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货号 产品名 纯度
A1375194 现货 IMT1B

IMT1B是一种口服活性的线粒体RNA聚合酶(POLRMT) 抑制剂,能够抑制线粒体DNA表达,对抗肿瘤具有潜力。

97%
A467807 现货 Methylproamine

Methylproamine is a DNA-binding radioprotector which, on the basis of published pulse radiolysis studies, acts by repair of transient radiation-induced oxidative species on DNA.

99%+
A1502421 现货 MM41

MM41是一种四聚体 DNA 稳定剂,对 MIA PaCa-2 胰腺癌细胞具有显著的抑制作用,IC50 值低于 10 nM,具有潜在的抗癌应用。

98%
A1937129 现货 Werner syndrome RecQ helicase-IN-3

Werner syndrome RecQ helicase-IN-3是一种口服活性的 WRN 抑制剂,IC50 为 0.06 µM。它能够显示出显著的抗增殖活性,适用于癌症治疗中针对 WRN 的研究,尤其在与抗增殖相关的肿瘤治疗中具有潜力。

98%
A746765 现货 Quarfloxin

Quarfloxin是一种氟喹诺酮类衍生物,具有抗肿瘤活性,其通过干扰核糖体DNA和G-四重螺旋结构相互作用,靶向抑制RNA聚合酶 I 的活性。

95%
A399015 现货 3,4-Dihydroxybenzylamine HBr/3,4-二羟基苄胺氢溴酸盐

3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits DNA polymerase activity in melanoma cells. 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity.

97%
A1365674 现货 Remdesivir nucleoside monophosphate

Remdesivir nucleoside monophosphate是 Remdesivir 的代谢产物,Remdesivir 是一种抗病毒药物,能够有效抑制 SARS-CoVMERS-CoV 的复制,适用于抗病毒药物及新冠病毒治疗的研究。

98%
A408549 现货 2'-O-Methylguanosine/2'-甲氧基鸟苷

2'-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine as a substrate.

98%
A472972 现货 3'-O-Acetylthymidine

3'-O-Acetylthymidine is a useful modified nucleoside.

98%
A724552 现货 HAMNO

HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. It has shown to significantly inhibits colony formation when combined with etoposide.

99%+
A288260 现货 FEN1-IN-4

FEN1 inhibitor C2 is an inhibitor of flap endonuclease 1 (FEN1) which is required for proficient DNA replication and the repair of DNA damage.

99%+
A758913 现货 Branaplam

LMI070 is a highly potent, selective and orally active small molecule SMN2 splicing modulator.

99%+
A115724 现货 5-Bromouridine/5-溴尿苷

5-Bromouridine is used to label RNA in measurement of RNA production.

98%
A1275150 现货 BMVC-8C3O

BMVC-8C3O is a DNA G-quadruplexes (G4s) ligand. It can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s.

98%
A1481278 现货 BVDV-IN-1

BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV) with EC50 value of 1.8μM. It directly binds to a hydrophobic pocket of the BVDV RdRp. BVDV-IN-1 has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC).

99%+
A348408 现货 Triapine/2-[(3-氨基吡啶-2-基)亚甲基]氨基硫脲

Triapine is a ribonucleotide reductase inhibitor and a CDK inhibtor.

99%+
A322509 现货 2'-Deoxycytidine hydrochloride/2'-脱氧胞苷盐酸盐

2'-Deoxyguanosine HCl is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose.

98%
A1441567 现货 NSAH

NSAH是一种非核苷类的核糖核苷酸还原酶(RNR)抑制剂,具有在细胞增殖和癌症治疗中的应用潜力。

98%+
A294505 现货 3’-O-t-Bulyldimethylsilylthymidine

3'-O-(TBDMS)Thymidine is a useful modified nucleoside.

97%
A605561 现货 FEN1-IN-3

FEN1 inhibitor C3 is an inhibitor of flap endonuclease 1 (FEN1) which is required for proficient DNA replication and the repair of DNA damage.

99%+
产品名 DNA synthesis helicase RdRp ribonucleotide reductase tRNA synthetase YB-1 其他靶点 纯度
Fexinidazole 98%
Daptomycin 98%
Blasticidin S·HCl 98%
Metronidazole 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

98%
Triglycidyl isocyanurate p53 98+%
Nedaplatin 99%+
Bendamustine 98+%
Trifluridine 98%
Robinetin 99%+
Carboplatin 99%
Cidofovir 99%
Cisplatin 99%
Cytarabine ++++

DNA synthesis, IC50: 16 nM

98%
Acelarin ++++

DNA synthesis, EC50: 0.2 nM

99%+
Oxaliplatin 98%
YK-4-279 99%+
ML216 +

BLMfull-length, IC50: 2.98 μM

BLM636-1298, IC50: 0.97 μM

99%+
RK-33 98%
Brr2-IN-3 99%+
Phen-DC3 Trifluoromethanesulfonate 98%
Favipiravir 97%
Suramin sodium salt ++

RdRp, IC50: 0.26 μM

99%+
Clofarabine ++

Ribonucleotide reductase, IC50: 65 nM

97%
Didox 98%
(E)-3-AP 97%
Halofuginone +++

prolyl-tRNA synthetase, Ki: 18.3nM

99%+
BC-LI-0186 +++

Leucyl-tRNA synthetase, IC50: 46.11 nM

Leucyl-tRNA synthetase, Kd: 42.1 nM

98%
SU056 +

YB-1, IC50: 1.73 μM

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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