Daunorubicin HCl | Daunorubicin hydrochloride | Daunomycin hydrochloride;RP 13057 hydrochloride;RP 13057;Ondena;NDC 0082-4155;Daunorubicin (hydrochloride);RP 13057 HCl;Rubidomycin HCl;Daunorubicin HCl;Rubidomycin hydrochloride | 柔红霉素盐酸盐 | Apoptosis Inducer | Anti-tumor | Tetracycline | Topoisomerase

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盐酸柔红霉素 /Daunorubicin HCl 98%

货号：A148164 同义名： 柔红霉素盐酸盐 / Daunomycin hydrochloride;RP 13057 hydrochloride

Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis.

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Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Daunorubicin HCl 化学结构
CAS号：23541-50-6

Daunorubicin HCl 3D分子结构
CAS号：23541-50-6

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Daunorubicin HCl 纯度/质量文件产品仅供科研

货号：A148164 标准纯度： 98% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024. Ambeed. [ A288696 ]; • JMC, 2024. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

拓扑异构酶亚型比较

产品名称	Topo I ↓ ↑	Topo II ↓ ↑	Topo IV ↓ ↑	Topoisomerase ↓ ↑	其他靶点	纯度
Ellagic acid	✔					99%+
β-Lapachone	✔					99%+
(s)-10-hydroxycamptothecin	✔					99%+
Camptothecin	++ Topo I, IC50: 0.68 μM					98%
Betulinic acid	++ Eukaryotic topoisomerase I, IC50: 5 μM					99%+
Topotecan	++++ Topo I (DU-145 Luc cells), IC50: 2 nM Topo I (MCF-7 Luc cells), IC50: 13 nM					99%+
Irinotecan HCl Trihydrate	✔					98%
SN-38	✔					98%
Levofloxacin hydrate		✔				99%+
Dexrazoxane		✔				99%+
Ofloxacin		✔				98+%
Enoxacin		✔				99%+
Flumequine		+ Topo II, IC50: 15 μM				99%+
Levofloxacin		✔				99%+
Etoposide		✔				98%
Pefloxacin mesylate dihydrate		✔				99+%
Marbofloxacin		✔				99%+
Voreloxin HCl		✔				98%
Mitoxantrone dihydrochloride		✔			PKC	99%+
Nalidixic acid		✔				99%+
Doxorubicin		✔				98%
Novobiocin sodium		✔				98%+
Amonafide		✔				99%+
Pirarubicin		✔				98%+
Idarubicin HCl		+++ Topo II (MCF-7 cells), IC50: 3.3 ng/mL				99%+
Genistein		✔			EGFR	98%
Teniposide		✔				98%
Moxifloxacin		✔				98%
Ciprofloxacin			✔			99%+
Clinafloxacin			✔			97%
Gatifloxacin				✔		99%+
Daunorubicin HCl				+++ DNA synthesis, Ki: 20 nM		98%
Epirubicin HCl				✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Daunorubicin HCl 生物活性

靶点	DNA synthesis DNA synthesis, Ki:20 nM Topoisomerase DNA synthesis, Ki:20 nM
描述	Daunorubicin (Daunomycin) hydrochloride acts as a topoisomerase II inhibitor with strong anti-cancer properties. It disrupts both DNA and RNA synthesis and functions as a cytotoxic agent that reduces cancer cell survival while triggering apoptosis and necrosis. Additionally, Daunorubicin hydrochloride classifies as an anthracycline antibiotic. It is utilized in studying infections and various cancers, such as leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, and Wilms' tumor^[1]^[2]^[4]^[5].
体内研究	Daunorubicin hydrochloride, administered via intravenous injection at 3 mg/kg in three doses at 48-hour intervals, causes cardiotoxicity and nephrotoxicity in rats^[5]. Daunorubicin hydrochloride (intraperitoneal injection, 10 mg/kg) leads to sister chromatid exchanges in mice^[7].
体外研究	Daunorubicin hydrochloride (0-256 μg/mL, 30 min) impedes DNA and RNA synthesis in both sensitive and resistant Ehrlich ascites tumor cells^[2]. Daunorubicin hydrochloride (7 nM-1.9 μM, 72 h) demonstrates chemosensitivity in Molt-4 and L3.6 cells^[3]^[4]. Daunorubicin hydrochloride (0.4 μM, 48 h) triggers apoptosis and necrosis in L3.6 cells^[4]. Daunorubicin hydrochloride (0.4 μM, 120 min) stimulates the production of reactive oxygen species (ROS) in L3.6 cells^[4]. Daunorubicin hydrochloride (2 μM, 24 h) prompts autophagy in K562 cells (a myeloid cell line)^[6].

