货号:A174646
同义名:
依托泊甘
/ VP-16;VP-16-213
Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 = 60.3 μM).
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产品名称 | Topo I ↓ ↑ | Topo II ↓ ↑ | Topo IV ↓ ↑ | Topoisomerase ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ellagic acid | ✔ | 99%+ | |||||||||||||||||
β-Lapachone | ✔ | 99%+ | |||||||||||||||||
(s)-10-hydroxycamptothecin | ✔ | 99%+ | |||||||||||||||||
Camptothecin |
++
Topo I, IC50: 0.68 μM |
98% | |||||||||||||||||
Betulinic acid |
++
Eukaryotic topoisomerase I, IC50: 5 μM |
99%+ | |||||||||||||||||
Topotecan |
++++
Topo I (DU-145 Luc cells), IC50: 2 nM Topo I (MCF-7 Luc cells), IC50: 13 nM |
99%+ | |||||||||||||||||
Irinotecan HCl Trihydrate | ✔ | 98% | |||||||||||||||||
SN-38 | ✔ | 98% | |||||||||||||||||
Levofloxacin hydrate | ✔ | 99%+ | |||||||||||||||||
Dexrazoxane | ✔ | 99%+ | |||||||||||||||||
Ofloxacin | ✔ | 98+% | |||||||||||||||||
Enoxacin | ✔ | 99%+ | |||||||||||||||||
Flumequine |
+
Topo II, IC50: 15 μM |
99%+ | |||||||||||||||||
Levofloxacin | ✔ | 99%+ | |||||||||||||||||
Etoposide | ✔ | 98% | |||||||||||||||||
Pefloxacin mesylate dihydrate | ✔ | 99+% | |||||||||||||||||
Marbofloxacin | ✔ | 99%+ | |||||||||||||||||
Voreloxin HCl | ✔ | 98% | |||||||||||||||||
Mitoxantrone dihydrochloride | ✔ | PKC | 99%+ | ||||||||||||||||
Nalidixic acid | ✔ | 99%+ | |||||||||||||||||
Doxorubicin | ✔ | 98% | |||||||||||||||||
Novobiocin sodium | ✔ | 98%+ | |||||||||||||||||
Amonafide | ✔ | 99%+ | |||||||||||||||||
Pirarubicin | ✔ | 98%+ | |||||||||||||||||
Idarubicin HCl |
+++
Topo II (MCF-7 cells), IC50: 3.3 ng/mL |
99%+ | |||||||||||||||||
Genistein | ✔ | EGFR | 98% | ||||||||||||||||
Teniposide | ✔ | 98% | |||||||||||||||||
Moxifloxacin | ✔ | 98% | |||||||||||||||||
Ciprofloxacin | ✔ | 99%+ | |||||||||||||||||
Clinafloxacin | ✔ | 97% | |||||||||||||||||
Gatifloxacin | ✔ | 99%+ | |||||||||||||||||
Daunorubicin HCl |
+++
DNA synthesis, Ki: 20 nM |
98% | |||||||||||||||||
Epirubicin HCl | ✔ | 99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Etoposide (VP-16; VP-16-213) is an anticancer chemotherapeutic agent. It functions by inhibiting topoisomerase II, thereby halting DNA replication. Etoposide induces cell cycle arrest, apoptosis, and autophagy [1]. |
体内研究 | Etoposide (50 μM) and Anti-Human VEGF-treated hypoxic cells, when injected intravenously into immunodeficient mice, demonstrate decreased ability to form lung colonies, which also occur after a prolonged latency period [2]. Etoposide (10 mg/kg/day, i.v.) in combination with NSC 109724 and NSC 241240, decreases tumor volume in NMRI nude mice injected with hepatoblastoma cells [3]. |
体外研究 | Etoposide induces cytotoxicity in pancreatic β-cells by activating apoptosis through the JNK/ERK-mediated GSK-3 downstream signaling pathway in RIN-m5F cells [1]. Etoposide and Anti-Human VEGF effectively eliminate the P1 sphere-forming capacity, which is linked to apoptosis in this cell subset [2]. Etoposide phosphate (0-1μM; 72 hours) inhibits HCT116 cells with different genotypes (FBXW+/+, FBXW-/-, and p53-/-) in a dose-dependent manner, demonstrating IC50 values of 0.945 μM, 0.375 μM, and 1.437 μM, respectively [5]. Etoposide (25 μM; 6 hours) delays p53 recovery in FBXW7-deficient cells. Moreover, FBXW7 expression is absent in FBXW7-/- cells [5]. |
细胞系 | 浓度 | 检测类型 | 检测时间 | 活动说明 | 数据源 |
A549 | Growth Inhibition Assay | 48 h | IC50=241.9 ± 31.23 μM | 24996136 | |
A549 | Growth Inhibition Assay | 48 h | IC50=139.54 ± 7.05 μM | 24793877 | |
BGC-823 | Growth Inhibition Assay | 48 h | IC50=43.74 ± 5.13 μM | 24793877 | |
Caco2 | 0.5-2.5 μM | Growth Inhibition Assay | 48 h | IC50=7.26 ± 1.68 μM | 25746763 |
Dose | Mice: 19 mg/kg[3] (i.p.) |
Administration | i.p. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.70mL 0.34mL 0.17mL |
8.50mL 1.70mL 0.85mL |
16.99mL 3.40mL 1.70mL |
CAS号 | 33419-42-0 |
分子式 | C29H32O13 |
分子量 | 588.557 |
别名 | 依托泊甘 ;VP-16;VP-16-213;Demethyl Epipodophyllotoxin Ethylidine Glucoside. epipodophyllotoxin. US brand names: Toposar. VePesid. Foreign brand name: Lastet. Abbreviation: EPEG Code names: VP16;VP-16-123;NSC 141540;EPE |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 40 mg/mL(67.96 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |
5% DMSO+40% PEG 300+5% Tween 80+water 15 mg/mL |