Epirubicin HCl | 盐酸表柔比星 | 4'-Epidoxorubicin hydrochloride | DNA/RNA Synthesis Inhibitor

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表阿霉素盐酸盐 /Epirubicin HCl 99%+

货号：A263227 同义名： 盐酸表柔比星 / 4'-Epidoxorubicin hydrochloride;Epirubicin (hydrochloride)

Epirubicin HCl, a L-arabino derivative of doxorubicin, can inhibit topoisomerase and used as antineoplastic agent.

Epirubicin HCl 化学结构
CAS号：56390-09-1

Epirubicin HCl 3D分子结构
CAS号：56390-09-1

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Epirubicin HCl 纯度/质量文件产品仅供科研

货号：A263227 标准纯度： 99%+ 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024. Ambeed. [ A288696 ]; • JMC, 2024. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

拓扑异构酶亚型比较

产品名称	Topo I ↓ ↑	Topo II ↓ ↑	Topo IV ↓ ↑	Topoisomerase ↓ ↑	其他靶点	纯度
Ellagic acid	✔					99%+
β-Lapachone	✔					99%+
(s)-10-hydroxycamptothecin	✔					99%+
Camptothecin	++ Topo I, IC50: 0.68 μM					98%
Betulinic acid	++ Eukaryotic topoisomerase I, IC50: 5 μM					99%+
Topotecan	++++ Topo I (DU-145 Luc cells), IC50: 2 nM Topo I (MCF-7 Luc cells), IC50: 13 nM					99%+
Irinotecan HCl Trihydrate	✔					98%
SN-38	✔					98%
Levofloxacin hydrate		✔				99%+
Dexrazoxane		✔				99%+
Ofloxacin		✔				98+%
Enoxacin		✔				99%+
Flumequine		+ Topo II, IC50: 15 μM				99%+
Levofloxacin		✔				99%+
Etoposide		✔				98%
Pefloxacin mesylate dihydrate		✔				99+%
Marbofloxacin		✔				99%+
Voreloxin HCl		✔				98%
Mitoxantrone dihydrochloride		✔			PKC	99%+
Nalidixic acid		✔				99%+
Doxorubicin		✔				98%
Novobiocin sodium		✔				98%+
Amonafide		✔				99%+
Pirarubicin		✔				98%+
Idarubicin HCl		+++ Topo II (MCF-7 cells), IC50: 3.3 ng/mL				99%+
Genistein		✔			EGFR	98%
Teniposide		✔				98%
Moxifloxacin		✔				98%
Ciprofloxacin			✔			99%+
Clinafloxacin			✔			97%
Gatifloxacin				✔		99%+
Daunorubicin HCl				+++ DNA synthesis, Ki: 20 nM		98%
Epirubicin HCl				✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Epirubicin HCl 生物活性

靶点

Topoisomerase

描述

Epirubicin, a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase^[3]. Epirubicin inhibits DNA and RNA synthesis. Epirubicin is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity{ Kashima H, Momose F, Umehara H, et al. Epirubicin, Identified Using a Novel Luciferase Reporter Assay for Foxp3 Inhibitors, Inhibits Regulatory T Cell Activity. PLoS One. 2016;11(6):e0156643. |https://pubmed.ncbi.nlm.nih.gov/27284967/}}. Epirubicin is cytotoxic to Hepatoma G2 cells with IC50 of 1.6 μg/mL at 24 hr. 1.6 μg/mL Epirubicin induces apoptosis of Hep G2 cells, and higher activity of catalase by 50%, Se-dependent glutathione peroxidase by 110%, Cu, Zn-superoxide dismutase by 172% and Mn-superoxide dismutase by 135%^[4]. Epirubicin at a dose of 3.5 mg/kg suppresses tumor mass of human breast tumor xenograft R-27 by 74.4 %^[5].

Epirubicin HCl 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
human A549 cells		Proliferation assay	48 h	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50=9.6 μM	23287057
human DU145 cells		Proliferation assay	48 h	Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay, IC50=9.9 μM	23287057
human HCT116 cells		Cytotoxic assay	6 days	Cytotoxicity against human HCT116 cells after 6 days by MTT assay, IC50=0.82 μM	22276679
human Hep3B cells		Cytotoxic assay	6 days	Cytotoxicity against human Hep3B cells after 6 days by MTT assay, IC50=0.96 μM	22276679

Epirubicin HCl 参考文献

[1]Ozkan A, Fişkin K. Epirubicin HCl toxicity in human-liver derived hepatoma G2 cells. Pol J Pharmacol. 2004 Jul-Aug;56(4):435-44.

[2]Cersosimo RJ, Hong WK. Epirubicin: a review of the pharmacology, clinical activity, and adverse effects of an adriamycin analogue. J Clin Oncol. 1986 Mar;4(3):425-39.