Daunorubicin HCl 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
african green monkey Vero cells		Cytotoxic assay	3 days	Cytotoxicity against african green monkey Vero cells after 3 days by MTS assay, IC50=2.5 μM	21094049
B16 mouse melanoma cells		Cytotoxic assay		Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in B16 mouse melanoma cells using MTS assay, EC50=0.16 μM	11020285
CCRF-CEM (human lymphoblastic leukemic) cells		Growth inhibition assay		In vitro growth inhibitory activity against CCRF-CEM (human lymphoblastic leukemic) cells, ID50=0.04 μM	6951049
CEM cells		Cytotoxic assay	72 h	Cytotoxicity against CEM cells after 72 hrs	17608396

Daunorubicin HCl 参考文献

[1]Lehmann M, et al. Activity of topoisomerase inhibitors daunorubicin, idarubicin, and aclarubicin in the Drosophila Somatic Mutation and Recombination Test. Environ Mol Mutagen. 2004;43(4):250-7.

[2]Dano K, et al. Inhibition of DNA and RNA synthesis by daunorubicin in sensitive and resistant Ehrlich ascites tumor cells in vitro. Cancer Res. 1972 Jun;32(6):1307-14.

[3]Svensson SP, et al. Melanin inhibits cytotoxic effects of Doxorubicin and Daunorubicin in MOLT 4 cells. Pigment Cell Res. 2003 Aug;16(4):351-4

[4]Gervasoni JE Jr, et al. An effective in vitro antitumor response against human pancreatic carcinoma with paclitaxel and Daunorubicin by induction of both necrosis and apoptosis. Anticancer Res. 2004 Sep-Oct;24(5A):2617-26

[5]Arozal W, et al. Telmisartan prevents the progression of renal injury in daunorubicin rats with the alteration of angiotensin II and endothelin-1 receptor expression associated with its PPAR-γ agonist actions. Toxicology. 2011 Jan 11;279(1-3):91-9.

[6]Emeline Bollaert, et al. MiR-15a-5p Confers Chemoresistance in Acute Myeloid Leukemia by Inhibiting Autophagy Induced by Daunorubicin. Int J Mol Sci. 2021 May 13;22(10):5153.

[7]Cheng Wu, et al. Doxorubicin suppresses chondrocyte differentiation by stimulating ROS production. Eur J Pharm Sci. 2021 Dec 1;167:106013.

Daunorubicin HCl 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.87mL

1.77mL

0.89mL

17.73mL

3.55mL

1.77mL

Daunorubicin HCl 技术信息

CAS号	23541-50-6
分子式	C₂₇H₃₀ClNO₁₀
分子量	563.981

别名	柔红霉素盐酸盐 ;Daunomycin hydrochloride;RP 13057 hydrochloride;RP 13057;Ondena;NDC 0082-4155;Daunorubicin (hydrochloride);RP 13057 HCl;Rubidomycin HCl;Daunorubicin HCl;Rubidomycin hydrochloride
运输	蓝冰

存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 50 mg/mL(88.66 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 30 mg/mL(53.19 mM)

