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盐酸柔红霉素 /Daunorubicin HCl {[allProObj[0].p_purity_real_show]}

货号：A148164 同义名： 柔红霉素盐酸盐 / Daunomycin hydrochloride;RP 13057 hydrochloride

Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis.

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Daunorubicin HCl 化学结构 CAS号：23541-50-6
Daunorubicin HCl 化学结构
CAS号：23541-50-6
Daunorubicin HCl 3D分子结构
CAS号：23541-50-6
Daunorubicin HCl 化学结构 CAS号：23541-50-6
Daunorubicin HCl 3D分子结构 CAS号：23541-50-6
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Daunorubicin HCl 纯度/质量文件 产品仅供科研

货号：A148164 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Topo I ↓ Topo II ↓ Topo IV ↓ Topoisomerase ↓ 其他靶点 纯度
Ellagic acid ✔ 98%
β-Lapachone ✔ 99%+
(s)-10-hydroxycamptothecin ✔ 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

 		98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

 		98%
Topotecan ++++

Topo I (MCF-7 Luc cells), IC50: 13 nM

Topo I (DU-145 Luc cells), IC50: 2 nM

 		98%
Irinotecan HCl Trihydrate ✔ 98%
SN-38 ✔ 98%
Levofloxacin hydrate ✔ 98%
Dexrazoxane ✔ 99%+
Ofloxacin ✔ 98+%
Enoxacin ✔ 99%+
Flumequine +

Topo II, IC50: 15 μM

 		98%
Levofloxacin ✔ 97%
Etoposide ✔ 98%
Pefloxacin mesylate dihydrate ✔ 99+%
Marbofloxacin ✔ 98+%
Voreloxin HCl ✔ 98%
Mitoxantrone dihydrochloride ✔ PKC 98%
Nalidixic acid ✔ 98%
Doxorubicin ✔ 98%
Novobiocin sodium ✔ 95%
Amonafide ✔ 99%+
Pirarubicin ✔ 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

 		99%+
Genistein ✔ EGFR 98%
Teniposide ✔ 98%
Moxifloxacin ✔ 98%
Ciprofloxacin ✔ 98%
Clinafloxacin ✔ 97%
Gatifloxacin ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Epirubicin HCl ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Daunorubicin HCl 生物活性

靶点

  • DNA synthesis

    DNA synthesis, Ki:20 nM

  • Topoisomerase

    DNA synthesis, Ki:20 nM
描述 Daunorubicin (Daunomycin) hydrochloride acts as a topoisomerase II inhibitor with strong anti-cancer properties. It disrupts both DNA and RNA synthesis and functions as a cytotoxic agent that reduces cancer cell survival while triggering apoptosis and necrosis. Additionally, Daunorubicin hydrochloride classifies as an anthracycline antibiotic. It is utilized in studying infections and various cancers, such as leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, and Wilms' tumor[1][2][4][5].
体内研究

Daunorubicin hydrochloride, administered via intravenous injection at 3 mg/kg in three doses at 48-hour intervals, causes cardiotoxicity and nephrotoxicity in rats[5].

Daunorubicin hydrochloride (intraperitoneal injection, 10 mg/kg) leads to sister chromatid exchanges in mice[7].
体外研究

Daunorubicin hydrochloride (0-256 μg/mL, 30 min) impedes DNA and RNA synthesis in both sensitive and resistant Ehrlich ascites tumor cells[2].

Daunorubicin hydrochloride (7 nM-1.9 μM, 72 h) demonstrates chemosensitivity in Molt-4 and L3.6 cells[3][4].

Daunorubicin hydrochloride (0.4 μM, 48 h) triggers apoptosis and necrosis in L3.6 cells[4].

Daunorubicin hydrochloride (0.4 μM, 120 min) stimulates the production of reactive oxygen species (ROS) in L3.6 cells[4].

Daunorubicin hydrochloride (2 μM, 24 h) prompts autophagy in K562 cells (a myeloid cell line)[6].

