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/ Ciprofloxacin

环丙沙星 /Ciprofloxacin {[allProObj[0].p_purity_real_show]}

货号：A208061 同义名： Bay-09867

Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.

Ciprofloxacin 化学结构 CAS号：85721-33-1
Ciprofloxacin 化学结构
CAS号：85721-33-1
Ciprofloxacin 3D分子结构
CAS号：85721-33-1
Ciprofloxacin 化学结构 CAS号：85721-33-1
Ciprofloxacin 3D分子结构 CAS号：85721-33-1
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Ciprofloxacin 纯度/质量文件 产品仅供科研

货号：A208061 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Topo I ↓ Topo II ↓ Topo IV ↓ Topoisomerase ↓ 其他靶点 纯度
Ellagic acid ✔ 98%
β-Lapachone ✔ 99%+
(s)-10-hydroxycamptothecin ✔ 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

 		98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

 		98%
Topotecan ++++

Topo I (MCF-7 Luc cells), IC50: 13 nM

Topo I (DU-145 Luc cells), IC50: 2 nM

 		98%
Irinotecan HCl Trihydrate ✔ 98%
SN-38 ✔ 98%
Levofloxacin hydrate ✔ 98%
Dexrazoxane ✔ 99%+
Ofloxacin ✔ 98+%
Enoxacin ✔ 99%+
Flumequine +

Topo II, IC50: 15 μM

 		98%
Levofloxacin ✔ 97%
Etoposide ✔ 98%
Pefloxacin mesylate dihydrate ✔ 99+%
Marbofloxacin ✔ 98+%
Voreloxin HCl ✔ 98%
Mitoxantrone dihydrochloride ✔ PKC 98%
Nalidixic acid ✔ 98%
Doxorubicin ✔ 98%
Novobiocin sodium ✔ 95%
Amonafide ✔ 99%+
Pirarubicin ✔ 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

 		99%+
Genistein ✔ EGFR 98%
Teniposide ✔ 98%
Moxifloxacin ✔ 98%
Ciprofloxacin ✔ 98%
Clinafloxacin ✔ 97%
Gatifloxacin ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Epirubicin HCl ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ciprofloxacin 生物活性

靶点

  • Topo IV
描述 Ciprofloxacin is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin has anti-proliferative activity and induces Apoptosis. Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Ciprofloxacin (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase[3]. Ciprofloxacin shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively[4]. Ciprofloxacin (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall. Ciprofloxacin (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall[5].

Ciprofloxacin 细胞研究

细胞系 浓度 检测类型 检测时间 活动说明 数据源
5637 cells Function assay 12 h Antibacterial activity against uropathogenic Escherichia coli UTI89 infected in human 5637 cells assessed as decrease in intracellular bacterial level at 2 to 3 ug/ml after 12 hrs by serial dilution method 20231390
Caco-2 cells Function assay 30 mins Antibacterial activity against wild type Salmonella enteritidis 5408 harboring gyrA D87Y mutant gene infected in human Caco-2 cells assessed as effect on bacterial cell adherence after 30 mins 19917752
CCRF-CEM cells 50 μM Proliferation assay Antiproliferative activity against human CCRF-CEM cells assessed as cell viability at 50 uM by CellTiter assay relative to DMSO control 24138941
human erythrocytes Growth inhibition assay 50 h Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay, IC50=33.9 μM 24650715

Ciprofloxacin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02423759 Benign Prostate Hyperplasia Phase 4 Completed - Egypt ... 展开 >> Urology and Nprhology Center Mansoura, Aldakahlia, Egypt, 35516 收起 <<
NCT03716804 Uncomplicated Urinary Tract In... 展开 >>fection Antibiotic Resistant Infection 收起 << Phase 4 Recruiting January 25, 2019 Bangladesh ... 展开 >> Combined Military Hosptal, Dhaka Recruiting Dhaka, Bangladesh Contact: Abdul Quddus Bhuiyan, MBBS, FCPS    1673615641 ext +880 收起 <<
NCT01873690 Urolithiasis Phase 3 Terminated(Due to the low recr... 展开 >>uitment rate and the large number lost to follow-up) 收起 << - Canada, Ontario ... 展开 >> St. Joseph's Hospital, St. Joseph's Health Care London London, Ontario, Canada, N6A 4V2 收起 <<

Ciprofloxacin 参考文献

[1]Pan XS, Ambler J, et al. Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae. Antimicrob Agents Chemother. 1996 Oct;40(10):2321-6.

[2]Wise R, Andrews JM, et al. In vitro activity of Bay 09867, a new quinoline derivative, compared with those of other antimicrobial agents. Antimicrob Agents Chemother. 1983 Apr;23(4):559-64.

[3]Tsai WC, Hsu CC, Tang FT, Wong AM, Chen YC, Pang JH. Ciprofloxacin-mediated cell proliferation inhibition and G2/M cell cycle arrest in rat tendon cells. Arthritis Rheum. 2008;58(6):1657-1663.

[4]Steenbergen J, Tanaka SK, Miller LL, Halasohoris SA, Hershfield JR. In Vitro and In Vivo Activity of Omadacycline against Two Biothreat Pathogens, Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017;61(5):e02434-16.

[5]LeMaire SA, Zhang L, Luo W, et al. Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice. JAMA Surg. 2018;153(9):e181804.

Ciprofloxacin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.02mL

0.60mL

0.30mL

15.09mL

3.02mL

1.51mL

30.18mL

6.04mL

3.02mL

Ciprofloxacin 技术信息

CAS号85721-33-1
分子式C17H18FN3O3
分子量 331.341
别名 Bay-09867
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

0.1 M HCL: 15 mg/mL(45.27 mM)，配合低频超声，水浴加热至45℃，并调节pH至2
动物实验配方

Tags: Ciprofloxacin | 85721-33-1 | Bay-09867 | Bay09867 | Bay 09867 | Topoisomerase IV Inhibitor | Cell Cycle/DNA Damage | Apoptosis | Anti-infection | Metabolic Enzyme/Protease | NF-κB | Immunology/Inflammation | Topoisomerase | Apoptosis | Antibiotic | Bacterial | Mitochondrial Metabolism | Reactive Oxygen Species | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Ciprofloxacin 纯度/质量文件 | Ciprofloxacin 亚型比较 | Ciprofloxacin 生物活性 | Ciprofloxacin 细胞研究 | Ciprofloxacin 临床数据 | Ciprofloxacin 参考文献 | Ciprofloxacin 实验方案 | Ciprofloxacin 技术信息

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