SN-38 | 7-Ethyl-10-hydroxycamptothecin;NK 012;irinotecan metabolite.;10-hydroxy-7-ethylcamptothecin;7-ethyl-10-hydroxy-20(S)-Camptothecin | 伊立替康杂质B | Apoptosis Inducer | Anti-tumor | Topoisomerase I Inhibitor | DNA Topoisomerase II Inhibitor | Topoisomerase

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7-乙基-10羟基喜树碱 /SN-38 {[allProObj[0].p_purity_real_show]}

货号：A366170 同义名： 伊立替康杂质B / 7-Ethyl-10-hydroxycamptothecin;NK 012

SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

SN-38 化学结构
CAS号：86639-52-3

SN-38 3D分子结构
CAS号：86639-52-3

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SN-38 纯度/质量文件产品仅供科研

货号：A366170 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell Host Microbe, 2024. Ambeed. [ A163338 ]; • Cancer Res., 2024. Ambeed. [ A295334 ]; • J. Pharm. Investig., 2024. Ambeed. [ A221527 , A691302 , A272538 , A187261 ]; • J. Fungi, 2024, 10(11): 751. Ambeed. [ A796919 ]; • JBC, 2024, 107935. Ambeed. [ A194396 ]; 更多 >

拓扑异构酶亚型比较

产品名称	Topo I ↓ ↑	Topo II ↓ ↑	Topo IV ↓ ↑	Topoisomerase ↓ ↑	其他靶点	纯度
Ellagic acid	✔					98%
β-Lapachone	✔					99%+
(s)-10-hydroxycamptothecin	✔					98+%
Camptothecin	++ Topo I, IC50: 0.68 μM					98%
Betulinic acid	++ Eukaryotic topoisomerase I, IC50: 5 μM					98%
Topotecan	++++ Topo I (MCF-7 Luc cells), IC50: 13 nM Topo I (DU-145 Luc cells), IC50: 2 nM					98%
Irinotecan HCl Trihydrate	✔					98%
SN-38	✔					98%
Levofloxacin hydrate		✔				98%
Dexrazoxane		✔				99%+
Ofloxacin		✔				98+%
Enoxacin		✔				99%+
Flumequine		+ Topo II, IC50: 15 μM				98%
Levofloxacin		✔				97%
Etoposide		✔				98%
Pefloxacin mesylate dihydrate		✔				99+%
Marbofloxacin		✔				98+%
Voreloxin HCl		✔				98%
Mitoxantrone dihydrochloride		✔			PKC	98%
Nalidixic acid		✔				98%
Doxorubicin		✔				98%
Novobiocin sodium		✔				95%
Amonafide		✔				99%+
Pirarubicin		✔				98%+
Idarubicin HCl		+++ Topo II (MCF-7 cells), IC50: 3.3 ng/mL				99%+
Genistein		✔			EGFR	98%
Teniposide		✔				98%
Moxifloxacin		✔				98%
Ciprofloxacin			✔			98%
Clinafloxacin			✔			97%
Gatifloxacin				✔		98%
Daunorubicin HCl				+++ DNA synthesis, Ki: 20 nM		98%
Epirubicin HCl				✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

SN-38 生物活性

靶点	Topo I
描述	SN-38, derived from the Topoisomerase I inhibitor Irinotecan, serves as its active metabolite. SN-38 impedes DNA and RNA synthesis, with IC50 values of 0.077 μM and 1.3 μM, respectively ^[1]^[2]^[3]^[4].
体内研究	SN-38 is the active and toxic metabolite of the anticancer prodrug Irinotecan. At 30 minutes post-administration, Irinotecan plasma concentrations in Slco1a/1b(−/−) mice are 1.9-fold higher compared to wild-type mice (1.89 vs. 1.01 μM, respectively), while SN-38 plasma concentrations in Slco1a/1b(−/−) mice are 8-fold higher than in wild-type mice (0.4 μg/mL vs. 0.05 μg/mL, respectively). The overall plasma exposure [AUC(5-240)] of Irinotecan is 1.7-fold higher in Oatp1a/1b knockout mice compared to wild-type mice (209.8±6.7 vs. 120.9±4.4 μM/min; P<0.01), and 2.9-fold higher for SN-38 (50±2.9 vs. 12±2 μM/min; P<0.001) ^[3].
体外研究	The IC50 values for LoVo, HCT116, and HT29 cell lines are 20 nM, 50 nM, and 130 nM, respectively. In all three SN-38 resistant cell lines, Top1 activity persists even in the presence of elevated concentrations of SN-38 ^[2].