Daunorubicin HCl 细胞研究

细胞系 浓度 检测类型 检测时间 活动说明 数据源
african green monkey Vero cells Cytotoxic assay 3 days Cytotoxicity against african green monkey Vero cells after 3 days by MTS assay, IC50=2.5 μM 21094049
B16 mouse melanoma cells Cytotoxic assay Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in B16 mouse melanoma cells using MTS assay, EC50=0.16 μM 11020285
CCRF-CEM (human lymphoblastic leukemic) cells Growth inhibition assay In vitro growth inhibitory activity against CCRF-CEM (human lymphoblastic leukemic) cells, ID50=0.04 μM 6951049
CEM cells Cytotoxic assay 72 h Cytotoxicity against CEM cells after 72 hrs 17608396

Daunorubicin HCl 参考文献

[1]Lehmann M, et al. Activity of topoisomerase inhibitors daunorubicin, idarubicin, and aclarubicin in the Drosophila Somatic Mutation and Recombination Test. Environ Mol Mutagen. 2004;43(4):250-7.

[2]Dano K, et al. Inhibition of DNA and RNA synthesis by daunorubicin in sensitive and resistant Ehrlich ascites tumor cells in vitro. Cancer Res. 1972 Jun;32(6):1307-14.

[3]Svensson SP, et al. Melanin inhibits cytotoxic effects of Doxorubicin and Daunorubicin in MOLT 4 cells. Pigment Cell Res. 2003 Aug;16(4):351-4

[4]Gervasoni JE Jr, et al. An effective in vitro antitumor response against human pancreatic carcinoma with paclitaxel and Daunorubicin by induction of both necrosis and apoptosis. Anticancer Res. 2004 Sep-Oct;24(5A):2617-26

[5]Arozal W, et al. Telmisartan prevents the progression of renal injury in daunorubicin rats with the alteration of angiotensin II and endothelin-1 receptor expression associated with its PPAR-γ agonist actions. Toxicology. 2011 Jan 11;279(1-3):91-9.

[6]Emeline Bollaert, et al. MiR-15a-5p Confers Chemoresistance in Acute Myeloid Leukemia by Inhibiting Autophagy Induced by Daunorubicin. Int J Mol Sci. 2021 May 13;22(10):5153.

[7]Cheng Wu, et al. Doxorubicin suppresses chondrocyte differentiation by stimulating ROS production. Eur J Pharm Sci. 2021 Dec 1;167:106013.

Daunorubicin HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.87mL

1.77mL

0.89mL

17.73mL

3.55mL

1.77mL

Daunorubicin HCl 技术信息

CAS号23541-50-6
分子式C27H30ClNO10
分子量 563.981
别名 柔红霉素盐酸盐 ;Daunomycin hydrochloride;RP 13057 hydrochloride;RP 13057;Ondena;NDC 0082-4155;Daunorubicin (hydrochloride);RP 13057 HCl;Rubidomycin HCl;Daunorubicin HCl;Rubidomycin hydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

DMSO: 50 mg/mL(88.66 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(53.19 mM)
动物实验配方

Tags: Daunorubicin HCl | Daunorubicin hydrochloride | Daunomycin hydrochloride;RP 13057 hydrochloride;RP 13057;Ondena;NDC 0082-4155;Daunorubicin (hydrochloride);RP 13057 HCl;Rubidomycin HCl;Daunorubicin HCl;Rubidomycin hydrochloride | 柔红霉素盐酸盐 | Apoptosis Inducer | Anti-tumor | Tetracycline | Topoisomerase | AmBeed-信号通路专用抑制剂 | Daunorubicin HCl 纯度/质量文件 | Daunorubicin HCl 亚型比较 | Daunorubicin HCl 生物活性 | Daunorubicin HCl 细胞研究 | Daunorubicin HCl 参考文献 | Daunorubicin HCl 实验方案 | Daunorubicin HCl 技术信息

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