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去甲氧基姜黄素 /Demethoxycurcumin {[allProObj[0].p_purity_real_show]}

货号：A982362 同义名： 脱甲氧姜黄 / Curcumin II;Desmethoxycurcumin

Monodemethoxycurcumin is a major active curcuminoid and possess anti-inflammatory properties and also exert cytotoxic effects in human cancer cells via induction of apoptosis.

Demethoxycurcumin 化学结构 CAS号：22608-11-3
Demethoxycurcumin 化学结构
CAS号：22608-11-3
Demethoxycurcumin 3D分子结构
CAS号：22608-11-3
Demethoxycurcumin 化学结构 CAS号：22608-11-3
Demethoxycurcumin 3D分子结构 CAS号：22608-11-3
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Demethoxycurcumin 纯度/质量文件 产品仅供科研

货号：A982362 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

 		98%
Loganin ++

AChE, IC50: 3.95 μM

 		99%+
topride HCl ++

AChE, IC50: 2.04 μM

 		98%
Dehydroevodiamine HCl ✔ 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

 		99%+
Palmatine ++

AChE, IC50: 0.51 μM

 		98%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		98%
Trospium chloride ✔ 99%
Tiotropium Bromide Monohydrate ✔ 98+%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		98%
Hexamethonium Bromide ✔ 99%
Pancuronium dibromide ✔ 98%
Neostigmine bromide ✔ 98%
Orphenadrine citrate ✔ 98%
Oxybutynin ✔ 98%
Irsogladine ✔ PDE 98%
Pyridostigmine bromide ✔ 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

 		98%
Paroxetine hydrochloride ✔ 97%
Rocuronium Bromide ✔ 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		98%
Diphenmanil methylsulfate ✔ 98%
Umeclidinium bromide ✔ 95%
Otilonium bromide ✔ 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		98%
Ipratropium bromide ✔ 98%
Diphenidol HCl ✔ 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		98%
Aclidinium Bromide ++++

M4 mAChR, Ki: 0.21 nM

M2 mAChR, Ki: 0.1 nM

 		98%
Oxybutynin chloride ✔ 99%
Pentoxyverine citrate ✔ 98%
Solifenacin ✔ 98%
Catharanthine ✔ 98%
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 Autophagy ↓ 其他靶点 纯度
SBI-0206965 +++

ULK2, IC50: 711 nM

ULK1, IC50: 108 nM

 		97%
Hydroxychloroquine sulfate ✔ 99%
Valproic acid sodium ✔ HDAC 97%
PFK-015 ++

PFKFB3, IC50: 207 nM

 		99%+
MRT68921 hydrochloride ++++

ULK2, IC50: 1.1 nM

ULK1, IC50: 2.9 nM

 		99%+
ROC-325 ✔ 99%+
Autophinib +++

Autophagy, IC50: 40 nM

 		97%
Lys05 ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Demethoxycurcumin 生物活性

描述 Monodemethoxycurcumin (demethoxycurcumin) is a major active curcuminoid and possess anti-inflammatory properties and also exert cytotoxic effects in human cancer cells via induction of apoptosis. DMC (demethoxycurcumin) significantly decreased NO secretion by 35-41% in our inflamed cell model[3]. Genes associated with DNA damage and repair, cell-cycle check point and apoptosis could be altered by DMC; in particular, 144 genes were found up-regulated and 179 genes down-regulated in NCI-H460 cells after exposure to DMC[4]. Administration of DMC to PD rats eased the protein expression of dopaminergic and apoptotic indices[5]. DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors[6].

Demethoxycurcumin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01982734 Pharmacokinetics of New Curcum... 展开 >>in Formulations Safety of New Curcumin Formulations 收起 << Early Phase 1 Completed - Germany ... 展开 >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 收起 <<
NCT01330810 Comparative Multidose Pharmaco... 展开 >>kinetics 收起 << Phase 1 Completed - United States, North Carolina ... 展开 >> UNC Department of Family Medicine Chapel Hill, North Carolina, United States, 27599 收起 <<
NCT03621865 Healthy Not Applicable Completed - France ... 展开 >> Biofortis Mérieux NutriSciences Saint-Herblain, France, 44800 收起 <<

Demethoxycurcumin 参考文献

[1]Somchit M, Changtam C, et al. Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model. Asian Pac J Cancer Prev. 2014;15(4):1807-10.

[2]Wang X, Kim JR, et al. Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models. BMC Complement Altern Med. 2014 Mar 5;14:88.

[3]Somchit M, Changtam C, Kimseng R, Utaipan T, Lertcanawanichakul M, Suksamrarn A, Chunglok W. Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model. Asian Pac J Cancer Prev. 2014;15(4):1807-10

[4]Ko YC, Hsu SC, Liu HC, Hsiao YT, Hsia TC, Yang ST, Hsu WH, Chung JG. Demethoxycurcumin alters gene expression associated with DNA damage, cell cycle and apoptosis in human lung cancer NCI-H460 cells in vitro. In Vivo. 2015 Jan-Feb;29(1):83-94. Erratum in: In Vivo. 2015 Nov-Dec;29(6):777

[5]Ramkumar M, Rajasankar S, Swaminathan Johnson WM, Prabu K, Venkatesh Gobi V. Demethoxycurcumin ameliorates rotenone-induced toxicity in rats. Front Biosci (Elite Ed). 2019 Jan 1;11:1-11

[6]Chueh FS, Lien JC, Chou YC, Huang WW, Huang YP, Huang JY, Kuo JY, Huang WN, Sheng SY, Tung HY, Chen HY, Peng SF. Demethoxycurcumin Inhibits In Vivo Growth of Xenograft Tumors of Human Cervical Cancer Cells. In Vivo. 2020 Sep-Oct;34(5):2469-2474

Demethoxycurcumin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.78mL

2.96mL

1.48mL

29.56mL

5.91mL

2.96mL

Demethoxycurcumin 技术信息

CAS号22608-11-3
分子式C20H18O5
分子量 338.35
别名 脱甲氧姜黄 ;Curcumin II;Desmethoxycurcumin;DMC;Monodemethoxycurcumin
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C
溶解度

DMSO: 105 mg/mL(310.33 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Demethoxycurcumin | 22608-11-3 | Curcumin II | Desmethoxycurcumin | Monodemethoxycurcumin | Bacterial Inhibitor | Apoptosis | Autophagy | Anti-infection | Apoptosis | Autophagy | Bacterial | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Demethoxycurcumin 纯度/质量文件 | Demethoxycurcumin 亚型比较 | Demethoxycurcumin 生物活性 | Demethoxycurcumin 临床数据 | Demethoxycurcumin 参考文献 | Demethoxycurcumin 实验方案 | Demethoxycurcumin 技术信息

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