SN-38 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
HEK293 cells		Cytotoxic assay	72 h	Intrinsic cytotoxicity against HEK293 cells assessed as reduction in cell viability after 72 hrs by MTT assay	25272055
human A2780 cells		Cytotoxic assay	72 h	Cytotoxicity against human A2780 cells overexpressing alpha5beta3 integrin assessed as cell survival after 72 hrs by SRB assay, IC50=9 nM	22959246
human A549 cells		Cytotoxic assay	3 days	Cytotoxicity against human A549 cells assessed as growth inhibition after 3 days by SRB assay, IC50=2.72 nM	24529870
human A549 cells		Cytotoxic assay		Cytotoxicity against human A549 cells, IC50=47 nM	21470864

SN-38 动物研究

Dose

Rat: 2 mg/kg^[3] (i.v.); 40 mg/kg (p.o.) Mice: 5 mg/kg- 75 mg/kg^[4] (i.v.)

Administration

i.v., p.o.

Pharmacokinetics

Animal	Mice^[4]
Dose	5 mg/kg
Administration	i.v. p.o.
C_max	647 ng/ml (i.v.) 30 ng/ml (p.o.)
AUC_0→∞	279 ng·h/ml (i.v.) 86 ng·h/ml (p.o.)
T_max	1 h (p.o.)

SN-38 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.25mL

12.74mL

2.55mL

1.27mL

25.48mL

5.10mL

2.55mL

SN-38 技术信息

CAS号	86639-52-3
分子式	C₂₂H₂₀N₂O₅
分子量	392.4

别名	伊立替康杂质B ;7-Ethyl-10-hydroxycamptothecin;NK 012;irinotecan metabolite.;10-hydroxy-7-ethylcamptothecin;7-ethyl-10-hydroxy-20(S)-Camptothecin
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 25 mg/mL(63.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