[3]Cersosimo RJ, Hong WK. Epirubicin: a review of the pharmacology, clinical activity, and adverse effects of an adriamycin analogue. J Clin Oncol. 1986;4(3):425-439.

[4]Ozkan A, Fişkin K. Epirubicin HCl toxicity in human-liver derived hepatoma G2 cells. Pol J Pharmacol. 2004;56(4):435-444.

[5]Bonadonna G, Gianni L, Santoro A, et al. Drugs ten years later: epirubicin. Ann Oncol. 1993;4(5):359-369.

Epirubicin HCl 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.72mL

0.34mL

0.17mL

8.62mL

1.72mL

0.86mL

17.24mL

3.45mL

1.72mL

Epirubicin HCl 技术信息

CAS号	56390-09-1
分子式	C₂₇H₃₀ClNO₁₁
分子量	579.98

别名	盐酸表柔比星 ;4'-Epidoxorubicin hydrochloride;Epirubicin (hydrochloride);4’-Epidoxorubicin;4'-epidoxorubicin HCl;NSC 256942 HCl;IMI 28 HCl;Epirubicin hydrochloride
运输	蓝冰

存储条件

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 25 mg/mL(43.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 50 mg/mL(86.21 mM)，配合低频超声助溶

动物实验配方

PO 0.5% CMC-Na 12 mg/mL suspension

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

human A549 cells		Proliferation assay	48 h	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay, IC50=9.6 μM	23287057
human DU145 cells		Proliferation assay	48 h	Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay, IC50=9.9 μM	23287057
human HCT116 cells		Cytotoxic assay	6 days	Cytotoxicity against human HCT116 cells after 6 days by MTT assay, IC50=0.82 μM	22276679
human Hep3B cells		Cytotoxic assay	6 days	Cytotoxicity against human Hep3B cells after 6 days by MTT assay, IC50=0.96 μM	22276679
human HepG2 cells		Cytotoxic assay	6 days	Cytotoxicity against human HepG2 cells after 6 days by MTT assay, IC50=1.65 μM	22276679
human HepG2 cells		Proliferation assay	48 h	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay, IC50=4.6 μM	23287057
human MCF7 cells		Proliferation assay	48 h	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay, IC50=3.7 μM	23287057
human MCF7 cells	5 μM	Cytotoxic assay	48 h	Cytotoxicity against human MCF7 cells assessed as change in cell viability at 5 uM after 48 hrs by MTT assay	23287057
human MCF7/ADR cells		Cytotoxic assay	6 days	Cytotoxicity against human MCF7/ADR cells after 6 days by MTT assay, IC50=1.65 μM	22276679
human MDA-MB-231 cells		Proliferation assay	48 h	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay, IC50=5.6 μM	23287057
human MDA-MB-231 cells	5 μM	Cytotoxic assay	48 h	Cytotoxicity against drug-resistant human MDA-MB-231 cells assessed as change in cell viability at 5 uM after 48 hrs by MTT assay	23287057
human PC3 cells		Cytotoxic assay	6 days	Cytotoxicity against human PC3 cells after 6 days by MTT assay, IC50=0.46 μM	22276679
human PC3 cells		Proliferation assay	48 h	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay, IC50=5.7 μM	23287057
human T47D cells		Proliferation assay	48 h	Antiproliferative activity against human T47D cells after 48 hrs by MTT assay, IC50=4.3 μM	23287057
human T47D cells	5 μM	Cytotoxic assay	48 h	Cytotoxicity against human T47D cells assessed as change in cell viability at 5 uM after 48 hrs by MTT assay	23287057
MCF-7 cells		Cytotoxic assay		Compound was tested for its toxicity against human breast cancer cells(MCF-7), IC50=0.2 μM	9548820
NIH/3T3 cells		Proliferation assay	48 h	Antiproliferative activity against mouse NIH/3T3 cells after 48 hrs by MTT assay, IC50=4.2 μM	23287057

表阿霉素盐酸盐 /Epirubicin HCl 99%+

Epirubicin HCl 纯度/质量文件产品仅供科研

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Epirubicin HCl 质控信息

Epirubicin HCl 生物活性

Epirubicin HCl 细胞研究

Epirubicin HCl 参考文献

Epirubicin HCl 实验方案

Epirubicin HCl 技术信息

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表阿霉素盐酸盐 /Epirubicin HCl 99%+

Epirubicin HCl 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Epirubicin HCl 质控信息

Epirubicin HCl 生物活性

Epirubicin HCl 细胞研究

Epirubicin HCl 参考文献

Epirubicin HCl 实验方案

Epirubicin HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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