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/ Hyperoside

金丝桃苷 /Hyperoside {[allProObj[0].p_purity_real_show]}

货号：A795483 同义名： 金丝桃甙 / Quercetin-3-O-galactoside;NSC 407304

Hyperoside是从 Hypericum perforatum L.（贯叶连翘）中提取的天然产物，具有神经保护、抗炎和抗氧化作用，能促进 ECV304 细胞增殖，可能与 CYP2D 底物共同使用时发生药物相互作用，并通过缓解小胶质细胞的激活，在帕金森病等疾病中起到保护作用。

Hyperoside 化学结构 CAS号：482-36-0
Hyperoside 化学结构
CAS号：482-36-0
Hyperoside 3D分子结构
CAS号：482-36-0
Hyperoside 化学结构 CAS号：482-36-0
Hyperoside 3D分子结构 CAS号：482-36-0
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Hyperoside 纯度/质量文件 产品仅供科研

货号：A795483 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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更多 >
产品名称 Ca2+ channel-like protein ↓ Calcium Channel ↓ Cav 2.2 ↓ 其他靶点 纯度
CDC25B-IN-2 ✔ Akt 99%+
Clevidipine ✔ 97%
Verapamil HCl ✔ 99%
Amlodipine ✔ 99%
Amlodipine maleate ✔ 98%
(+)-cis-Diltiazem HCl ✔ 99%
Zegocractin ++

Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM

 		99%+
Tanshinone IIA sulfonate sodium ✔ 98%
Ulixacaltamide ++

hCaV3.2, IC50: 110 nM

hCaV3.1, IC50: 50 nM

 		99%+
Dronedarone Hydrochloride ✔ 95%
Nitrendipine +

Calcium channel, IC50: 95 nM

 		98%
Efonidipine HCl monoethanolate ✔ 98%
Cinnarizine ✔ 98%
SEA0400 ++

NCX, IC50: 33 nM

 		p38 MAPK,ERK,ROS 99%+
Fasudil HCl ✔ Rho,PKA 98%
ML-9 ✔ MLCK,Akt 99%+
Flunarizine 2HCl +

Calcium channel, Ki: 68 nM

 		95%
Lomerizine 2HCl ✔ 98%
Efonidipine ✔ 98%
Levamlodipine ✔ 98%
Nisoldipine ++

L-type Cav1.2, IC50: 10 nM

 		97%
Isradipine ✔ 98%
Lacidipine ✔ 98%
Lercanidipine ✔ 99%
Loureirin B ✔ Potassium Channel 99%+
Tetracaine HCl ✔ 98%
Manidipine +++

Calcium channel, IC50: 2.6 nM

 		99%
Manidipine Dihydrochlorid +++

Calcium channel, IC50: 2.6 nM

 		98%
Nicardipine ✔ 99%
Wilforgine ✔ 98+%
Econazole ✔ 99%+
Ginsenoside Rd ✔ NF-κB 98%
Fendiline HCl ✔ 98+%
Mesaconitine ✔ 98%
Tetrandrine ✔ 95%
Nifedipine ✔ 95%
Nilvadipine ++++

Calcium channel, IC50: 0.03 nM

 		98%
Barnidipine ++++

[3H]nitrendipine, Ki: 0.21 nM

 		95+%
Azelnidipine ✔ 97%
Levetiracetam ✔ 98%
Nimodipine ✔ 95%
Benidipine HCl ✔ 98%
Pinaverium bromide ✔ 98%
Pranidipine ✔ 99%
NP118809 +

L-type calcium channel, IC50: 12.2 μM

N-type Ca2+ channel, IC50: 0.11 μM

 		98%
Amlodipine Besylate +++

Calcium channel, IC50: 1.9 nM

 		97%
Cilnidipine ✔ 99%
Cinepazide Maleate ✔ 99% (HPLC)
Terfenadine ✔ 98%
YM-58483 ✔ 99%+
Ranolazine ✔ 98%
Praeruptorin A ✔ p38 MAPK,Akt 98%
Ranolazine 2HCl ✔ 98%
Felodipine ++++

L-type calcium channel, IC50: 0.15 nM

 		98%
PD173212 +++

N-type Ca2+ channel, IC50: 36 nM

 		98%
Levamlodipine besylate ✔ 97%
Carboxyamidotriazole Orotate ✔ 98%
IGS-1.76 ✔ 98+%
WH-4-023 ++++

Cav 2.2, IC50: 0.001 μM

 		++++

Cav 2.2, IC50: 0.001 μM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 NF-κB ↓ 其他靶点 纯度
PDTC ammonium ✔ 98%
QNZ ++++