IP 2% DMSO+2% Tween80+40% PEG300+water 1 mg/mL clear

PO 0.5% CMC-Na 50 mg/mL suspension

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

HEK293 cells	Cytotoxic assay	72 h	Intrinsic cytotoxicity against HEK293 cells assessed as reduction in cell viability after 72 hrs by MTT assay	25272055
human A2780 cells	Cytotoxic assay	72 h	Cytotoxicity against human A2780 cells overexpressing alpha5beta3 integrin assessed as cell survival after 72 hrs by SRB assay, IC50=9 nM	22959246
human A549 cells	Cytotoxic assay	3 days	Cytotoxicity against human A549 cells assessed as growth inhibition after 3 days by SRB assay, IC50=2.72 nM	24529870
human A549 cells	Cytotoxic assay		Cytotoxicity against human A549 cells, IC50=47 nM	21470864
human Bel-7402 liver cancer cell line	Function assay		Inhibitory concentration against human Bel-7402 liver cancer cell line, IC50=3.19 μM	15808456
human breast cancer cell line (SK-BR-3)	Cytotoxic assay		In Vitro cytotoxicity against human breast cancer cell line (SK-BR-3), IC50=4 nM	11334569
human colon cancer cell line (WiDr)	Cytotoxic assay		In Vitro cytotoxicity against human colon cancer cell line (WiDr), IC50=14 nM	11334569
human DU145 cells	Proliferation assay	96 h	Antiproliferative activity against human DU145 cells after 96 hrs, IC50=4 nM	18276141
human DU145 prostate cell line	Proliferation assay		Antiproliferative activity against human DU145 prostate cell line, IC50=13 nM	10498216
human H460 cell	Growth inhibition assay		Inhibition of human H460 cell growth, IC50=80 nM	16913706
human HCT116 cells	Proliferation assay	3 days	Antiproliferative activity against human HCT116 cells after 3 days, IC50=0.55 nM	19254843
human HCT116 cells	Cytotoxic assay	72 h	Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B assay, IC50=4.28 nM	25835359
human HCT116 colon cancer cell line	Function assay		Inhibitory concentration against human HCT116 colon cancer cell line, IC50=7 nM	15808456
human HT-29 cells	Cytotoxic assay		Cytotoxicity against human HT-29 cells, IC50=5.9 nM	21470864
human KB3-1 cells	Cytotoxic assay	4 days	Cytotoxicity against human KB3-1 cells after 4 days by MTT method, IC50=4 nM	19303306
human KBH5.0 cells	Cytotoxic assay	4 days	Cytotoxicity against BCRP overexpressing human KBH5.0 cells after 4 days by MTT method, IC50=0.3 μM	19303306
human KBV1 cells	Cytotoxic assay	4 days	Cytotoxicity against MDR1 overexpressing human KBV1 cells after 4 days by MTT method, IC50=46 nM	19303306
human lung cancer cell line (A549)	Cytotoxic assay		In Vitro cytotoxicity against human lung cancer cell line (A549)	11334569
human lung cancer cell line (H128)	Cytotoxic assay		In Vitro cytotoxicity against human lung cancer cell line (H128), IC50=6 nM	11334569
human MCF-7 breast cell line	Proliferation assay		Antiproliferative activity against human MCF-7 breast cell line, IC50=0.37 μM	10498216
human MDA-MB-231 cells	Cytotoxic assay		Cytotoxicity against human MDA-MB-231 cells, IC50=176 nM	24529870
human MIA PaCa cells	Proliferation assay		Antiproliferative activity against human MIA PaCa cells after 96 hrs, IC50=6 nM	18276141
human NCI-H460 cells	Proliferation assay	3 days	Antiproliferative activity against human NCI-H460 cells after 3 days, IC50=3.3 nM	19254843
human ovarian cancer cell line (SK-OV-3)	Cytotoxic assay		In Vitro cytotoxicity against human ovarian cancer cell line (SK-OV-3), IC50=11 nM	11334569
human PC3 cells	Cytotoxic assay	72 h	Cytotoxicity against human PC3 cells expressing alpha5beta3 integrin assessed as cell survival after 72 hrs by SRB assay, IC50=2.6 nM	22959246
human PC6 cells	Proliferation assay	6 days	Antiproliferative activity against human PC6 cells carrying pRC after 6 days, IC50=0.43 nM	19254843
human QG56 cells	Proliferation assay	3 days	Antiproliferative activity against human QG56 cells after 3 days, IC50=2.8 nM	19254843
human SKOV-3 ovarian cell line	Proliferation assay		Antiproliferative activity against human SKOV-3 ovarian cell line, IC50=0.72 μM	10498216
human stomach cancer cell line (MKN45)	Cytotoxic assay		In Vitro cytotoxicity against human stomach cancer cell line (MKN45), IC50=8 nM	11334569
human tumor HL60 cell-line	Function assay	3 days	In-vitro inhibitory concentration for human tumor HL60 cell-line was determined using SRB assay after 3 days of incubation, IC50=19 nM	15913996
MDA-MB-435 S human breast cancer cells	Function assay		Inhibition against MDA-MB-435 S human breast cancer cells in the absence of albumin, IC50=5 nM	11052802
MDA-MB-435 S human breast cancer cells	Function assay		Inhibition against MDA-MB-435 S human breast cancer cells in the presence of 30 mg/mL HSA, IC50=50 nM	11052802
NSCLC-H460	Cytotoxic assay		Cytotoxicity against human non-small-cell lung carcinoma cell line H460 (NSCLC-H460), IC50=80 nM	11563925
PC-3 carcinoma cell line	Growth inhibition assay		Concentration required to inhibit growth of human prostate PC-3 carcinoma cell line, IC50=35.6 nM	15454230

7-乙基-10羟基喜树碱 /SN-38 {[allProObj[0].p_purity_real_show]}

SN-38 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

SN-38 质控信息

SN-38 生物活性

SN-38 细胞研究

SN-38 动物研究

SN-38 实验方案

SN-38 技术信息

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7-乙基-10羟基喜树碱 /SN-38 {[allProObj[0].p_purity_real_show]}

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全球学术期刊中引用的产品

SN-38 质控信息

SN-38 生物活性

SN-38 细胞研究

SN-38 动物研究

SN-38 实验方案

SN-38 技术信息

最近浏览的产品

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摩尔计算器

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总药量计算器

工作液计算器

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临床研究

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