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/ Doxorubicin

阿霉素 /Doxorubicin {[allProObj[0].p_purity_real_show]}

货号：A206785 同义名： Hydroxydaunorubicin

Doxorubicin is a Topoisomerase II (Top2) catalytic inhibitor, also is a broad spectrum antibiotic used in the treatment of cancers, with IC50 of 374 nM for Hela cells.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Doxorubicin 化学结构 CAS号：23214-92-8
Doxorubicin 化学结构
CAS号：23214-92-8
Doxorubicin 3D分子结构
CAS号：23214-92-8
Doxorubicin 化学结构 CAS号：23214-92-8
Doxorubicin 3D分子结构 CAS号：23214-92-8
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Doxorubicin 纯度/质量文件 产品仅供科研

货号：A206785 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Topo I ↓ Topo II ↓ Topo IV ↓ Topoisomerase ↓ 其他靶点 纯度
Ellagic acid ✔ 98%
β-Lapachone ✔ 99%+
(s)-10-hydroxycamptothecin ✔ 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

 		98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

 		98%
Topotecan ++++

Topo I (MCF-7 Luc cells), IC50: 13 nM

Topo I (DU-145 Luc cells), IC50: 2 nM

 		98%
Irinotecan HCl Trihydrate ✔ 98%
SN-38 ✔ 98%
Levofloxacin hydrate ✔ 98%
Dexrazoxane ✔ 99%+
Ofloxacin ✔ 98+%
Enoxacin ✔ 99%+
Flumequine +

Topo II, IC50: 15 μM

 		98%
Levofloxacin ✔ 97%
Etoposide ✔ 98%
Pefloxacin mesylate dihydrate ✔ 99+%
Marbofloxacin ✔ 98+%
Voreloxin HCl ✔ 98%
Mitoxantrone dihydrochloride ✔ PKC 98%
Nalidixic acid ✔ 98%
Doxorubicin ✔ 98%
Novobiocin sodium ✔ 95%
Amonafide ✔ 99%+
Pirarubicin ✔ 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

 		99%+
Genistein ✔ EGFR 98%
Teniposide ✔ 98%
Moxifloxacin ✔ 98%
Ciprofloxacin ✔ 98%
Clinafloxacin ✔ 97%
Gatifloxacin ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Epirubicin HCl ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Doxorubicin 生物活性

靶点

  • Topo II
描述 Doxorubicin is a Topoisomerase II (Top2) catalytic inhibitor, also is a broad spectrum antibiotic used in the treatment of cancers, with IC50 of 374 nM for Hela cells.

Doxorubicin 动物研究

Dose Rat: 1 mg/kg - 3 mg/kg[3] (i.v.); 6 mg/kg - 18 mg/kg[4] (i.p.); 20 mg/kg[5] (i.p.)
Administration i.v., i.p.
Pharmacokinetics
Animal Mice[6] Rats[6]
Dose 10 mg/kg 1 mg/kg
Administration i.v. i.v.
Cmax 2115 ± 61 ng/ml 470 ± 144 ng/ml
AUCinf 2204 ng/ml·h 468 ± 66 ng/ml·h
AUClast 2037 ± 82 ng/ml·h 356 ± 20 ng/ml·h

