |
PKA | 95+% | ||||||||||||||||
DMAT |
+++
CK2, Ki: ~40 nM |
99%+ | |||||||||||||||||
Hematein |
++
CK2, IC50: 0.55 μM |
98+% | |||||||||||||||||
Silmitasertib sodium salt |
++++
CK2α, IC50: 1 nM CK2α', IC50: 1 nM |
99%+ | |||||||||||||||||
LY294002 |
+++
CK2, IC50: 98 nM |
99%+ | |||||||||||||||||
A-3 HCl |
+
CK1, Ki: 80 μM |
++
CK2, Ki: 5.1 μM |
PKC,PKA,MLCK | 98+% | |||||||||||||||
TBB |
+
CK1, Ki: 47 μM |
++
CK2, Ki: 0.4 μM |
99%+ | ||||||||||||||||
TTP 22 |
++
CK2, IC50: 100 nM |
98%+ | |||||||||||||||||
DRB | ✔ | 99%+ | |||||||||||||||||
BioE-1115 |
+
CK2α, IC50: 10 μM |
99%+ | |||||||||||||||||
(E/Z)-GO289 |
++++
CK2, IC50: 7 nM |
99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive CK2 (Casein kinase 2) inhibitor, with an IC50 of 40 nM and a Ki of 20 nM[3]. Ellagic acid (EA; 10 mg/kg/day; p.o., 14 days) strongly decreases MDA brain content by 17%, and reduces the levels of brain TNF-α by 42% in rats. Ellagic acid markedly increases the reduced brain contents of 5-HT (39%), dopamine (DA, 71%), and norepinephrine (NE, 77%). Ellagic acid (10 mg/kg, p.o., 14 days) causes decreased histopathological changes induced by Doxorubicin in rats[4]. Ellagic acid (10 μM) exhibits cytotoxic effects on MCF-7 cells after treatment of radiation. Ellagic acid (10 μM) in combination with Irradiation (IR) significantly abridges the capacity of MCF-7 cells to form colonies equated with individual treatments. Ellagic acid with IR also induces cell apoptosis, and facilitates the upregulation of pro-apopttotic Bax and downregulation of Bcl-2 in MCF-7 cells[5]. The antitumor activity of EA has been mostly attributed to direct antiproliferative and apoptotic effects. Moreover, EA can inhibit tumour cell migration, extra-cellular matrix invasion and angiogenesis[6]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00788866 | Intrauterine Growth Restrictio... 展开 >>n 收起 << | Not Applicable | Completed | - | United States, Missouri ... 展开 >> St Louis Children's Hospital St Louis, Missouri, United States, 63110 收起 << |
NCT02333461 | Overweight Ob... 展开 >>esity 收起 << | Not Applicable | Completed | - | - |
NCT03140280 | Myelodysplastic Syndromes | Phase 2 | Recruiting | April 1, 2020 | United States, Wisconsin ... 展开 >> Froedtert & the Medical College of Wisconsin Recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Ehab Atallah, MD 414-805-4600 eatallah@mcw.edu Contact: Medical College of Wisconsin Cancer Center Clinical Trials Office 414-805-8900 cccto@mcw.edu 收起 << |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.31mL 0.66mL 0.33mL |
16.55mL 3.31mL 1.65mL |
33.09mL 6.62mL 3.31mL |
CAS号 | 476-66-4 |
分子式 | C14H6O8 |
分子量 | 302.193 |
别名 | Gallogen;Elagostasine;HSDB 7574;CCRIS 774;Benzoaric acid;Alizarine Yellow;TBBD;Lagistase |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 2 mg/mL(6.62 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |