Fexinidazole is a 5-nitroimidazole drug for the treatment of human sleeping sickness (human African trypanosomiasis [HAT]), caused by infection with species of the protozoan parasite Trypanosoma brucei.
Human African Trypanosomiasis (HAT), or sleeping sickness, is a life-threatening, neglected tropical disease (NTD). The etiological agent of HAT is the kinetoplastid protozoan parasite Trypanosoma brucei (T. b.). Two subspecies of this parasite are pathogenic for humans: T. b. gambiense (g-HAT) responsible for the chronic form of the disease occurring in western and central Africa, and T. b. rhodesiense (r-HAT) responsible for a more acute form occurring in eastern and southern Africa. Fexinidazole, a 5-nitroimidazole derivative DNA synthesis inhibitor, is the only, all-oral treatment for HAT and is indicated for use by adults and children (aged ≥ 6 years and weighing ≥ 20 kg) for both g-HAT stages[3]. This molecule and its metabolites (sulfoxide and sulfone) have shown trypanocidal activity in vitro in the 0.7-to-3.3 μM (0.2-to-0.9 μg/ml) range against all parasite strains tested. In vivo, fexinidazole is orally effective in curing both acute and chronic diseases in the mouse at doses of 100 mg/kg of body weight/day for 4 days and 200 mg/kg/day for 5 days, respectively[4].
Chagas Disease
... 展开 >> Trypanosomiasis, South American
South American Trypanosomiasis
Disease, Chagas 收起 <<
Phase 2
Unknown
February 2016
Bolivia
... 展开 >> Plataforma Atención Integral de Pacientes con Enfermedad de Chagas
Recruiting
Cochabamba, Bolivia
Contact: Faustino Torrico, MD 59177411905 foxtorrico@yahoo.com
Contact: Cristina Alonso, MD 59172211312 calonso@dndi.org
Principal Investigator: Faustino Torrico, MD
Plataforma de Atención Integral de Pacientes con Enfermedad de Chagas
Recruiting
Tarija, Bolivia
Contact: Lourdes O Daza, MD 5916672252 lourdesortizd@yahoo.es
Contact: Erika Ribeiro, Pharm D 59175969924 ecorreia@dndi.org
Principal Investigator: Lourdes O Daza, MD 收起 <<
Chagas Disease
... 展开 >> Trypanosomiasis, South American
South American Trypanosomiasis
Disease, Chagas 收起 <<
Phase 2
Unknown
February 2016
Bolivia
... 展开 >> Plataforma Atención Integral de Pacientes con Enfermedad de Chagas
Recruiting
Cochabamba, Bolivia
Contact: Faustino Torrico, MD 59177411905 foxtorrico@yahoo.com
Contact: Cristina Alonso, MD 59172211312 calonso@dndi.org
Principal Investigator: Faustino Torrico, MD
Plataforma de Atención Integral de Pacientes con Enfermedad de Chagas
Recruiting
Tarija, Bolivia
Contact: Lourdes O Daza, MD 5916672252 lourdesortizd@yahoo.es
Contact: Erika Ribeiro, Pharm D 59175969924 ecorreia@dndi.org
Principal Investigator: Lourdes O Daza, MD 收起 <<
Congo, The Democratic Republic... 展开 >> of the
Hôpital de Dipumba
Recruiting
Mbuji-Mayi, Kasaï Oriental, Congo, The Democratic Republic of the
Contact: Dieudonné Mpoyi, Doctor dmpoyi@dndi.org
Contact: Médard Ilunga, Doctor milunga@dndi.org
Principal Investigator: Dieudonné Mpoyi, Doctor
Sub-Investigator: Médard Ilunga, Doctor
Hopital General de réference
Recruiting
Bagata, Congo, The Democratic Republic of the
Contact: Papy Kavunga, MD plukula@dndi.org
Principal Investigator: Papy Kavunga, Doctor
Sub-Investigator: Mathieu Nkeri, Doctor
Sub-Investigator: John Twampo, Doctor
Hopital Général de réference
Recruiting
Bandundu, Congo, The Democratic Republic of the
Contact: Helen Mahenzi, MD hmahenzi@dndi.org
Principal Investigator: Helene Mahenzi, Doctor
Sub-Investigator: Joseph MAKAYA, Doctor
Sub-Investigator: Bedel Mulumba, Doctor
Hopital de Kimpese
Recruiting
Kimpese, Congo, The Democratic Republic of the
Contact: Jean-Papa Mavakala, Dr jpmavakala@dndi.org
Principal Investigator: Jean-Papa Mavakala, Dr
Hôpital Général de Référence Roi Baudouin
Recruiting
Kinshasa, Congo, The Democratic Republic of the
Contact: Luwawu Ntoya, Doctor lntoya@dndi.org
Principal Investigator: Luwawu Ntoya, Doctor
Sub-Investigator: Vincent Kobo, Doctor
Hopital Genral de Reference Masi MAnimba
Recruiting
Masi-Manimba, Congo, The Democratic Republic of the
Contact: Willy Kuziena, Doctor
Principal Investigator: Willy Kuziena Mindele, Doctor
Sub-Investigator: Augustin Kukembila Musoki, Doctor
Sub-Investigator: Felix Akwaso Masa, Doctor
Hopital General de réference
Recruiting
Mushie, Congo, The Democratic Republic of the
Contact: Guylain Mandula, MD gmandula@dndi.org
Principal Investigator: Guylain Mandula, Doctor
Sub-Investigator: Tim Mayala, Doctor
HGR Nkara
Recruiting
Nkara, Congo, The Democratic Republic of the
Contact: Steve Inzodi, Dr sinzodi@dndi.org
Principal Investigator: Steve Inzodi, Dr
Guinea
Hopital de Dubreka
Recruiting
Dubreka, Guinea
Contact: Mariame Camara, Dr mcamara@dndi.org
Principal Investigator: Mariame Camara, Dr 收起 <<
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