Hyperoside

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Chemical Structure| 482-36-0 同义名 : 金丝桃甙 ;Quercetin-3-O-galactoside;NSC 407304;Quercetin 3-D-galactoside;Quercetin 3-galactoside;Hyperin
CAS号 : 482-36-0
货号 : A795483
分子式 : C21H20O12
纯度 : 99%+
分子量 : 464.376
MDL号 : MFCD00016933
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(258.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Hyperoside (quercetin 3-o-β-d-galactopyranoside) is one of the flavonoid glycosides with anti-inflammatory, antidepressant, and anti-cancer effects. The viability and migration capability of Michigan Cancer Foundation-7 (MCF-7) and 4T1 cells were inhibited by hyperoside, while the apoptosis of cells were increased. Tumor volume was significantly decreased in subcutaneous homotransplant mouse model in hyperoside-treated group[3]. Hyp (Hyperoside) inhibited IL-1β-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, Hyp attenuated IL-1β-induced destruction of the extracellular matrix (ECM) by downregulating the expression of MMPs and ADAMTS5, and meanwhile upregulating the expression of collagen II, aggrecan, and SOX9. Also, Hyp pretreatment reduced IL-1β-induced overproduction of ROS and apoptosis of chondrocytes[4]. Hyperoside treatment ameliorated fibrotic pathological changes and collagen deposition in the lungs of mice with bleomycin-induced pulmonary fibrosis. In addition, hyperoside might inhibit the epithelial-mesenchymal transition (EMT) via the AKT/GSK3β pathway[5]. Hyperoside has potential therapeutic properties against periodontitis via promotion of proliferation and osteogenic differentiation of rBMSCs (rat bone mesenchymal stem cells) via activation of the NF-κB signaling pathway[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.22mL

10.77mL

2.15mL

1.08mL

21.53mL

4.31mL

2.15mL
参考文献

[1]Huo Y, Yi B, et al. Induction of Nur77 by hyperoside inhibits vascular smooth muscle cell proliferation and neointimal formation. Biochem Pharmacol. 2014 Dec 15;92(4):590-8.

[2]Ku SK, Zhou W, et al. Anti-inflammatory effects of hyperoside in human endothelial cells and in mice. Inflammation. 2015 Apr;38(2):784-99.

[3]Qiu J, Zhang T, Zhu X, Yang C, Wang Y, Zhou N, Ju B, Zhou T, Deng G, Qiu C. Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway. Int J Mol Sci. 2019 Dec 24;21(1):131

[4]Sun K, Luo J, Jing X, Xiang W, Guo J, Yao X, Liang S, Guo F, Xu T. Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study. Phytomedicine. 2021 Jan;80:153387

[5]Huang J, Tong X, Zhang L, Zhang Y, Wang L, Wang D, Zhang S, Fan H. Hyperoside Attenuates Bleomycin-Induced Pulmonary Fibrosis Development in Mice. Front Pharmacol. 2020 Oct 22;11:550955

[6]Xu T, Wu X, Zhou Z, Ye Y, Yan C, Zhuge N, Yu J. Hyperoside ameliorates periodontitis in rats by promoting osteogenic differentiation of BMSCs via activation of the NF-κB pathway. FEBS Open Bio. 2020 Sep;10(9):1843-1855