Etoposide | VP-16;VP-16-213;Demethyl Epipodophyllotoxin Ethylidine Glucoside. epipodophyllotoxin. US brand names: Toposar. VePesid. Foreign brand name: Lastet. Abbreviation: EPEG Code names: VP16;VP-16-123;NSC 141540;EPE | 依托泊甘 | Apoptosis Inducer | Drug Standard | DNA Topoisomerase II Inhibitor | Topoisomerase

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依托泊苷 /Etoposide {[allProObj[0].p_purity_real_show]}

货号：A174646 同义名： 依托泊甘 / VP-16;VP-16-213

Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 = 60.3 μM).

Etoposide 化学结构
CAS号：33419-42-0

Etoposide 3D分子结构
CAS号：33419-42-0

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Etoposide 纯度/质量文件产品仅供科研

货号：A174646 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell Host Microbe, 2024. Ambeed. [ A163338 ]; • Cancer Res., 2024. Ambeed. [ A295334 ]; • J. Pharm. Investig., 2024. Ambeed. [ A221527 , A691302 , A272538 , A187261 ]; • J. Fungi, 2024, 10(11): 751. Ambeed. [ A796919 ]; • JBC, 2024, 107935. Ambeed. [ A194396 ]; 更多 >

拓扑异构酶亚型比较

产品名称	Topo I ↓ ↑	Topo II ↓ ↑	Topo IV ↓ ↑	Topoisomerase ↓ ↑	其他靶点	纯度
Ellagic acid	✔					98%
β-Lapachone	✔					99%+
(s)-10-hydroxycamptothecin	✔					98+%
Camptothecin	++ Topo I, IC50: 0.68 μM					98%
Betulinic acid	++ Eukaryotic topoisomerase I, IC50: 5 μM					98%
Topotecan	++++ Topo I (MCF-7 Luc cells), IC50: 13 nM Topo I (DU-145 Luc cells), IC50: 2 nM					98%
Irinotecan HCl Trihydrate	✔					98%
SN-38	✔					98%
Levofloxacin hydrate		✔				98%
Dexrazoxane		✔				99%+
Ofloxacin		✔				98+%
Enoxacin		✔				99%+
Flumequine		+ Topo II, IC50: 15 μM				98%
Levofloxacin		✔				97%
Etoposide		✔				98%
Pefloxacin mesylate dihydrate		✔				99+%
Marbofloxacin		✔				98+%
Voreloxin HCl		✔				98%
Mitoxantrone dihydrochloride		✔			PKC	98%
Nalidixic acid		✔				98%
Doxorubicin		✔				98%
Novobiocin sodium		✔				95%
Amonafide		✔				99%+
Pirarubicin		✔				98%+
Idarubicin HCl		+++ Topo II (MCF-7 cells), IC50: 3.3 ng/mL				99%+
Genistein		✔			EGFR	98%
Teniposide		✔				98%
Moxifloxacin		✔				98%
Ciprofloxacin			✔			98%
Clinafloxacin			✔			97%
Gatifloxacin				✔		98%
Daunorubicin HCl				+++ DNA synthesis, Ki: 20 nM		98%
Epirubicin HCl				✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Etoposide 生物活性

靶点	Topo II
描述	Etoposide (VP-16; VP-16-213) is an anticancer chemotherapeutic agent. It functions by inhibiting topoisomerase II, thereby halting DNA replication. Etoposide induces cell cycle arrest, apoptosis, and autophagy ^[1].
体内研究	Etoposide (50 μM) and Anti-Human VEGF-treated hypoxic cells, when injected intravenously into immunodeficient mice, demonstrate decreased ability to form lung colonies, which also occur after a prolonged latency period ^[2]. Etoposide (10 mg/kg/day, i.v.) in combination with NSC 109724 and NSC 241240, decreases tumor volume in NMRI nude mice injected with hepatoblastoma cells ^[3].
体外研究	Etoposide induces cytotoxicity in pancreatic β-cells by activating apoptosis through the JNK/ERK-mediated GSK-3 downstream signaling pathway in RIN-m5F cells ^[1]. Etoposide and Anti-Human VEGF effectively eliminate the P1 sphere-forming capacity, which is linked to apoptosis in this cell subset ^[2]. Etoposide phosphate (0-1μM; 72 hours) inhibits HCT116 cells with different genotypes (FBXW+/+, FBXW-/-, and p53-/-) in a dose-dependent manner, demonstrating IC50 values of 0.945 μM, 0.375 μM, and 1.437 μM, respectively ^[5]. Etoposide (25 μM; 6 hours) delays p53 recovery in FBXW7-deficient cells. Moreover, FBXW7 expression is absent in FBXW7-/- cells ^[5].