NF-κB, IC50: 11 nM

 		99%+
Sodium 4-Aminosalicylate Dihydrate ✔ 98%
Sodium Salicylate ✔ 95%
Parthenolide ✔ p53 97% HPLC
JSH-23 +

NF-κB, IC50: 7.1 μM

 		98%
Phenethyl caffeate ✔ 98%
Andrographolide ✔ 98+%
Curcumin ✔ Nrf2,HDAC 98%
SC75741 +++

NF-κB, EC50: 200 nM

 		99%+
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

 		p53 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Hyperoside 生物活性

描述 Hyperoside (quercetin 3-o-β-d-galactopyranoside) is one of the flavonoid glycosides with anti-inflammatory, antidepressant, and anti-cancer effects. The viability and migration capability of Michigan Cancer Foundation-7 (MCF-7) and 4T1 cells were inhibited by hyperoside, while the apoptosis of cells were increased. Tumor volume was significantly decreased in subcutaneous homotransplant mouse model in hyperoside-treated group[3]. Hyp (Hyperoside) inhibited IL-1β-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, Hyp attenuated IL-1β-induced destruction of the extracellular matrix (ECM) by downregulating the expression of MMPs and ADAMTS5, and meanwhile upregulating the expression of collagen II, aggrecan, and SOX9. Also, Hyp pretreatment reduced IL-1β-induced overproduction of ROS and apoptosis of chondrocytes[4]. Hyperoside treatment ameliorated fibrotic pathological changes and collagen deposition in the lungs of mice with bleomycin-induced pulmonary fibrosis. In addition, hyperoside might inhibit the epithelial-mesenchymal transition (EMT) via the AKT/GSK3β pathway[5]. Hyperoside has potential therapeutic properties against periodontitis via promotion of proliferation and osteogenic differentiation of rBMSCs (rat bone mesenchymal stem cells) via activation of the NF-κB signaling pathway[6].

Hyperoside 参考文献

[1]Huo Y, Yi B, et al. Induction of Nur77 by hyperoside inhibits vascular smooth muscle cell proliferation and neointimal formation. Biochem Pharmacol. 2014 Dec 15;92(4):590-8.

[2]Ku SK, Zhou W, et al. Anti-inflammatory effects of hyperoside in human endothelial cells and in mice. Inflammation. 2015 Apr;38(2):784-99.

[3]Qiu J, Zhang T, Zhu X, Yang C, Wang Y, Zhou N, Ju B, Zhou T, Deng G, Qiu C. Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway. Int J Mol Sci. 2019 Dec 24;21(1):131

[4]Sun K, Luo J, Jing X, Xiang W, Guo J, Yao X, Liang S, Guo F, Xu T. Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study. Phytomedicine. 2021 Jan;80:153387

[5]Huang J, Tong X, Zhang L, Zhang Y, Wang L, Wang D, Zhang S, Fan H. Hyperoside Attenuates Bleomycin-Induced Pulmonary Fibrosis Development in Mice. Front Pharmacol. 2020 Oct 22;11:550955

[6]Xu T, Wu X, Zhou Z, Ye Y, Yan C, Zhuge N, Yu J. Hyperoside ameliorates periodontitis in rats by promoting osteogenic differentiation of BMSCs via activation of the NF-κB pathway. FEBS Open Bio. 2020 Sep;10(9):1843-1855

Hyperoside 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.22mL

10.77mL

2.15mL

1.08mL

21.53mL

4.31mL

2.15mL

Hyperoside 技术信息

CAS号482-36-0
分子式C21H20O12
分子量 464.376
别名 金丝桃甙 ;Quercetin-3-O-galactoside;NSC 407304;Quercetin 3-D-galactoside;Quercetin 3-galactoside;Hyperin
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C
溶解方案

DMSO: 120 mg/mL(258.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方

Tags: Hyperoside | Quercetin-3-O-galactoside;NSC 407304;Quercetin 3-D-galactoside;Quercetin 3-galactoside;Hyperin | 金丝桃甙 | Apoptosis Inducer | Plant Standard | Calcium Channel | Apoptosis | Influenza Virus | NF-κB | Antifungal | Hypericum | Flavonoids | AmBeed-信号通路专用抑制剂 | Hyperoside 纯度/质量文件 | Hyperoside 亚型比较 | Hyperoside 生物活性 | Hyperoside 参考文献 | Hyperoside 实验方案 | Hyperoside 技术信息

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