货号:A510593
同义名:
菲宁达
/ Hoe-280;DL8280
Ofloxacin, a fluoroquinolone compound, can inhibit bacterial DNA gyrase.
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产品名称 | Topo I ↓ ↑ | Topo II ↓ ↑ | Topo IV ↓ ↑ | Topoisomerase ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ellagic acid | ✔ | 99%+ | |||||||||||||||||
β-Lapachone | ✔ | 99%+ | |||||||||||||||||
(s)-10-hydroxycamptothecin | ✔ | 99%+ | |||||||||||||||||
Camptothecin |
++
Topo I, IC50: 0.68 μM |
98% | |||||||||||||||||
Betulinic acid |
++
Eukaryotic topoisomerase I, IC50: 5 μM |
99%+ | |||||||||||||||||
Topotecan |
++++
Topo I (DU-145 Luc cells), IC50: 2 nM Topo I (MCF-7 Luc cells), IC50: 13 nM |
99%+ | |||||||||||||||||
Irinotecan HCl Trihydrate | ✔ | 98% | |||||||||||||||||
SN-38 | ✔ | 98% | |||||||||||||||||
Levofloxacin hydrate | ✔ | 99%+ | |||||||||||||||||
Dexrazoxane | ✔ | 99%+ | |||||||||||||||||
Ofloxacin | ✔ | 98+% | |||||||||||||||||
Enoxacin | ✔ | 99%+ | |||||||||||||||||
Flumequine |
+
Topo II, IC50: 15 μM |
99%+ | |||||||||||||||||
Levofloxacin | ✔ | 99%+ | |||||||||||||||||
Etoposide | ✔ | 98% | |||||||||||||||||
Pefloxacin mesylate dihydrate | ✔ | 99+% | |||||||||||||||||
Marbofloxacin | ✔ | 99%+ | |||||||||||||||||
Voreloxin HCl | ✔ | 98% | |||||||||||||||||
Mitoxantrone dihydrochloride | ✔ | PKC | 99%+ | ||||||||||||||||
Nalidixic acid | ✔ | 99%+ | |||||||||||||||||
Doxorubicin | ✔ | 98% | |||||||||||||||||
Novobiocin sodium | ✔ | 98%+ | |||||||||||||||||
Amonafide | ✔ | 99%+ | |||||||||||||||||
Pirarubicin | ✔ | 98%+ | |||||||||||||||||
Idarubicin HCl |
+++
Topo II (MCF-7 cells), IC50: 3.3 ng/mL |
99%+ | |||||||||||||||||
Genistein | ✔ | EGFR | 98% | ||||||||||||||||
Teniposide | ✔ | 98% | |||||||||||||||||
Moxifloxacin | ✔ | 98% | |||||||||||||||||
Ciprofloxacin | ✔ | 99%+ | |||||||||||||||||
Clinafloxacin | ✔ | 97% | |||||||||||||||||
Gatifloxacin | ✔ | 99%+ | |||||||||||||||||
Daunorubicin HCl |
+++
DNA synthesis, Ki: 20 nM |
98% | |||||||||||||||||
Epirubicin HCl | ✔ | 99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Ofloxacin (Hoe-280) is a fluoroquinolone antibiotic primarily acting through the inhibition of bacterial DNA gyrase. It exhibits a broad spectrum of activity against aerobic Gram-negative and Gram-positive bacteria in vitro, but shows limited efficacy against anaerobes[1]. Unlike many other front-line antibacterial drugs that target cell wall or protein synthesis, ofloxacin and other 4-quinolones uniquely interfere with bacterial DNA synthesis, distinguishing their mechanism of action in treating bacterial infections[2]. |
体内研究 | Ofloxacin (Hoe-280) at a dosage of 20 mg/kg, norfloxacin at 40 mg/kg, pefloxacin mesylate dihydrate at 40 mg/kg, and ciprofloxacin at 50 mg/kg are administered by gavage to test animals twice daily for three consecutive weeks. Six weeks post-treatment, the animals are euthanized, and Achilles tendon specimens are harvested for biomechanical testing using a computer-monitored tensile testing machine[3]. |
体外研究 | Ofloxacin (Hoe-280) is a fluoroquinolone antibiotic primarily acting through the inhibition of bacterial DNA gyrase. It exhibits a broad spectrum of activity against aerobic Gram-negative and Gram-positive bacteria in vitro, but shows limited efficacy against anaerobes[1]. Unlike many other front-line antibacterial drugs that target cell wall or protein synthesis, ofloxacin and other 4-quinolones uniquely interfere with bacterial DNA synthesis, distinguishing their mechanism of action in treating bacterial infections[2]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02711943 | - | Completed | - | - | |
NCT00720980 | - | Completed | - | United States, Michigan ... 展开 >> Henry Ford Medical Center Detroit, Michigan, United States, 48202 收起 << | |
NCT00210886 | Urinary Tract Infections ... 展开 >> Pyelonephritis 收起 << | Phase 3 | Completed | - | - |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.77mL 0.55mL 0.28mL |
13.84mL 2.77mL 1.38mL |
27.67mL 5.53mL 2.77mL |
CAS号 | 82419-36-1 |
分子式 | C18H20FN3O4 |
分子量 | 361.37 |
别名 | 菲宁达 ;Hoe-280;DL8280 |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 3 mg/mL(8.3 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |