Ellagic acid | Gallogen;Elagostasine;HSDB 7574;CCRIS 774;Benzoaric acid;Alizarine Yellow;TBBD;Lagistase | Plant Standard | Casein Kinase

首页 / / / / Ellagic acid

鞣花酸 /Ellagic acid {[allProObj[0].p_purity_real_show]}

货号：A106247 同义名： Gallogen;Elagostasine

Ellagic acid is a potent and cell permeable casein kinase 2 (CK2) inhibitor with Ki of 20 nM, acts as a potent antioxidant and anti-mutagenic.

Ellagic acid 化学结构
CAS号：476-66-4

Ellagic acid 3D分子结构
CAS号：476-66-4

规格	价格	会员价	库存	数量
{[ item.pr_size ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]}	现货	咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

Ellagic acid 纯度/质量文件产品仅供科研

货号：A106247 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

Casein Kinase 亚型比较

产品名称	CK1 ↓ ↑	CK2 ↓ ↑	其他靶点	纯度
PF-670462 2HCl	++++ CK1ε, IC50: 90 nM CK1δ, IC50: 13 nM			99%+
D4476	++ CK1 from Schizosaccharomyces pombe, IC50: 200 nM CK1δ, IC50: 300 nM			98%
SR-3029	+++ CK1ε, IC50: 260 nM CK1δ, IC50: 44 nM			99%+
IWP-2	+++ ^M82FCK1δ, IC50: 40 nM		Wnt	98%
LY364947	++ CK1δ, IC50: 0.22 μM			98%
TA-01	++++ CK1ε, IC50: 6.4 nM CK1δ, IC50: 6.8 nM		p38 MAPK	99%+
IC261	+ CK1, IC50: 16 μM			98%
PF-4800567	+++ casein kinase 1 delta, IC50: 711 nM casein kinase 1 epsilon, IC50: 32 nM			99%+
CK1-IN-1	++++ CK1ε, IC50: 16 nM CK1δ, IC50: 15 nM			98%
Longdaysin	+ CKIα, IC50: 5.6 μM CKIδ, IC50: 8.8 μM			99%+
Silmitasertib		++++ CK2, IC50: 1 nM		99%+
Ellagic acid (hydrate)		+++ CK2, IC50: 0.04 μM	PKA	95+%
DMAT		+++ CK2, Ki: ~40 nM		98%
Hematein		++ CK2, IC50: 0.55 μM		98+%
Silmitasertib sodium salt		++++ CK2α, IC50: 1 nM CK2α', IC50: 1 nM		99%+
LY294002		+++ CK2, IC50: 98 nM		99%+
A-3 HCl	+ CK1, Ki: 80 μM	++ CK2, Ki: 5.1 μM	MLCK,PKA,PKC	98+%
TBB	+ CK1, Ki: 47 μM	++ CK2, Ki: 0.4 μM		98%
TTP 22		++ CK2, IC50: 100 nM		98%+
DRB		✔		99%+
BioE-1115		+ CK2α, IC50: 10 μM		99%+
(E/Z)-GO289		++++ CK2, IC50: 7 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ellagic acid 生物活性

靶点

Topo I

描述

Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive CK2 (Casein kinase 2) inhibitor, with an IC50 of 40 nM and a Ki of 20 nM^[3]. Ellagic acid (EA; 10 mg/kg/day; p.o., 14 days) strongly decreases MDA brain content by 17%, and reduces the levels of brain TNF-α by 42% in rats. Ellagic acid markedly increases the reduced brain contents of 5-HT (39%), dopamine (DA, 71%), and norepinephrine (NE, 77%). Ellagic acid (10 mg/kg, p.o., 14 days) causes decreased histopathological changes induced by Doxorubicin in rats^[4]. Ellagic acid (10 μM) exhibits cytotoxic effects on MCF-7 cells after treatment of radiation. Ellagic acid (10 μM) in combination with Irradiation (IR) significantly abridges the capacity of MCF-7 cells to form colonies equated with individual treatments. Ellagic acid with IR also induces cell apoptosis, and facilitates the upregulation of pro-apopttotic Bax and downregulation of Bcl-2 in MCF-7 cells^[5]. The antitumor activity of EA has been mostly attributed to direct antiproliferative and apoptotic effects. Moreover, EA can inhibit tumour cell migration, extra-cellular matrix invasion and angiogenesis^[6].

