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/ Hydroxychloroquine sulfate

硫酸羟基氯喹 /Hydroxychloroquine sulfate {[allProObj[0].p_purity_real_show]}

货号：A105779 同义名： 硫酸羟氯喹 / HCQ sulfate;Hydroxychloroquine (sulfate) (CRM)

Hydroxychloroquine sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9.

Hydroxychloroquine sulfate 化学结构 CAS号：747-36-4
Hydroxychloroquine sulfate 化学结构
CAS号：747-36-4
Hydroxychloroquine sulfate 3D分子结构
CAS号：747-36-4
Hydroxychloroquine sulfate 化学结构 CAS号：747-36-4
Hydroxychloroquine sulfate 3D分子结构 CAS号：747-36-4
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Hydroxychloroquine sulfate 纯度/质量文件 产品仅供科研

货号：A105779 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Autophagy ↓ 其他靶点 纯度
SBI-0206965 +++

ULK1, IC50: 108 nM

ULK2, IC50: 711 nM

 		97%
Hydroxychloroquine sulfate ✔ 99%
Valproic acid sodium ✔ HDAC 97%
PFK-015 ++

PFKFB3, IC50: 207 nM

 		99%+
MRT68921 hydrochloride ++++

ULK1, IC50: 2.9 nM

ULK2, IC50: 1.1 nM

 		99%+
ROC-325 ✔ 99%+
Autophinib +++

Autophagy, IC50: 40 nM

 		97%
Lys05 ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Hydroxychloroquine sulfate 生物活性

靶点

  • Autophagy
描述 Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling. It is effective at inhibiting SARS-CoV-2 infection in vitro[1].[2].[3].
体内研究

Hydroxychloroquine sulfate is also prescribed for lupus treatment, and together with its analog chloroquine, it inhibits TLR7 and TLR9 signaling[2].
体外研究

Originally derived from 4-aminoquinoline, it has been used for several decades to treat rheumatic diseases such as rheumatoid arthritis (RA)[1].

At a concentration of five micromolar, Hydroxychloroquine sulfate or chloroquine does not affect intracellular pH, though it can inhibit TLR9 or 7 signaling triggered by DNA or RNA ligands[2].

Hydroxychloroquine sulfate 动物研究

Dose Mice: 3 mg/kg - 100 mg/kg[3] (p.o.) Dog: 7.5 mg/kg - 12.5 mg/kg[4] (p.o.)
Administration p.o.

Hydroxychloroquine sulfate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02603146 Healthy Participants ... 展开 >> Rheumatoid Arthritis (RA) Prevention 收起 << Phase 2 Recruiting March 2020 -
NCT01897116 Melanoma Phase 1 Completed - United States, Pennsylvania ... 展开 >> Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 收起 <<
NCT00430807 Giant Cell Arteritis Phase 3 Completed - France ... 展开 >> Hospital Agen, France, 47923 Hospital Albi, France, 81000 Hospital Auch Auch, France, 32008 Hospital Avignon Avignon, France, 84902 University Hospital Besançon Besançon, France, 25030 Hospital Béziers Beziers, France, 34525 University Hospital Côte de Nacre Caen, France, 14033 University Hospital Dijon Dijon, France, 21035 Hospital Foix, France, 09017 Hospital Lavaur, France, 81500 University Hospital Dupuytren Limoges, France, 87042 Hospital Lisieux, France, 14100 Hospital Lourdes, France, 65107 Hospital Mazamet, France, 81200 Hospital Montauban, France, 82013 University Hospital Nantes, France, 44035 Saint Louis Hospital Paris, France, 75010 University Hospital Saint Antoine Paris, France, 75012 University Hospital Bichat Paris, France, 75018 Hospital Suresnes Suresnes, France, 92151 University Hospital Toulouse Toulouse, France, 31059 University Hospital Toulouse, France, 31059 University Hospital Bretonneau Tours, France, 37044 收起 <<

Hydroxychloroquine sulfate 参考文献

[1]Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6.

[2]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

[3]Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

Hydroxychloroquine sulfate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.30mL

0.46mL

0.23mL

11.52mL

2.30mL

1.15mL

23.04mL

4.61mL

2.30mL

Hydroxychloroquine sulfate 技术信息

CAS号747-36-4
分子式C18H28ClN3O5S
分子量 433.95
别名 硫酸羟氯喹 ;HCQ sulfate;Hydroxychloroquine (sulfate) (CRM);HCQ;NSC 4375
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 105 mg/mL(241.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(230.44 mM)
动物实验配方

PO 0.5% CMC-Na 120 mg/mL clear

Tags: Hydroxychloroquine sulfate | HCQ sulfate;Hydroxychloroquine (sulfate) (CRM);HCQ;NSC 4375 | 硫酸羟氯喹 | Insect Repellent | Autophagy | TLR | AmBeed-信号通路专用抑制剂 | Hydroxychloroquine sulfate 纯度/质量文件 | Hydroxychloroquine sulfate 亚型比较 | Hydroxychloroquine sulfate 生物活性 | Hydroxychloroquine sulfate 动物研究 | Hydroxychloroquine sulfate 临床数据 | Hydroxychloroquine sulfate 参考文献 | Hydroxychloroquine sulfate 实验方案 | Hydroxychloroquine sulfate 技术信息

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