Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive CK2 (Casein kinase 2) inhibitor, with an IC50 of 40 nM and a Ki of 20 nM[3]. Ellagic acid (EA; 10 mg/kg/day; p.o., 14 days) strongly decreases MDA brain content by 17%, and reduces the levels of brain TNF-α by 42% in rats. Ellagic acid markedly increases the reduced brain contents of 5-HT (39%), dopamine (DA, 71%), and norepinephrine (NE, 77%). Ellagic acid (10 mg/kg, p.o., 14 days) causes decreased histopathological changes induced by Doxorubicin in rats[4]. Ellagic acid (10 μM) exhibits cytotoxic effects on MCF-7 cells after treatment of radiation. Ellagic acid (10 μM) in combination with Irradiation (IR) significantly abridges the capacity of MCF-7 cells to form colonies equated with individual treatments. Ellagic acid with IR also induces cell apoptosis, and facilitates the upregulation of pro-apopttotic Bax and downregulation of Bcl-2 in MCF-7 cells[5]. The antitumor activity of EA has been mostly attributed to direct antiproliferative and apoptotic effects. Moreover, EA can inhibit tumour cell migration, extra-cellular matrix invasion and angiogenesis[6].
United States, Wisconsin
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Froedtert & the Medical College of Wisconsin
Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Ehab Atallah, MD 414-805-4600 eatallah@mcw.edu
Contact: Medical College of Wisconsin Cancer Center Clinical Trials Office 414-805-8900 cccto@mcw.edu 收起 <<
United States, Wisconsin
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Froedtert & the Medical College of Wisconsin
Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Ehab Atallah, MD 414-805-4600 eatallah@mcw.edu
Contact: Medical College of Wisconsin Cancer Center Clinical Trials Office 414-805-8900 cccto@mcw.edu 收起 <<
United States, District of Col... 展开 >>umbia
Sibley Memorial Hospital
Recruiting
Washington, District of Columbia, United States, 20016
Contact: Channing Paller, MD 202-660-6500 cpaller1@jhmi.edu
United States, Maryland
Johns Hopkins Hospital
Recruiting
Baltimore, Maryland, United States, 21205
Contact: Donna Dowling, RN 410-614-9526 ddowlin1@jhmi.edu
Principal Investigator: Channing Paller, MD 收起 <<
United States, Ohio
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Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
Columbus, Ohio, United States, 43210 收起 <<
United States, New York
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Mount Sinai Hospital
Recruiting
New York, New York, United States, 10029
Contact: Patrick Maher, MD 404-550-9559 patrick.maher@mountsinai.org
Contact: Daniel Katz, MD 732-322-6675 daniel.katz@mountsinai.org
Principal Investigator: Patrick Maher, MD 收起 <<
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