Etoposide 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
A549		Growth Inhibition Assay	48 h	IC50=241.9 ± 31.23 μM	24996136
A549		Growth Inhibition Assay	48 h	IC50=139.54 ± 7.05 μM	24793877
BGC-823		Growth Inhibition Assay	48 h	IC50=43.74 ± 5.13 μM	24793877
Caco2	0.5-2.5 μM	Growth Inhibition Assay	48 h	IC50=7.26 ± 1.68 μM	25746763

Etoposide 动物研究

Dose	Mice: 19 mg/kg^[3] (i.p.)
Administration	i.p.

Etoposide 参考文献

[1]Lee KI, et al. Etoposide induces pancreatic β-cells cytotoxicity via the JNK/ERK/GSK-3 signaling-mediated mitochondria-dependent apoptosis pathway. Toxicol In Vitro. 2016 Jul 26. pii: S0887-2333(16)30147-3.

[2]Calvani M, det al. Etoposide-Anti-Human VEGF a new strategy against human melanoma cells expressing stem-like traits. Oncotarget. 2016 Jun 9. doi: 10.18632/oncotarget.9939.

[3]Fuchs, J., et al. Comparative activity of NSC 119875, NSC 109724, NSC 123127, NSC 241240, and etoposide in heterotransplanted hepatoblastoma. Cancer, 1998. 83(11): p. 2400-7.

[4]Cui D, et al. FBXW7 Confers Radiation Survival by Targeting p53 for Degradation.Cell Rep. 2020 Jan 14;30(2):497-509.e4.

Etoposide 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.70mL

0.34mL

0.17mL

8.50mL

1.70mL

0.85mL

16.99mL

3.40mL

1.70mL

Etoposide 技术信息

CAS号	33419-42-0
分子式	C₂₉H₃₂O₁₃
分子量	588.557

别名	依托泊甘 ;VP-16;VP-16-213;Demethyl Epipodophyllotoxin Ethylidine Glucoside. epipodophyllotoxin. US brand names: Toposar. VePesid. Foreign brand name: Lastet. Abbreviation: EPEG Code names: VP16;VP-16-123;NSC 141540;EPE
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Room Temperature