Ellagic acid 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00788866	Intrauterine Growth Restrictio... 展开 >>n 收起 <<	Not Applicable	Completed	-	United States, Missouri ... 展开 >> St Louis Children's Hospital St Louis, Missouri, United States, 63110 收起 <<
NCT02333461	Overweight Ob... 展开 >>esity 收起 <<	Not Applicable	Completed	-	-
NCT03140280	Myelodysplastic Syndromes	Phase 2	Recruiting	April 1, 2020	United States, Wisconsin ... 展开 >> Froedtert & the Medical College of Wisconsin Recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Ehab Atallah, MD 414-805-4600 eatallah@mcw.edu Contact: Medical College of Wisconsin Cancer Center Clinical Trials Office 414-805-8900 cccto@mcw.edu 收起 <<

Ellagic acid 参考文献

[1]Narayanan BA, Geoffroy O, et al. p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett. 1999 Mar 1;136(2):215-21.

[2]Mandal S, Shivapurkar NM, et al. Inhibition of N-nitrosobenzylmethylamine metabolism and DNA binding in cultured rat esophagus by ellagic acid. Carcinogenesis. 1988 Jul;9(7):1313-6.

[3]Cozza G, Bonvini P, Zorzi E, Poletto G, Pagano MA, Sarno S, Donella-Deana A, Zagotto G, Rosolen A, Pinna LA, Meggio F, Moro S. Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. J Med Chem. 2006 Apr 20;49(8):2363-6

[4]Rizk HA, Masoud MA, Maher OW. Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats. J Biochem Mol Toxicol. 2017 Dec;31(12)

[5]Ahire V, Kumar A, Mishra KP, Kulkarni G. Ellagic Acid Enhances Apoptotic Sensitivity of Breast Cancer Cells to γ-Radiation. Nutr Cancer. 2017 Aug-Sep;69(6):904-910

[6]Ceci C, Lacal PM, Tentori L, De Martino MG, Miano R, Graziani G. Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid. Nutrients. 2018 Nov 14;10(11):1756