动物实验配方

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

african green monkey Vero cells		Cytotoxic assay	3 days	Cytotoxicity against african green monkey Vero cells after 3 days by MTS assay, IC50=2.5 μM	21094049
B16 mouse melanoma cells		Cytotoxic assay		Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in B16 mouse melanoma cells using MTS assay, EC50=0.16 μM	11020285
CCRF-CEM (human lymphoblastic leukemic) cells		Growth inhibition assay		In vitro growth inhibitory activity against CCRF-CEM (human lymphoblastic leukemic) cells, ID50=0.04 μM	6951049
CEM cells		Cytotoxic assay	72 h	Cytotoxicity against CEM cells after 72 hrs	17608396
Dx5 cell lines		Growth inhibition assay		The compound was evaluated for the growth inhibition of Dx5 cell lines using MTT assay, ic50=2 μM	10698449
Dx5 w/PSC cell lines		Growth inhibition assay		The compound was evaluated for the growth inhibition of Dx5 w/PSC cell lines using MTT assay, IC50=14 nM	10698449
HL60 cells		Function assay		In vitro inhibitory concentration against proliferation of HL60 cells, IC50=0.005 μM	12877593
HL60 cells		Function assay		In vitro concentration required to induce apoptosis in HL60 cells, AC50=0.04 μM	12877593
HOS cells		Cytotoxic assay	72 h	Cytotoxicity against HOS cells after 72 hrs	17608396
human A2780 cells		Cytotoxic assay	72 h	Cytotoxicity against human A2780 cells after 72 hrs by MTT assay, IC50=0.11749 μM	17890094
human A2780/ADR cells		Cytotoxic assay	72 h	Cytotoxicity against human A2780/ADR cells after 72 hrs by MTT assay, IC50=18.6209 μM	17890094
human A549 cells		Cytotoxic assay		Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay, GI50=0.08 μM	19968258
human breast carcinoma line cells		Function assay		compound was tested in vitro for inhibition activity against a sensitive human breast carcinoma line cells, IC50=0.06 μM	9258351
human CRL7761 cells		Cytotoxic assay	3 days	Cytotoxicity against human CRL7761 cells after 3 days by MTS assay, IC50=10.5 μM	21094049
human Detroit 551 cells		Cytotoxic assay	72 h	Cytotoxicity against human Detroit 551 cells after 72 hrs by XTT assay, GI50=1.77 μM	20591678
human DU145 cells		Proliferation assay	72 h	Antiproliferative activity against human DU145 cells after 72 hrs by MTS assay, IC50=0.09 μM	22260166
human epidermoid carcinoma cell line KB-3-1		Cytotoxic assay		In vitro cytotoxic activity was evaluated using the human epidermoid carcinoma cell line KB-3-1, IC50=7 nM	12443763
human ES2 cells		Cytotoxic assay	24 h	Cytotoxicity against human ES2 cells after 24 hrs by XTT assay, IC50=25.5 μM	24900668
human fibroblast (NHF) cells		Cytotoxic assay		Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in normal human fibroblast (NHF) cells using MTS assay, EC50=0.22 μM	11020285
human G361 cells		Cytotoxic assay	72 h	Cytotoxicity against human G361 cells after 72 hrs	17608396
human H1299 cells		Proliferation assay		Antiproliferative activity against human H1299 cells by XTT assay, IC50=0.096 μM	25467291
human HeLa3 cell line		Cytotoxic assay		Cytotoxicity against human HeLa3 cell line by MTT assay, IC50=2.96 μM	16942037
human HepG2 cells		Cytotoxic assay	24 h	Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay, IC50=0.7 μM	21094049
human HL60 cells		Cytotoxic assay	48 h	Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by trypan blue staining-based hemocytometric analysis, GI50=0.1 μM	25874335
human HT-29 cells		Cytotoxic assay	72 h	Cytotoxicity against human HT-29 cells after 72 hrs by sulforhodamine B assay, GI50=0.07 μM	19968258
human HT-29 cells		Proliferation assay	96 h	Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay, IC50=0.133 μM	2778449
human K562 cells		Cytotoxic assay	72 h	Cytotoxicity against human K562 cells after 72 hrs by XTT assay, GI50=7.4 nM	20591678
human KB cells		Cytotoxic assay	48 h	Cytotoxicity against human KB cells after 48 hrs by MTT assay, IC50=0.64 μM	20363142
human LNCAP cells		Cytotoxic assay	4 days	Cytostatic activity against human LNCAP cells after 4 days by MTT assay, IC50=0.1 μM	22480495
human MCF7 cells		Cytotoxic assay	4 days	Cytostatic activity against human MCF7 cells after 4 days by MTT assay, IC50=0.4 μM	22480495
human MCF7 cells		Cytotoxic assay	72 h	Cytotoxicity against human MCF7 cells after 72 hrs by XTT assay, GI50=0.86 μM	20591678
