货号:A148164
同义名:
柔红霉素盐酸盐
/ Daunomycin hydrochloride;RP 13057 hydrochloride
Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis.
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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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产品名称 | Topo I ↓ ↑ | Topo II ↓ ↑ | Topo IV ↓ ↑ | Topoisomerase ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ellagic acid | ✔ | 99%+ | |||||||||||||||||
β-Lapachone | ✔ | 99%+ | |||||||||||||||||
(s)-10-hydroxycamptothecin | ✔ | 99%+ | |||||||||||||||||
Camptothecin |
++
Topo I, IC50: 0.68 μM |
98% | |||||||||||||||||
Betulinic acid |
++
Eukaryotic topoisomerase I, IC50: 5 μM |
99%+ | |||||||||||||||||
Topotecan |
++++
Topo I (DU-145 Luc cells), IC50: 2 nM Topo I (MCF-7 Luc cells), IC50: 13 nM |
99%+ | |||||||||||||||||
Irinotecan HCl Trihydrate | ✔ | 98% | |||||||||||||||||
SN-38 | ✔ | 98% | |||||||||||||||||
Levofloxacin hydrate | ✔ | 99%+ | |||||||||||||||||
Dexrazoxane | ✔ | 99%+ | |||||||||||||||||
Ofloxacin | ✔ | 98+% | |||||||||||||||||
Enoxacin | ✔ | 99%+ | |||||||||||||||||
Flumequine |
+
Topo II, IC50: 15 μM |
99%+ | |||||||||||||||||
Levofloxacin | ✔ | 99%+ | |||||||||||||||||
Etoposide | ✔ | 98% | |||||||||||||||||
Pefloxacin mesylate dihydrate | ✔ | 99+% | |||||||||||||||||
Marbofloxacin | ✔ | 99%+ | |||||||||||||||||
Voreloxin HCl | ✔ | 98% | |||||||||||||||||
Mitoxantrone dihydrochloride | ✔ | PKC | 99%+ | ||||||||||||||||
Nalidixic acid | ✔ | 99%+ | |||||||||||||||||
Doxorubicin | ✔ | 98% | |||||||||||||||||
Novobiocin sodium | ✔ | 98%+ | |||||||||||||||||
Amonafide | ✔ | 99%+ | |||||||||||||||||
Pirarubicin | ✔ | 98%+ | |||||||||||||||||
Idarubicin HCl |
+++
Topo II (MCF-7 cells), IC50: 3.3 ng/mL |
99%+ | |||||||||||||||||
Genistein | ✔ | EGFR | 98% | ||||||||||||||||
Teniposide | ✔ | 98% | |||||||||||||||||
Moxifloxacin | ✔ | 98% | |||||||||||||||||
Ciprofloxacin | ✔ | 99%+ | |||||||||||||||||
Clinafloxacin | ✔ | 97% | |||||||||||||||||
Gatifloxacin | ✔ | 99%+ | |||||||||||||||||
Daunorubicin HCl |
+++
DNA synthesis, Ki: 20 nM |
98% | |||||||||||||||||
Epirubicin HCl | ✔ | 99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Daunorubicin (Daunomycin) hydrochloride acts as a topoisomerase II inhibitor with strong anti-cancer properties. It disrupts both DNA and RNA synthesis and functions as a cytotoxic agent that reduces cancer cell survival while triggering apoptosis and necrosis. Additionally, Daunorubicin hydrochloride classifies as an anthracycline antibiotic. It is utilized in studying infections and various cancers, such as leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, and Wilms' tumor[1][2][4][5]. |
体内研究 | Daunorubicin hydrochloride, administered via intravenous injection at 3 mg/kg in three doses at 48-hour intervals, causes cardiotoxicity and nephrotoxicity in rats[5]. Daunorubicin hydrochloride (intraperitoneal injection, 10 mg/kg) leads to sister chromatid exchanges in mice[7]. |
体外研究 | Daunorubicin hydrochloride (0-256 μg/mL, 30 min) impedes DNA and RNA synthesis in both sensitive and resistant Ehrlich ascites tumor cells[2]. Daunorubicin hydrochloride (7 nM-1.9 μM, 72 h) demonstrates chemosensitivity in Molt-4 and L3.6 cells[3][4]. Daunorubicin hydrochloride (0.4 μM, 48 h) triggers apoptosis and necrosis in L3.6 cells[4]. Daunorubicin hydrochloride (0.4 μM, 120 min) stimulates the production of reactive oxygen species (ROS) in L3.6 cells[4]. Daunorubicin hydrochloride (2 μM, 24 h) prompts autophagy in K562 cells (a myeloid cell line)[6]. |
细胞系 | 浓度 | 检测类型 | 检测时间 | 活动说明 | 数据源 |
african green monkey Vero cells | Cytotoxic assay | 3 days | Cytotoxicity against african green monkey Vero cells after 3 days by MTS assay, IC50=2.5 μM | 21094049 | |
B16 mouse melanoma cells | Cytotoxic assay | Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in B16 mouse melanoma cells using MTS assay, EC50=0.16 μM | 11020285 | ||
CCRF-CEM (human lymphoblastic leukemic) cells | Growth inhibition assay | In vitro growth inhibitory activity against CCRF-CEM (human lymphoblastic leukemic) cells, ID50=0.04 μM | 6951049 | ||
CEM cells | Cytotoxic assay | 72 h | Cytotoxicity against CEM cells after 72 hrs | 17608396 | |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.77mL 0.35mL 0.18mL |
8.87mL 1.77mL 0.89mL |
17.73mL 3.55mL 1.77mL |
CAS号 | 23541-50-6 |
分子式 | C27H30ClNO10 |
分子量 | 563.981 |
别名 | 柔红霉素盐酸盐 ;Daunomycin hydrochloride;RP 13057 hydrochloride;RP 13057;Ondena;NDC 0082-4155;Daunorubicin (hydrochloride);RP 13057 HCl;Rubidomycin HCl;Daunorubicin HCl;Rubidomycin hydrochloride |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 50 mg/mL(88.66 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 30 mg/mL(53.19 mM) |
动物实验配方 |