Ellagic acid 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.55mL

3.31mL

1.65mL

33.09mL

6.62mL

3.31mL

Ellagic acid 技术信息

CAS号	476-66-4
分子式	C₁₄H₆O₈
分子量	302.193

别名	Gallogen;Elagostasine;HSDB 7574;CCRIS 774;Benzoaric acid;Alizarine Yellow;TBBD;Lagistase
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 2 mg/mL(6.62 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00788866	Intrauterine Growth Restrictio... 展开 >>n 收起 <<	Not Applicable	Completed	-	United States, Missouri ... 展开 >> St Louis Children's Hospital St Louis, Missouri, United States, 63110 收起 <<
NCT02333461	Overweight Ob... 展开 >>esity 收起 <<	Not Applicable	Completed	-	-
NCT03140280	Myelodysplastic Syndromes	Phase 2	Recruiting	April 1, 2020	United States, Wisconsin ... 展开 >> Froedtert & the Medical College of Wisconsin Recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Ehab Atallah, MD 414-805-4600 eatallah@mcw.edu Contact: Medical College of Wisconsin Cancer Center Clinical Trials Office 414-805-8900 cccto@mcw.edu 收起 <<
NCT02935777	Mental Processes	Phase 1	Completed	-	United Kingdom ... 展开 >> Queen Margaret University Edinburgh, Scotland, United Kingdom, EH21 6UU 收起 <<
NCT03482401	Breast Cancer	Not Applicable	Active, not recruiting	June 1, 2019	Spain ... 展开 >> Hospital General Universitario Reina Sofía Murcia, Spain, 30003 收起 <<
NCT00455416	Follicular Lymphoma	Phase 2	Unknown	December 2009	Norway ... 展开 >> RRHF RIkshospitalet Radiumhospitalet HF Recruiting Montebello, Oslo, Norway, 0310 Contact: Kjell Magne Russnes, MD +4722934000 k.m.russnes@medisin.uio.no Contact: Harald JR Holte, MD, PhD +4722934000 harald.holte@radiumhospitalet.no Principal Investigator: Harald Jr Holte, Md, PhD Sub-Investigator: Kjell Magne Russnes, MD 收起 <<
NCT03535675	Adenocarcinoma of the Prostate	Phase 3	Recruiting	December 2021	United States, District of Col... 展开 >>umbia Sibley Memorial Hospital Recruiting Washington, District of Columbia, United States, 20016 Contact: Channing Paller, MD 202-660-6500 cpaller1@jhmi.edu United States, Maryland Johns Hopkins Hospital Recruiting Baltimore, Maryland, United States, 21205 Contact: Donna Dowling, RN 410-614-9526 ddowlin1@jhmi.edu Principal Investigator: Channing Paller, MD 收起 <<
NCT01961869	Healthy Volunteers	Phase 1	Active, not recruiting	December 2019	United States, Ohio ... 展开 >> Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Columbus, Ohio, United States, 43210 收起 <<
NCT01249469	Solar Lentigines	Not Applicable	Unknown	June 2011	Taiwan ... 展开 >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Yi-Hua Liao, MD, PhD 886-2-23562141 yihualiao@ntu.edu.tw Principal Investigator: Yi-Hua Liao, MD, PhD 收起 <<
NCT03318042	Genotype, Metabotype and Dieta... 展开 >>ry Habits 收起 <<	Not Applicable	Completed	-	Spain ... 展开 >> Cebas-Csic Murcia, Spain, 30100 收起 <<
NCT01916239	Colorectal Cancer	Phase 1 Phase 2	Completed	-	Spain ... 展开 >> Hospital General Universitario Reina Sofía Murcia, Spain, 30003 收起 <<
NCT01705093	Childhood Obesity ... 展开 >> Cardiovascular Disease 收起 <<	Phase 2	Completed	-	United States, California ... 展开 >> Ragle Human Nutrition Research Center, Academic Surge, UC Davis Davis, California, United States, 95616 收起 <<
NCT03548701	-		Recruiting	May 21, 2020	United States, New York ... 展开 >> Mount Sinai Hospital Recruiting New York, New York, United States, 10029 Contact: Patrick Maher, MD 404-550-9559 patrick.maher@mountsinai.org Contact: Daniel Katz, MD 732-322-6675 daniel.katz@mountsinai.org Principal Investigator: Patrick Maher, MD 收起 <<
NCT02056496	Healthy	Phase 1	Completed	-	Spain ... 展开 >> UCAM (San Antonio Catholic University from Murcia) Murcia, Spain, 30107 收起 <<
NCT02263378	HPV Infection	Not Applicable	Completed	-	-
NCT03713164	Healthy	Phase 1 Phase 2	Completed	-	United States, California ... 展开 >> UCLA Center for Human Nutrition, 900 Veteran Ave. Los Angeles, California, United States, 90095 收起 <<
NCT02370641	Urolith	Not Applicable	Completed	-	-

鞣花酸 /Ellagic acid {[allProObj[0].p_purity_real_show]}

Ellagic acid 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Ellagic acid 质控信息

Ellagic acid 生物活性

Ellagic acid 临床研究

Ellagic acid 参考文献

Ellagic acid 实验方案

Ellagic acid 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

鞣花酸 /Ellagic acid {[allProObj[0].p_purity_real_show]}

Ellagic acid 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Ellagic acid 质控信息

Ellagic acid 生物活性

Ellagic acid 临床研究

Ellagic acid 参考文献

Ellagic acid 实验方案

Ellagic acid 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Ellagic acid 纯度/质量文件产品仅供科研