human MDA-MB-231 cells		Cytotoxic assay	72 h	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay, GI50=0.02 μM	19968258
human MDA-MB-231 cells		Proliferation assay		Antiproliferative activity against human MDA-MB-231 cells by XTT assay, IC50=0.091 μM	25467291
human MRC5 cells		Proliferation assay		Antiproliferative activity against human MRC5 cells by XTT assay, IC50=0.078 μM	25467291
human MRC5 cells		Proliferation assay		Antiproliferative activity against human MRC5 cells, IC50=0.88 μM	21599000
human NCI-H460 cells		Function assay		Anticancer activity against human NCI-H460 cells, IC50=0.38 μM	21599000
human prostate cancer HTB-81 cells		Cytotoxic assay		Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in human prostate cancer HTB-81 cells using MTS assay, EC50=0.058 μM	11020285
human SF268 cells		Function assay		Anticancer activity against human SF268 cells, IC50=0.6 μM	21599000
human SKMES1 cells		Proliferation assay	72 h	Antiproliferative activity against human SKMES1 cells after 72 hrs by MTS assay, IC50=0.17 μM	22260166
human SKOV3 cells		Cytotoxic assay	24 h	Cytotoxicity against human SKOV3 cells after 24 hrs by XTT assay, IC50=20.6 μM	24900668
human uterine sarcoma cell line MES-SA		Cytotoxic assay		In vitro cytotoxic activity was evaluated using the human uterine sarcoma cell line MES-SA, IC50=0.07 μM	12443763
Jurkat T lymphocytes		Cytotoxic assay		Cytotoxicity against Jurkat T lymphocytes by MTT assay, IC50=0.0826 μM	16366602
MCF-7 cells		Cytotoxic assay		Compound was tested for its toxicity against human breast cancer cells(MCF-7), IC50=0.06 μM	9548820
MDA MB 361(mammary carcinoma cell line)		Cytotoxic assay		The compound was tested for intracellular cytotoxicity against MDA MB 361(mammary carcinoma cell line) expressing LacZ (beta-galactosidase), IC50=17 nM	10395490
MDA435/LCC6 cells		Proliferation assay		Antiproliferative activity against MDA435/LCC6 cells by ELISA, IC50=0.079 μM	17154505
MDA435/LCC6 cells		Proliferation assay		Antiproliferative activity against multidrug resistant MDA435/LCC6 cells by ELISA, IC50=0.977 μM	17154505
MES-SA uterine tumor cell lines		Growth inhibition assay		The compound was evaluated for the growth inhibition of MES-SA uterine tumor cell lines using MTT assay, IC50=0.021 μM	10698449
mouse DA-3 cells		Cytotoxic assay	24 h	Cytotoxicity against mouse DA-3 cells after 24 hrs by XTT assay, IC50=1.9 μM	24900668
mouse DA-3 cells	20 μM	Cytotoxic assay	60 mins	Cytotoxicity against mouse DA-3 cells assessed as reduction in cell viability at 20 uM after 60 mins by XTT assay	24900668
mouse L1210 cells		Function assay		Inhibition of RNA synthesis in mouse L1210 cells, ED50=0.23 μM	690999
mouse L5178Y cells		Cytotoxic assay	24 h	Cytotoxicity against mouse L5178Y cells after 24 hrs by MTT assay, IC50=0.72 μM	23199479
mouse L5178Y cells		Cytotoxic assay	24 h	Cytotoxicity against mouse L5178Y cells expressing p-gp after 24 hrs by MTT assay, IC50=7.73 μM	23199479
mouse NIH/3T3 cells		Cytotoxic assay	72 h	Intrinsic cytotoxicity against wild type mouse NIH/3T3 cells after 72 hrs by MTT assay, IC50=0.044 μM	18954040
mouse NIH/3T3 cells		Cytotoxic assay	72 h	Intrinsic cytotoxicity against mouse NIH/3T3 cells overexpressing MDR1 after 72 hrs by MTT assay, IC50=1.01 μM	18954040
murine L1210 leukemia cells		Function assay		Inhibitory activity was measured against murine L1210 leukemia cells, IC50=30 nM	9733483
NCI-H69 cell line		Proliferation assay		Antiproliferative activity against drug sensitive NCI-H69 cell line by Alamar Blue assay, IC50=0.1 μM	17286393
P388 leukemia cell line		Cytotoxic assay		Compound was evaluated for cytotoxicity against P388 leukemia cell line, IC50=3 nM	10479297

盐酸柔红霉素 /Daunorubicin HCl 98%

Daunorubicin HCl 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Daunorubicin HCl 质控信息

Daunorubicin HCl 生物活性

Daunorubicin HCl 细胞研究

Daunorubicin HCl 参考文献

Daunorubicin HCl 实验方案

Daunorubicin HCl 技术信息

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DNA synthesis	DNA synthesis, Ki:20 nM
Topoisomerase	DNA synthesis, Ki:20 nM

盐酸柔红霉素 /Daunorubicin HCl 98%

Daunorubicin HCl 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Daunorubicin HCl 质控信息

Daunorubicin HCl 生物活性

Daunorubicin HCl 细胞研究

Daunorubicin HCl 参考文献

Daunorubicin HCl 实验方案

Daunorubicin HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Daunorubicin HCl 纯度/质量文件产品仅供科研