Hyperoside, a natural product isolated and purified from the herb of Hypericum perforatum L., with neuro-protective, anti-inflammatory and antioxidative effects, promotes ECV304 cell proliferation, may cause herb-drug interactions when co-administrated with CYP2D substrates and serve as a protective agent by alleviating microglia activation in disorders such as Parkinson's disease.
Hyperoside (quercetin 3-o-β-d-galactopyranoside) is one of the flavonoid glycosides with anti-inflammatory, antidepressant, and anti-cancer effects. The viability and migration capability of Michigan Cancer Foundation-7 (MCF-7) and 4T1 cells were inhibited by hyperoside, while the apoptosis of cells were increased. Tumor volume was significantly decreased in subcutaneous homotransplant mouse model in hyperoside-treated group[3]. Hyp (Hyperoside) inhibited IL-1β-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, Hyp attenuated IL-1β-induced destruction of the extracellular matrix (ECM) by downregulating the expression of MMPs and ADAMTS5, and meanwhile upregulating the expression of collagen II, aggrecan, and SOX9. Also, Hyp pretreatment reduced IL-1β-induced overproduction of ROS and apoptosis of chondrocytes[4]. Hyperoside treatment ameliorated fibrotic pathological changes and collagen deposition in the lungs of mice with bleomycin-induced pulmonary fibrosis. In addition, hyperoside might inhibit the epithelial-mesenchymal transition (EMT) via the AKT/GSK3β pathway[5]. Hyperoside has potential therapeutic properties against periodontitis via promotion of proliferation and osteogenic differentiation of rBMSCs (rat bone mesenchymal stem cells) via activation of the NF-κB signaling pathway[6].
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