溶解度

DMSO: 40 mg/mL(67.96 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

5% DMSO+40% PEG 300+5% Tween 80+water 15 mg/mL

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

A549		Growth Inhibition Assay	48 h	IC50=241.9 ± 31.23 μM	24996136
A549		Growth Inhibition Assay	48 h	IC50=139.54 ± 7.05 μM	24793877
BGC-823		Growth Inhibition Assay	48 h	IC50=43.74 ± 5.13 μM	24793877
Caco2	0.5-2.5 μM	Growth Inhibition Assay	48 h	IC50=7.26 ± 1.68 μM	25746763
CAL27		Growth Inhibition Assay	24 h	IC50=52.1 ± 1.09 μM	25220729
CAL27		Growth Inhibition Assay	48 h	IC50=18.24 ± 1.15 μM	25220729
CAL27		Growth Inhibition Assay	72 h	IC50=4.27 ± 1.14 μM	25220729
COLO 205	0.5-2.5 μM	Growth Inhibition Assay	48 h	IC50=1.61 ± 0.02 μM	25746763
DOHH-2		Growth Inhibition Assay	24 h	IC50＞100 μM	25048236
DOHH-2		Growth Inhibition Assay	48 h	IC50=19.9 μM	25048236
DOHH-2		Growth Inhibition Assay	72 h	IC50=5 μM	25048236
DU145		Growth Inhibition Assay		IC50=2.28 ± 0.04 μM	25603122
DU145	10-100 μM	Apoptosis Assay	8 h	induces cell death significantly in a very low concentration	25149681
DU145	10-100 μM	Function Assay	2 h	increases the pCHK1 expression and decreases the pCHK1 expression in a dose-dependent manner	25149681
DU145 stem-like	10-100 μM	Apoptosis Assay	8 h	induces cell death in a dose-dependent manner	25149681
DU145 stem-like	10-100 μM	Function Assay	2 h	increases the pCHK1 expression and decreases the pCHK1 expression in a dose-dependent manner	25149681
FaDu		Growth Inhibition Assay	24 h	IC50=25.89 ± 1.13 μM	25220729
FaDu		Growth Inhibition Assay	48 h	IC50=6.43 ± 1.13 μM	25220729
FaDu		Growth Inhibition Assay	72 h	IC50=5.02 ± 1.15 μM	25220729
HCT116	0.5-2.5 μM	Growth Inhibition Assay	48 h	IC50=1.73 ± 0.21 μM	25746763
HCT15		Growth Inhibition Assay		IC50=0.81 ± 0.01 μM	25603122
HD-MY-Z		Growth Inhibition Assay	24/48/72 h	IC50＞100 μM	25048236
HEK293		Growth Inhibition Assay		IC50=7.14 ± 0.36 μM	25603122
HEK293T	1-5 μM	Growth Inhibition Assay	48 h	IC50=2.42 ± 0.05 μM	25746763
HeLa		Growth Inhibition Assay	72 h	IC50=3.9 ± 2.3 μM	25486219
HeLa		Growth Inhibition Assay		GI50=0.64 ± 0.4 μM	24953821
HeLa		Growth Inhibition Assay	48 h	IC50=4.71 ± 1.4 μM	24953027
HeLa		Growth Inhibition Assay	48 h	IC50=209.90 ± 13.42 μM	24793877
Hep3B	10 μM	Function Assay	48 h	reduces the enhancing effect of BMP-6	25633564
Hep3B	0.1-10 μM	Function Assay	24 h	suppresses the expression of hepcidin mRNA	25633564
HepG2		Growth Inhibition Assay		IC50=30.16 ± 0.50 μM	25078311
HepG2		Growth Inhibition Assay	48 h	IC50=13.65 ± 0.92 μM	24996136
HH		Growth Inhibition Assay	24 h	IC50=104.7 μM	25048236
HH		Growth Inhibition Assay	48 h	IC50=48.6 μM	25048236
HH		Growth Inhibition Assay	72 h	IC50=14.7 μM	25048236
HK-2		Growth Inhibition Assay	48 h	IC50=9.17 ± 1.58 μM	24793877
HL-60		Growth Inhibition Assay	72 h	IC50=0.12 μM	24993014
HL-60[R]		Growth Inhibition Assay	72 h	IC50=3.12 μM	24993014
HT1080	1-100 μM	Growth Inhibition Assay	4/24/48 h	induces cell death significantly in a very low concentration	25078064
HT1080	0.0001-100 μM	Function Assay	1-24 h	induces p-p53(ser15) in both time- and concentration-dependent manner	25078064
HT1080	0.0001-100 μM	Growth Inhibition Assay	24 h	causes an increase in the number of cells in G2/M, while decreasing S and G1 phase cells	25078064
HT-29	0.5-2.5 μM	Growth Inhibition Assay	48 h	IC50=7.2 ± 1.04 μM	25746763
HT-29		Growth Inhibition Assay	48 h	IC50=21.45 ± 3.87 μM	24953027
HuT-78		Growth Inhibition Assay	24 h	IC50=9.3 μM	25048236
HuT-78		Growth Inhibition Assay	48 h	IC50=4.3 μM	25048236
HuT-78		Growth Inhibition Assay	72 h	IC50=4.2 μM	25048236
Jurkat		Growth Inhibition Assay	72 h	IC50=1.2 ± 1.5 μM	25486219
K/VP.5		Growth Inhibition Assay	72 h	IC50=4.9 μM	25282653
K562		Growth Inhibition Assay	72 h	IC50=0.29 μM	25282653
Kelly		Growth Inhibition Assay		IC50=0.12 ± 0.01 μM	25960282