Doxorubicin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01891539 - Unknown December 2017 Italy ... 展开 >> Azienda Ospedaliera Ospedali Riuniti Marche Nord, Presidio Ospedaliero San Salvatore Recruiting Pesaro, PU, Italy, 61122 Contact: Giammaria Fiorentini, MD    +390721364124    giammaria.fiorentini@ospedalimarchenord.it    Principal Investigator: Giammaria Fiorentini, MD 收起 <<
NCT00815945 Mesenchymal Tumor ... 展开 >> Carcinosarcoma Leiomyosarcoma 收起 << Phase 2 Completed - Germany ... 展开 >> Charité, Campus Virchow Klinikum, Frauenklinik Berlin, Germany, 13353 Malteser Krankenhaus, Gynäkologie und Geburtshilfe Bonn, Germany, 53123 Klinikum Bremen-Mitte gGmbH, Frauenklinik Bremen, Germany, 28177 Universitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe Dresden, Germany, 01307 Evangelisches Krankenhaus Düsseldorf, Frauenklinik Duesseldorf, Germany, 40217 Universitätsklinikum Essen, Frauenklinik Essen, Germany, 45122 Klinikum der J. W. Goethe-Universität, Klinik für Gynäkologie und Geburtshilfe Frankfurt, Germany, 60590 University Hospital Hamburg-Eppendorf Hamburg, Germany, 20251 Gynäkologisch-onkologische Praxis Hannover, Germany, 30177 St. Vincentius Kliniken AG, Frauenklinik Karlsruhe, Germany, 76135 Universitätsklinikum Giessen und Marburg GmbH, Klinik für Gynäkologie, Gynäkologische Endokrinologie und Onkologie Marburg, Germany, 35043 Klinikum Großhadern, Frauenklinik München, Germany, 81377 Universitätsklinikum Tübingen, Frauenklinik Tübingen, Germany, 72076 Universitätsklinikum Ulm, Universitätsfrauenklinik Ulm, Germany, 89075 Dr. Horst Schmidt Kliniken GmbH, Klinik für Gynäkologie und gynäkologische Onkologie Wiesbaden, Germany, 65199 收起 <<
NCT00755261 Sarcoma Soft ... 展开 >>Tissue Sarcoma 收起 << Phase 2 Terminated(The study has been ... 展开 >>terminated due to low accrual.) 收起 << - United States, Maryland ... 展开 >> Johns Hopkins SKCCC Baltimore, Maryland, United States, 21231 收起 <<

Doxorubicin 参考文献

[1]Nitiss JL. Targeting DNA topoisomerase II in cancer chemotherapy. Nat Rev Cancer. 2009 May;9(5):338-50.

[2]El-Zawahry A, McKillop J, Voelkel-Johnson C. Doxorubicin increases the effectiveness of Apo2L/TRAIL for tumor growth inhibition of prostate cancer xenografts. BMC Cancer. 2005 Jan 7;5:2.

[3]Wapstra FH, van Goor H, et al. Dose of doxorubicin determines severity of renal damage and responsiveness to ACE-inhibition in experimental nephrosis. J Pharmacol Toxicol Methods. 1999 Apr-Jun;41(2-3):69-73.

[4]Alshabanah OA, Hafez MM, et al. Doxorubicin toxicity can be ameliorated during antioxidant L-carnitine supplementation. Oxid Med Cell Longev. 2010 Nov-Dec;3(6):428-33. Epub 2010 Nov 1.

[5]Sun XP, Wan LL, et al. Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. Arch Pharm Res. 2017 Jul;40(7):875-883.

[6]Chung SW, Kim GC, et al. Metronomic oral doxorubicin in combination of Chk1 inhibitor MK-8776 for p53-deficient breast cancer treatment. Biomaterials. 2018 Nov;182:35-43.

Doxorubicin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.84mL

0.37mL

0.18mL

9.20mL

1.84mL

0.92mL

18.40mL

3.68mL

1.84mL

Doxorubicin 技术信息

CAS号23214-92-8
分子式C27H29NO11
分子量 543.519
别名 Hydroxydaunorubicin
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,2-8°C
溶解度
动物实验配方

Tags: Doxorubicin | 23214-92-8 | Hydroxydaunorubicin | Topoisomerase Inhibitor | Induced Disease Models Products | Antibody-drug Conjugate/ADC Related | Cell Cycle/DNA Damage | Epigenetics | PI3K/Akt/mTOR | Autophagy | Apoptosis | Anti-infection | Cardiovascular System Disease Models | ADC Cytotoxin | Antibiotic | Bacterial | Topoisomerase | AMPK | HIV | Autophagy | Mitophagy | Apoptosis | HBV | Heart Disease Models | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Doxorubicin 纯度/质量文件 | Doxorubicin 亚型比较 | Doxorubicin 生物活性 | Doxorubicin 动物研究 | Doxorubicin 临床数据 | Doxorubicin 参考文献 | Doxorubicin 实验方案 | Doxorubicin 技术信息

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