N,3,4-三羟基苯甲酰胺 /Didox
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货号：A107593
同义名：
NSC-324360
Didox can prevent LPS-induced NF-KB activation and translocation of NF-kappa beta p65 subunits.
Didox 化学结构
Didox 3D分子结构
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Didox 纯度/质量文件 产品仅供科研
货号：A107593
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Didox 质控信息
Didox 生物活性
靶点
描述
Didox is a synthetic antioxidant and a potent ribonucleotide reductase (RNR) inhibitor. Didox treatment of mouse bone marrow-derived mast cells (BMMC) reduced IgE-stimulated degranulation and cytokine production, including IL-6, IL-13, TNF and MIP-1a (CCL3). Furthermore, Didox increased expression of the antioxidant genes superoxide dismutase and catalase, and suppressed DCFH-DA fluorescence, indicating reduced reactive oxygen species production[3] [4] [5] [6]
Didox 参考文献
[1] Shah KN, Wilson EA, et al. Targeting Ribonucleotide Reductase M2 and NF-κB Activation with Didox to Circumvent Tamoxifen Resistance in Breast Cancer. Mol Cancer Ther. 2015 Nov;14(11):2411-21.
[2] Abdel-Latif GA, Al-Abd AM, et al. The chemomodulatory effects of resveratrol and didox on herceptin cytotoxicity in breast cancer cell lines. Sci Rep. 2015 Jul 9;5:12054.
[3] McLeod JJA, Caslin HL, Spence AJ, Kolawole EM, Qayum AA, Paranjape A, Taruselli M, Haque TT, Kiwanuka KN, Elford HL, Ryan JJ. Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription. Cell Immunol. 2017 Dec;322:41-48
[4] Cook GJ, Caudell DL, Elford HL, Pardee TS. The efficacy of the ribonucleotide reductase inhibitor Didox in preclinical models of AML. PLoS One. 2014 Nov 17;9(11):e112619
[5] Raje N, Kumar S, Hideshima T, Ishitsuka K, Yasui H, Chhetri S, Vallet S, Vonescu E, Shiraishi N, Kiziltepe T, Elford HL, Munshi NC, Anderson KC. Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells. Br J Haematol. 2006 Oct;135(1):52-61
[6] Matsebatlela TM, Anderson AL, Gallicchio VS, Elford H, Rice CD. 3,4-Dihydroxy-benzohydroxamic acid (Didox) suppresses pro-inflammatory profiles and oxidative stress in TLR4-activated RAW264.7 murine macrophages. Chem Biol Interact. 2015 May 25;233:95-105
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Didox 实验方案
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摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
5.91mL
1.18mL
0.59mL
29.56mL
5.91mL
2.96mL
59.12mL
11.82mL
5.91mL
Didox 技术信息
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