Kelly	0-10 μM	Growth Inhibition Assay	72 h	IC50=1.518 μM	25008900
KellyCis83		Growth Inhibition Assay		IC50=0.16 ± 0.02 μM	25960282
MCF 7BMI1	10-100 μM	Function Assay	2 h	induces production of γH2AX	25088203
MCF7	5-100 μM	Growth Inhibition Assay	7 d	inhibits cell growth in a dose-dependent manner	25472619
MCF7		Growth Inhibition Assay	48 h	IC50=81.09 ± 14.21 μM	24996136
MCF-7		Growth Inhibition Assay	72 h	IC50=10.9 ± 2.1 μM	25486219
MCF-7		Growth Inhibition Assay	48 h	IC50=7.2 ± 0.8 μM	25216378
MCF-7		Growth Inhibition Assay		GI50=0.25 ± 0.1 μM	24953821
MCF-7		Growth Inhibition Assay	48 h	IC50=23.9 ± 0.3 μM	24953027
MCF7 BMI1	10-100 μM	Function Assay	2 h	ETOP induces ATM activation	25088203
MCF7 EV	10-100 μM	Function Assay	2 h	induces production of γH2AX	25088203
MCF7 EV	10-100 μM	Function Assay	2 h	ETOP induces ATM activation	25088203
MDA-MB-231		Growth Inhibition Assay	72 h	IC50=21.2 ± 4.2 μM	25486219
MDA-MB-231		Growth Inhibition Assay	48 h	IC50=12.8 ± 1.0 μM	25216378
MDA-MB-231		Growth Inhibition Assay	48 h	IC50=24.22 ± 2.94 μM	24953027
MDA-MB-453		Growth Inhibition Assay	48 h	IC50=12.5 ± 0.85 μM	24953027
ME 180		Growth Inhibition Assay	48 h	IC50=8.9 ± 0.3 μM	24953027
MIAPACA		Growth Inhibition Assay		GI50=1.3 ± 0.03 μM	24953821
MKL-1	10-1000 nM	Function Assay	4 d	induces the induction of MHC-I expression	25116754
MO59J		Growth Inhibition Assay	7 d	IC50=0.1 μM	24953561
MO59K		Growth Inhibition Assay	7 d	IC50=0.17 μM	24953561
MOLT-3		Growth Inhibition Assay		IC50=0.051 ± 0.002 μM	25078311
NSCs	0.01-300 μM	Growth Inhibition Assay	48 h	IC50=0.3-3 μM	25119185
OPM-2		Growth Inhibition Assay	24 h	IC50=24.1 μM	25048236
OPM-2		Growth Inhibition Assay	48 h	IC50=4 μM	25048236
OPM-2		Growth Inhibition Assay	72 h	IC50=1.3 μM	25048236
PC-3		Growth Inhibition Assay	48 h	IC50=14.4 ± 3.23 μM	24953027
REH		Growth Inhibition Assay	24 h	IC50=0.027 μM	25048236
REH		Growth Inhibition Assay	48 h	IC50=0.014 μM	25048236
REH		Growth Inhibition Assay	72 h	IC50=0.015 μM	25048236
RPMI-8226		Growth Inhibition Assay	24 h	IC50=106.6 μM	25048236
RPMI-8226		Growth Inhibition Assay	48 h	IC50=91.1 μM	25048236
RPMI-8226		Growth Inhibition Assay	72 h	IC50=14.9 μM	25048236
SCC25		Growth Inhibition Assay	24 h	IC50=43.3 ± 1.12 μM	25220729
SCC25		Growth Inhibition Assay	48 h	IC50=20.86 ± 1.07 μM	25220729
SCC25		Growth Inhibition Assay	72 h	IC50=8.41 ± 1.11 μM	25220729
SH-EP	20 μg/ml	Function Assay	24 h	increases the expression of endogenous DEPP	25261981
SH-SY5Y	0-10 μM	Growth Inhibition Assay	72 h	IC50=0.754 μM	25008900
SK-N-AS		Growth Inhibition Assay		IC50=0.24 ± 0.03 μM	25960282
SK-N-AS	0-10 μM	Growth Inhibition Assay	72 h	IC50=1.712 μM	25008900
SK-N-ASCis24		Growth Inhibition Assay		IC50=0.57 ± 0.11 μM	25960282
SK-N-DZ	0-10 μM	Growth Inhibition Assay	72 h	IC50=5.485 μM	25008900
SMMC-7721	40 μM	Function Assay	48 h	induces γH2AX foci formation	25544361
SW480	0.5-2.5 μM	Growth Inhibition Assay	48 h	IC50=4.92 ± 0.33 μM	25746763
T47D		Growth Inhibition Assay		IC50=3.18 ± 0.11 μM	25603122
T-47D		Growth Inhibition Assay	48 h	IC50=7.7 ± 0.7 μM	25216378
U-266		Growth Inhibition Assay	24 h	IC50=86.2 μM	25048236
U-266		Growth Inhibition Assay	48 h	IC50=68.4 μM	25048236
U-266		Growth Inhibition Assay	72 h	IC50=27.4 μM	25048236
U87	0-50 μM	Growth Inhibition Assay	48 h	decreases cell viability which can be enhanced by silibinin	25750273
UW228-3	0.01-300 μM	Growth Inhibition Assay	48 h	IC50=0.99 μM	25119185

依托泊苷 /Etoposide {[allProObj[0].p_purity_real_show]}

Etoposide 纯度/质量文件产品仅供科研

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Etoposide 生物活性

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Etoposide 参考文献

Etoposide 实验方案

Etoposide 技术信息

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Etoposide 动物研究

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