Flumequine (R-802) acts as a topoisomerase II inhibitor, with an IC50 of 3.92 μg/mL, and inhibits Gyrase less effectively, with an IC50 of 1764 μg/mL. Flumequine (0-625 μg/mL) leads to increased migration of nuclear DNA from CHL cells[1]. Flumequine (R-802) effectively inhibits Spanish field isolates of B. hyodysenteriae with MIC50 and MIC90 of 50 and 100 μg/mL, and MBC50 and MBC90 of 50, 200 μg/mL, respectively[2]. Flumequine (R-802) inhibits A. salmonicida isolates with MIC values ranging from 0.06 to 32 μg/mL[3].
体内研究
Flumequine (R-802) (0-500 mg/kg, p.o.) induces dose-dependent DNA damage in the stomach, colon, and urinary bladder of mice, observable 1 and 3 hours, but not 24 hours post administration[1].
体外研究
Flumequine (R-802) acts as a topoisomerase II inhibitor, with an IC50 of 3.92 μg/mL, and inhibits Gyrase less effectively, with an IC50 of 1764 μg/mL. Flumequine (0-625 μg/mL) leads to increased migration of nuclear DNA from CHL cells[1].
Flumequine (R-802) effectively inhibits Spanish field isolates of B. hyodysenteriae with MIC50 and MIC90 of 50 and 100 μg/mL, and MBC50 and MBC90 of 50, 200 μg/mL, respectively[2].
Flumequine (R-802) inhibits A. salmonicida isolates with MIC values ranging from 0.06 to 32 μg/mL[3].
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